Advanced brain diffusion MRI and image texture measures have the potential to predict multi-domain functional outcomes in multiple sclerosis.

Background: Multiple sclerosis (MS) causes diverse functional impairments that require early accurate characterization, but pertinent methods are scarce. This study aimed to develop new imaging-driven approaches for predicting MS functions.

New Method: 19 women with MS [10 relapsing-remitting (RRMS) and 9 secondary progressive (SPMS) subtypes] and 19 matched controls were examined including 3T imaging.

UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) represents a significant global health burden. The absence of reliable biomarkers and the heterogeneity in treatment responses continue to hinder improvements in patient prognosis. This study aimed to identify novel biomarkers capable of predicting patient outcomes and therapeutic responsiveness, while also assessing their potential as intervention targets for LUAD.

Comparative Chloroplast Genomics, Phylogenomics, and Divergence Times of (Lauraceae).

In the traditional classification system of the Lauraceae family based on morphology and anatomy, the phylogenetic position of the genus has long been controversial. Chloroplast (cp) evolution of has not yet been illuminated. In this study, we first sequenced and assembled the complete cp genomes of , and conducted the comparative cp genomics, phylogenomics, and divergence time estimation of this ecological and economic important genus.

Evolutionary legacy of the "living fossil" genus Parrotia (Hamamelidaceae): genomic insights into species divergence and polygenic adaptation.

Despite their long evolutionary history, the genomic basis of adaptation and speciation in "living fossil" plants remain largely unexplored. Parrotia, a Tertiary relict tree genus with two extant species, P. subaequalis and P.

Extracellular vesicles in atherosclerosis cardiovascular disease: emerging roles and mechanisms.

The pathogenesis of atherosclerotic cardiovascular disease is complex, involving multiple cell types and biological processes. Extracellular Vesicles (EVs) are small, cell-derived particles increasingly recognized for their role in cardiovascular diseases. EVs are believed to play key roles in this context by promoting inflammation, regulating intercellular communication, and influencing lipid metabolism.

Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis.

Objective: The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi-quantitative MRI measure sensitive to MS-related tissue microstructural changes, in the cSC and its relationship with clinical outcomes in radiologically isolated syndrome (RIS) and MS.

Methods: MTR data were acquired from 52 RIS, 201 relapsing-remitting MS (RRMS), 47 primary progressive MS (PPMS), and 43 control (CON) participants across four sites in the Canadian Prospective Cohort Study to Understand Progression in MS (CanProCo) using 3.

Phylogeography and Population Demography of , a Hamamelidaceous Tertiary Relict 'Living Fossil' Tree Endemic to East Asia Refugia: Implications from Molecular Data and Ecological Niche Modeling.

The diverse topography and mild monsoon climate in East Asia are considered to be important drivers for the long-term ecological success of the Tertiary relict 'living fossil' plants during the glacial/interglacial cycles. Here we investigated the phylogeographic pattern and demographic history of a hamamelidaceous Tertiary relict 'living fossil' tree () endemic to the subtropical forests of eastern China, employing molecular data and ecological niche modeling. In the long evolutionary history, has accumulated a high haplotype diversity.

Camrelizumab Plus Famitinib versus Camrelizumab Alone and Investigator's Choice of Chemotherapy in Recurrent or Metastatic Cervical Cancer: A Randomized, Phase II Study.

Purpose: To compare camrelizumab (an anti-PD-1 monoclonal antibody) plus famitinib (a multitarget receptor tyrosine kinase inhibitor) versus camrelizumab and chemotherapy in recurrent or metastatic cervical cancer (R/M CC).

Methods: Patients with pretreated R/M CC were randomly assigned to receive camrelizumab (200 mg intravenously once every 3 weeks) plus famitinib (20 mg orally once daily), camrelizumab, or investigator's choice of chemotherapy. The primary end point was comparison of objective response rate (ORR) per blinded independent central review (BICR) for camrelizumab-famitinib versus camrelizumab in the intention-to-treat population.

Assessment of cancer-associated fibroblast signature genes in ovarian cancer patients: impact on immunity, drug resistance, and prognosis.

Ovarian cancer (OC) is women's third most common gynecologic tumor and is highly lethal. Cancer-associated fibroblasts (CAFs) are associated with cancer at all stages of disease progression and are involved in biological processes, including inflammatory processes, tumor development occurrence, and immune rejection. This study aimed to construct prognosis-related CAFs regulatory factors to predict the survival of OC patients.

The association of chronotype on depression in adolescents: the mediating role of sensation seeking and sleep quality.

Objectives: This study explores the relationships among chronotype, sensation seeking, sleep quality and depressive symptoms in adolescents with diagnosed depression, aiming to clarify the mechanisms by which chronotype is associated with depression.

Methods: This cross-sectional study assessed 216 adolescents with diagnosed depression using a demographic questionnaire, the Morningness-Eveningness Questionnaire, the Sensation Seeking Scale, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory. Descriptive and correlational analyses were performed using SPSS 27.

cGAMP-targeting injectable hydrogel system promotes periodontal restoration by alleviating cGAS-STING pathway activation.

