Recent advances on the roles of epidermal growth factor receptor in psoriasis.

Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses.

LION: a simple and rapid method to achieve CRISPR gene editing.

The RNA-guided CRISPR-Cas9 technology has paved the way for rapid and cost-effective gene editing. However, there is still a great need for effective methods for rapid generation and validation of CRISPR/Cas9 gRNAs. Previously, we have demonstrated that highly efficient generation of multiplexed CRISPR guide RNA (gRNA) expression array can be achieved with Golden Gate Assembly (GGA).

Clinical classification and individualized design for the treatment of basicranial artery injuries.

This study aims to explore the principles of clinical classification and individualized treatment of basicranial artery injuries based on its anatomical correlation.The data of 172 patients with various types of basicranial artery injuries were retrospectively analyzed. Among these patients, 128 patients were male and 44 patients were female, and the average age of these patients was 28.

Improvement of Mechanical Stability for Single Unit Recording Based on Skull Cap in Living Chinchilla.

Three-point head fixation was constructed to provide mechanical stability for single unit recording (SUR) on vestibular sensory system in living chinchilla previously. However, it is no more qualified to this work when the stimulation intensity becomes large because of frequent unit losing and neuron damage, which strongly implies that the mechanical stability has been broken during the stimulation. Here, we constructed a novel head fixation (skull cap assistant head fixation) provided by skull cap on the basis of three-point head fixation in order to improve the mechanical stability for SUR under the stimulation with large magnitude.

Chemisorption of Atomically Precise 42-Carbon Graphene Quantum Dots on Metal Oxide Films Greatly Accelerates Interfacial Electron Transfer.

Graphene quantum dots (GQDs) are emerging as environmentally friendly, low-cost, and highly tunable building blocks in solar energy conversion architectures, such as solar (fuel) cells. Specifically, GQDs constitute a promising alternative for organometallic dyes in sensitized oxide systems. Current sensitized solar cells employing atomically precise GQDs are based on physisorbed sensitizers, with typically limited efficiencies.

The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression.

N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates protein expression in various posttranscriptional levels. Functional studies of m6A in nervous system have focused on its writers and erasers so far, whether and how m6A readers mediate m6A functions through recognizing and binding their target mRNA remains poorly understood. Here, we find that the expression of axon guidance receptor Robo3.

The complete mitochondrial genomes of two sibling species of camellia weevils (Coleoptera: Curculionidae) and patterns of Curculionini speciation.

Complete mitochondrial genomes contain large and diverse datasets for species delineation. To better understand the divergence of the two morphologically indistinguishable weevil species in Curculionini, we first sequenced and compared their complete mitochondrial genomes. The complete mitochondrial genomes of Curculio chinensis and Curculio sp.

Temporal Variation and Statistical Assessment of the Value off the Pacific Coast of Tokachi, Hokkaido, Japan.

The Gutenberg-Richter Law describes the frequency-magnitude distribution of earthquakes. A number of studies have shown that the slope ( value) of the relationship between frequency and magnitude decreased before large earthquakes. In this paper, we investigate the temporal variation of the value off the Pacific coast of Tokachi, Hokkaido, Japan, during 1990-2014.

Metabolomics approach for predicting response to neoadjuvant chemotherapy for colorectal cancer.

Introduction: Colorectal cancer (CRC) is a clinically heterogeneous disease, which necessitates a variety of treatments and leads to different outcomes. Only some CRC patients will benefit from neoadjuvant chemotherapy (NACT).

Objectives: An accurate prediction of response to NACT in CRC patients would greatly facilitate optimal personalized management, which could improve their long-term survival and clinical outcomes.

Clinical diagnosis and genetic counseling of atypical ataxia‑telangiectasia in a Chinese family.

Ataxia‑telangiectasia (A‑T) is an autosomal recessive chromosome breakage disorder caused by mutations in the ATM serine/threonine kinase (ATM) gene. Typically, it presents in early childhood with progressive cerebellar dysfunction, accompanied by immunodeficiency and oculocutaneous telangiectasia. In the present study, the clinical and genetic findings of a Chinese family affected with A‑T in two live siblings, the proband (II‑2) and his elder brother (II‑1), as well as a fetus (II‑3) were reported.

Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia-inducible factor-1α via inhibition of proteasome.

Virus reprogramming of host cellular function is a critical strategy for viral survival and replication. A better understanding of virus-host interaction may provide new potential avenues for the treatment of viral diseases. It has been reported that hypoxia-inducible factor-1 (HIF-1) pathway is activated by a range of pathogens via different mechanisms, but the impact of Influenza A virus on HIF-1 signaling is still unclear.

Identification of causative variants in patients with non-syndromic hearing loss in the Minnan region, China by targeted next-generation sequencing.

Background: Due to extreme genetic heterogeneity, targeted next-generation sequencing (NGS) can be an efficient tool for rapid genetic diagnosis of hereditary non-syndromic hearing loss (NSHL).

Aims/objectives: This study was aiming to identify causative variants in NSHL patients from the Minnan region through targeted NGS.

Material And Methods: Genomic DNA samples from 90 NSHL subjects were extracted and subjected to SureSelect target enrichment system to capture the entire coding exons and flanking intronic regions of gene GJB2, SLC26A4, and MT-RNR1.

Vitamin D improves sunburns by increasing autophagy in M2 macrophages.

Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D enables anti-inflammation to promote tissue repair in response to injury.

