The surgical burden score: a novel continuous metric to predict postoperative complications after hepatectomy for hepatocellular carcinoma.

Background: No validated model incorporates surgical parameters for complication risk in hepatocellular carcinoma (HCC) resection. We evaluated a novel Surgical Burden Score (SBS), integrating adjusted blood loss (aBL; mL/kg) and operative time (hours) via a Pythagorean formula, and developed an SBS-based model to predict complications.

Methods: Patients undergoing curative-intent hepatectomy for HCC(2000-2023) were identified from an international database.

Heart failure diagnosis and ejection fraction classification via feature fusion model using non-contact vital sign signals.

Background And Objectives: Ballistocardiography (BCG) has emerged as a promising modality for home-based heart failure (HF) monitoring, yet existing single-dimensional manual feature analyses fail to adequately characterize left ventricular ejection fraction (LVEF < 40%) dynamics. We address this limitation by developing a hybrid feature fusion framework that synergizes manual feature engineering with deep learning for improved HF diagnosis and LVEF classification.

Methods: 83 participants were recruited from a hospital, with their samples categorized into two (healthy and HF) and three classes (healthy, LVEF ≥ 40% HF, and LVEF < 40% HF) based on clinical diagnosis.

Laparoscopic Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (L‑ALPPS) of Right Hemihepatectomy and Regional Lymph Node Dissection for Intrahepatic Cholangiocarcinoma (With Video).

Background: Although the application of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in intrahepatic cholangiocarcinoma (ICC) is still controversial, it continues to be attempted in selected patients. This video case discusses the key technical points for a complete laparoscopic ALPPS (L-ALPPS) of right hemihepatectomy and regional lymph node (LN) dissection for ICC.

Methods: A 61-year-old ICC patient received L-ALPPS for right hemihepatectomy and regional LN dissection.

Characteristics of "Very Early" Intrahepatic Cholangiocarcinoma Undergoing Liver Resection and Its Relationship With Carbohydrate Antigen 19-9.

Introduction: The concept of "very early" ICC ( ≤ 2 cm, single tumor) has been introduced in the context of LT. Due to the limited number of patients in this subset, the characteristics and long-term outcomes have been ill-defined. We sought to assess long-term outcomes of very early ICC patients undergoing liver resection using a large, multi-institutional database.

Heterogeneity in prognosis for early-stage hepatocellular carcinoma after hepatectomy: A multicenter analysis of 4,623 patients across five major staging systems.

Background & Aims: Multiple staging systems for hepatocellular carcinoma (HCC) have led to heterogeneous definitions of "early-stage" disease, potentially affecting treatment decisions and outcomes. This study aimed to quantify the prognostic variations among patients undergoing curative hepatic resection for "early-stage" HCC, as defined by five major staging systems.

Methods: In this multicenter study, 4623 patients who underwent curative resection for newly diagnosed HCC (2014-2023) across 11 tertiary hospitals were analyzed.

Preoperative ASAP score predicts recurrence and survival following curative hepatic resection for hepatitis B virus-related hepatocellular carcinoma: A multicenter cohort study.

Background & Aims: The ASAP score, integrating age, sex, alpha-fetoprotein (AFP), and protein induced by vitamin K absence or antagonist-II (PIVKA-II), has demonstrated value for early detection of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. This study sought to assess whether the ASAP score could also predict recurrence and survival following curative resection of HBV-related HCC.

Methods: This multicenter study included patients undergoing curative hepatic resection for HBV-related HCC.

Association between time weighted average mechanical power normalized to compliance and prognosis of critically ill patients: A retrospective cohort study based on the MIMIC-IV database.

Objective: This study aims to evaluate the association of time‑weighted average mechanical power normalized to compliance (TWA-MP) with all-cause mortality to determine its value as a prognostic tool in intensive care patients.

Design: Retrospective observational study.

Setting: Intensive care unit (ICU).

Photoacoustic and fluorescence hybrid microscope for cortex-wide imaging of neurovascular dynamics with subcellular resolution.

