Efficacy and safety of cold snare polypectomy for outpatient treatment of sessile polyps smaller than 10mm.

Background: Screening colonoscopy plays a critical role in reducing colorectal cancer incidence by identifying and removing polyps. Simple and safe treatment is the most common request of both doctors and patients. Cold snare polypectomy (CSP) is increasingly favored for polyps < 10 mm, yet concerns remain regarding residual tissue.

Validation and Refinement of Scores to Predict Stroke Risk: Prospective Cohort Study.

Background: In China, the "8+2" stroke risk score has been widely used to identify individuals at high risk of stroke, despite insufficient evidence confirming its predictive ability for stroke events.

Objective: We aimed to validate the risk score's ability to predict the risk of stroke within a 10-year timeframe in community cohort populations and to optimize the scoring method to improve its predictive accuracy.

Methods: By reviewing previous literature to obtain the parameters for constructing the logistic regression model and the Rothman-Keller model, the risk threshold points of the models were determined using a sample of 100,000 participants.

Machine learning-aided design, synthesis and biological evaluation of novel 4-(imidazo[1,2-a]pyridine-3‑carbonyl) phenyl urea derivatives as potent FLT3 inhibitors.

FLT3 protein kinase is a promising target for the treatment of acute myeloid leukemia (AML), and the development of this kinase inhibitor is highly desirable to overcome FLT3-positive AML. Herein, the bioactive predictions and screening were conducted based on our previous machine learning model in this work. Using ZY06 as a candidate, the design, synthesis and biological evaluation of a series of 4-(imidazo[1,2-a]pyridine-3‑carbonyl) phenyl urea derivatives as novel FLT3 inhibitors were systematically investigated.

Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy.

Programmed death-ligand 1 (PD-L1) carried by tumor-derived exosomes has emerged as a critical mediator of immune evasion and resistance to immune checkpoint blockade therapy. Unlike membrane-bound PD-L1, exosomal PD-L1 is systemically distributed and capable of suppressing T cell activity at distant sites. This review summarizes the current understanding of exosomal PD-L1 biogenesis, its immunosuppressive mechanisms, and its clinical relevance across multiple cancer types.

Readmission After Ischemic Stroke in Ningxia, China, From 2017 to 2021: Retrospective Cohort Study.

Background: Stroke remains a major cause of death and disability worldwide. Ischemic stroke is the most common type of stroke. Readmissions after hospitalization increase the patient burden and waste health resources.

Optimization of Medium Composition for High Cell Density Culture of Bifidobacterium longum HSBL001 Using Response Surface Methodology.

Bifidobacterium longum plays a critical role in the human gut and exhibits diverse probiotic functions. Achieving high-density fermentation of B. longum largely depends on the composition of the culture medium and fermentation conditions.

Disruption of Multimodal Brain Networks and Structural-Functional Coupling in Adolescents with Major Depressive Disorder.

Background: Adolescent MDD has become a significant public health issue, yet its underlying mechanisms remain unclear. Multimodal brain imaging techniques offer a powerful method for exploring complex mental disorders. However, evidence focusing on the multimodal brain networks and structural-functional coupling in adolescent depression is still limited.

Infection prevention and control measures for multidrug-resistant organisms: a systematic review and network meta-analysis.

Background: The effectiveness of infection prevention and control measures combating multidrug-resistant organisms (MDROs) in healthcare settings remains controversial.

Methods: PubMed, Embase, MEDLINE, Cochrane Library, and CINAHL were searched from inception to June 1, 2024. The interventions encompassed standard precautions (SP), contact precautions (CP), hand hygiene (HH), environmental cleaning (ENV), antimicrobial stewardship programs (ASP), decolonization (DCL), and chlorhexidine baths (CHG).

AmplitudeArrow: On-the-Go AR Menu Selection Using Consecutive Simple Head Gestures and Amplitude Visualization.

Heads-up computing aims to provide synergistic digital assistance that minimally interferes with users' on-the-go daily activities. Currently, the input modalities of heads-up computing are mainly voice and finger gestures. In this work, we propose and evaluate the AmplitudeArrow (AA) technique designed for on-the-go AR menu selection to demonstrate that consecutive simple head gestures can also be an effective input modality for heads-up computing.

Angiogenesis after acute myocardial infarction: a bibliometric -based literature review.

Objective: The prevalence of acute myocardial infarction, a severe ischemic cardiac disease, is on the rise annually. The establishment of coronary collateral circulation in the border zone of the infarct can effectively relieve myocardial ischemia and impede cell death, while angiogenesis can promote the formation of collateral circulation in the ischemic tissues. Over the past two decades, studies related to angiogenesis in acute myocardial infarction have increased rapidly.

Changing trends in human brucellosis in pastoral and agricultural China, 2004-2019: a Joinpoint regression analysis.

Background: The incidence of human brucellosis has risen sharply in China but little is known about trends in pastoral and agricultural areas respectively. This study aimed to analyze the annual and monthly incidence trends of human brucellosis in China from 2004 to 2019. It sought to identify factors contributing to higher incidence rates at specific times and to compare incidence trends across pastoral, agricultural/pastoral, and agricultural areas.

