Integrin β3 dysregulation impairs megakaryopoiesis and microparticle production via disrupting ROCK-dependent cytoskeletal dynamics.

Background: Megakaryocyte (MK) fragmentation into proplatelets (PPTs) and microparticles (MKMPs) is well established, yet the mechanisms underlying MKMP generation remain unclear.

Objectives: In order to investigate the role of integrin β3 and cytoskeletal dynamics during megakaryopoiesis and explore potential therapeutic targets for thrombocytopenia.

Methods: Proplatelet formation and MKMP release were evaluated both in vivo and in vitro under integrin β3 receptor impaired environment.

Assessing the impact of radiofrequency ablation on hilar cholangiocarcinoma: a systematic review and meta-analysis.

Background And Aims: Hilar cholangiocarcinoma (HC) is a challenging malignancy with limited treatment options. Radiofrequency ablation (RFA) has emerged as a potential palliative treatment, but its efficacy and safety remain controversial. This systematic review and meta-analysis aimed to evaluate the impact of RFA + stent (RFA + S) and stent only (S-only) on HC patients.

Case Report: Mimicking benignity: hepatic sinusoidal metastasis masquerading as diffuse liver disease in small cell lung cancer.

Background: Small cell lung cancer is extremely aggressive. Although liver metastasis is common, cases of diffuse intra-sinusoidal metastasis leading to liver failure and death are quite rare.

Case Presentation: This paper reports a case of a 58-year-old male diagnosed with small cell lung cancer through a pathological biopsy, who died due to the rapid progression of liver failure caused by diffuse hepatic sinusoidal metastasis during subsequent treatment.

Dark triad traits and career adaptability: the mediating role of political skill.

Background: This study investigated the mechanism through which the Dark Triad traits (Machiavellianism, narcissism, psychopathy) relate to career adaptability. While previous research primarily focused on the role of bright traits in enhancing career adaptability, the potential benefits of dark traits on career adaptability have often been overlooked. By integrating career construction theory (CCT) and conservation of resources theory (COR), this study proposed that adaptive readiness, operationalized in terms of the Dark Triad traits, would be related to career adaptability through political skill, offering a novel perspective on how dark traits, like the Dark Triad, can be related to career adaptability.

A comparative study of extracorporeal shock wave lithotripsy and cholangioscopy-guided lithotripsy in the management of complex biliary stones: A randomized trial.

Background: Large and impacted common bile duct stones (CBDSs) cannot be removed by conventional endoscopic retrograde cholangiopancreatography (ERCP), and extracorporeal shock wave lithotripsy (ESWL) or cholangioscopy-guided lithotripsy is recommended as a second-line treatment. The aim of this study is to compare safety and efficacy of ESWL for difficult CBDS.

Methods: Patients at our hospital diagnosed with complex large CBDS between January 2021 and June 2022 were randomly assigned to the ESWL group or the cholangioscopy group for lithotripsy.

Evaluation of photon-counting CT-derived attenuation parameters for noninvasive liver fat assessment.

Objective: To evaluate the diagnostic performance of multiple photon-counting CT (PCCT)-derived parameters for hepatic fat quantification, using MRI-derived proton density fat fraction (PDFF) as the reference standard.

Methods: This prospective study included 59 adult participants who underwent both MRI and PCCT within 2 h. Standardized CT values, Liver-virtual non-contrast (VNC) fat fraction, and liver-to-spleen/fat-derived indices (L-S, L/S, L-F, L + F, L/F) were obtained from non-contrast PCCT.

Detection of lumbar disc herniation and degeneration using photon-counting detector CT with virtual non-calcium imaging.

Objectives: This study aimed to compare the diagnostic performance of virtual non-calcium (VNCa) imaging using photon-counting detector CT (PCD-CT) with MRI in assessing lumbar disc herniation (LDH) and intervertebral disc degeneration (IDD).

Materials And Methods: Patients with low back pain underwent PCD-CT and MRI within 2 h. Quantitative analysis included VNCa-derived CT values and T2 relaxation times in manually placed regions of interest.

Robot-assisted three column trans-intervertebral osteotomy by combined navigated trajectories: A feasibility study and technical report.

