Comorbidities and their impact on in-hospital mortality in hospitalized adult patients with bacterial community-acquired pneumonia: a cohort study.

Background: As a leading global health burden, community-acquired pneumonia (CAP) continues to account for substantial morbidity and mortality, particularly among patients with pre-existing comorbidities. This study investigated the prognostic impact of comorbidities on in-hospital mortality in adult patients with bacterial CAP.

Methods: Secondary diagnoses were considered comorbidities if present at admission and reflective of chronic conditions.

Shu-Feng-Jie-Biao Formula Ameliorates Influenza A Virus-Induced Acute Lung Injury by Inhibiting NF-κB and ERK MAPK Signaling Pathways.

Purpose: Shu-Feng-Jie-Biao formula (SFJBF) has been used to treat acute respiratory infections for a dozen years. This study aimed to explore its mechanisms and effects for the treatment of influenza.

Methods: Network pharmacology was used to explore the underlying mechanism of SFJBF against influenza.

Multimodal assessment of treatment with proprotein convertase subtilisin/kexin type 9 inhibitors combined with statins for regulating coronary artery plaque regression in patients with chronic/acute coronary syndrome: A meta-analysis.

BackgroundStatins are the standard treatment for coronary atherosclerosis; however, some patients require additional therapies for optimal plaque regression. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (PCSK9i), including monoclonal antibodies and small interfering RNA-based therapies, have shown promise as adjuncts to statins, although their efficacy for coronary plaque regression, as assessed by intravascular imaging, remains uncertain.MethodsWe conducted a meta-analysis to compare the treatment efficacy of statins combined with PCSK9i (PCSK9i group) versus statins alone or statins combined with placebo (control group) in adults with coronary atherosclerosis (INPLASY registration number: INPLASY202550027).

Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis.

This study uses Mendelian randomization (MR) to investigate the potential causal relationships between viral infections, including Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), SARS-CoV-2, cytomegalovirus (CMV), human herpes virus 6 (HHV-6), varicella-zoster virus (VZV), herpes simplex virus (HSV), influenza A virus, and hepatitis B virus, and the risk of systemic sclerosis (SSc). Summary-level data on viral exposures and SSc outcomes were obtained from public genome-wide association studies (GWAS) databases. Causality was assessed using the inverse-variance weighted (IVW), MR-Egger, and weighted median methods.

Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: study protocol for a cross-sectional and prospective study.

Background: Postmenopausal osteoporosis (PMOP) and knee osteoarthritis (KOA) are common musculoskeletal disorders that share risk factors such as aging, hormonal changes, and inflammation. PMOP often remains asymptomatic until fractures occur, while KOA leads to pain and disability. Their comorbidity remains underexplored, particularly in community settings.

Identification and characterization of the de novo methyltransferases for eukaryotic -methyladenine (6mA).

-methyladenine (6mA) is an intensively investigated epigenetic modification in eukaryotes. 6mA is maintained through semiconservative transmission during DNA replication, but the identity of de novo methyltransferase (MTase) catalyzing its establishment remains unknown. Here, we identified MT-A70 family proteins AMT2 and AMT5 as the de novo MTases responsible for 6mA establishment, using the unique sexual reproduction process of the unicellular eukaryote .

Sodium-Intercalated Vanadium Oxide Coated on Carbon Cloth for Electrode Materials in High-Performance Aqueous Zinc-Ion Batteries.

In this work, novel sodium-intercalated vanadium oxide nanowire electrode materials (NaXV@CC) were successfully designed as cathode materials for Aqueous Zinc-Ion Batteries (AZIBs) through a two-step electrochemical process. The optimized electrode material, Na30V@CC, exhibited superior capacity, excellent rate capability, and outstanding stability. The intercalation of sodium ions into the nanowire lattice induced a significant transformation in the overall nanostructure, leading to altered nanowire morphology.

Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein.

Introduction: Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes acute febrile illness with thrombocytopenia and a high mortality rate in humans. Currently, no specific antiviral agents have been approved for the prevention or treatment of SFTSV infection. The viral nucleoprotein (NP) is a critical component involved in viral RNA replication and transcription, representing a promising target for antiviral drug development.

Berberine partially ameliorates cardiolipotoxicity in diabetic cardiomyopathy by modulating SIRT3-mediated lipophagy to remodel lipid droplets homeostasis.