Ecological and Functional Changes in the Hindgut Microbiome of Holstein Cows at High Altitudes.

The extreme environmental conditions of the Qinhai-Tibetan Plateau (QTP) challenge livestock survival and productivity, yet little is known about how high-altitude environments impact the gut microbiota of dairy cows. To fill this gap, we systematically investigated the differences in the hindgut microbiome between 87 plateau Holstein cows and 72 plain Holstein cows using 16S rRNA gene sequencing. Our analysis revealed that the hindgut microbiota of the plateau group exhibited lower species richness but higher evenness than that in the plain group.

Eco-friendly cellulose paper based triboelectric material regulated by lignocellulose composition.

Applying cellulose paper on the triboelectric material is the trend of developing eco-friendly triboelectric nanogenerator (TENG). However, the researchers always pay attention to improve the triboelectric property of cellulose paper by the grafting of functional groups and the introduction of conductive or high dielectric property materials, while neglecting the effects of lignocellulose fiber composition including hemicellulose and lignin. In this work, the contents of hemicellulose and lignin were adjusted by sodium hydroxide and sodium chlorite, respectively; and the effects of hemicellulose and lignin on the triboelectric performance of cellulose paper were evaluated.

Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study.

Dyslipidemia has been established as a potential risk factor for venous thromboembolism (VTE) in several observational studies. Statins and novel lipid-modifying agents are being explored for their potential in VTE prevention, encompassing deep vein thrombosis (DVT), and pulmonary embolism (PE). Nonetheless, conclusive evidence supporting the effectiveness remains uncertain.

Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency.

Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual targeting interleukin-17 (IL-17) and IL-36 enhances anti-inflammatory activity, bispecific Ab HB0043 was generated by linking the single chain fragment variables (scFvs) from humanized anti-IL-36R antibody (HB0034) to the C-terminus of the heavy chain of anti-IL-17A IgG1 (HB0017) Fc using a flexible peptide linker. HB0043 largely maintained the binding affinities and biological activities of the two parent monoclonal antibodies (mAbs) .

An oxidative metal ions-free lignin-catalyzed multifunctional hydrogel bioelectronics for codable eye communication.

To meet the stringent requirements of wearable and flexible electronics for functionality and comfort, it is urgent to develop green conductive, self-adhesive, and stretchable functional hydrogels. The chelates of transition metal ions and lignosulfonate sodium (LS) can impart multi-functionality to the hydrogel and significantly improve the hydrogel's gelation speed. However, the presence of metal ions may weaken the adhesiveness of hydrogels by shielding the functional adhesive groups.

Deciphering Explicit and Implicit Features for Reliable, Interpretable, and Actionable User Churn Prediction in Online Video Games.

The burgeoning online video game industry has sparked intense competition among providers to both expand their user base and retain existing players, particularly within social interaction genres. To anticipate player churn, there is an increasing reliance on machine learning (ML) models that focus on social interaction dynamics. However, the prevalent opacity of most ML algorithms poses a significant hurdle to their acceptance among domain experts, who often view them as "opaque models".

Application of small animal ultrasound imaging technology for identification of polycystic ovary syndrome in a mouse model.

Background And Aims: Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age, characterized by irregular menstrual periods, elevated levels of androgens, and polycystic ovaries, leading to various symptoms and complications such as infertility, metabolic issues, and increased risk of diabetes and heart disease. This study aimed to compare traditional histological methods and ultrasound imaging for consistency in identifying PCOS in a mouse model. The shortest time to construct the PCOS model using letrozole was determined.

CompositingVis: Exploring Interactions for Creating Composite Visualizations in Immersive Environments.

Composite visualization represents a widely embraced design that combines multiple visual representations to create an integrated view. However, the traditional approach of creating composite visualizations in immersive environments typically occurs asynchronously outside of the immersive space and is carried out by experienced experts. In this work, we aim to empower users to participate in the creation of composite visualization within immersive environments through embodied interactions.

Platelet-derived exosomes regulate endothelial cell inflammation and M1 macrophage polarization in coronary artery thrombosis via modulating miR-34a-5p expression.

As the important factors in coronary artery thrombosis, endothelial injury and M1 macrophage polarization are closely related to the expression of miR-34a-5p. Exosomes in plasma are mainly derived from platelets and play an important role in thrombosis. Based on these facts, this study was conducted to investigate the acting mechanism of platelet-derived exosomes (PLT-exo) in the effects of endothelial injury and M1 macrophage polarization on coronary artery thrombosis.

Enhancing plant fiber antibacterial and antiviral performance through synergistic action of amino and sulfonic acid groups.

As the most abundant renewable resource, cellulose fibers are potential candidates for use in health-protective clothing. Herein, we demonstrate a novel strategy for preparing cellulose fiber with prominent antibacterial and antiviral performance by the synergistic effect of amino groups and sulfonic acid groups. Specifically, guanylated chitosan oligosaccharide (GCOS) and N-sulfopropyl chitosan oligosaccharide (SCOS) were synthesized and chemically grafted onto cellulose fibers (CFs) to endow the fibers with antibacterial and antiviral properties.