Activation of Chlorite with Sunlight for the Efficient Disinfection of Antibiotic-Resistant Bacteria: the Overlooked Contribution of Cytomembrane-Bound Chlorite.

Current antibiotic-resistant bacteria (ARB) disinfection techniques commonly rely on large dosages of oxidants, resulting in the presence of considerable amounts of residuals and toxic disinfection byproducts (DBPs) in water. Herein, we propose a highly effective ARB disinfection approach via activating an ultralow concentration (10 μM) of chlorite (ClO) by naturally abundant sunlight to generate various reactive species (i.e.

Comprehensive carbohydrate profiling by mass spectrometry for the valorization of pomegranate side streams.

Pomegranate processing generates large quantities of pomace and mesocarp, yet their carbohydrate composition remains largely unexplored. Here, we applied comprehensive mass spectrometry-based profiling to characterize monosaccharides, oligosaccharides, and polysaccharides from these side streams. Fructose and glucose dominated the free sugar fraction in both tissues.

Dataset of real time multi-parameter monitoring for loess slopes in Gaolan mountain, Lanzhou, China: Multi-sensor network for hydrology and geophysics.

Landslides pose significant threats to human life and infrastructure globally. In China, the intensification of urbanization and human activities has exacerbated loess landslide risks, making monitoring and mitigation efforts increasingly critical. Rainfall, surface displacement, pore pressure, and seismic waves as key parameters for landslide monitoring.

Biochemical impact and therapeutic efficacy of laparoscopic surgery in early-stage ovarian cancer: Modulation of vascular endothelial growth factor and tumor markers.

Background: The objective of this study was to investigate the biochemical impact of laparoscopic surgery on angiogenesis, focusing on vascular endothelial growth factor (VEGF), and the modulation of key tumor markers in patients with early-stage ovarian cancer.

Methods: A total of 76 patients diagnosed with early ovarian cancer were enrolled and divided into two groups based on the surgical approach: the control group (n=38) underwent open surgery, and the observation group (n=38) underwent laparoscopic surgery. Surgical parameters, VEGF levels, tumor markers [matrix metalloproteinase 9 (MMP9), stromal cell-derived factor-1a (SDF-1a), and carcinoembryonic antigen (CEA)], survival rates, and incidence of complications were compared between the two groups.

The transcription factor HOXB7 significantly enhances the expression of PIGT through the Wnt/β-catenin signaling pathway, thereby promoting the proliferation and deterioration of HCC.

Background: Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contribute to cancer progression, with their glycolipid modification mediated by glycosylphosphatidylinositol transamidase (GPIT). Phosphatidylinositol glycan anchor biosynthesis class T (PIGT), a key GPIT subunit, influences GPI-APs biosynthesis and tumor biology. This study investigates PIGT expression in hepatocellular carcinoma (HCC) and its regulatory mechanisms.

Optimization and applications of air-plasma dynamic aperture-based terahertz microscopy.

Terahertz (THz) microscopy has become an important far-infrared inspection method because it possesses a high spatial resolution and retains THz spectral information. For further exploiting applications of THz microscopy, we propose an air-plasma dynamic aperture-based THz near-field technique to achieve sub-wavelength THz imaging without approaching a sample surface. In this work, the measurement mode of the technique was improved and a corresponding data processing method was applied to upgrade the system performances.

Phase-Continuous Reconfigurable Transmissive Metasurface without Air Gaps.

Reconfigurable metasurfaces, as planar devices with powerful capabilities to regulate, have attracted extensive attention. Conventional phase-continuous reconfigurable transmissive metasurfaces have air gaps, which make the design of metasurfaces more complex. Although several studies have explored metasurfaces without air gaps, their phase-tunable resolution is still not optimal.

Efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infection in children: a multicenter, randomized, double-blind, placebo-controlled trial.

Objective: To evaluate the efficacy and safety of inhaled ambroxol solution in improving sputum of lower respiratory tract infections (LRTIs) in children.

Study Design: This study was a randomized, double-blind, parallel-group, placebo-controlled, multicenter trial. The patients were administered inhaled ambroxol or a placebo twice a day for 7 days.

A PEDOT: PSS-based miniature sodium sensor using polarization technique to improve reproducibility.

