BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.

Despite optimized guideline-directed medical therapy, patients with myocardial infarction (MI) often develop heart failure (HF) primarily because of excessive fibrosis. Bone morphogenetic protein 1 (BMP1) plays a critical role in the fibrotic process, yet its specific role in post-MI myocardial fibrosis remains unclear. In this study, we investigated the complex dynamics between BMP1 and fibrotic processes, offering critical insights for novel strategies to mitigate pathological fibrosis in cardiovascular diseases.

Structural and functional properties of soy protein isolates from different cultivars.

To investigate the structural and functional properties of soy protein isolates (SPIs) derived from different natural soybean cultivars, while avoiding interference from artificial modifications, SPIs were extracted from seven different cultivars. Their composition, structure, and functional characteristics were systematically analysed. The results revealed significant differences among the samples.

Characterization, Microbial Community Structure, and Pathogen Occurrence in Two Typical Eel Farms.

Pollutants and pathogens in aquaculture systems may cause economic losses and threaten public health. Yet, the risks associated with microbiological contaminants and their relationship with environmental factors remain largely unknown. In this study, two typical eel farms in southeast China were chosen for investigation of water quality and microbial community in the treatment processes.

Two Halobismuthates Decorated by Cesium and N-Methylated Isonicotinato: Crystal Architectures, Optical/Photoelectrical Performances, and Theoretical Insights.

Seeking novel halobismuthate-based hybrids is of great research importance for enriching the structural chemistry and physicochemical applications of this family, but it is fraught with enormous challenges. In this paper, using cesium and the in situ-generated MCP (HMCP = 1-methyl-4-(carboxyl)pyridinium) ligand as the cotemplates, we have successfully obtained two new hybrid halobismuthate numbers with abundant weak interactions, namely, Cs[MCP]BiBr () and Cs[Bi(MCP)I]BiI (), which are then structurally characterized and theoretically analyzed. Compound features the chain-like [BiBr] anions decorated by MCP ligands, while compound has the classical [BiI] motifs characteristic of unfrequent T-typed [Bi(MCP)I] cations.

[Clinical Value of a Novel Prognostic Prediction Model in Diffuse Large B-Cell Lymphoma].

Objective: To explore a predictive model that can better predict the prognosis of patients with diffuse large B-cell lymphoma (DLBCL), and validate its clinical value.

Methods: Clinical data of 134 newly treated DLBCL patients were collected from Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2015 to January 2020. Several risk factors of the patients were screened and analyzed, a novel prognostic model were then established based on this, and its clinical application potential was validated.

Biallelic pathogenic variants presenting as neonatal cholestasis, liver fibrosis and neurological manifestations.

Background: Biallelic pathogenic variants have been associated with a novel ciliopathy named hepatorenocardiac degenerative fibrosis, which is characterised by hepatic fibrosis in childhood or early adulthood, fibrocystic kidney disease later in life and hypertrophic cardiomyopathy in the elderly. Its genotype and phenotype spectrum are largely unknown.

Methods: Patients presenting with liver diseases between 2015 and 2023 at The Center for Pediatric Liver Diseases, Children's Hospital of Fudan University, Shanghai, and carrying biallelic rare variants of were studied.

Development and validation of a visual impairment prediction nomogram in chronic kidney diseases: the National Health and Nutrition Examination Survey, 1999-2008.

Aim: To develop a nomogram to predict the risk of visual impairment (VI) in patients with chronic kidney disease (CKD).

Methods: Totally 897 patients with CKD were selected from the National Health and Nutrition Examination Survey (NHANES). The training and validation sets were divided in a 7:3 ratio.

C-reactive protein-mediated dementia.

Loss of memory is the main feature of dementia, accompanied by personality changes. Alzheimer's disease (AD) is the most prevalent type of dementia globally and a major contributor to disability and mortality in older individuals. Most notably, the neurological damage caused by AD is irreversible, but the current market still lacks effective medications for the treatment of dementia.

In-depth insight into structure-reactivity/regioselectivity relationship of Lewis acid catalyzed cascade 4πe-cyclization/dicycloexpansion reaction.

The Lewis acid-catalyzed tittle reaction of 1,3-dicycloalkenlidine ketones is recognized as so far the shortest and most effective 1-step method for construction of angular tricyclic scaffolds, which are extensively found in bioactive terpenoids. Here, a further kinetic study of this reaction with 30 reaction examples is carried out using in situ IR technology and DFT calculation. That enables the creation of well-fitted linear relationships of lnk/(ΔG/T), ΔG/ΔG, ln(k/k)/σ, reflecting the structure's effect on reactivity/selectivity, and validating the reaction mechanism.

1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells.

Hepatic fibrosis (HF) is a pathological process in many liver diseases, which lack of specific agents. Pirfenidone (PFD) derivatives are potential new drug. The purpose of this study was to investigate the effect and immunological mechanism of PFD derivatives on HF.

Clinical features and long-term outcomes of patients with ZFYVE19 variants.

Background: ZFYVE19-associated progressive familial intrahepatic cholestasis is a rare ciliopathy, with limited information on its natural history.

Aims: Investigate long-term outcomes, especially after liver transplantation (LT), in ZFYVE19-deficient patients.

Methods: Medical data of 13 Chinese individuals genetically diagnosed with ZFYVE19 deficiency, including 4 unreported patients, were reviewed.

Electronic structure modulation of ultrathin PtRuMoCoNi high-entropy alloy nanowires for boosting peroxidase-like activity and sensitive colorimetric determination of isoniazid and hydrazine.

