Pharmacological inhibition of IL12β is effective in treating pressure overload-induced cardiac inflammation and heart failure.

Background And Objective: Emerging evidence indicates that inflammation regulates cardiac remodeling and heart failure (HF). IL12β is a subunit for proinflammatory cytokines IL12 and IL23. However, the effect of IL12β inhibition on HF development and the underlying mechanism is not understood.

Prognostic implications of the high sensitivity C-reactive protein to albumin ratio for major cardiovascular adverse events in patients undergoing noncardiac surgery.

The prognostic significance of the C-reactive protein-to-albumin ratio (CAR) in patients undergoing noncardiac surgery has not been conclusively determined. This study aimed to investigate the correlation and predictive capacity of the CAR for major perioperative adverse cardiovascular events (MACEs) in noncardiac surgical patients. Individuals who underwent noncardiac surgical procedures were identified within the perioperative medicine database (INSPIRE 1.

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain.

Objectives: Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in our previous studies, we demonstrated a clear sex difference in oxytocin's effects at the spinal level in rodents.

Ocular and confocal manifestations of Mainland Chinese with Fabry disease: a cross-sectional controlled study.

Background: This cross-sectional controlled study aims to characterize ocular manifestations and corneal microstructure via in vivo confocal microscopy (IVCM) in mainland Chinese patients with Fabry disease (FD). We evaluated 30 FD patients (mean age: 38 ± 14.41 years; range: 10-60 years), divided equally into enzyme replacement therapy (ERT)-treated and untreated groups, alongside 30 age- and gender-matched healthy controls.

Allogeneic human umbilical cord blood for acute ischemic stroke: Phase I clinical trial.

Objectives: Transplantation of human umbilical cord blood cells (hUCB) may enhance neuroprotection, and thus, the intravenous (IV) infusion of hUCB in patients with acute ischemic stroke (AIS) is being tested for its safety and efficacy.

Materials And Methods: We conducted a 12-month, open-label, and single-center, phase I trial of hUCB treatment in AIS patients at the age of 45-80 years, with magnetic resonance imaging evidence of acute infarction in the internal carotid artery supplied territory and the National Institute of Health Stroke Scale (NIHSS) score between 6 and 18. Eligible participants received a single-dose IV infusion of hUCB followed by the two doses of mannitol infusion within 9 days after the onset of stroke symptoms.

Carrier-Free Nanocapsule with Dual-Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with limited therapeutic outcomes. Macrophages are the key gatekeepers of intestinal immune homeostasis and have vital influence on IBD. Hence, macrophages are recognized as attractive targets to develop new therapeutic.

Exploring the interplay of stigma, family care, and discharge readiness in patients with malignant obstructive jaundice undergoing percutaneous transhepatic cholangial drainage recovery.

Objective: To investigate the current status of stigma, family care, and discharge readiness in patients with malignant obstructive jaundice undergoing percutaneous transhepatic cholangial drainage (PTCD) and analyze its influencing factors.

Methods: A cross-sectional survey was conducted on 399 patients with malignant obstructive jaundice who underwent PTCD using a general information questionnaire, the readiness for hospital discharge scale (RHDS), the social impact scale (SIS), and the family APGAR index.

Results: The total average stigma score in patients with malignant obstructive jaundice who underwent PTCD was 59.

Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics.

Introduction: Saussureae Involucratae Herba (SIH), a traditional Chinese Medicine, is clinically used in treating rheumatoid arthritis (RA). However, the anti-RA mechanisms of SIH remain unclear. Dysregulation of sphingolipid metabolism is related to the pathogenesis of RA.

Prevalence and Clinical Implications of Bovine Arch Variant in Type B Aortic Dissection: Radiological Study, Systematic Review and Meta-Analysis.

Background: To provide comprehensive perspective on the prevalence and clinical relevance of the bovine arch variant in type B aortic dissection (TBAD).

