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Objective: This study investigates the association between dietary anthocyanidins consumption and the risk of frailty in the general adult population using data from the National Health and Nutrition Examination Survey (NHANES).
Methods: A cross-sectional analysis of NHANES data was conducted, examining the relationship between dietary anthocyanidins intake and frailty risk. Dose-response relationships and subgroup analyses were performed to provide a comprehensive understanding of the associations.
Results: The results indicate a significant inverse relationship between the consumption of specific anthocyanidin types, including malvidin and delphinidin, as well as total anthocyanidins, and the odds of frailty. Particularly, individuals aged 41-60 years and males exhibited a notable protective effect of anthocyanidins against frailty. Dose-response analyses revealed a U-shaped relationship between total anthocyanidins intake and frailty risk, with an optimal consumption level of 33.322 mg per day.
Conclusion: This pioneering study emphasizes the potential protective role of dietary anthocyanidins in mitigating frailty, especially among middle-aged individuals and males.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316302 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0328489 | PLOS |
Vet World
July 2025
Research Center for Horticulture, National Research and Innovation Agency, Jl. Raya Jakarta-Bogor No.32, Pakansari, Kec. Cibinong, Kabupaten Bogor, West Java 16915, Indonesia.
Background And Aim: Purple sweet potatoes ( var. Ayamurasaki) possess high nutritional potential due to their rich content of amino acids, minerals, and fatty acids. However, their nutritional profile can be further improved through fermentation.
View Article and Find Full Text PDFFood Funct
September 2025
Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province 361021, PR China.
Depression is a widespread mental health condition associated with impaired neuroplasticity and disrupted brain-derived neurotrophic factor (BDNF)/TrkB signaling. Black mulberry, rich in anthocyanins, shows promise as a natural intervention for its anti-oxidative and anti-inflammatory profiles. This study evaluated the antidepressant-like effects of black mulberry anthocyanins in mice subjected to chronic mild stress (CMS).
View Article and Find Full Text PDFNeuroscience
September 2025
Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:
Visual motion perception declines during natural aging in most animals including humans. Edible berries of blackcurrant (BC) and its extracted anthocyanins (BCAs) have beneficial effects on human eyes. However, the effect of BCAs on the perception of moving objects and other dynamic visual patterns remains unknown.
View Article and Find Full Text PDFMol Nutr Food Res
September 2025
Department of Translational Genomics, GROW - Research Institute For Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands.
A diet rich in fruits and vegetables (F&Vs) reduces chronic disease risk by modulating oxidative stress, inflammatory cytokines, and immune cell activity in the blood. Given the complexity of peripheral blood and its cellular components, understanding cell-type-specific responses to F&V interventions remains essential and challenging. We used CIBERSORTx to analyze immune cell fractions and gene expression profiles from RNA sequencing data of the MiBLEND study, which assessed the impact of seven F&V blends on chronic disease markers, phytochemical absorption, and gene expression changes in blood.
View Article and Find Full Text PDFNutrients
August 2025
Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Armauer Hansens vei 30, 4011 Stavanger, Norway.
Background: Identifying compounds with neuroprotective properties that target the neurogenic process will have a considerable impact on dementia prevention.
Methods: This is a secondary analysis of a 24-week randomised, double-blind, placebo-controlled anthocyanin supplementation trial in 181 participants. Using blood-derived serum collected during this trial, we treated hippocampal progenitor cells and analysed the ensuing cellular changes in the context of the participant's clinical and blood-based biomarker data.