Self-supported ultrathin PtRuMoCoNi high-entropy alloy nanowires (HEANWs) were synthesized by a one-pot co-reduction method, whose peroxidase (POD)-like activity and catalytic mechanism were elaborated in detail. As expected, the PtRuMoCoNi HEANWs showed excellent POD-like activity. It can quickly catalyze the oxidization of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue TMB through decomposition of HO to superoxide radicals.

Comprehensive Breslow thickness (BT)-based analysis to identify biological mechanisms associated with melanoma pathogenesis.

Breslow thickness (BT), a parameter measuring the depth of invasion of abnormally proliferating melanocytes, is a key indicator of melanoma severity and prognosis. However, the mechanisms underlying the increase in BT remain elusive. Utilizing data from The Cancer Genome Atlas (TCGA) human skin cutaneous melanoma (SKCM), we identified a set of BT-related molecules and analyzed their expression and genomic heterogeneity across pan-cancerous and normal tissues.

SHMT2 regulates CD8+ T cell senescence via the reactive oxygen species axis in HIV-1 infected patients on antiretroviral therapy.

Background: Although antiretroviral therapy (ART) effectively inhibits viral replication, it does not fully mitigate the immunosenescence instigated by HIV infection. Cellular metabolism regulates cellular differentiation, survival, and senescence. Serine hydroxymethyltransferase 2 (SHMT2) is the first key enzyme for the entry of serine into the mitochondria from the de novo synthesis pathway that orchestrates its conversion glutathione (GSH), a key molecule in neutralising ROS and ensuring the stability of the immune system.

Association of dietary patterns with chronic respiratory health among U.S. adults.

Background: Respiratory health is closely related to immune system function, and diet can also influence immune homeostasis. Diet, an important part of a healthy lifestyle, is also linked to respiratory health. We aimed to explore the relationship between different dietary patterns and the risk of chronic respiratory diseases (CRDs), including chronic bronchitis (CB), emphysema, and asthma.

Uniform PtCoRuRhFe high-entropy alloy nanoflowers: Multi-site synergistic signal amplification for colorimetric assay of captopril.

Uniform PtCoRuRhFe high-entropy alloy nanoflowers (HEANFs) were fabricated by a simple wet-chemical co-reduction method in oleylamine for quantitative colorimetric determination of captopril (CAP) based on multi-site synergistic signal amplification. Specifically, the peroxidase mimetic activity of the PtCoRuRhFe HEANFs was examined through catalysis of 3,3',5,5'-tetramethylbenzidine (TMB) oxidation, whose catalytic mechanism was investigated by electron paramagnetic resonance (EPR) spectroscopy. The role of the ·O was figured out during the catalytic procedure.

Reliability and Convergent Validity of Endurance Indices Derived from Near-Infrared Spectroscopy and Electromyography during a Bilateral Hanging Task in Amateur Rock Climbers.

The ability to hang for a long time before forearm muscle fatigue is a crucial element of successful rock climbing. Electromyography (EMG) and near-infrared spectroscopy (NIRS) are also useful for measuring hemoglobin oxygenation for determining muscle endurance. In the present study, we aimed to evaluate the reliability and validity of muscle endurance indices derived using EMG and NIRS during a hanging task.

Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue.

Aims: β3-Adrenergic receptor (β3-AR) is essential for cardiovascular homoeostasis through regulating adipose tissue function. Perivascular adipose tissue (PVAT) has been implicated in the pathogenesis of aortic dissection and aneurysm (AD/AA). Here, we aim to investigate β3-AR activation-mediated PVAT function in AD/AA.

Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy (NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: To investigate whether the combination of chemotherapy with staged Chinese herbal medicine (CHM) therapy could enhance health-related quality of life (QoL) in non-small-cell lung cancer (NSCLC) patients and prolong the time before deterioration of lung cancer symptoms, in comparison to chemotherapy alone.

Methods: A prospective, double-blind, randomized, controlled trial was conducted from December 14, 2017 to August 28, 2020. A total of 180 patients with stage I B-IIIA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM (chemo+CHM) group (120 cases) or chemotherapy combined with placebo (chemo+placebo) group (60 cases) using stratified blocking randomization.

Gut promotes protective immunity to foodborne infection.

Unlabelled: The gut microbiota, a pivotal component of the intestinal mucosal barrier, is critical for host resistance to enteric pathogen infection. Here, we report a novel function of the potentially probiotic strain LG1 ( strain LG1) in maintaining intestinal mucosal barrier integrity and protecting against foodborne () infection. was isolated from the intestinal contents of Chinese Mongolian sheep (MS) and exhibited potential probiotic properties.

What influences the implementation of clinical guidelines related to enteral nutrition in the intensive care unit: A mixed-methods systematic review.

Aims: To systematically evaluate and analyse literature concerning the factors influencing the implementation of clinical practice guidelines related to enteral nutrition in the adult intensive care unit.

Background: Guidelines serve as crucial tools for guiding clinical practice. However, a significant gap persists between current clinical practice and guidelines pertaining to enteral nutrition.

Coordination of oxysterol binding protein 1 and VAP-A/B modulates the generation of cholesterol and viral inclusion bodies to promote grass carp reovirus replication.

Similar to other RNA viruses, grass carp reovirus, the causative agent of the hemorrhagic disease, replicates in cytoplasmic viral inclusion bodies (VIBs), orchestrated by host proteins and lipids. The host pathways that facilitate the formation and function of GCRV VIBs are poorly understood. This work demonstrates that GCRV manipulates grass carp oxysterol binding protein 1 (named as gcOSBP1) and vesicle-associated membrane protein-associated protein A/B (named as gcVAP-A/B), 3 components of cholesterol transport pathway, to generate VIBs.