The cation channel Trpa1 and chemokine Cxcl1 mediate axonal degeneration in spared nerve injury-induced neuropathic pain.

Demyelination of peripheral nerve injury is a vital cause of neuropathic pain. Schwann cells play an important role in supporting and maintaining the removal and regeneration of myelin debris from neuronal axons in the peripheral nervous system. Creating a good immune microenvironment would promote the Schwann cells to repair the injured nerve and reverse the allodynia of neuropathic pain.

Identification of key genes associated with anthracnose resistance in Camellia sinensis.

Anthracnose, a prevalent fungal disease in tea plantations, cause substantial economic losses in tea production. Identifying resistance-associated genes in tea plants is crucial for developing anthracnose-resistant cultivars. This study used eight tea samples with differential anthracnose resistance for phenotypic evaluation, weighted gene co-expression network analysis (WGCNA) of RNA-seq data, WGCNA- QTL co-localization to identify resistance gene, and qRT-PCR validation of candidate genes.

Combination of culprit plaque enhancement ratio and hypoperfusion contributes to short-term outcomes of patients with atherosclerotic stenosis in the middle cerebral artery.

Objective: To investigate the differences in intracranial culprit plaque characteristics in the middle cerebral artery (MCA) and in hypoperfusion between patients with and without favourable functional outcomes and to explore the association of functional outcome of patients with ischaemic cerebrovascular events.

Methods: A total of 121 patients with acute/subacute ischaemic stroke stemming from atherosclerotic plaques in the MCA were retrospectively enrolled and grouped into patients with favourable functional outcomes and those with unfavourable functional outcomes. Each patient underwent high-resolution vessel wall imaging and dynamic susceptibility contrast-enhanced perfusion weighted imaging on a 3.

Teacher-Student relationships and academic grades in Chinese high schools: the roles of perceived teaching quality and students' mental health symptoms.

Background: Teacher-student relationships (TSRs) are recognized as playing an important role in students' academic success. However, the potential mechanisms linking TSRs to academic grades remain underexplored, particularly in non-Western contexts such as China, where academic achievement is highly emphasized, and grades play a critical role in determining students' college entrance opportunities.

Objectives: This study examined the associations among TSRs, perceived teaching quality, students' mental health symptoms, and academic grades among Chinese high school students.

sp. nov., a novel endophytic actinobacterium isolated from bark of and emended description of the genus .

A novel strain, KQZ13P-5, was isolated from the bark of collected from Maowei Sea Mangrove Nature Reserve of Guangxi Zhuang Autonomous Region, China. Cells of strain KQZ13P-5 were Gram-stain-positive, aerobic and non-spore producing. A polyphasic taxonomic approach was investigated to resolve its taxonomic position.

Proposal of Paenibacillus kandeliae sp. nov, Isolataed from Leaf of Kandelia candel.

A novel bacterial strain, designated JQZ6Y-1, was isolated from the leaf of Kandelia candel at Maowei sea Mangrove Nature Reserve, Guangxi Zhuang Autonomous Region, China. The 16S rRNA gene sequence phylogenetic and phylogenomic analysis revealed that strain JQZ6Y-1 formed a stable clade with Paenibacillus wenxiniae DSM 100576 and Paenibacillus hunanensis CGMCC 1.8907 within the genus Paenibacillus.

Effect of etomidate added to propofol target-controlled infusion in bidirectional endoscopy: A randomized clinical trial.

Background: Propofol has been widely used in bidirectional gastrointestinal endoscopy sedation; however, it frequently leads to cardiovascular adverse events and respiratory depression. Propofol target-controlled infusion (TCI) can provide safe sedation but may require higher dosages of propofol. On the contrary, etomidate offers hemodynamic stability.

Enhancing the Built-in Electric Field in Oxygen Vacancies-Enriched I-Doped BiOCl for Visible Light-Driven Photocatalytic Oxidation.

In semiconductor catalysts, rational doping of nonmetallic elements holds significant scientific and technological importance for enhancing photocatalytic performance. Here, using a one-step hydrothermal technique, we synthesized iodine-doped BiOCl composite and evaluated the impact of iodine doping on its photocatalytic capability for organic dye degradation under visible light irradiation. In this study, we demonstrate that the introduction of iodide ions not only provides an ideal built-in electric field (BIEF) for BiOCl but also induces the generation of additional oxygen vacancies (OVs).

Charge-redistributed RuNi/MoN heterojunction enables efficient hydrogen evolution in a wide pH range.

Electrocatalytic hydrogen production offers a promising solution to address current energy depletion. Herein, a RuNi/MoN heterostructure on carbon cloth (CC), RuNi/MoN@CC, was successfully constructed using a simple method, allowing for dual regulation of morphology and electronic structure. Under the influence of Ni, the in-situ generated MoN inherits the morphology of the NiMoO precursor, presenting a nanowire morphology, which is favorable for increasing electrochemical active area.

Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue.

Aims: β3-Adrenergic receptor (β3-AR) is essential for cardiovascular homoeostasis through regulating adipose tissue function. Perivascular adipose tissue (PVAT) has been implicated in the pathogenesis of aortic dissection and aneurysm (AD/AA). Here, we aim to investigate β3-AR activation-mediated PVAT function in AD/AA.

