Quasi-2D Perovskite Luminescent Solar Concentrators Enable Large Field-of-View and High-Speed Visible Light Communication.

Luminescent solar concentrators (LSCs) based on high photoluminescence quantum yield (PLQY) quasi-2D perovskites demonstrate superior edge light collection capability, which breaks the étendue limit and achieves signal reception in visible light communication (VLC). Herein, 2,7-bis(diphenylphosphoryl)-9,9-spirobifluorene (SPPO13) is introduced into the Q-2D RP-phase perovskite (BACsPbBr, <> = 5), realizing dual effects of defect passivation and small value phase suppression. The emission peak of the optimized film is at 518 nm with a maximum PLQY of 99.

Across ice-water-air visible light communications.

Visible light communication (VLC) technology has gained significant attention due to its abundant spectrum resources and high channel capacity for future LiFi and underwater optical wireless communication applications in the 6 G era. Aiming at ubiquitous wireless communication, the study of VLC across different media becomes an important research topic. In particular, the optical wireless communication in ice remains limited.

Beyond 50 Gbps 100 m visible light laser communication single-transmitter-multi-receiver system utilizing triple branch neural network.

In the forthcoming 6 G communication era, traditional electromagnetic spectra are increasingly inadequate to meet growing demands. Visible Light Communication (VLC) technology offers a promising high-speed solution due to its flexible deployment and cost-effectiveness. However, long-distance VLC applications are challenged by factors such as atmospheric turbulence and nonlinear distortions.

Flexible multi-access scheme for indoor VLC using multiband N-dimensional CAP and a wide field-of-view white laser transmitter.

Visible light communication (VLC) has emerged as a crucial technology for next-generation (6 G) communication, integrating illumination and data transmission. However, the modulation bandwidths of light-emitting diodes (LEDs) are relatively limited, which restricts communication capacity. In contrast, laser diodes (LDs) offer distinct advantages, including high luminous flux, compact size, and large modulation bandwidth.

Herpes zoster recurrence, and safety and immunogenicity of the recombinant zoster vaccine in adults aged ≥50 years with a history of herpes zoster: A phase 3, randomized controlled trial.

Objectives: To assess HZ recurrence (primary objective), safety and immunogenicity of the recombinant zoster vaccine (RZV) in adults with prior HZ.

Methods: This phase 3, observer-blind, multi-country study (NCT04091451) enrolled participants ≥50 years with one resolved HZ episode >6 months prior, randomized 1:1 to receive two RZV or placebo doses 2 months apart. Recurrent HZ cases were confirmed by an algorithm comprising varicella-zoster virus-PCR and HZ adjudication determination.

MRI Delta-Radiomics and Morphological Feature-Driven TabPFN Model for Preoperative Prediction of Lymphovascular Invasion in Invasive Breast Cancer.

BackgroundTraditional dynamic contrast-enhanced MRI (DCE-MRI) radiomics approaches for predicting lymphovascular invasion (LVI) in invasive breast cancer (IBC) frequently neglect the importance of dynamic phase alterations, and their diagnostic efficacy is often constrained by limited sample sizes. We have developed the Tabular Prior-data Fitted Network (TabPFN) algorithm, which synergistically combines clinical and MR morphological features with delta-radiomics, thereby substantially improving the performance of binary classification.MethodIn this retrospective study, 276 IBC patients were divided into a training group (n = 193, 70%) and a validation set (n = 83, 30%).

An integrative approach for imaging and quantitative analysis of gut microbiota growth using fluorescent D-amino acid labeling and fluorescence hybridization.

The profound influence of gut microbiota on human health has been well-recognized; however, substantial gaps remain in our understanding of the highly diverse and dynamic processes of microbial growth and activities in the gut. Conventional methods, which primarily rely on DNA sequencing, provide limited insights into these aspects. This paper presents a protocol that integrates fluorescent D-amino acid (FDAA) metabolic labeling with fluorescence hybridization (FISH) for imaging and quantitatively analyzing the growth of gut microbiota.

Seamless optical cloud computing across edge-metro network for generative AI.

The rapid advancement of generative artificial intelligence (AI) in recent years has profoundly reshaped modern lifestyles, necessitating a revolutionary architecture to support the growing demands for computational power. Cloud computing has become the driving force behind this transformation. However, it consumes significant power and faces computation security risks due to the reliance on extensive data centers and servers in the cloud.