A major obstacle in the development of solid contact ion-selective electrodes (SC-ISEs) is the frequent calibration procedures due to the low reproducibility of standard potential(E) and the unstable signals. To address these challenges, we developed an all-solid state miniature sodium ion-selective electrode (Na-ISE) based on acid-doped poly(3,4-ethylenedioxythiophene)-polystyrene sulphonate (PEDOT: PSS) as the solid contact layer, in combination with an external polarization technique. Acid doping minimized the Coulomb interaction between PEDOT and PSS, inducing significant phase separation and conformational re-aggregation of PEDOT chains, thus creating more contact points to facilitate charge transport and ion-to-electron transduction.

1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention.

Purpose: Compared with long-term dual antiplatelet therapy (DAPT, aspirin with clopidogrel or ticagrelor), short-term DAPT followed by single antiplatelet therapy (SAPT, clopidogrel or ticagrelor) has demonstrated superiority in reducing bleeding risk while maintaining non-inferior in cardiovascular benefits in coronary heart disease (CHD) after successful percutaneous coronary intervention (PCI). However, no prospective study has explored the benefits of this short-term regimen on patients with chronic total occlusion (CTO) undergoing PCI.

Methods: Consecutive patients who underwent successful elective CTO-PCI were prospectively enrolled from April 2019 to May 2021.

Overcoming Asymmetric Carrier Injection in III-Nitride Light-Emitting Diodes through Defect Engineering.

The rapid advancements in the semiconductor industry are often accompanied by a breakthrough in defect engineering. While defects usually hinder device performance, they can also offer new opportunities for manipulating semiconductor properties. In this Letter, we present an effective approach to solving the long-standing asymmetric injection of carriers problem in LEDs by introducing nitrogen vacancies (V_{N}) at the GaN/AlN quantum well (QW) interface.

Effect of Earlier Age of Tobacco Exposure on Accelerated Biological Aging in Adulthood.

Objective: To investigate how early-life tobacco exposures implicate accelerated biological aging in adulthood and the potential mechanism.

Participants And Methods: This study used questionnaires to determine when the participants smoked and whether their mothers smoked when pregnant. Early-life tobacco exposures included in utero tobacco exposure and age of smoking initiation.

Boosting Low-Dose Ferrate(VI) Activation by Layered FeOCl for the Efficient Removal of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes via Enhancing Fe(IV)/Fe(V) Generation.

Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquatic environments pose threats to ecosystem safety and human health, which could not be efficiently removed by conventional disinfection techniques. Herein, layered FeOCl with coordinatively unsaturated Fe sites were fabricated and used to activate Fe(VI) for the efficient ARB/ARG removal in the present study. We found that highly reactive Fe(IV)/Fe(V) intermediates were generated in the FeOCl/Fe(VI) system, rapidly disinfecting 1 × 10 CFU mL ARB to below the limit of detection within only 6 min.

An Outbreak of ST80 Vancomycin-Resistant in a Hospital in Guangzhou, China: Clinical and Genomic Epidemiology Study from 2022 to 2023.

A notable increase in the incidence of vancomycin-resistant (VREfm) was observed at a hospital in Guangzhou, China, during 2022-2023. We conducted a retrospective cross-sectional study from January 1, 2022, to August 31, 2023, to investigate the clinical and genomic characteristics of VREfm. Clinical data were extracted from electronic medical records, and infection control measures were reviewed from the relevant department.

Research on the Application of Nano-Additives in Gel-like Lubricants.

In the field of mechanical motion, friction loss and material wear are common problems. As one of the essential components for enhancing the lubricating performance of gel-like lubricants, nano-additives leverage their unique physical and chemical properties to form an efficient protective film on friction surfaces. This effectively reduces friction resistance and inhibits wear progression, thereby playing a significant role in promoting energy conservation, emissions reduction, and the implementation of green development principles.

Development and validation of a deep learning-based pathomics signature for prognosis and chemotherapy benefits in colorectal cancer: a retrospective multicenter cohort study.

Introduction: The conventional tumor-node-metastasis (TNM) classification system remains limited in accurately forecasting prognosis and guiding adjuvant chemotherapy decisions for patients with colorectal cancer (CRC). To address this gap, we introduced and validated a novel pathomics signature (PS) derived from hematoxylin and eosin-stained whole slide images, leveraging a deep learning framework.

Methods: This retrospective study analyzed 883 slides from two independent cohorts.

Machine learning-selected minimal features drive high-accuracy rule-based antibiotic susceptibility predictions for via metagenomic sequencing.

