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Objective: To investigate the current status of stigma, family care, and discharge readiness in patients with malignant obstructive jaundice undergoing percutaneous transhepatic cholangial drainage (PTCD) and analyze its influencing factors.
Methods: A cross-sectional survey was conducted on 399 patients with malignant obstructive jaundice who underwent PTCD using a general information questionnaire, the readiness for hospital discharge scale (RHDS), the social impact scale (SIS), and the family APGAR index.
Results: The total average stigma score in patients with malignant obstructive jaundice who underwent PTCD was 59.1 ± 10.34, and the average scores of each dimension, from low to high, were: social exclusion, economic discrimination, intrinsic stigma, and social isolation. The overall average score of discharge readiness was 61.08 ± 17.94, and the average scores of each dimension from low to high were personal status, adaptability, and predictive support. The total score of the family care scale was 5.00 (4.00, 7.00). Patients with malignant obstructive jaundice undergoing PTCD had a negative correlation between their sense of stigma and discharge readiness, r = -0.748 (P < 0.01). There was a positive correlation between family care and discharge readiness, r = 0.904 (P < 0.01), and a negative correlation between sense of stigma and family care, r = -0.854 (P < 0.01). The results of multiple linear regression analysis showed that age, lifestyle, PTCD time, and hospitalization interval were all correlated with patients' sense of stigma, family care, and discharge readiness (P < 0.05).
Conclusions: Patients with malignant obstructive jaundice who underwent PTCD had a moderate level of stigma, family care, and discharge readiness. There were pairwise correlations among family care, discharge readiness, and sense of stigma. Clinical medical staff should attach importance to the quality of discharge guidance and the importance of family support, help patients establish good social support systems, and promote the safety management of patients after discharge.
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http://dx.doi.org/10.1186/s40359-025-03085-1 | DOI Listing |
J Environ Pathol Toxicol Oncol
January 2025
Department of Gynecology, Pucheng County People's Hospital, Weinan, China.
Long non-coding RNAs (lncRNAs) are involved in the numerous types of tumors. The aim of this study is to comprehend the pathological mechanism of lncRNA CASC19 in ovarian cancer. CASC19, miR-761 and CBX2 expression in the samples was quantitatively detected by real-time quantitative polymerase chain reaction (RT-qPCR) reaction.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
September 2025
Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Background: Breast cancer is one of the most common malignancies worldwide and is often treated with surgery. Post-mastectomy pain syndrome (PMPS) can have disabling consequences. The incidence of PMPS ranges from 20% to 68%.
View Article and Find Full Text PDFJ Neurosurg Case Lessons
September 2025
Department of Neurosurgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Background: Anaplastic lymphoma kinase (ALK)-positive primary CNS anaplastic large cell lymphoma (ALCL) is an extremely rare pediatric malignancy. Its radiological appearance often mimics infectious or glial lesions, complicating diagnosis and delaying treatment.
Observations: The authors report the case of a 10-year-old immunocompetent female who presented with absence seizures and vomiting.
JMIR Cancer
September 2025
Department of Health Outcomes and Biomedical Informatics, University of Florida, 1889 Museum Road, Suite 7000, Gainesville, FL, 32611, United States, 1 352 294-5969.
Background: Disparities in cancer burden between transgender and cisgender individuals remain an underexplored area of research.
Objective: This study aimed to examine the cumulative incidence and associated risk factors for cancer and precancerous conditions among transgender individuals compared with matched cisgender individuals.
Methods: We conducted a retrospective cohort study using patient-level electronic health record (EHR) data from the University of Florida Health Integrated Data Repository between 2012 and 2023.
Neurology
October 2025
Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, WA.
Background And Objectives: Neuroimaging findings in immune effector cell-associated neurotoxicity syndrome (ICANS) have not been systematically described. We created the chimeric antigen receptor (CAR) T-cell Neurotoxicity Imaging Virtual Archive Library (CARNIVAL), a centralized imaging database for children and young adults receiving CAR T-cell therapy. Objectives of this study were to (1) characterize neuroimaging findings associated with ICANS and (2) determine whether specific ICANS-related neuroimaging findings are associated with individual neurologic symptoms.
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