The Orofacial Somatosensory Changes of Edentulous Mandible After Full Arch Implant Surgery-A Six-Month Follow Up.

Aims: To evaluate somatosensory function changes and recovery time in patients with mandibular edentulous jaw after full arch flap implant surgery using a standardized quantitative sensory testing (QST) protocol.

Materials And Methods: Fourteen patients with edentulous mandibles underwent full-arch alveolar flap implant surgery, with three to four implants placed in each case. A QST battery including cold detection threshold (CDT), warmth detection threshold (WDT), thermal sensory limen (TSL), paradoxical heat sensation (PHS), cold pain threshold (CPT), heat pain threshold (HPT), mechanical detection threshold (MDT), mechanical pain threshold (MPT), wind-up ratio (WUR), vibration detection threshold (VDT), and pressure pain threshold (PPT) was performed at skin of mental region and keratinized gingiva of right canine.

Extensive nrDNA Polymorphism in L. and Its Application.

The internal transcribed spacer (ITS) is one of the most extensively utilized in the taxonomy of the genus due to its generally concerted evolution. Although non-concerted evolution of nuclear ribosomal DNA (nrDNA) has been reported in some species, genome-wide nrDNA characteristics in the genus remain poorly understood. In this study, 158 single-nucleotide polymorphisms (SNPs) and 15 insertions and deletions (InDels) were identified within the nrDNA regions of 542 mulberry accessions representing sixteen species.

Diosmetin augments BRAF-targeted therapy via concurrent suppression of MAPK and STAT3 pathways in melanoma.

Despite the well-established therapeutic benefits of BRAF inhibitors in prolonging progression-free survival (PFS) for melanoma patients with BRAF mutants, their long-term efficacy is often compromised by the emergence of acquired resistance, particularly through compensatory activation of Janus kinase 2/Signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. Confronting this challenge, concurrent inhibition of Mitogen-activated protein kinase (MAPK) and JAK2/STAT3 pathways offers a novel approach to overcome therapeutic resistance. Diosmetin (DIOS), a naturally occurring flavonoid compound, has a spectrum of bioactivities including antioxidant, anti-infective, and anti-tumor properties.

Heterogeneity of anxiety in vitiligo: A systematic review and quantitative analysis with a focus on adolescents.

Background: Although anxiety has emerged as a prevalent comorbidity among vitiligo patients, a comprehensive investigation into its relationship with the disorder, incorporating recent discoveries, remains elusive.

Objective: This study aims to conduct a systematic review with quantitative synthesis examining the anxiety-vitiligo relationship across populations, with an emphasis on adolescents.

Methods: A systematic search was conducted across four major databases, spanning their inception to April 30, 2025.

Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment.

Background: Melanoma is a highly aggressive form of skin cancer. Despite significant advances in targeted therapies and immunotherapeutic approaches, some patients still have poor response rates, making a deeper understanding of melanoma pathogenesis essential.

Methods: The expression of Claspin (CLSPN), prognosis and immune infiltration in skin cutaneous melanoma patients were analyzed by public databases.

Molybdenum-modified ZnInS with a bifunctional cocatalyst for efficient photocatalytic overall water splitting under simulated sunlight.

Photocatalytic overall water splitting (POWS) is a promising technique for sustainable hydrogen production that can potentially tackle the current energy and environmental challenges. As a visible-light-active photocatalyst, ZnInS is an ideal candidate for POWS; however, it exhibits low efficiency due to poor charge separation and improper surface reactions. Here, ZnInS was modified by doping Mo and depositing a bifunctional cocatalyst for efficient POWS under sunlight.

Genistein reverses the exacerbating effect of 17β-estradiol on experimental occlusal interference induced chronic masseter hyperalgesia through suppressing ERK1/2 signal pathway in spinal trigeminal nucleus of ovariectomized rats.

Background: Temporomandibular disorder (TMD) pain is more prevalent in females than in males, with high estrogen levels potentially being a risk factor. Research indicates that 17β-estradiol (E2) exacerbates experimental occlusal interference (EOI)-induced orofacial hyperalgesia, which can be reversed by genistein. This study aimed to explore the central mechanisms within the spinal trigeminal nucleus (Sp5) related to the pain-exacerbating effect of E2 and the antiestrogenic properties of genistein in a model of EOI-induced chronic masseter pain.

Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K/AKT pathway in mice.

Aflatoxin B1 (AFB1), a prevalent agricultural mycotoxin, represents a serious health hazard to humans and animals owing to its toxic effects. Diosmetin (DIOS), a naturally occurring flavonoid, has demonstrated potential hepatoprotective properties. This research seeks to investigate the mechanisms by which DIOS mitigates AFB1-induced hepatotoxicity in mice.

CRKL silencing inhibits melanoma growth and enhances its chemotherapy sensitivity through the PI3K/AKT and NLRP3/GSDMD pathways.

Great advances have been made in malignant melanoma treatments, whereas drug resistance still limits many drug applications. CRKL has been reported to be overexpressed in various tumors and showed poor prognosis. However, its specific function and mechanism in melanoma remain unclear.

Effects of Citrus-derived Diosmetin on Melanoma: Induction of Apoptosis and Autophagy Mediated by PI3K/Akt/mTOR Pathway Inhibition.

Background: Diosmetin (DIOS) is a naturally abundant flavonoid and possesses various biological activities that hold promise as an anti-cancer agent. However, the anti-cancer activities and underlying mechanism of DIOS on cutaneous melanoma remain unclear.