Antimicrobial resistance (AMR) represents a critical global health challenge, demanding rapid and accurate antimicrobial susceptibility testing (AST) to guide timely treatments. Traditional culture-based AST methods are slow, while existing whole-genome sequencing (WGS)-based models often suffer from overfitting, poor interpretability, and diminished performance on clinical metagenomic data. In this study, we developed an interpretable genotypic AST approach for using minimal genomic determinants.

Clinical validation of AI assisted animal ultrasound models for diagnosis of early liver trauma.

The study aimed to develop an AI-assisted ultrasound model for early liver trauma identification, using data from Bama miniature pigs and patients in Beijing, China. A deep learning model was created and fine-tuned with animal and clinical data, achieving high accuracy metrics. In internal tests, the model outperformed both Junior and Senior sonographers.

Development and evaluation of cepharanthine-β-cyclodextrin inclusion complex oral tablets for prevention and treatment of COVID-19 lung injury.

The symptoms of coronavirus disease 2019 (COVID-19) range from severe lung disease to milder manifestations, such as cough and throat irritation. As a bisbenzylisoquinoline alkaloid, cepharanthine (CEP) has various pharmacological properties, such as antifibrotic, anti-inflammatory, antioxidant, and antiviral effects. However, its poor solubility and low bioavailability hinder subsequent drug development.

KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression.

Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasion. Our research aimed to expound the biological function of the collagen alpha-1(IX) chain (COL9A1) in colorectal cancer (CRC) and the upstream mechanism regarding KMT2D/ZNF460. COL9A1 contributed to maintaining colorectal cancer stem cells (CCSC) self-renewal and proliferative capacity, and COL9A1 knockdown attenuated CCSC stemness, which was activated by 20.

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway.

Purpose: Upon corneal injury, early and late transit amplifying (TA) cells, the progeny of epithelial stem cells, migrate to the site of the wound, which facilitates its closure. Understanding the targetable signals that guide such cell migration is essential for the development of novel wound-healing strategies.

Methods: Single-cell RNA sequencing (scRNA-seq) was conducted in wild-type cornea.

Research on nighttime IPPG algorithm based on ROI delay expansion and fundamental frequency constrained FastICA.

This study aims to enhance the accuracy and reliability of imaging photoplethysmography (IPPG) for heart rate (HR) measurements during nighttime by introducing an innovative approach that combines fast independent component analysis (FastICA) with aime-elayedulti-imensionalxtendedegionsfnteresttraction () technique, specifically tailored to overcome the challenges posed by motion artefacts and the difficulty in identifying regions of interest (ROIs).This research employs a dual-method strategy for the precise extraction of ROIs and robust processing of HR signals in nighttime IPPG scenarios. Initially, a face detection algorithm is integrated with a grayscale clustering technique to pinpoint optimal ROIs.

Hyperglycemia induces an immunosuppressive microenvironment in colorectal cancer liver metastases by recruiting peripheral blood monocytes through the CCL3-CCR1 axis.

Background: The treatment of colorectal cancer liver metastasis (CRLM), a leading cause of mortality in patients with colorectal cancer, is complicated by type 2 diabetes (T2D). This study aimed to investigate the CRLM immune microenvironment in the context of T2D and identify potential therapeutic targets.

Methods: A hyperglycemic CRLM mouse model was established.

Genomic and machine learning approaches to predict antimicrobial resistance in .

Unlabelled: is a multidrug-resistant pathogen, which poses a major challenge to clinical management due to its increasing resistance to common antibiotics, such as levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT), and poor clinical response to treatment. There is an urgent need for rapid and reliable antimicrobial susceptibility testing (AST) methods to improve treatment outcomes. This study collected 441 strains, performed whole-genome sequencing, and used machine learning to identify key resistance determinants for LEV and SXT, constructing predictive models for resistance phenotypes.

Analysis and characterization of extrachromosomal circular DNA in prostate cancer: Potential biomarker discovery from urine, plasma, and tumor samples.

Extrachromosomal circular DNA (eccDNA) may contribute to genomic rearrangements and tumor heterogeneity, playing a role in cancer development and progression. This study evaluates eccDNA as a biomarker for prostate cancer by characterizing its profiles in urine, plasma, and tumor tissues from patients at different disease stages. We studied 49 prostate cancer patients (23 early-stage; 26 late-stage, including 19 with metastasis), 23 patients with prostatitis, and 21 healthy individuals.