Mitochondrial Complex Member VdNuo1 Recruits Superoxide Dismutases VdSOD2/4 to Maintain Superoxide Anion Homeostasis During Pathogenesis in Verticillium dahliae.

During oxidative phosphorylation, the leaked electrons generate superoxide anions to attack the mitochondrial inner membrane and impair mitochondrial activity. Three superoxide dismutases (SODs) are secreted to degrade host superoxide anions in Verticillium dahliae. However, the roles of mitochondrial SODs (mtSODs) in superoxide anion detoxification and in virulence are unknown in this fungus.

The role of microflow patterns combined with greyscale ultrasound in enhancing diagnostic validity and reducing unnecessary biopsy rate of thyroid nodules.

Objective: To explore the value of microflow patterns based on superb microvascular imaging (SMI) combined with greyscale ultrasound in thyroid nodule diagnosis and biopsy recommendation.

Materials And Methods: Adult patients with thyroid nodules were recruited from May 2023 to February 2024. The greyscale features of nodules were evaluated according to the five ultrasound risk stratification systems (RSSs).

Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis.

Objectives: Study the efficacy and safety of mycophenolate mofetil (MMF) combined with methotrexate (MTX) compared to cyclophosphamide (CYC) followed by azathioprine (AZA) to treat active Takayasu arteritis (TAK).

Methods: Adults with active TAK were randomised in a 2:1 ratio to receive oral MMF plus MTX or intravenous CYC followed by oral AZA. All subjects also received high-dose oral glucocorticoids with a predefined taper.

Mitochondrial Metabolism in T-Cell Exhaustion.

T cells play a vital role in resisting pathogen invasion and maintaining immune homeostasis. However, T cells gradually become exhausted under chronic antigenic stimulation, and this exhaustion is closely related to mitochondrial dysfunction in T cells. Mitochondria play a crucial role in the metabolic reprogramming of T cells to achieve the desired immune response.

Comparative Chloroplast Genomics, Phylogenomics, and Divergence Times of (Lauraceae).

In the traditional classification system of the Lauraceae family based on morphology and anatomy, the phylogenetic position of the genus has long been controversial. Chloroplast (cp) evolution of has not yet been illuminated. In this study, we first sequenced and assembled the complete cp genomes of , and conducted the comparative cp genomics, phylogenomics, and divergence time estimation of this ecological and economic important genus.

Optimizing ultrasound evaluation of carotid artery stenosis in Takayasu's Arteritis: a focus on residual inner diameter as a key parameter.

Objectives: Takayasu's arteritis (TAK) is a chronic inflammatory disease that often leads to stenosis or occlusion of the common carotid artery (CCA), posing significant risks such as stroke and cognitive impairment. Despite the widespread use of ultrasound in diagnosing and monitoring TAK, the lack of standardized criteria for assessing CCA stenosis has resulted in inconsistent evaluations. This study aims to establish standardized ultrasound diagnostic criteria for CCA stenosis in TAK, focusing on residual inner diameter and wall thickness.

A facile photonics reconfigurable memristor with dynamically allocated neurons and synapses functions.

The dynamic neural network function realized by reconfigurable memristors to implement artificial neurons and synapses is an effective method to complete the next generation of neuromorphic computing. However, due to the limitation of reconfiguration conditions, there are inconsistencies in the turn-on voltage and operating current before and after the reconfiguration of neuromorphic devices, which leads to huge difficulties in hardware application development and is an urgent problem to be solved. In this work, we introduced light as a regulatory means in the memristor and achieved the reconfiguration of volatile (endurance ~10 cycles) and non-volatile (retention ~10 s) characteristics with a unified working parameter through the photoelectric coupling mode.

NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210.

Chronic hypoperfusion-induced neuronal damage is the pathological basis of vascular dementia (VD). Hypoxia enhances the paracrine effects of neural stem cells (NSCs) by promoting neuroprotection and synaptic plasticity, which may be mediated by extracellular vehicles (EVs) secretion. In this study, we aimed to investigate the therapeutic effects and underlying mechanisms of hypoxic NSC-derived EVs (hypoxic NSC-EVs) in VD.

The relationship between compassion fatigue and psychological resilience among Chinese midwives: a cross-sectional study.

Background: Midwives are at high risk of compassion fatigue (CF) due to the demanding nature of their workplaces. They also face greater occupational risks and prolonged mental stress in their daily work. Psychological resilience serves as a protection factor in fostering positive psychological outcomes.

Enhancing lactoferrin stability in ethanol aqueous systems through oligosaccharide modulation: Mechanisms and functional implications.

To improve protein stability in ethanol aqueous systems, this study investigated the effects of three oligosaccharides-oligofructose (FOS), oligogalactose (GOS), and oligoxylose (XOS)-on the conformational and thermal stability of lactoferrin (LF). Results demonstrated that these oligosaccharides significantly increased LF's thermal denaturation temperature (Tm) and elevated the energy barrier for conformational changes in ethanol aqueous systems, thereby enhancing thermostability. Specifically, FOS, GOS, and XOS raised the Tm of LF from 69.