Methods: This study included two parts. The first part was a radiological study that included TBAD patients at two institutions to identify the prevalence of the bovine arch and its subtypes.

Integrating Network Pharmacology and Experimental Validation to Elucidate the Mechanisms of Tang Shen Ping Decoction in Diabetic Kidney Disease.

Diabetic kidney disease (DKD) is a severe complication of diabetes, characterized by chronic inflammation and fibrosis. Tang Shen Ping Decoction (TSPD), a traditional Chinese medicine formulation, has shown therapeutic efficacy in DKD, yet its molecular mechanisms remain to be fully elucidated. To explore the multitarget mechanisms of TSPD, this study integrated network pharmacology, transcriptomic analysis, molecular docking, and molecular dynamics simulations, followed by in vivo and in vitro validation.

Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype.

Obesity is a significant risk factor for cancer and is associated with breast cancer metastasis. Nevertheless, the mechanism by which alterations in systemic metabolism affect tumor microenvironment (TME) and consequently influence tumor metastasis remains inadequately understood. Herein, we found that perturbations in circulating metabolites induced by obesity promote metastasis-like phenotypes in breast cancer.

The present and future of geriatric internal medicine: a bibliometric analysis.

With the gradual progress of global aging, geriatric medicine is becoming increasingly popular, and within geriatric medicine, internal medicine holds a very important position. Understanding the situation in the field of geriatric internal medicine helps researchers gain a comprehensive understanding of this area. In this study, we analyzed and visualized relevant literature from the Web of Science Core Collection database using bibliometric methods, collecting a total of 831 articles, with a time span from 1978 to August 2024.

Genomic and Transcriptomic Profiling of Amino Acid Compositions in Common Carp Fillets.

Fish are rich sources of amino acids (AAs), particularly human essential amino acids (HEAAs). Exploring the regulatory mechanisms behind the changes in the combined AA content in the fillet and enhancing the content of AAs, especially HEAAs, in fillets of farmed fish is crucial for meeting human nutritional needs. After hot acidic hydrolysis of 304 common carp fillets, we quantified the contents of 17 single AAs and 5 AA groups and observed significant variations among them.

Phylogenomic analyses revealed a new lineage of house mouse (Mus musculus) in Gyirong Basin of Xizang Autonomous Region, China.

In the present study, we collected 20 individuals and 12 individuals of wild mice from the Gyirong Basin of Xizang Autonomous Region in China and Sudurpashchim in Nepal. Phylogeny and genetic structure inferred from different types of genomic markers suggest that these samples all belong to Mus musculus, among which individuals from Gyirong Basin represent a new genomic lineage (named as M. m.

Catching CRISPR-Cas9 in Action.

CRISPR-Cas9 has revolutionized genome editing, yet its structural dynamics and functional properties remain incompletely understood, partly due to limited atomic-level characterization of its active conformation with a full R-loop. Capitalizing on recent advances in Cas9 structural determination, we constructed a catalytic-state Cas9 model bound to a R-loop and performed an integrated computational investigation. Our molecular dynamics simulations reveal substantial conformational heterogeneity in the PAM (protospacer-adjacent motif)-distal nontarget DNA strand and adjacent Cas9 regions, leading to dynamically fluctuating interactions, thereby challenging experimental resolution of the full R-loop complex.

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study.

Purpose: This investigation aimed to elucidate the causal role of inflammatory cytokines in the risk of developing refractive errors.

Methods: Genetic variants previously associated with inflammatory cytokines served as instrumental variables in genome-wide association studies (GWASs) of European ancestry. Bidirectional two-sample Mendelian randomization (MR) analyses were conducted using summary data from GWAS meta-analyses.

Ecotoxicological risk assessment of N-nitrosamines to Selenastrum capricornutum in surface waters: Insights into toxicity mechanisms and environmental Implications.

N-nitrosamines, one of the most common nitrogen-containing organic compounds in freshwater systems such as rivers or reservoirs, are toxic and carcinogenic to human. However, the aquatic hazard of these compounds to algae which is ubiquitous in surface water is still unclear. In this study, nine N-nitrosamines were investigated in the Pearl River Delta, China, with the total concentrations ranged from 27.