Simultaneously monitoring cortex-wide microvascular dynamics, blood oxygenation metabolism, and neuronal activities with high spatiotemporal resolution is essential for understanding neurovascular coupling (NVC). However, it remains a challenge for existing neuroimaging tools. Here, we report a linear transducer array-based hybrid microscope (LiTA-HM) that integrates photoacoustic microscopy and confocal fluorescence microscopy to achieve simultaneous neurovascular imaging with a field of view (FOV) of 6 millimeters by 5 millimeters, a spatial resolution of ~6 micrometers, and a temporal resolution of 0.

Development of Low-Immunogenic AFPs for Cell Cryopreservation by Hydrophilic Modification.

The successful application of antifreeze proteins (AFPs) for cell cryopreservation is limited by their immunogenicity. In this work, a strategy has been reported to reduce the immunogenicity of AFPs by hydrophilic modification. Two hydrophilic polypeptides (KE and GES) were designed and conjugated to natural AFPs (MAFPs) to prepare AKE and AGES.

International validation of a natural-killer-cell-based model to predict recurrence-free survival in hepatocellular carcinoma.

Background: Models estimating recurrence-free survival (RFS) after hepatectomy for hepatocellular carcinoma (HCC) rely on clinical variables and often overlook tumor immunobiology. The Liver Immune Status Index (LISI), derived from BMI, albumin, and Fibrosis-4 (FIB-4), reflects liver-resident natural killer (NK) cell activity. We validated the HISCO-HCC score, combining LISI, tumor burden score (TBS), and alpha-fetoprotein (AFP), using an international cohort.

Real-world efficacy and safety of anlotinib combined with chemotherapy for advanced pancreatic cancer: a retrospective study.

Background: Pancreatic cancer (PC) is often diagnosed at advanced stages, limiting surgical options. There is no standardized treatment for second-line or beyond therapies, necessitating alternative treatments. This study evaluates the efficacy and safety of anlotinib combined with chemotherapy in advanced PC patients receiving second-line or subsequent treatments.

An easy-to-use online calculator to identify patients least likely to benefit from surgical resection of intrahepatic cholangiocarcinoma.

Background And Objective: Although it is the primary curative-intent treatment option for intrahepatic cholangiocarcinoma, liver resection can be associated with high postoperative morbidity and mortality. As such, a high-risk resection may not be warranted when the oncological benefits are minimal. In the current study, we sought to develop 2 preoperative models to predict 90-day mortality and overall survival after liver resection for intrahepatic cholangiocarcinoma.

Danning tablets for the treatment of multiple gallbladder polyps: Study protocol of multicentre, randomised, open-labelled, controlled trial.

Introduction: Gallbladder polyps (GPs) are protrusions of the gallbladder wall into the lumen, and are commonly detected during ultrasound examinations. Traditional management of multiple GPs (MGPs) has been conservative, including lifestyle interventions, regular monitoring, and surgical intervention in certain cases, but this approach poses risks of polyps enlargement and increase of number, as well as patients' psychological burdens. Danning Tablets, a traditional Chinese medicine, have emerged as a potential non-surgical treatment for GPs, showing promise in reducing polyp size and alleviating symptoms, backed by their anti-inflammatory and antitumor properties demonstrated in preclinical studies.

Oncological Resectability Criteria for Intrahepatic Cholangiocarcinoma: A Preoperative Framework for Multidisciplinary Management.

Introduction: Recent advancements in systemic chemotherapy have fueled debates regarding the feasibility of combining systemic therapy with surgery for advanced intrahepatic cholangiocarcinoma (ICC). However, the absence of consensus on oncological resectability criteria has hindered discussions on optimal multidisciplinary management. This study sought to propose preoperative oncological resectability criteria for ICC.

Preoperative Systemic Immune-Inflammatory Index Predicts Occult Nodal Disease in Clinically Node-Negative Intrahepatic Cholangiocarcinoma.

Background: Accurate preoperative diagnosis of nodal status in intrahepatic cholangiocarcinoma (ICC) remains challenging. The objective of the current study was to determine if the systemic immune-inflammatory index (SII) was associated with occult nodal disease (OND) among cN0 patients undergoing resection for ICC.

Methods: Patients who underwent curative resection for ICC were identified from an international multi-institutional database.