Association of sodium-glucose cotransporter 2 inhibitors with risk of incident dementia and all-cause mortality in older patients with type 2 diabetes: A retrospective cohort study using the TriNetX US collaborative networks.

Background: Limited evidence exists to support any specific medication over others to prevent dementia in older patients with type 2 diabetes (T2D). We investigated whether treatment with sodium-glucose cotransporter 2 (SGLT-2) inhibitors is associated with a lower risk of incident dementia and all-cause mortality, relative to dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RA).

Methods: In this retrospective, active-comparator cohort study, we used data from the TriNetX electronic health records network.

Metabolites of pathogenic microorganisms database (MPMdb) and its seed metabolite applications.

Seed metabolites are the combination of essential compounds required by an organism across various potential environmental conditions. The seed metabolites screening framework based on the network topology approach can capture important biological information of species. This study aims to identify comprehensively the relationship between seed metabolites and pathogenic bacteria.

Association between the fetal-type posterior cerebral artery and intracranial anterior and posterior circulating atherosclerotic plaques using multi-contrast magnetic resonance vessel wall imaging.

Background: Intracranial atherosclerotic disease (ICAD) is one of the most common causes of ischemic stroke. The fetal-type posterior cerebral artery (FTP) affects intracranial collateral circulation, which is closely related to the occurrence and development of ICAD. Knowledge of the relationship between FTP and ICAD is important for developing treatment strategies for FTP patients diagnosed with atherosclerotic diseases.

POCl/Sulfoxide-Promoted Synthesis of Indolizino[8,7-]indoles.

A mild chlorocyclization of pyrrole-tethered indoles has been realized using POCl as the chlorine source and tetramethylene sulfoxide as the promoter. A variety of chlorinated indolizino[8,7-]indole derivatives have been constructed efficiently under this reaction system in moderate to good yields (19 examples, up to 93% yield).

Research Progress on Microbial Community Succession in the Postmortem Interval Estimation.

The postmortem interval (PMI) estimation is a key and difficult point in the practice of forensic medicine, and forensic scientists at home and abroad have been searching for objective, quantifiable and accurate methods of PMI estimation. With the development and combination of high-throughput sequencing technology and artificial intelligence technology, the establishment of PMI model based on the succession of the microbial community on corpses has become a research focus in the field of forensic medicine. This paper reviews the technical methods, research applications and influencing factors of microbial community in PMI estimation explored by using high-throughput sequencing technology, to provide a reference for the related research on the use of microbial community to estimate PMI.

Puerarin prevents sepsis-associated encephalopathy by regulating the AKT1 pathway in microglia.

Background: Previous studies have reported that puerarin possesses cardioprotective, vasodilatory, anti-inflammatory, anti-apoptotic, and hypoglycemic properties. However, the impact of puerarin on sepsis-associated encephalopathy (SAE) remains unexplored. In this study, we explored whether puerarin can modulate microglia-mediated neuroinflammation for the treatment of SAE and delved into the underlying mechanisms.

Association of culprit plaque enhancement ratio, hypoperfusion and HbA1c with recurrent ischemic stroke in patients with atherosclerotic stenosis of the middle cerebral artery.

Purpose: To investigate the differences in intracranial culprit plaque characteristics of the middle cerebral artery (MCA), collateral circulation and hypoperfusion in patients with and without recurrent ischemic stroke and to identify the association with the recurrent ischemic cerebrovascular events.

Method: Eighty-six patients with acute/subacute ischemic stroke caused by atherosclerotic plaques of the MCA were retrospectively enrolled and grouped into patients with recurrence (n = 36) and without recurrence (n = 50). All patients underwent high-resolution vessel wall imaging and dynamic susceptibility contrast-enhanced perfusion weighted imaging.

NHOAc/DMSO-Promoted Benzylation of Pyrrolo[2,1-]isoquinolines.

Benzylation of pyrrolo[2,1-]isoquinoline derivatives has been realized with various phenols by the use of ammonium acetate as a promoter (20 examples, up to 84% yield). DMSO served as the source of methylene and solvent. The employment of iron chloride as a catalyst can also afford the desired benzylated products in moderate to good yields (11 examples, up to a 74% yield).

Modulating adsorption energy on nickel nitride-supported ruthenium nanoparticles through in-situ electrochemical activation for urea-assisted alkaline hydrogen production.

The rational design of electrocatalysts with exceptional performance and durability for hydrogen production in alkaline medium is a formidable challenge. In this study, we have developed in-situ activated ruthenium nanoparticles dispersed on NiN nanosheets, forming a bifunctional electrocatalyst for hydrogen evolution and urea oxidation. The results of experimental analysis and theoretical calculations reveal that the enhanced hydrogen evolution reaction (HER) performance of O-Ru-NiN stems primarily from the optimized hydrogen adsorption and hydroxyl adsorption on Ru sites.

Constructing of CoP-NbO p-n heterojunction with built-in electric field to accelerate the charge migration in electrocatalytic hydrogen evolution.

Studying interfacial charge transfer is of great significance for the preparation of electrocatalysts with high activity for the hydrogen evolution reaction (HER). Particularly, exploring the in-depth catalytic mechanisms and facile fabrication methods of narrow bandgap metal phosphides remains worthwhile. This work successfully combined catalytically inert n-type NbO with p-type CoP to prepare a p-n heterojunction (CoP-NbO).