Smoking disrupts the relationship between cerebrospinal fluid IL-1β and multiple subdimensions of sleep.

Objective: Inflammatory factors and cigarette smoking have been associated with sleep disorders but molecular mechanisms that regulate sleep, specifically the role of interleukin-1β (IL-1β), remain controversial. Individuals' cerebrospinal fluid (CSF) IL-1β, smoking behavior, and sleep data were collected to investigate how smoking may influence the relationship between CSF IL-1β and sleep via moderation analysis.

Methods: A total of 191 Chinese male patients, including 104 non-smokers and 87 active smokers, scheduled for anterior cruciate ligament reconstructive surgery, were recruited.

A tri-compound formula comprising Ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model.

Background: Atopic dermatitis (AD) is characterized by both IgE- and non-IgE-mediated immune responses, as well as skin barrier dysfunction. Ginsenoside Rg1, tetrandrine, and icariin each exhibit distinct properties that may contribute to the management of AD. Ginsenoside Rg1 has demonstrated efficacy in mitigating IgE-mediated allergic rhinitis, while tetrandrine is known to suppress abnormal T-cell activation.

Advancing tissue analysis: Integrating mass tags with mass spectrometry imaging and immunohistochemistry.

In biological and biomedical research, it's a crucial task to detect or quantify proteins or proteomes accurately across multiple samples. Immunohistochemistry (IHC) and spatial proteomics based on mass spectrometry imaging (MSI) are used to detect proteins in tissue samples. IHC can detect precisely but has a limited throughput, whereas MSI can simultaneously visualize thousands of specific chemical components but hindered by detailed protein annotation.

NaCl-Assisted electrospinning of bifunctional carbon fibers for High-Performance flexible zinc-air batteries.

With the increasing demand for flexible, rechargeable zinc-air batteries (ZABs), developing efficient oxygen electrocatalysts is challenging. A large specific surface area and porous structure are critical for electrochemical performance but can compromise mechanical strength and flexibility. Herein, a novel strategy with NaCl-assisted electrospinning and pyrolysis has been proposed to fabricate self-supported carbon fibers with a solid core and mesoporous shell as bifunctional oxygen electrocatalysts for flexible ZABs.

Serum-derived exosomal microRNAs as biomarkers for postoperative delirium.

Introduction: Postoperative delirium (POD) is a frequent and challenging complication in elderly surgical patients, marked by abrupt cognitive and attentional disturbances. Current POD diagnosis depends on clinical assessments that are time-intensive and lack predictive accuracy before surgery. Although previous research has explored biomarkers such as neuroinflammatory factors and Alzheimer's-related proteins to enhance POD prediction, single molecular markers have proven insufficient for reliable prognosis.

Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy: A randomized clinical trial.

Background: Propofol has been widely used in bidirectional gastrointestinal endoscopy sedation; however, it frequently leads to cardiovascular adverse events and respiratory depression. Propofol target-controlled infusion (TCI) can provide safe sedation but may require higher dosages of propofol. On the contrary, etomidate offers hemodynamic stability.

A comprehensive reconnaissance and risk assessment of rubber additives and their transformation products (RATPs) in groundwater: 1,3-Diphenylguanidine (DPG) as a pressing ecological concern.

The widespread detection of rubber additives and their transformation products (RATPs) in surface water environments is well-documented, but their pollution characteristics in groundwater remain unclear. This study comprehensively revealed the occurrence and distribution of 27 RATPs in groundwater across southern China (n = 212). RATPs were detected in groundwater at total levels of 1.

A New Allele HLA-DPA1*02:02:02:19 Identified by HLA-Targeted Third-Generation Sequencing.

HLA-DPA1*02:02:02:19 differs from HLA-DPA1*02:02:02:02 by one nucleotide change in intron 1.