Dual . isolated anti-Ro antibody positivity in rheumatoid arthritis.

Objective: This study aimed to evaluate the clinical and immunological significance of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies in rheumatoid arthritis (RA), particularly the association of dual antibody positivity with disease severity, systemic manifestations, and therapeutic resistance.

Methods: We conducted a cohort study involving 670 RA patients, stratified into four groups according to anti-Ro52 and anti-Ro60 antibody status: Ro52+/Ro60+, Ro52+/Ro60-, Ro52-/Ro60+, and Ro52-/Ro60-. Clinical characteristics, disease activity scores (DAS28-ESR, DAS28-CRP), systemic complications, and treatment responses were compared among groups.

Dual positivity for Anti-Ro52 and Anti-Ro60 antibodies is linked to greater organ involvement and disease progression in systemic sclerosis.

Objectives: To investigate the distinct and combined effects of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies on the clinical features and prognosis of patients with systemic sclerosis (SSc).

Methods: A single-center observational study was conducted using data from the Renji Scleroderma Longitudinal Cohort (Renji-SLOC), including 379 SSc patients with at least 1 year of follow-up. The patients were categorized into four groups based on serological status: double-negative (Ro52/Ro60), isolated anti-Ro52/TRIM21 positive (Ro52), isolated anti-Ro60/SSA positive (Ro60), double-positive (Ro52/Ro60).

Self-referenced electro-optic response measurement of dual-parallel Mach-Zehnder modulators employing single-tone level control and low-frequency bias swing.

A self-referenced method is proposed to characterize the electro-optic frequency response of dual-parallel Mach-Zehnder modulators (DPMZMs) based on single-tone level control and low-frequency bias swing. The single-tone driving signal and the low-frequency bias signal of the DPMZM mix with each other after photodetection, and a low-frequency beat note is generated in the electrical domain. The functional relationship between the desired low-frequency amplitude and the single-tone driving level is investigated and established, from which the modulation depth and half-wave voltage are extracted with the help of regression analysis.

Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma.

The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The microenvironment provides an optimum condition for the initiation, growth, and dissemination of hepatocellular carcinoma (HCC). As one of the critical and abundant components in tumor microenvironment, cancer-associated fibroblasts (CAFs) have been implicated in the progression of HCC.

A meta-analysis of secondary osteoporosis in systemic lupus erythematosus: prevalence and risk factors.

Purpose: This study aimed to evaluate the prevalence and risk factors of secondary osteoporosis (OP) in patients with systemic lupus erythematosus (SLE) and provide a theoretical basis for clinical prevention and treatment of SLE.

Methods: Take systematic review and meta-analysis of relevant studies. Data sources are CINAHL databases, PubMed, Embase, Wan Fang, Weipu, and CNKI databases.

Periodontal disease in Chinese patients with rheumatoid arthritis: A case-control study.

Objective: To evaluate the prevalence and severity of periodontal disease in Chinese rheumatoid arthritis patients.

Subjects And Methods: This cross-sectional study included 128 RA and 109 healthy controls. Two dentists conducted periodontal status including Plaque index (PI), Gingival index (GI), pocket probing depths (PPDs), Clinical attachment level (CAL) and Bleeding on probing (BOP) independently.

The impact of systemic lupus erythematosus on health-related quality of life assessed using the SF-36: a systematic review and meta-analysis.

To identify the impact of systemic lupus erythematosus (SLE) on health-related quality of life (HRQoL) domains compared with the results of healthy controls by systematically reviewing the literature. A systematic literature search was performed on MEDLINE, Web of Science and EMBASE until April, 2018 to obtain eligible studies reporting mean and standard deviation scores for each domain of the 36-item Short-Form Health Survey (SF-36) in SLE patients and healthy controls. Random effect model was performed to summarize the scores of each domain.