The inverse relationship between dietary anthocyanidins consumption and frailty: Findings from the National Health and Nutrition Examination Survey.

PLoS One

Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Published: August 2025


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Article Abstract

Objective: This study investigates the association between dietary anthocyanidins consumption and the risk of frailty in the general adult population using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: A cross-sectional analysis of NHANES data was conducted, examining the relationship between dietary anthocyanidins intake and frailty risk. Dose-response relationships and subgroup analyses were performed to provide a comprehensive understanding of the associations.

Results: The results indicate a significant inverse relationship between the consumption of specific anthocyanidin types, including malvidin and delphinidin, as well as total anthocyanidins, and the odds of frailty. Particularly, individuals aged 41-60 years and males exhibited a notable protective effect of anthocyanidins against frailty. Dose-response analyses revealed a U-shaped relationship between total anthocyanidins intake and frailty risk, with an optimal consumption level of 33.322 mg per day.

Conclusion: This pioneering study emphasizes the potential protective role of dietary anthocyanidins in mitigating frailty, especially among middle-aged individuals and males.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316302PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0328489PLOS

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