Alternating Multilayered TiCT/Co Sandwich with Co Frosting for Superior Electromagnetic Wave Absorption Performance and Infrared Stealth Ability.

MXene-based wave-absorbing materials face challenges in practical applications such as severe sheet stacking and low dielectric loss. Herein, we used two-dimensional (2D) layered TiCT MXene as the backbone and stereoscopic magnetic cobalt (Co) crystals as the buttress and coating to design a connected three-dimensional layered sandwich heterostructure. By adjustment of the ratio of raw materials, Co crystals were anchored both within the interlayer gaps of the adjacent 2D sheets and on their surfaces through electrostatic and ion-dipole interactions with the functional groups of TiCT.

Multimodal assessment of treatment with proprotein convertase subtilisin/kexin type 9 inhibitors combined with statins for regulating coronary artery plaque regression in patients with chronic/acute coronary syndrome: A meta-analysis.

BackgroundStatins are the standard treatment for coronary atherosclerosis; however, some patients require additional therapies for optimal plaque regression. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (PCSK9i), including monoclonal antibodies and small interfering RNA-based therapies, have shown promise as adjuncts to statins, although their efficacy for coronary plaque regression, as assessed by intravascular imaging, remains uncertain.MethodsWe conducted a meta-analysis to compare the treatment efficacy of statins combined with PCSK9i (PCSK9i group) versus statins alone or statins combined with placebo (control group) in adults with coronary atherosclerosis (INPLASY registration number: INPLASY202550027).

Cervical and vaginal metastases from ascending colon cancer: a case report and literature review.

Background: Colorectal cancer commonly metastasizes to the liver and lungs; however, cervical and vaginal involvement is exceedingly rare. This report describes in detail a unique case of cervical and vaginal metastasis of ascending colon cancer.

Case Presentation: A patient presented with vaginal bleeding.

C nanofibers dotted with metal-organic framework (MOF)-derived square Fe@C crystals for enhanced electromagnetic wave absorption performance.

C nanofibers dotted with square Fe@C crystals derived from metal-organic frameworks (MOFs) with a novel 3D hierarchical architecture were successfully prepared through electrospinning, hydrothermal processing, and high-temperature pyrolysis. The introduction of carbon nanofibers endowed the particles with directional action and mechanical support, inhibiting local agglomeration and the collapse of the Fe@C crystals. The unique overall 3D porous structure with micro-concavities on its surface provided sufficient paths for electromagnetic wave transmission, abundant heterostructured interfaces for interfacial polarization and a connected network for conductive loss.

Case Report: F-FDG PET/CT revealed diffuse pancreatic metastasis in paranasal sinuses rhabdomyosarcoma after treatment improvement.

Metastasis of rhabdomyosarcoma (RMS) from primary paranasal sinuses to the pancreas is rare. Herein, we present a rare case of diffuse pancreatic metastasis in a 44-year-old man. He was diagnosed with sinus RMS 1 year ago and the lesion disappeared after systematic treatment.

The Neuroprotective Role of Ginsenoside Rg1 Against Cerebral Ischemia-Reperfusion Damage Through Inhibition of Mitophagy via Blocking Mitophagosome-Lysosome Fusion.

Ginsenoside Rg1 has shown promise in ameliorating cerebral ischemia-reperfusion injury (CIRI). However, its precise molecular mechanisms remain unclear. In this study, an in vitro CIRI model was established using SH-SY5Y and SK-N-AS neuronal cell lines subjected to oxygen-glucose deprivation followed by reoxygenation (OGD/R).

Study on the evolution of ecological environment and irrigation behavior since mulched drip irrigation in Yanqi basin, Xinjiang.

Analyzing the ecological and behavioral effects of changes in irrigation practices in oases provides valuable insights for water resource management and the sustainable development of oasis agriculture in arid regions. Taking the Yanqi Basin as a case study, this research draws on long-term empirical data and remote sensing information to evaluate the ecological and irrigation behavior effects resulting from shifts in irrigation methods. And explores the deep societal causes behind these behavioral changes.

6'-O-caffeoylarbutin attenuates D-galactose-induced brain and liver damage in aging mice via regulating SIRT1/NF-κB pathway.