Phylogeography and Population Demography of , a Hamamelidaceous Tertiary Relict 'Living Fossil' Tree Endemic to East Asia Refugia: Implications from Molecular Data and Ecological Niche Modeling.

The diverse topography and mild monsoon climate in East Asia are considered to be important drivers for the long-term ecological success of the Tertiary relict 'living fossil' plants during the glacial/interglacial cycles. Here we investigated the phylogeographic pattern and demographic history of a hamamelidaceous Tertiary relict 'living fossil' tree () endemic to the subtropical forests of eastern China, employing molecular data and ecological niche modeling. In the long evolutionary history, has accumulated a high haplotype diversity.

[Pharmacodynamics study and establishment of a PK-PD model for Epimedii Folium-Chuanxiong Rhizoma in treating osteoarthritis in rats].

This study aims to reveal the correlation between the pharmacokinetics(PK) and pharmacodynamics(PD) of multiple components in Epimedii Folium-Chuanxiong Rhizoma and clarify the pharmacodynamic material basis and mechanism of this herb pair in treating osteoarthritis. The Hulth method was used to establish the rat model of osteoarthritis and plasma was collected at various time points after drug administration. The plasma concentrations of multiple components were measured.

Population Dynamics of and Its Aggregation Behavior in Aquaculture System.

The aquatic vegetable Gmel. (Nymphaeales: Cabombaceae), widely cultivated in China, faces severe challenges from pest disturbances. With a field investigation, occurred for several generations in the mono-cultivation system.

Non-starch polysaccharides from nutmeg: Preparation process and bioactivity.

This study was for the preparation of bioactive non-starch polysaccharides from nutmeg (NEP), addressing the high content of lipids and starch in nutmeg. First, lipids were removed by 3 times defatted with petroleum ether. Then, the optimal extraction process was 170 min at 82 °C with a liquid solid ratio of 15: 1 mL/g.

Anti-osteoporotic effects and good biocompatibility of novel bioactive carbon quantum dots and in ovariectomized mice.

Osteoporosis is a prevalent condition among the elderly, and current treatments are limited by their side effects. This study aimed to develop a safe nanocarbon material with anti-osteoporotic properties. A promising candidate, carbon quantum dots (CQDs), was synthesized using a single-step liquid-phase pulse method and characterized by transmission electron microscopy (TEM).

An experimental study on subharmonic-aided pressure estimation with commercial scanners.

This study evaluates the performance of subharmonic-aided pressure estimation (SHAPE) with ultrasound contrast agents using data obtained from calibration procedures. A commercial scanner of ultrasonography (GE Healthcare Logiq E20, Wuxi, China) was used to perform SHAPE on a flowing contrast agent (Sonazoid) in a phantom setup under controlled microbubble stability and flow velocity conditions. Subharmonic time-intensity curves were collected during the SHAPE calibration procedure for analysis.

Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice.

Background: Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicles in vivo. Berberine (BBR) possesses multiple pharmacological properties, but its impact on primordial follicle activation remains unclear.

The 24-kDa subunit of mitochondrial complex I regulates growth, microsclerotia development, stress tolerance, and virulence in Verticillium dahliae.

Background: The complete mitochondrial respiratory chain is a precondition for maintaining cellular energy supply, development, and metabolic balance. Due to the evolutionary differentiation of complexes and the semi-autonomy of mitochondria, respiratory chain subunits have become critical targets for crop improvement and fungal control. In fungi, mitochondrial complex I mediates growth and metabolism.

Licochalcone A loaded multifunctional chitosan hyaluronic acid hydrogel with antibacterial and inflammatory regulating effects to promote wound healing.

The wound healing process is characterized by persistent infection and long-term inflammation. The licochalcone A (LicA) has the potential for skin wound healing and needs a good drug-loading platform to apply its antibacterial and anti-inflammatory effects. In this study, the LicA@chitosan (CS) -hyaluronic acid (HA) hydrogel with antibacterial and anti-inflammatory was developed for wound healing in mice.

Identification and validation of a novel robust glioblastoma prognosis model based on bioinformatics.

Background: Glioblastoma (GBM) is a very common primary malignant tumor of the central nervous system (CNS). Aging, macrophage, autophagy, and methylation related genes are hypothesized to be crucial to its pathogenesis. In this study, we aimed to explore the role of these genes in the prognosis of GBM.

Imaging findings of Budd-Chiari syndrome caused by intravenous leiomyomatosis: a case report.

Intravenous leiomyomatosis (IVL) is a rare gynecological-related tumor. It can invade and extend in the blood vessel and eventually involve the cardiac cavity or even the pulmonary artery. IVL generally does not adhere to the vein wall and infrequently leads to the manifestation of Budd-Chiari syndrome (BCS).

Role of 8-hydroxyguanine DNA glycosidase 1 deficiency in exacerbating diabetic cardiomyopathy through the regulation of insulin resistance.

Diabetic cardiomyopathy (DCM) is a heart failure syndrome, and is one of the major causes of morbidity and mortality in diabetes. DCM is mainly characterized by ventricular dilation, myocardial hypertrophy, myocardial fibrosis and cardiac dysfunction. Clinical studies have found that insulin resistance is an independent risk factor for DCM.