Coaxial differential dynamic microscopy for measurement of Brownian motion in weak optical field.

Weak optical fields cause less damage to active cells and are easier to realize than traditional and tightly focused optical fields. While these fields are promising for biomedical science and particle manipulation applications, they lack a method for precise particle diffusion measurement because the weak fields cause the small changes in particle motion caused by weak fields. In this paper, we present a coaxial differential dynamic microscopy (CDDM) technique that uses a differential dynamic microscopy system, combined with an adjustable optical field.

Comparative transcriptome analysis reveals regulators mediating breast muscle growth and development in three chicken breeds.

The goal of this study was to investigate the mechanisms of muscle growth and development of three chicken breeds. Eighteen chickens, including three different breeds with different growth speeds (White Broiler, Daheng, and Commercial Layers of Roman), were used. Total RNA from breast muscle of these chickens was subjected to a gene expression microarray.

Development of a Correlative Strategy To Discover Colorectal Tumor Tissue Derived Metabolite Biomarkers in Plasma Using Untargeted Metabolomics.

The metabolic profiling of biofluids using untargeted metabolomics provides a promising choice to discover metabolite biomarkers for clinical cancer diagnosis. However, metabolite biomarkers discovered in biofluids may not necessarily reflect the pathological status of tumor tissue, which makes these biomarkers difficult to reproduce. In this study, we developed a new analysis strategy by integrating the univariate and multivariate correlation analysis approach to discover tumor tissue derived (TTD) metabolites in plasma samples.

Understanding the Behavior and Mechanism of Oxygen-Deficient Anatase TiO toward Sodium Storage.

TiO has drawn increasing research attention as negative electrode material in sodium ion battery because of its natural abundance, low cost, nontoxicity, and facile preparation. Despite tremendous studies carried out, the sodium storage mechanism is still under discussion, and the electronic and local structures of TiO during sodiation/desodiation process are not well understood either. Herein, we reported a mechanism study of graphene-supported oxygen-deficient anatase TiO nanotubes (nanowires) as the negative electrode material for sodium ion batteries.

Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases.

Background: DNA methylation plays a vital role in reproduction. Entire genome DNA methylation changes during the oestrous phase (ES) and dioestrous phase (DS) in the ovaries of Guanzhong dairy goats were investigated using bisulphite sequencing to understand the molecular biological mechanisms of these goats' oestrous cycle.

Results: We discovered distinct genome-wide DNA methylation patterns in ES and DS ovaries.

Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features.

The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening for LS was implemented, including immunohistochemistry for mismatch repair (MMR) proteins, BRAF mutation test and germline sequencing.

Polarization determination based on the longitudinal field of a converging terahertz wave.

Based on coherently measuring the longitudinal field of a converging terahertz (THz) wave, a polarization determination method to the THz radiation is proposed. By utilizing the method, the arbitrary uniform polarization state of a THz field can be effectively identified in a single measurement. By using the vector diffraction integral, the principle of the method is theoretically discussed in detail.

High-mobility band-like charge transport in a semiconducting two-dimensional metal-organic framework.

Metal-organic frameworks (MOFs) are hybrid materials based on crystalline coordination polymers that consist of metal ions connected by organic ligands. In addition to the traditional applications in gas storage and separation or catalysis, the long-range crystalline order in MOFs, as well as the tunable coupling between the organic and inorganic constituents, has led to the recent development of electrically conductive MOFs as a new generation of electronic materials. However, to date, the nature of charge transport in the MOFs has remained elusive.

Plasma metabolomic profiling distinguishes right-sided from left-sided colon cancer.

Background: Many studies have demonstrated that right-sided colon cancer (RCC) has a higher mortality rate and worse prognosis than left-sided colon cancer (LCC). However, the underlying biological mechanism that can account for these differences is unclear.

Methods: In this study, plasma metabolic profiles in 147 LCC patients and 105 RCC patients were systematically analyzed by the ultra high performance liquid chromatography quadruple time-of-flight mass spectrometry (UHPLC-QTOF/MS) platform in conjunction with univariate and multivariate statistical analysis.

Defective graphene for electrocatalytic CO reduction.

The rational synthesis of earth-abundant materials with excellent electrocatalytic performances plays a critical role in electrochemical CO reduction (ECR) to obtain value-added chemical products or fuels. Here we demonstrate a defective graphene (DG) as such an electrocatalyst candidate via a nitrogen removal method. The graphene with a large amount of topological defects offered abundant catalytically active sites, high electronic conductivity and strong adsorption of CO.

Electronic structures and unusually robust bandgap in an ultrahigh-mobility layered oxide semiconductor, BiOSe.

Semiconductors are essential materials that affect our everyday life in the modern world. Two-dimensional semiconductors with high mobility and moderate bandgap are particularly attractive today because of their potential application in fast, low-power, and ultrasmall/thin electronic devices. We investigate the electronic structures of a new layered air-stable oxide semiconductor, BiOSe, with ultrahigh mobility (~2.

Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma.

Previous studies have indicated that abnormal methylation is a critical and early event in the pathogenesis of most types of human cancer, which contributes to tumorigenesis. However, there has been little focus on the potential of DNA methylation patterns as predictive markers for the prognosis of colon adenocarcinoma (COAD). In the present study, a genome-wide comparative analysis of DNA methylation profiles was performed between 315 COAD samples and 38 matched tumor-adjacent normal tissue samples.