A combined model integrating deep learning, radiomics, and clinical ultrasound features for predicting mutation in papillary thyroid carcinoma with Hashimoto's thyroiditis.

Objective: This study aims to develop an integrated model that combines radiomics, deep learning features, and clinical and ultrasound characteristics for predicting mutations in patients with papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT).

Methods: This retrospective study included 717 thyroid nodules from 672 patients with PTC combined with HT from four hospitals in China. Deep learning and radiomics were employed to extract deep learning and radiomics features from ultrasound images.

MXene-Powered Terahertz Metamaterials as a Real-Time Biosensing Platform for In Vivo Thrombus Monitoring.

Precise, timely, and personalized in vivo thrombus monitoring is critical for improving the treatment effectiveness and clinical outcomes of cardiovascular diseases (CVDs). Terahertz (THz) spectroscopy has become increasingly important as a novel tool in biomedical engineering due to its rapid analysis ability, high temporal resolution, and label-free measurement modality. However, achieving high thrombus sensing performance in real blood environments remains a significant challenge.

Biodegradable ultrasound contrast tape for tracing intestinal motility.

Postoperative complications such as intestinal motility disorders and obstructions require regular monitoring following small intestine resection. While imaging techniques like MRI and CT offer high-resolution visualization of internal organs, their use is limited by the need for trained operators and constraints on frequent monitoring. Ultrasonography, although capable of continuous imaging of deep tissues, is challenged by the weak acoustic reflections from soft intestinal tissue.

Laparoscopic Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (L‑ALPPS) of Right Hemihepatectomy and Regional Lymph Node Dissection for Intrahepatic Cholangiocarcinoma (With Video).

Background: Although the application of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in intrahepatic cholangiocarcinoma (ICC) is still controversial, it continues to be attempted in selected patients. This video case discusses the key technical points for a complete laparoscopic ALPPS (L-ALPPS) of right hemihepatectomy and regional lymph node (LN) dissection for ICC.

Methods: A 61-year-old ICC patient received L-ALPPS for right hemihepatectomy and regional LN dissection.

Silk fibroin hollow microneedle system for sustained transdermal administration of liraglutide: development and characterization.

Liraglutide demonstrates a glucose-dependent hypoglycemic mechanism with significant therapeutic potential for type 2 diabetes mellitus. This study developed a hollow microneedle system featuring dual drug loading mechanisms cavity encapsulated and matrix embedded to achieve sustained release of liraglutide. The cavity structure avoids direct contact between the drug and the silk fibroin shell, as well as the binding state transition caused by hydrophobic interactions.

A comparative study of extracorporeal shock wave lithotripsy and cholangioscopy-guided lithotripsy in the management of complex biliary stones: A randomized trial.

Background: Large and impacted common bile duct stones (CBDSs) cannot be removed by conventional endoscopic retrograde cholangiopancreatography (ERCP), and extracorporeal shock wave lithotripsy (ESWL) or cholangioscopy-guided lithotripsy is recommended as a second-line treatment. The aim of this study is to compare safety and efficacy of ESWL for difficult CBDS.

Methods: Patients at our hospital diagnosed with complex large CBDS between January 2021 and June 2022 were randomly assigned to the ESWL group or the cholangioscopy group for lithotripsy.

Genetic Associations of Myopia and Axial Length with Diabetic Retinopathy.

Purpose: To investigate the genetic associations of myopia and axial length (AL) with diabetic retinopathy (DR).

Methods: We performed Mendelian randomization (MR) analyses using publicly available genome-wide association study (GWAS) summary statistics. Genetic variants were used as instrumental variables.

Preliminary investigation into the mechanical implications of excessive trabecularization in the left ventricle.

Background: Whether left ventricular excessive trabecularization (LVET) has an effect on cardiac function has been controversial. Some previous studies have suggested that LVET has no effect on cardiac function and the prognosis of the disease, whereas others have suggested that it has a certain effect. The present study aimed to investigate the impact of LVET on its mechanical alterations using an ultrasonic speckle tracking technique.

Ocular and confocal manifestations of Mainland Chinese with Fabry disease: a cross-sectional controlled study.