Background And Purpose: Emerging evidence indicated that the excessive lipid droplets (LDs) accumulation and lipotoxicity play a significant role in the development of diabetic cardiomyopathy (DCM), yet the regulatory mechanisms governing the function of cardiac LDs are still unknown. Lipophagy has been shown to be involved in the maintenance of LDs homeostasis. The objective of this study was to explore the mechanism of lipophagy in cardiomyocytes and investigate whether berberine could mitigate DCM by modulating this pathway.

Integrative deep learning and radiomics analysis for ovarian tumor classification and diagnosis: a multicenter large-sample comparative study.

Purpose: This study aims to evaluate the effectiveness of combining transvaginal ultrasound (US)-based radiomics and deep learning model for the accurate differentiation between benign and malignant ovarian tumors in large-scale studies.

Materials And Methods: A multicenter retrospective study collected grayscale and color US images of ovarian tumors. Patients were divided into training, internal, and external validation groups.

Jing-Yin-Gu-Biao formula protects mice from postinfluenza infection by ameliorating acute lung injury and improving hypercoagulable state via inhibiting NETosis.

Background: Jing-Yin-Gu-Biao formula (JYGBF) is a Chinese medicine derived from Yupingfeng power, Huoxiangzhengqi powder and Yinqiao powder, and has been widely used to treat acute respiratory infections. This study aims to observe the effects of JYGBF against postinfluenza () infection.

Purpose And Study Design: A mouse model of secondary infection following PR8 infection was established to evaluate the protective effects of JYGBF against postinfluenza () infection and related mechanisms were validated and .

Transferable Contextual Network for Rural Road Extraction from UAV-Based Remote Sensing Images.

Road extraction from UAV-based remote sensing images in rural areas presents significant challenges due to the diverse and complex characteristics of rural roads. Additionally, acquiring UAV remote sensing data for rural areas is challenging due to the high cost of equipment, the lack of clear road boundaries requiring extensive manual annotation, and limited regional policy support for UAV operations. To address these challenges, we propose a transferable contextual network (TCNet), designed to enhance the transferability and accuracy of rural road extraction.

Novel findings on the mitochondria in ciliates, with description of mitochondrial genomes of six representatives.

Unlabelled: Determining and comparing mitochondrial genomes (mitogenomes) are essential for assessing the diversity and evolution of mitochondria. Ciliates are ancient and diverse unicellular eukaryotes, and thus are ideal models for elucidating the early evolution of mitochondria. Here, we report on six new mitogenomes of spirotrichs, a dominant ciliate group, and perform comparative analyses on 12 representative species.

Synergistic Interactions Among Iron and Cobalt Atoms Within Bimetallic Molybdate@Carbon Paper Composite Create Bifunctional Nanoflower Electrocatalyst, Enhancing Efficiency for Overall Water Splitting in Alkaline Environment.

Electrocatalytic water splitting is a promising approach for obtaining clean hydrogen energy. In this work, novel molybdate@carbon paper composite electrocatalysts (CoxFe10-xMoO@CP), displaying outstanding electrocatalytic capabilities, were deriving from anchoring cobalt/iron molybdate materials onto the surface of carbon paper fibers. By adjusting the cobalt-to-iron ratio, the composite (Co5Fe5MoO@CP), with the optimal molar proportion (Co/Fe = 5/5), exhibited a distinctive nanoflower morphology (50-100 nm), which provided a significant number of active sites for electrocatalytic reactions, and showed the strongest electrocatalytic potency for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER).

Lanthanide-Porphyrin MOF as a Multifunctional Platform for Detection and Integrated Elimination of Cr(VI) and Ciprofloxacin.

Environmental concerns are driving the development of eco-friendly and effective methods for contaminant monitoring and remediation. In this study, a lanthanide porphyrin-based MOF with dual fluorescence sensing and photocatalytic properties was synthesized and applied for the detection and combined removal of Cr(VI) and ciprofloxacin (CIP). Using different excitation wavelengths, the material exhibited selective detection of Cr(VI) via fluorescence quenching and CIP through fluorescence enhancement.

Association between exposure to urinary metal and all-cause and cardiovascular mortality in US adults.

Background: Further evidence is required regarding the influence of metal mixture exposure on mortality. Therefore, we employed diverse statistical models to evaluate the associations between eight urinary metals and the risks of all-cause and cardiovascular mortality.

Methods: We measured the levels of 8 metals in the urine of adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018.

Physiological Mechanism of EBR for Grain-Filling and Yield Formation of Tartary Buckwheat.