The impaired function of periodontal ligament stem cells (PDLSCs) impedes restoration of periodontal tissues. The cGAS-cGAMP-STING pathway is an innate immune pathway that sensing cytosolic double-stranded DNA (dsDNA), but its role in regulating the function of PDLSCs is still unclear. In this study, we found that mitochondrial DNA (mtDNA) was released into the cytoplasm through the mitochondrial permeability transition pore (mPTP) in PDLSCs upon inflammation, which binds to cGAS and activated the STING pathway by promoting the production of cGAMP, and ultimately impaired the osteogenic differentiation of PDLSCs.

Ultra-high absorption efficiency of InN nanowires with a wide bandwidth in the short-wave infrared range.

The group III-V semiconductor InN is a highly promising candidate for photoelectric detectors in the short-wave infrared (SWIR) range but faces significant challenges in material quality. In recent years, one-dimensional nanowires (NWs) have allowed their high-quality growth and have added structural advantages. However, the performance potential of InN NWs is little known.

lncRNA HIF1A-AS2 acts as an oncogene to regulate malignant phenotypes in cervical cancer.

Background: Long noncoding RNAs (lncRNAs) HIF1A-AS2 is upregulated in multiple human cancers and are associated with various aspects of tumor progression. However, the molecular mechanisms of HIF1A-AS2 in cervical cancer (CC) remain largely unknown. In this study, we aim to investigate the expression pattern and signaling pathways of HIF1A-AS2 in CC.

Radiomics feature is a risk factor for locally advanced cervical cancer treated using concurrent chemoradiotherapy based on magnetic resonance imaging: a retrospective study.

Background: Although concurrent chemoradiotherapy (CCRT) is the standard treatment strategy for locally advanced cervical squamous carcinoma (LACSC), there are still individual differences. It is of vital importance to establish a radiomics-based model for predicting overall survival (OS) of LACSC patients treated using CCRT, and evaluating the feasibility of adjuvant chemotherapy (ACT).

Methods: 122 LACSC patients were retrospectively analyzed who underwent pelvic MRI before standard CCRT between January 2013 and September 2016, including 85 patients in training set and 37 patients in testing set.

Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway.

Prostate cancer (PCa) is one of the most common malignancies for male individuals globally. Androgen deprivation therapy (ADT) initially demonstrated significant efficacy in treating PCa; however, most cases of PCa eventually progress to castration-resistant prostate cancer (CRPC), which becomes increasingly challenging to manage. Notably, the loss or disruption of primary cilia in PCa cells may play a critical role in the progression of the disease, and there are no reports on the role of circular RNAs in ciliogenesis.

Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery.

Background: Intracerebral hemorrhage (ICH) causes prominent deposition of extracellular matrix molecules, particularly the chondroitin sulphate proteoglycan (CSPG) member neurocan. In tissue culture, neurocan impedes the properties of oligodendrocytes. Whether therapeutic reduction of neurocan promotes oligodendrogenesis and functional recovery in ICH is unknown.

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.

Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood.

Phase II study of enlonstobart (SG001), a novel PD-1 inhibitor in patients with PD-L1 positive recurrent/metastatic cervical cancer.

Background: Platinum-based chemotherapy with or without bevacizumab is the first-line treatment for patients with recurrent or metastatic cervical cancer (r/mCC), and the treatment options are limited for r/mCC after first-line treatment. Enlonstobart (SG001) is a fully humanized and high-affinity anti-PD-1 immunoglobulin G4 monoclonal antibody. Previous phase Ib study demonstrated that SG001 had a promising efficacy in patients with PD-L1 positive r/mCC.

RecQ protein-like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2.

Cervical cancer is a common malignant tumor in women with high morbidity and mortality. Chemotherapy drugs such as cisplatin (DDP) are easy to cause chemotherapy resistance and affect the therapeutic effect. Hence, it is critical to design new therapies that can reverse chemotherapy resistance and increase sensitivity to chemotherapy drugs.

Ubiquitin-independent degradation of Bim blocks macrophage pyroptosis in sepsis-related tissue injury.

Pyroptosis, a typical inflammatory cell death mode, has been increasingly demonstrated to have therapeutic value in inflammatory diseases such as sepsis. However, the mechanisms and therapeutic targets of sepsis remain elusive. Here, we reported that REGγ inhibition promoted pyroptosis by regulating members of the gasdermin family in macrophages.

A Novel Tumor-Associated Neutrophil-Related Risk Signature Based on Single-Cell and Bulk RNA-Sequencing Analyses Predicts the Prognosis and Immune Landscape of Breast Cancer.

Tumor-associated neutrophils (TANs) are increasingly recognized as contributors to cancer prognosis and therapeutics. However, TAN-related targets of breast cancer (BRCA) remain scarce. This study aimed to develop a novel TAN-associated risk signature (TANRS) of BRCA using single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data.

Computed Tomography Imaging Guided Microenvironment-Responsive Ir@WO Dual-Catalytic Nanoreactor for Selective Radiosensitization.

Radiotherapy (RT) is often administered, either alone or in combination with other therapies, for most malignancies. However, the degree of tumor oxygenation, damage to adjacent healthy tissues, and inaccurate guidance remain issues that result in discontinuation or failure of RT. Here, a multifunctional therapeutic platform based on Ir@WO is developed which simultaneously addresses these critical issues above for precision radiosensitization.

Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6.

Prostate cancer (PCa) incidence and cancer-related deaths are both high in the male population. Once castration-resistant prostate cancer (CRPC) has developed, PCa can be difficult to manage. Circular RNAs (circRNAs) play essential roles in the regulation of carcinogenesis and cancer progression.