Background: This cross-sectional controlled study aims to characterize ocular manifestations and corneal microstructure via in vivo confocal microscopy (IVCM) in mainland Chinese patients with Fabry disease (FD). We evaluated 30 FD patients (mean age: 38 ± 14.41 years; range: 10-60 years), divided equally into enzyme replacement therapy (ERT)-treated and untreated groups, alongside 30 age- and gender-matched healthy controls.

Discovery-Replication Strategy Identifies Serum Metabolite Biomarkers for Colorectal Cancer in a Chinese Cohort.

Early diagnosis of colorectal cancer (CRC) is difficult to achieve. The use of serum metabolites may be a noninvasive diagnostic method for CRC; however, few studies have examined this method in China. This study aimed to analyze serum metabolite alterations and their diagnostic value for CRC in a Chinese cohort.

Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials.

Background: The dietary supplement industry offers a wide range of orally consumed products that claim to combat skin photoaging, however, there is a lack of research on the proof of safety and effectiveness of dietary supplements in anti-skin photoaging. To further confirm their safety and efficacy, this article provides a detailed review and meta-analysis.

Methods: Four databases, including PubMed, Embase, Web of Science, and the Cochrane Library (Central Database), were searched for relevant literature up to October 2024.

Frailty index is positively associated with stroke risk in nationally representative cohorts from the united States and China.

Frailty has been linked to adverse health outcomes, but its relationship with stroke remains insufficiently understood in general populations. In this study, we examined the association between frailty and stroke using two nationally representative cohorts: the U.S.

Interface-Engineered 2H-MoS/MXene Heterostructures for High-Performance Ammonium-Ion Hybrid Supercapacitors.

Aqueous ammonium-ion hybrid supercapacitors (AAHSCs) have received significant interest due to their environmental friendliness and excellent electrochemical performance. 2D transition metal carbides and nitrides (MXenes) are promising cathode candidates for AAHSCs owing to their high conductivity and redox activity. However, their tendency to restack severely limits ion accessibility and rate performance.

The inverse relationship between dietary anthocyanidins consumption and frailty: Findings from the National Health and Nutrition Examination Survey.

Objective: This study investigates the association between dietary anthocyanidins consumption and the risk of frailty in the general adult population using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: A cross-sectional analysis of NHANES data was conducted, examining the relationship between dietary anthocyanidins intake and frailty risk. Dose-response relationships and subgroup analyses were performed to provide a comprehensive understanding of the associations.

Intramuscular iron supplementation enhances intestinal barrier function in weaned piglets challenged with enterotoxigenic .

Background: Since iron is an essential mineral for both host and microbial communities, how to scientifically replenish the iron in the context of bacterial infection has become a critical issue. The aim of this study was to compare the influence of intramuscular and oral iron supplementation on the progression of bacterial infection.

Methods: Weaned piglets served as an experimental model for iron supplementation following enterotoxigenic (ETEC) K88 infection.

Synthesis and Cytotoxicity Evaluation of Denitroaristolochic Acids: Structural Insights and Mechanistic Implications in Nephrotoxicity.

The efficient synthetic routes and evaluates cytotoxic profiles of denitroaristolochic acids II-V (DAA-II-V) were demonstrated in this study. Based on retrosynthetic analysis, a modular synthetic strategy was developed through Suzuki-Miyaura coupling, Wittig reaction, and bismuth triflate-catalyzed intramolecular Friedel-Crafts cyclization to efficiently construct the phenanthrene core. Process optimization significantly improved yields: aryl bromide intermediate A reached 50.

Association between meat consumption and incident acute pancreatitis: a prospective cohort study.

: Previous studies indicated the potential role of consumption of different types of meat in the etiology of acute pancreatitis (AP), but no clear link has been established. This study aimed to investigate the association between consumption of 4 types of meat (processed meat, unprocessed red meat, poultry, and fish) and the risk of incident AP. : We included 489 708 participants from the UK Biobank between 2006 and 2010.

Multimodal Fusion Image Stabilization Algorithm for Bio-Inspired Flapping-Wing Aircraft.