Background: Aging-related liver and brain damage caused by oxidative stress and inflammation significantly impacts health and quality of life. Natural bioactive compounds, such as 6'-O-caffeoylarbutin (CA), which is primarily distributed in Vaccinium species, have been studied for their antioxidant and anti-inflammatory properties. This study aims to investigate the protective effect on liver and brain damage induced by D-galactose (D-gal) in mice and to explore its potential molecular mechanisms.

piRNA28846 has the potential to be a novel RNA nucleic acid drug for ovarian cancer.

Conventional targeted therapies primarily rely on small molecules and proteins. However, they often struggle to enter specific protein conformations, which limits their therapeutic effectiveness. In contrast, RNA therapy is emerging as a more precise and effective targeting strategy.

Construction of non-noble decorated Z-scheme Bi-BiVO-BiTiO for enhanced full solar-spectrum driven photocatalytic activity.

Currently, to deal with the increasingly severe energy crisis and environmental consequences, photocatalytic technology is considered as a promise solution, and the construction of Z-scheme heterostructures are important strategies to maximize the utilization of solar energy and improve photocatalytic performance. Herein, a novel full spectrum-responsive Z-scheme Bi-BiVO-BiTiO heterojunction was constructed by a facile hydrothermal method without any templates or surfactants. A series of detailed analyses revealed that the novel Bi-BiVO-BiTiO heterojunction catalyst were prepared successfully.

Research on autonomous walking performance and electromechanical characteristics of mining double-track chassis.

To study the autonomous walking performance and corresponding electromechanical characteristics of unmanned mining equipment under different slopes, turning radii, and ground conditions. Firstly, the autonomous walking systems based on PID, fuzzy PID, and BP PID, in this paper, are constructed, and then the electromechanical coupling simulation is carried out to analyse autonomous walking performance and electromechanical characteristics of mining double-track chassis under different working conditions. Finally, the feasibility of the autonomous walking system based on fuzzy PID is verified by the path-tracking experiment.

MdSVWC1, a new pattern recognition receptor triggers multiple defense mechanisms against invading bacteria in Musca domestica.

Background: Single-domain von Willebrand factor type C (SVWC) constitute a protein family predominantly identified in arthropods, characterized by a SVWC domain and involved in diverse physiological processes such as host defense, stress resistance, and nutrient metabolism. Nevertheless, the physiological mechanisms underlying these functions remain inadequately comprehended.

Results: A massive expansion of the SVWC gene family in Musca domestica (MdSVWC) was discovered, with a count of 35.

Utilizing cerium as a surrogate for actinide aerosols: Real-time characterization and formation mechanisms in nuclear fire scenarios.

Characterizing radioactive aerosol particles released from actinide metals on fires represents a pivotal process in nuclear emergency response. However, the precise characterization of these particles and the deep understanding of their formation mechanism remain a daunting challenge due to the lack of in-situ measurement techniques. We presented the first real-time investigation of respirable particles with the size ranging from 2 nm to 10 μm, emitted from the combustion of cerium metal (CM) as surrogate for actinide counterparts.

Investigation on the mechanism of androsta-4,6,8,14-tetraene-3,11,16-trione against acute lymphoblastic leukemia.

Steroids are potential anti-leukemia agents, and Epigynum auritum is a Yunnan folk medicine with high levels of androsterone, pregnane, and steroid derivatives. However, the underlying therapeutic mechanism of androsta-4,6,8,14-tetraene-3,11,16-trione (ATT), an androsterone isolated from Epigynum auritum, is not yet clear. This study aimed to explore the anti-leukemia mechanism of ATT using molecular biology, network pharmacology, and molecular docking technology.

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway.

Que Zui tea (QT) is an important herbal tea in the diet of the 'Yi' people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage in mice and its potential mechanisms. QE was identified as UHPLC-HRMS/MS for its chemical composition and possible bioactive substances.

LINC00629, a HOXB4-downregulated long noncoding RNA, inhibits glycolysis and ovarian cancer progression by destabilizing c-Myc.

Ovarian cancer (OC) cells typically reprogram their metabolism to promote rapid proliferation. However, the role of long noncoding RNAs (lncRNAs) in the metabolic reprogramming of ovarian cancer, especially in glucose metabolic reprogramming, remains largely unknown. LINC00629 has been reported in our previous study to promote osteosarcoma progression.

