Antidepressant-like actions of lanifibranor and its related mechanisms in mouse models of depression: Involvement of hippocampal PPARα and BDNF.

Current commercial antidepressants worldwide are mainly developed according to the monoaminergic hypothesis of depression and have various limitations. Thus, exploring new antidepressants with better therapeutic efficacy and fewer adverse effects remain a hot topic in the field of neuropsychiatric research. Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to closely participate in the pathophysiology of depression, and here we assume that lanifibranor, a novel pan-PPAR agonist for α, δ, and γ, may induce antidepressant-like actions by PPARs activation.

The Psychological Resonance of Place: Spatial Narratives and Identity in the Historical Educational Landscapes of Rongxiang, China.

Educational space not only shapes the learning environment, but also profoundly affects people's psychological experience and identity. However, its psychological mechanisms in specific cultural-historical contexts remain understudied. This paper takes historical educational sites in Rongxiang, China, as a case study to explore how these spaces stimulate emotional resonance and identity formation through architectural structure and cultural narrative during a time of societal transition.

Increasing methane production from coal under the application of an electric field system by enriching microorganisms on electrode.

The functional microbial community, especially the electrode microorganisms, are crucial for the increment of biomethane production from coal by the application of an electric field. In this paper, the effect of electrode microorganisms on methane production from coal was investigated. They were enriched using the electrically domesticated flora (EF) and the primitive flora (PF) under 1.

Exploring How AI Literacy and Self-Regulated Learning Relate to Student Writing Performance and Well-Being in Generative AI-Supported Higher Education.

The integration of generative artificial intelligence (GAI) into higher education is transforming students' learning processes, academic performance, and psychological well-being. Despite the increasing adoption of GAI tools, the mechanisms through which students' AI literacy and self-regulated learning (SRL) relate to their academic and emotional experiences remain underexplored. This study investigates how AI literacy and SRL are associated with writing performance and digital well-being among university students in GAI-supported higher learning contexts.

Evidence to shared genetic correlation of ischemic stroke and intracerebral hemorrhage and cardiovascular related traits.

Background: Previous studies have demonstrated the genetic basis of stroke and also revealed their genetic correlation with some cardiovascular related diseases or traits at the entire genome, which, however, would not give the answer which regions may mainly account for the genetic overlap. This study aims to identify specific genetic loci that contribute to the shared genetic basis between ischemic stroke subtypes and common cardiovascular traits.

Methods: We used Local Analysis of [co]Variant Annotation (LAVA), a recent developed local genetic correlation method, to perform a system local genetic correlation analysis on GWAS summary data of two major subtypes of stroke, including any ischemic stroke (AIS) and intracerebral hemorrhage (ICH), and ten common cardiovascular related diseases or traits (CRTs).

Prevalence of Pentatrichomonas hominis and Tritrichomonas foetus in dogs and cats in Nanchang City, China.

Tritrichomonas foetus and Pentatrichomonas hominis are two causative agents of trichomoniasis in dogs and cats, manifesting primarily through diarrhea symptoms. However, information on the prevalence and identification of T. foetus and P.

Electric field-induced conformational dynamics of CA9: a potential biomarker for glioblastoma multiforme.

GBM, a malignant brain tumor prevalent in adults, can be treated using Electric field (EF) therapy. However, the underlying mechanism of EF-based GBM therapy is not well understood. In this study, we used bioinformatics and MD analysis to explore CA9 in EF therapy for GBM.

Direct current electric field exposure changes the conformational dynamics of IL-1β in RAW 264.7 macrophages.

Wearable devices have led to a growing interest in the effects of physical stimuli, such as electric fields (EF), on cells. However, the impact of EF on macrophages remains largely unexplored. To address this gap, we developed an electric-field chamber that applies direct current electric field (dcEF) to RAW 264.

Surface Modification of Organic Chromium-Free Tanned Leather Shavings and the Immobilization of Lipase.

Following the concept of "waste into resources", a mild and controllable light grafting technique was used to immobilize pancreatic lipase (PPL) in situ on modified organic, chromium-free tanned leather scraps to catalyze the hydrolysis of waste oil. The experimental results showed that immobilized PPL significantly improved the catalytic activity, operational stability, reusability, and storage stability compared to free PPL. Furthermore, the study evaluated the environmental compatibility of the system through biological risk assessment of soil extracts after degradation, indicating that the system has good environmental compatibility.

Focus-Driven Augmented Feedback: Enhancing Focus and Maintaining Engagement in Upper Limb Virtual Reality Rehabilitation.

Integrating biofeedback technology, such as real-time eye-tracking, has revolutionized the landscape of virtual reality (VR) rehabilitation games, offering new opportunities for personalized therapy. Motivated to increase patient focus during rehabilitation, the Focus-Driven Augmented Feedback (FDAF) system was developed to enhance focus and maintain engagement during upper limb VR rehabilitation. This novel approach dynamically adjusts augmented visual feedback based on a patient's gaze, creating a personalised rehabilitation experience tailored to individual needs.

CSPG4 overexpression implicates higher risks of recurrence and tumorigenesis after surgical intervention of vocal fold Leukoplakia.

Background: Vocal fold leukoplakia (VFL), a precancerous lesion of the larynx, is characterized by white plaques on the vocal fold mucous membrane. Currently, there are no reliable biomarkers to predict the recurrence and malignant transformation of VFL. Considering chondroitin sulfate proteoglycan 4 (CSPG4) as a biomarker for malignant tumors such as laryngeal squamous cell carcinoma (LSCC), we conducted this cohort study to evaluate the prognostic influence of CSPG4 expression on VFL patients.

Pathway analysis of the impact of dysphagia on the prognosis of patients with stroke: Based on structural equation modeling.