This paper presents FWStab, a specialized video stabilization dataset tailored for flapping-wing platforms. The dataset encompasses five typical flight scenarios, featuring 48 video clips with intense dynamic jitter. The corresponding Inertial Measurement Unit (IMU) sensor data are synchronously collected, which jointly provide reliable support for multimodal modeling.

Telescoping Synthesis of γ-Lactone-Fused Indanones via C-H Activation and Rearrangement-Cyclization.

Telescoping synthesis represents a powerful strategy for the rapid assembly of complex molecular scaffolds, while obviating the need for isolation and purification of intermediates, making this strategy particularly appealing in modern synthetic efforts targeting pharmaceuticals and natural products. In this study, we present a rhodium-catalyzed -C(sp)-H olefination of -alkyl aryl ketones with methyl acrylate, followed by cascade double cyclizations that efficiently produce rare γ-lactone-fused indanones. The sequential rearrangement-cyclizations proceed through acid-promoted, carbonyl 1,3-transposition and 1,2-alkyl migration of -alkyl substituents to the enone β-carbon.

Comparison of the Efficacy of Polyvinyl Alcohol Colorless Embolic Microspheres (8Spheres) and Gelatin Embolic Microspheres (Embosphere) in Uterine Artery Embolization for Symptomatic Uterine Fibroids in Women Without Fertility Requirements: A Multicenter Observational Study.

Objective: To evaluate the differences in efficacy between polyvinyl alcohol colorless embolic microspheres (8Spheres) and gelatin embolic microspheres (Embosphere) in uterine artery embolization for symptomatic uterine fibroids.

Methods: We included 259 patients from 12 hospitals who underwent uterine artery embolization for symptomatic uterine fibroids. We collected preoperative general conditions, menstrual status, and uterine and fibroid sizes as indicated by magnetic resonance imaging, as well as changes in ovarian hormone levels before and 6 months after the procedure.

Relationship of prolonged sit-to-stand test duration and cardiovascular disease risk in Middle-aged and older adults: evidence from CHARLS.

Background: The 5-repetition sit-to-stand (5STS) test, a common physical performance measure, has been associated with various health outcomes, but its relationship with cardiovascular disease (CVD) risk warrants further investigation.

Objectives: This study examined the association between 5STS test duration and CVD risk in middle-aged and elderly Chinese adults.

Methods: Data were from the China Health and Retirement Longitudinal Study (CHARLS).

Ecological dynamics and microbial community composition of in the coastal ecosystems of Hainan province.

, a resilient plant species found in the coastal ecosystems of Hainan Province, thrives in nutrient-poor, isolated habitats. This study examines the microbial community composition and ecological dynamics of across several islands in the South China Sea, aiming to understand how environmental factors like soil pH, nitrogen (N), and phosphorus (P) availability influence the plant's microbial communities and ecological success. The study was conducted across seven plots located on different islands, including Zhaoshu Island, Yongxing Island, and Wuzhizhou Island, among others.

Faciobrachial dystonic seizure can be triggered by swallowing in LGI1 encephalitis.

Background: Leucine-rich glioma inactivated 1 (LGI1) antibodies are associated with a limbic encephalitis syndrome characterized by faciobrachial dystonic seizures (FBDSs) that is responsive to immunotherapy. The precise pathophysiology, neural origins, and underlying mechanisms of FBDS remain incompletely understood.

Case Report: We present a 54-year-old Chinese female patient with LGI1-related isolated FBDS triggered by swallowing.

Amplifying Chirality-Induced Spin Selectivity in Helical Covalent Organic Frameworks through Fullerene Encapsulation.

The chirality-induced spin selectivity (CISS) is fundamental to spintronics and molecular electronics; however, achieving high and tunable spin polarization remains challenging due to the difficulty in precisely engineering chiral architectures and modulating spin-orbit interactions. Here, we report a host-guest strategy to amplify the CISS effect by encapsulating fullerenes (C and C) within three-dimensional (3D) helical chiral covalent organic frameworks (CCOFs). Two pairs of enantiomeric CCOFs ( and ) are synthesized from chiral binaphthalene dialdehydes and a tetraamine, forming right- and left-handed helical structures.