Tartary buckwheat is characterized by its numerous inflorescences; however, the uneven distribution of resources can lead to an overload in certain areas, significantly limiting plant productivity. Plant growth regulators effectively modulate plant growth and development. This study investigated the effects of three concentrations of brassinosteroids (EBR) on the Tartary buckwheat cultivar with high seed-setting rates, specifically Chuanqiao No.

Splicing factor SRSF1 attenuates cardiomyocytes apoptosis via regulating alternative splicing of Bcl2L12.

Background: Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a member of the SR protein family, have been implicated in various pathological processes. However, the function and mechanism of SRSF1 in cardiovascular diseases remain unclear.

Results: In this study, we found that the expression of SRSF1 was significantly down-regulated in the hearts of mice with acute myocardial infarction (AMI) and H9C2 cells exposed to HO.

The abnormal expression of peripheral blood CD4+ T lymphocyte subsets are correlated with primary Sjögren's syndrome complicated with haematological involvement.

Objectives: Complicated primary Sjögren's syndrome (pSS) with haematological involvement (HI) is not uncommon; however, the aetiology of this condition remains obscure. The clinical characteristics, cytokine levels, and expression of peripheral blood lymphocyte subsets (CD4+ T lymphocyte subsets in particular) of patients with pSS-HI were investigated in this study.

Methods: The pSS-HI group (n = 43), the pSS complicated without HI (pSS-non-HI) group (n = 94), and the healthy controls (HCs) group (n = 40) were enrolled in the Second Hospital of Shanxi Medical University.

Correlation Between Symptom Clusters and Self-Management Among Maintenance Haemodialysis Patients: A Cross-Sectional Study.

Aims And Objectives: The purpose of this study was to explore the relationship between symptom clusters and self-management among maintenance haemodialysis (MHD) patients.

Background: MHD patients experience disease progression and multiple symptom burdens that severely impact quality of life, and self-management of symptoms may significantly improve patient-reported outcomes.

Design: A cross-sectional study.

Gender differences in the relationship between the systemic immune-inflammation index and all-cause and cardiovascular mortality among adults with hypertension: evidence from NHANES 1999-2018.

Background: There are gender differences in hypertension and the effect of gender on the relationship between systemic immune-inflammation index (SII) and mortality in hypertensive patients is unclear.

Methods: Hypertensive patients (n=7444) from ten cycles of the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018 were enrolled in this study. The maximally selected rank statistics method was employed to identify the optimal cut-off value for the SII.

Lactobacillus rhamnosus GG-derived extracellular vesicles promote wound healing via miR-21-5p-mediated re-epithelization and angiogenesis.

Extracellular vesicles (EVs), especially those derived from stem cells, have emerged as a novel treatment for promoting wound healing in regenerative medicine. However, the clinical application of mammalian cells-derived EVs is hindered by their high cost and low yields. Inspired by the ability of EVs to mediate interkingdom communication, we explored the therapeutic potential of EVs released by the probiotic strain Lactobacillus rhamnosus GG (LGG) in skin wound healing and elucidated the underlying mechanism involved.

Design and biological evaluation of candidate drugs against zoonotic porcine deltacoronavirus (PDCoV).

Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus with zoonotic potential. PDCoV spillovers were recently detected in Haitian children with acute undifferentiated febrile illness, underscoring the urgent need to develop anti-PDCoV therapeutics. Coronavirus 3C-like protease (CoV 3CL) is essential for viral replication, and therefore provides an attractive target for drugs directed against CoV.

Effect of impregnation strategy on structural characteristics of Ce-Mn/AlO and its catalytic ozonation of benzoic acid.

Ce-Mn binary oxides supported on AlO (Ce-Mn/AlO), with enhanced activity and stability for catalytic ozonation of benzoic acid, were synthesized using a facile impregnation method. The competitive synergetic effects between cerium and manganese significantly influenced the structural characteristics and catalytic performance of the catalysts depending on the impregnation sequence. Catalysts prepared the one-step impregnation process exhibited a higher concentration of homogeneous Ce species on the catalyst surface.

Self-assembled FeO-COOH @ hydrogen-bonded organic framework composites for magnetic solid-phase extraction of tetracycline in food samples coupled with HPLC determination.

Magnetic solid-phase extraction (MSPE) technology for tetracycline (TCC) was developed by employing the novel and pre-designed FeO-COOH@hydrogen-bonded organic frameworks (HOFs) adsorbents in complex food samples. The HOF shell was grown onto the FeO-COOH core by in-situ self-assembled method. The excellent MSPE performances with less solvent, less adsorbent and time consumption were derived from the hydrogen bonding, π-π and hydrophobic interactions between HOF shell and TCC.