Identification and drug resistance of pathogen of ulcerative skin disease and its immune responses and protective efficacy after vaccination in a giant spiny frog, Quasipaa spinosa.

Objective: In order to explore the pathogen of the ulcerative skin disease in giant spiny frog (Quasipaa spinosa), and to provide theoretical basis for the prevention and control of the disease in practical production, this study was carried out to isolate and identify the pathogenic bacteria from the sick frogs suffering from rotting skin disease and to carry out the immunization test of the inactivated vaccine.

Methods: Physiological and biochemical characterization, and molecular biology of the pathogenic bacteria were identified, and drug screening and immunization responses were also carried out.

Results: The dominant bacterium QS01 was isolated from the lesions of diseased giant spiny frogs, which was confirmed to be the causative agent of the rotting skin disease of giant spiny frogs by artificial regression infection test.

Layer-by-layer reinforced-mediated sustained-release nanoantioxidants for long-lasting prevention against drug-induced liver injury.

Drug-induced liver injury (DILI) is a commonly encountered and diagnostically complex etiology of acute liver failure, characterized by early indications of hepatic oxidative stress. The most economical approach for DILI treatment is effective and durable oxidative stress prevention. Herein, we propose a long-lasting nanoantioxidant called PDA-Zn-BAI NPs characterized by sustained-release of baicalein (a natural antioxidant) for the long-lasting prevention of DILI.

Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice.

Anneslea fragrans Wall. (AF) is an important medicinal and edible plant in China. The principal objectives of this study are to explore the hepatoprotective effect of ethanol-aqueous (AFE) and hot-water (AFW) extracts in vitro and in vivo.

A single-center retrospective study of the COCO technique in the treatment of chronic internal carotid artery occlusion.

Objective: To introduce a novel endovascular recanalization method and to investigate its success rate, periprocedural complications, and early outcomes in patients with chronic internal carotid artery occlusion (CICAO). As this novel technique was designed to treat ICA with a full axial system, we named it the COCO technique.

Methods: Data from consecutive patients with symptomatic CICAO who underwent endovascular recanalization in our institution were retrospectively reviewed.

TEAD4 predicts poor prognosis and transcriptionally targets PLAGL2 in serous ovarian cancer.

The oncogenic function of TEA domain transcription factor 4 (TEAD4) has been confirmed in multiple human malignancies, while its potential role and regulatory mechanism in serous ovarian cancer progression are left unknown. By the gene expression analyses from Gene Expression Profiling Interactive Analysis (GEPIA) database, TEAD4 expression is shown to be up-regulated in serous ovarian cancer samples. Here, we confirmed the high expression of TEAD4 in clinical serous ovarian cancer specimens.

Increased Two-Hour Post-Load Plasma Glucose Fluctuation Corresponds with Worse Clinical Prognoses among Acute Ischemic Stroke Patients without a History of Diabetes Mellitus.

Introduction: This study aimed to evaluate the relationship between 2-h post-load minus fasting plasma glucose (2hPG-FPG) and 1-year clinical outcomes, such as death, stroke recurrence, and modified Rankin Scale (mRS) ≥2-3 among acute ischemic stroke (AIS) patients without diabetes mellitus (DM) history.

Methods: 1,214 AIS patients without DM history, obtained from ACROSS-China, were divided into 4 quartiles, based on 2hPG-FPG measurements obtained 14 days post-admission. Four models were constructed using multivariate Cox and logistic regression analyses, based on the inclusion of age, gender, trial of ORG 10172 in acute stroke treatment, NIH Stroke Scale scores (model 1), plus 10 other clinical parameters (model 2), plus newly diagnosed DM (NDDM) post-admission (model 3), plus 2hPG and FPG (model 4).

Endovascular treatment for acute M2 occlusion stroke within 6 hours-a retrospective real-world evidence.

Background: We compared the efficacy and safety of endovascular therapy (EVT), intravenous (IV) thrombolysis and conservative treatment in M2 segment occlusion stroke based on a real-world database.

Methods: We retrospectively analyzed the database of admitted patients with M2 segment occlusion between January 2018 and December 2020. The patients who were eligible for reperfusion treatment were assigned to EVT, IV thrombolysis or conservative treatment according to the exact management proceeding.