ZEB1 silencing protects against ferroptosis and mitochondrial dysfunction in osteoarthritis by inhibiting HSPA5 expression.

Background: Zinc finger E-box binding homeobox 1 (ZEB1), a ferroptosis-associated gene, is upregulated in osteoarthritis (OA) articular cartilage. However, whether ZEB1 regulates ferroptosis in OA progression remain unclear.

Methods: ZEB1 protein levels in cartilage specimens from OA patients and normal controls were measured.

Postoperative adjuvant transarterial chemoembolization prolongs overall survival in alpha-fetoprotein-negative hepatocellular carcinoma with bile duct tumor thrombosis: a long-term retrospective cohort study.

Background: Hepatocellular carcinoma (HCC) with bile duct tumor thrombosis (BDTT) is a rare clinical condition with rapid disease progression and poor prognosis. This study aimed to evaluate the prognostic value of postoperative adjuvant transarterial chemoembolization (PA-TACE) among HCC-BDTT patients after radical resection (R0).

Methods: Between January 2002 and December 2010, 93 HCC-BDTT patients who underwent R0 resection were enrolled for a retrospective study, including 46 patients with PA-TACE and 47 patients without PA-TACE within two months postoperatively.

The expression and prognostic predictive value of PD-L2 in patients undergoing radical gastric cancer surgery.

Background: The expression and prognostic predictive value of programmed death-ligand 2 (PD-L2) in patients undergoing radical gastric cancer (GC) surgery remains unclear.

Methods: PD-L2 expression in tumor cells (TC) and tumor-infiltrating immune cells (TIIC) was evaluated by immunohistochemistry. Kaplan-Meier and Cox models were used to evaluate the association of PD-L2 with disease-free survival (DFS) and overall survival (OS).

Distinct patterns of late recurrence in long-term hepatocellular carcinoma survivors.

Background: Among patients with hepatocellular carcinoma (HCC), late recurrence - defined as recurrence occurring ≥2 years after treatment - has often been treated as a singular, uniform event, despite being inherently heterogeneous and driven by diverse biologic mechanisms. This study aimed to identify prognostic factors associated with recurrence among long-term survivors of HCC after treatment, with particular emphasis on the role of underlying liver fibrosis and intrinsic tumor aggressiveness.

Methods: Patients who underwent hepatectomy for HCC between 2000 and 2021 were identified from an international database.

Data-driven mechanisms for network freight platforms: An evolutionary game perspective.

This paper examines the impact of data-driven mechanisms in network freight platforms. The main objective is to understand how these mechanisms can improve operational efficiency and encourage cooperation among key stakeholders, including a risk-neutral shipper, a loss-averse carrier and network freight platform. The study uses evolutionary game theory to model the interactions between these parties.

Chinese Expert Consensus on the Whole-Course Management of Hepatocellular Carcinoma (2023 Edition).

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. Most HCC patients have the complications of chronic liver disease and need overall consideration and whole-course management, including diagnosis, treatment, and follow-up. To develop a reasonable, long-term, and complete management plan, multiple factors need to be considered, including the patient's general condition, basic liver diseases, tumor stage, tumor biological characteristics, treatment requirements, and economic cost.

Lymphocyte-C-Reactive Protein Ratio: Impact on Prognosis of Patients Following Resection of Primary Liver Cancer.

Objective: We sought to characterize the prognostic value of lymphocyte-C-reactive protein ratio (LCR) among patients undergoing liver resection (LR) for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

Methods: Patients who underwent curative-intent LR for HCC and ICC between 2000 and 2023 were identified from a multiinstitutional database. The prognostic value of nine different inflammatory markers were evaluated relative to short- (i.

Unraveling the obesity paradox in hepatocellular carcinoma: relative role of elevated body mass index on detrimental effects of postoperative complications.

Background: The "obesity paradox" suggests higher body mass index (BMI) may correlate with better long-term outcomes in cancers. The impact of BMI on hepatocellular carcinoma (HCC) resection, regarding postoperative complications, remains unclear. We examined the interplay between BMI and complications on recurrence-free survival (RFS) among patients undergoing HCC resection.