Background And Aims: Dysphagia is significantly correlated with prognostic outcomes in patients with stroke; however, the intrinsic mechanism of action between the two remains unclear. This study aimed to model the intrinsic mechanism of action between dysphagia and prognostic outcomes in patients with stroke based on structural equation modeling.

Methods: A retrospective analysis of 900 inpatients with stroke from three large hospitals was performed.

Endothelial FUNDC1 Deficiency Drives Pulmonary Hypertension.

Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.

Regulation of de novo and maintenance DNA methylation by DNA methyltransferases in postimplantation embryos.

DNA methylation is mainly catalyzed by three DNA methyltransferase (DNMT) proteins in mammals. Usually DNMT1 is considered the primary DNMT for maintenance DNA methylation, whereas DNMT3A and DNMT3B function in de novo DNA methylation. Interestingly, we found DNMT3A and DNMT3B exerted maintenance and de novo DNA methylation in postimplantation mouse embryos.

Choroidal vascular changes in early-stage myopic maculopathy from deep learning choroidal analysis: a hospital-based SS-OCT study.

Background: The objective of this study is to illustrate the changes in the choroidal vasculature in individuals with diffuse chorioretinal atrophy (DCA, early-stage myopic maculopathy) and investigate the association between them.

Methods: This study included 1418 highly myopic eyes from 720 participants aged 18 - 60 years from the Wenzhou High Myopia Cohort Study. These participants underwent comprehensive ophthalmic assessments.

DNA methylation plays important roles in lifestyle transition of Arthrobotrys oligospora.

Trap formation is the key indicator of carnivorous lifestyle transition of nematode-trapping fungi (NTF). Here, the DNA methylation profile was explored during trap induction of Arthrobotrys oligospora, a typical NTF that captures nematodes by developing adhesive networks. Whole-genome bisulfite sequencing identified 871 methylation sites and 1979 differentially methylated regions (DMRs).

Pedestrian Pose Recognition Based on Frequency-Modulated Continuous-Wave Radar with Meta-Learning.

With the continuous advancement of autonomous driving and monitoring technologies, there is increasing attention on non-intrusive target monitoring and recognition. This paper proposes an ArcFace SE-attention model-agnostic meta-learning approach (AS-MAML) by integrating attention mechanisms into residual networks for pedestrian gait recognition using frequency-modulated continuous-wave (FMCW) millimeter-wave radar through meta-learning. We enhance the feature extraction capability of the base network using channel attention mechanisms and integrate the additive angular margin loss function (ArcFace loss) into the inner loop of MAML to constrain inner loop optimization and improve radar discrimination.

Corn straw-saccharification fiber improved the reproductive performance of sows in the late gestation and lactation via lipid metabolism.

With the development of animal husbandry, the shortage of animal feedstuffs has become serious. Dietary fiber plays a crucial role in regulating animal health and production performance. The aim of this study was to investigate the effects of three kinds of corn straw-saccharification fibers (CSSF) such as high-fiber and low-saccharification (HFLS), medium-fiber and medium-saccharification (MFMS), low-fiber and high-saccharification (LFHS) CSSF on the reproductive performance of sows.

Fabrication of soy protein nanoparticles based on metal-phenolic networks for stabilization of nano-emulsions delivery system.

The use of soy protein isolate (SPI) nanoparticles as a stabilizer in nano-emulsion systems has garnered significant interest. While metal-phenolic networks (MPNs) have been explored for their multifunctional surface modification capabilities, their integration with food protein-based delivery systems remains less explored. In this study, we attempt to develop a novel strategy to encapsulate cinnamaldehyde using MPNs (EGCG-Fe) with self-assembling soy protein nanoparticles (SE-Fe NPs) as a stabilizer for nano-emulsions.

Epigenetic regulation in adult neural stem cells.

Neural stem cells (NSCs) exhibit self-renewing and multipotential properties. Adult NSCs are located in two neurogenic regions of adult brain: the ventricular-subventricular zone (V-SVZ) of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Maintenance and differentiation of adult NSCs are regulated by both intrinsic and extrinsic signals that may be integrated through expression of some key factors in the adult NSCs.

Modulatory role of neuropeptide FF system in macrophages.

Neuropeptide FF (NPFF) is an octapeptide that regulates various cellular processes, especially pain perception. Recently, there has been a growing interest in understanding the modulation of NPFF in neuroendocrine inflammation. This review aims to provide a thorough overview of the regulation of NPFF in macrophage-mediated biological processes.

The transcriptomic landscape of canonical activation of NLRP3 inflammasome from bone marrow-derived macrophages.

The NLRP3 inflammasome has gained significant attention due to its participation in diverse cellular processes. Nevertheless, the detailed framework of the canonical NLRP3 inflammasome assembly still remains unrevealed. This study aims to elucidate the transcriptomic landscape of the various stages involved in the canonical activation of the NLRP3 inflammasome in BMDMs by integrating RNA-seq, bioinformatics, and molecular dynamics analyses.

Quantitative energy spectrum CT in differential diagnosis of aldosterone-producing adenoma and cortisol-producing adenoma.

Background: Patients with aldosterone-producing adenoma (APA) and cortisol-producing adenoma (CPA) show some similar clinical symptoms, and a large overlap of conventional imaging manifestations, which make the differentiation difficult. The purpose of our study was to explore the value of gemstone spectral imaging (GSI) dual-energy computed tomography (DECT) in differential diagnosis of APA and CPA, screen out meaningful energy spectral indicators and provide theoretical basis for the differential diagnosis of the two.

Methods: We retrospectively analyzed the imaging and clinical data of 30 patients with APA and 27 patients with CPA who underwent GSI DECT in The First Affiliated Hospital of Zhengzhou University (a tertiary care institution).