Influence of and Individual and Collaborative Inoculation on Flavor Characteristics of Rose Fermented Beverage.

This study investigates the impact of using and , either individually or in co-culture, on the fermentation of rose beverage. We comprehensively analyzed the resulting changes in quality characteristics and volatile compound profiles. Fermentation significantly altered the physicochemical properties, appearance, color, and free amino acid/organic acid content.

Metabolomics and network pharmacology reveal the anti-inflammatory core substances and mechanisms of a new cultivar of high-polyphenol lettuce.

Background: Diet plays a significant role in mitigating inflammation, with lettuce and its polyphenols showing potential for improving inflammatory conditions. However, research on the material basis and mechanisms of action remains unclear.

Results: This study investigated the primary components and anti-inflammatory effects of the new lettuce cultivar Binfen-1, which is rich in polyphenols and may offer enhanced health benefits.

Prognostic significance of different lymph node staging systems in patients with resectable, node-positive, stage III, non-small cell lung cancer: Identifying the optimal classification for enhanced prognostic stratification.

Purpose: The traditional N staging system fails to adequately stratify the prognostic heterogeneity in patients with resectable node-positive, stage III, non-small cell lung cancer, particularly in those undergoing postoperative radiotherapy. The purpose of this study was to determine the optimal nodal status classification strategy: the traditional N classification, the positive lymph nodes-based classification, or the lymph node ratio-based classification. Furthermore, we aimed to identify the population that would benefit the most from postoperative radiotherapy using the best classification strategy.

Amur linden honey and its principal polyphenols alleviate obesity and regulate gut microbiota in high-fat diet-induced mice.

Obesity has emerged as a critical global health challenge in recent decades, driving increased scientific interest in honey as a sugar alternative. Despite its perceived nutritional benefits, the inherent high fructose-glucose ratio in honey continues to raise concerns regarding metabolic implications for overweight individuals. In this study, Amur linden honey (LH) was evaluated as a low-glycemic-index (GI) dietary intervention, demonstrating significant anti-obesity effects through murine model.

TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process.

The global COVID-19 pandemic caused by SARS-CoV-2 has underscored the urgent need for the development of new broad-spectrum antivirals to combat its high mutation rate and the emerging variants. Host ER α-glucosidases I/II are promising host-targeted therapeutic targets for the development of broad-spectrum antivirals against viral strains that depend on ERQC for infectivity. Herein, we designed and synthesized a series of TCM theory-inspired DNJ-flavonoid conjugates as novel α-glucosidase inhibitors, which were screened against their in vitro antiviral activities in non-replicative SARS-CoV-2 pseudovirus (PsV) assay.

Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ.

The translocation of bacteria from intestinal tracts into blood vessels and distal organs plays pivotal roles in the pathogenesis of numerous severe diseases. Intravital monitoring of bacterial translocation, however, is not yet feasible, which greatly hinders us from comprehending this spatially and temporally dynamic process. Here we report an in vivo fluorogenic labeling method, which enables in situ imaging of mouse gut microbiota and real-time tracking of the translocated bacteria.

Three-Dimensional Imaging of Native Microbiota in Intact Colon.

Mapping the spatial locations of gut bacteria in their native environment enhances our understanding of bacteria-host interactions and the physiological and pathological roles these microbes play. However, the intricate composition of bacterial communities in millimeter-scale intestinal tissues presents a great challenge for in situ imaging of their spatial distributions. To address this, we introduce a three-dimensional (3D) imaging strategy that combines a fluorescent tetrapeptide (TetraAA-AcLys) metabolic labeling probe with a tissue clearing protocol.

Edge-guided inverse design of digital metamaterial-based mode multiplexers for high-capacity multi-dimensional optical interconnect.

The escalating demands of compute-intensive applications urgently necessitate the adoption of optical interconnect technologies to overcome bottlenecks in scaling computing systems. This requires fully exploiting the inherent parallelism of light across scalable dimensions for data loading. Here we experimentally demonstrate a synergy of wavelength- and mode- multiplexing combined with high-order modulation formats to achieve multi-tens-of-terabits-per-second optical interconnects using foundry-compatible silicon photonic circuits.