Introduction: Spinal osteotomy is indicated for malalignment and deformity, but the degree of osseous resection is mainly determined by the surgeon's experience. Navigation and robotics are techniques for the precise placement of pedicle screws.

Research Question: Can an innovative combined navigated trajectory (CNT) design based on a spinal robot achieve precise 3-column osteotomy.

Association between meat consumption and incident acute pancreatitis: a prospective cohort study.

: Previous studies indicated the potential role of consumption of different types of meat in the etiology of acute pancreatitis (AP), but no clear link has been established. This study aimed to investigate the association between consumption of 4 types of meat (processed meat, unprocessed red meat, poultry, and fish) and the risk of incident AP. : We included 489 708 participants from the UK Biobank between 2006 and 2010.

MRI Delta-Radiomics and Morphological Feature-Driven TabPFN Model for Preoperative Prediction of Lymphovascular Invasion in Invasive Breast Cancer.

BackgroundTraditional dynamic contrast-enhanced MRI (DCE-MRI) radiomics approaches for predicting lymphovascular invasion (LVI) in invasive breast cancer (IBC) frequently neglect the importance of dynamic phase alterations, and their diagnostic efficacy is often constrained by limited sample sizes. We have developed the Tabular Prior-data Fitted Network (TabPFN) algorithm, which synergistically combines clinical and MR morphological features with delta-radiomics, thereby substantially improving the performance of binary classification.MethodIn this retrospective study, 276 IBC patients were divided into a training group (n = 193, 70%) and a validation set (n = 83, 30%).

Carrier-Free Nanocapsule with Dual-Target Capacity for Synergistically Restoring Inflammatory Microenvironment and Microbiota Dysbiosis in Colitis.

Inflammatory bowel disease (IBD) is a chronic inflammatory disease with limited therapeutic outcomes. Macrophages are the key gatekeepers of intestinal immune homeostasis and have vital influence on IBD. Hence, macrophages are recognized as attractive targets to develop new therapeutic.

Multi-modality model predicts lung metastasis of hepatocellular carcinoma using MRI and pathological: a retrospective multicenter study.

Background And Purpose: Lung metastasis directly affects the prognosis of patients with hepatocellular carcinoma, How to predict the occurrence of lung metastasis and assist in advance can improve the efficacy of surgical treatment for hepatocellular carcinoma. This study aimed to develop and validate a model for predicting future lung metastasis of hepatocellular carcinoma (HCC) to assist in timely intervention.

Methods: We retrospectively collected MRI (T2W, CE-T1W, and DWI) images of liver tumors and their full slide images of H&E stained biopsy sections for annotation and feature extraction.

Evaluation and comparison of large language models' responses to questions related optic neuritis.

Objectives: Large language models (LLMs) show promise as clinical consultation tools and may assist optic neuritis patients, though research on their performance in this area is limited. Our study aims to assess and compare the performance of four commonly used LLM-Chatbots-Claude-2, ChatGPT-3.5, ChatGPT-4.

Acute Myeloid Leukemia With Extramedullary Infiltration-Gastric Myeloid Sarcoma: A Case Report and Literature Review.

Gastric myeloid sarcoma (MS) is a rare disease with numerous endoscopic manifestations and is typically diagnosed on the basis of immunohistochemistry. However, the epidemiology, treatment, and prognosis of gastric MS remain controversial. The goal of this study is to preliminarily analyze these controversial aspects of gastric MS.

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma.

Tertiary lymphoid structures (TLSs), organized clusters of immune cells within non-lymphoid tissues, significantly influence tumor progression and therapeutic response. However, their prognostic relevance and underlying regulatory mechanisms in clear cell renal cell carcinoma (ccRCC) remain insufficiently characterized. We integrated transcriptomic and clinical data from 928 ccRCC patients to construct a TLS-related prognostic RiskScore using machine learning algorithms.

Robustness of radiomic features in photon-counting CT: Impact of radiation dose and virtual monoenergetic reconstructions compared to dual-energy CT.