Objective: This study seeks to explore the anti-tumor effect and mechanism of DIOS in cutaneous melanoma.

Fluorine-expedited nitridation of layered perovskite SrTiO for visible-light-driven photocatalytic overall water splitting.

Photocatalytic overall water splitting is a promising approach for a sustainable hydrogen provision using solar energy. For sufficient solar energy utilization, this reaction ought to be operated based on visible-light-active semiconductors, which is very challenging. In this work, an F-expedited nitridation strategy is applied to modify the wide-bandgap semiconductor SrTiO for visible-light-driven photocatalytic overall water splitting.

Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage.

Although cisplatin is a widely used chemotherapeutic agent, it is severely toxic and causes irreversible hearing loss, restricting its application in clinical settings. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. Here, we established in vitro and in vivo ototoxicity models of cisplatin-induced hair cell loss, and our results showed that reducing STING levels decreased inflammatory factor expression and hair cell death.

Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.

Chitosan oligosaccharide (COS), a water-soluble derivative of chitin, has been recognized for its diverse biological properties. Deoxynivalenol (DON) is a prevalent mycotoxin, causing extreme liver damage. However, the mechanism whereby COS alleviates DON-induced liver injury remains unclear.

The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.

Background: Tumor-associated tertiary lymphoid structures (TLSs) are functional immune-responsive aggregates, which have been reported to be associated with better prognosis in various tumors. However, their exact characteristics and prognostic value in extramammary Paget's disease (EMPD) remain unknown.

Objective: To explore the features of TLSs in EMPD and their association with clinicopathological characteristics.

Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.

The current study investigated differences in ethanol-induced apoptosis of spinal cord dorsal horn neurons at different developmental stages and the molecular mechanisms involved. A mouse ethanol intervention model was established on postnatal days 4, 7, and 12. Primary cells were derived from the spinal cord at postnatal day 4.

An Artificial Leaf with Patterned Photocatalysts for Sunlight-Driven Water Splitting.

Plant leaves can turn entirely absorbed light into chemical energy due to their spatially separated photosystems I and II in the thylakoid membrane that enables unidirectional Z-scheme type charge transfer between them. In artificial systems that mimic leaves, a lack of spatial and interfacial control of active units (i.e.

Illness perception and family resilience in gynaecologic cancer patients: A study on the mediating role of hope.

Objective: To investigate the level of family resilience among patients with gynaecologic cancer and explore hope as a mediator between perceptions of illness and family resilience.

Design: A cross-sectional study.

Method: From May to October 2022, researchers used convenience sampling to survey 320 patients with gynaecological cancer at a level 3A hospital in Jinan City.

Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis.

The endoplasmic reticulum (ER) is the main site of protein synthesis, transport, and modification. Its abnormal status has now emerged as an established cause of many pathological processes, such as tumors and autoimmune diseases. Recent studies also demonstrated that the defective functions of ER may lead to pigmentary diseases.

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

Pathological retinal angiogenesis is not only the hallmark of retinopathies, but also a major cause of blindness. Guanylate binding protein 2 (GBP2) has been reported to be associated with retinal diseases such as diabetic retinopathy and hypoxic retinopathy. However, GBP2-mediated pathological retinal angiogenesis remains largely unknown.

Corn straw-saccharification fiber improved the reproductive performance of sows in the late gestation and lactation via lipid metabolism.

With the development of animal husbandry, the shortage of animal feedstuffs has become serious. Dietary fiber plays a crucial role in regulating animal health and production performance. The aim of this study was to investigate the effects of three kinds of corn straw-saccharification fibers (CSSF) such as high-fiber and low-saccharification (HFLS), medium-fiber and medium-saccharification (MFMS), low-fiber and high-saccharification (LFHS) CSSF on the reproductive performance of sows.

Liquid metal-embraced photoactive films for artificial photosynthesis.

The practical applications of solar-driven water splitting pivot on significant advances that enable scalable production of robust photoactive films. Here, we propose a proof-of-concept for fabricating robust photoactive films by a particle-implanting technique (PiP) which embeds semiconductor photoabsorbers in the liquid metal. The strong semiconductor/metal interaction enables resulting films efficient collection of photogenerated charges and superior photoactivity.

Enhancing regenerative medicine: the crucial role of stem cell therapy.

Stem cells offer new therapeutic avenues for the repair and replacement of damaged tissues and organs owing to their self-renewal and multipotent differentiation capabilities. In this paper, we conduct a systematic review of the characteristics of various types of stem cells and offer insights into their potential applications in both cellular and cell-free therapies. In addition, we provide a comprehensive summary of the technical routes of stem cell therapy and discuss in detail current challenges, including safety issues and differentiation control.

Crystal Facet Engineering on SrTiO Enhances Photocatalytic Overall Water Splitting.

Single-crystal semiconductor-based photocatalysts exposing unique crystallographic facets show promising applications in energy and environmental technologies; however, crystal facet engineering through solid-state synthesis for photocatalytic overall water splitting is still challenging. Herein, we develop a novel crystal facet engineering strategy through solid-state recrystallization to synthesize uniform SrTiO single crystals exposing tailored {111} facets. The presynthesized low-crystalline SrTiO precursors enable the formation of well-defined single crystals through kinetically improved crystal structure transformation during solid-state recrystallization process.