Objectives: To evaluate the impact of Virtual Monoenergetic Image (VMI) reconstructions and radiation dose on radiomic feature reproducibility in photon-counting CT (PCCT) and compare its performance with dual-energy CT (DE-CT).

Methods: An anthropomorphic abdominal phantom (Kyoto Kagaku CTU-41) simulating liver, kidney, and vertebral tissues was scanned on a PCCT system at four dose levels (1, 3, 6, 12 mGy) with VMI reconstructions (40-100 keV). DE-CT acquisitions (80/140 kVp) at matched doses served as the comparator.

Multifunctional protein-polysaccharide hydrogel with antimicrobial and angiogenic properties to promote infected wound healing.

Bacterial infections, slow angiogenesis, and wound irregularities continue to present great clinical challenges in infected wound repair. While recent years have seen increasing interest in advanced composite hydrogels with antibacterial, angiogenic, and wound-healing properties, traditional dynamic hydrogels remain limited by inadequate mechanical strength despite their adaptability to irregular wounds. Here, we used double-bonded functionalized recombinant collagen (CFGMA), sulfhydrylated hyaluronic acid (HA-SH), silver ions (Ag), and VEGF peptide (V-pep), which formed a composite hydrogel that could accommodate irregular wounds as well as have excellent mechanical properties.

Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.

Background: Coronary artery disease is a chronic and multifactorial disease with acute manifestations. Little is known about the concomitant impact of hypercholesterolemia and hypertension on the development of coronary atherosclerosis.

Methods: (apolipoprotein E) and (scavenger receptor class B, type I), both associated with human hypercholesterolemia, were inactivated in mice by inserting a knockdown cassette downstream of the promoter.

Interaction Between Glycoside Hydrolase FsGH28c from and PnPUB35 Confers Resistance in .

Pathogens deploy various molecular mechanisms to overcome host defenses, among which glycoside hydrolases (GHs) play a critical role as virulence factors. Understanding the functional roles of these enzymes is essential for uncovering pathogen-host interactions and developing strategies for disease management. wilt has occurred in the main cultivation regions, which seriously affects the yield and quality of .

Accuracy of Low-Dose Chest CT-Based Artificial Intelligence Models in Osteoporosis Detection: A Systematic Review and Meta-analysis.

The purpose of this study is to systematically review and evaluate the accuracy of low-dose chest CT-based artificial intelligence in osteoporosis screening. A systematic literature search for relevant studies up to 13th December 2024 was performed in the PubMed, Scopus, Web of Science, and Cochrane Library databases. This meta-analysis was conducted in accordance with the PRISMA-DTA statement.

Spatially segregated APOE macrophages restrict immunotherapy efficacy in clear cell renal cell carcinoma.

Immunotherapy has revolutionized cancer treatment and holds great potential for them, including metastatic clear cell renal cell carcinoma (ccRCC). However, immune resistance remains a major obstacle, limiting its efficacy and durability. Understanding the mechanisms of immune tolerance in the tumor microenvironment (TME) is pivotal for overcoming these challenges and enhancing therapeutic outcomes.

Endoscopic ultrasound-guided ethanol vs ethanol combined with paclitaxel for the ablation of pancreatic cystic lesions: a systematic review and meta-analysis.

Background: Some pancreatic cystic lesions (PCLs) have the risk of malignant transformation, but the complications of pancreatic surgery are high, and minimally invasive treatment is imperative. Endoscopic ultrasound (EUS) -guided ablation has been utilized to treat pancreatic cysts. We undertook the meta-analysis and systematic review to assess the efficacy and safety of this technique in PCLs.

Unlocking the Synergy: ABA Seed Priming Enhances Drought Tolerance in Seedlings of Sweet Sorghum Through ABA-IAA Crosstalk.

Abscisic acid (ABA) seed priming impacts plant growth and stress resistance, yet its precise physiological and molecular mechanisms remain elusive. This study explored the role of ABA-priming in enhancing drought acclimation in sweet sorghum (Sorghum bicolor Moench) using physiological assessments and comparative transcriptomics. Under drought stress, ABA-primed seedlings exhibited increased plant height, larger leaves, and higher leaf water content compared to non-primed plants.