An anomaly detection scheme for data stream in cold chain logistics.

Anomaly detection is widely used in cold chain logistics (CCL). But, because of the high cost and technical problem, the anomaly detection performance is poor, and the anomaly can not be detected in time, which affects the quality of goods. To solve these problems, the paper presents a new anomaly detection scheme for CCL.

Radiomics integration based on intratumoral and peritumoral computed tomography improves the diagnostic efficiency of invasiveness in patients with pure ground-glass nodules: a machine learning, cross-sectional, bicentric study.

Background: Radiomics has shown promise in the diagnosis and prognosis of lung cancer. Here, we investigated the performance of computed tomography-based radiomic features, extracted from gross tumor volume (GTV), peritumoral volume (PTV), and GTV + PTV (GPTV), for predicting the pathological invasiveness of pure ground-glass nodules present in lung adenocarcinoma.

Methods: This was a retrospective, cross-sectional, bicentric study with data collected from January 1, 2018, to June 1, 2022.

A Dehydrogenative Diels-Alder/Aromatization Sequence to Access 6/6/6/6/5 Pentacyclic Steroids: Their Anti-inflammatory Activities.

6/6/6/6/5 Pentacyclic steroids represent an emerging class of architecturally unique and biologically promising steroids. Herein, we developed a DDQ-mediated dehydrogenative Diels-Alder/aromatization cascade reaction between ergosterol derivatives and dienophiles inspired by plausible biosynthetic pathways, which enabled straightforward access to various 6/6/6/6/5 pentacyclic steroids in 24-66% yields. This work offers significant advantages in assembling 6/6/6/6/5 pentacyclic steroids such as the use of inexpensive starting materials, mild reaction conditions, and simple operations.

Assessment of intratumor heterogeneity for preoperatively predicting the invasiveness of pulmonary adenocarcinomas manifesting as pure ground-glass nodules.

Background: The increased use of low-dose computed tomography (CT) for lung cancer screening has improved the detection of ground-glass nodules. However, as the clinical utility of CT findings to predict the invasiveness of pure ground-glass nodules (pGGNs) is currently limited, differentiating pGGNs that indicate invasive adenocarcinoma (IAC) from those that represent other histological entities is challenging. We aimed to quantify intratumor heterogeneity of lung adenocarcinomas characterized by pGGNs on CT to assess its efficacy in predicting IACs before surgery.

Effect of Different Probiotic Fermentations on the Quality of Plant-Based Hempseed Fermented Milk.

This study investigated the effects of three different single-strain probiotics XD117, LC-37, and LGG, on the quality of hempseed fermented milk. The main findings were that adding probiotics increased the inhibition rate of α-glucosidase and pancreatic lipase in hempseed fermented milk significantly. Non-targeted metabolomic correlation analysis results confirmed that 14 substances, including three flavonoids, six amino acids and their derivatives, and five short peptides, were positively correlated with the hypoglycemic and hypolipidemic activities of hempseed fermented milk.

Multi-kilometer visible light communication utilizing nonlinearity-adaptive hybrid probabilistic-geometric shaping.

In this paper, we propose and experimentally demonstrate a high rate-distance product visible light communication (VLC) system based on nonlinearity-adaptive hybrid probabilistic-geometric constellation shaping (NA-HCS) for multi-kilometer free space transmission. A pairwise optimization algorithm is employed within the probabilistic shaping (PS) to achieve NA-HCS for constellation according to the pre-estimated signal-to-noise ratio (SNR) of the long-distance nonlinear channel, which proves its efficacy in channel capacity optimization. Using a modified physical free space optical communication equivalent link, the QAM based on NA-HCS technology can flexibly control the net data rate (NDR) to accommodate different intensities of nonlinear impairment within 1 km transmission channel, consistently outperforming PS-APSK and PS-QAM.

Mobile fronthaul solution based on visible light fiber communication and zero-padding 8-D CAP modulation.

With the deployment of the fifth-generation (5 G) emerging technologies, such as massive multiple-input multiple-output (mMIMO), conventional mobile fronthaul (FH) schemes based on Common Public Radio Interface (CPRI) are limited in their abilities to support ultra-high data rate, large bandwidth and massive connectivity. This has led to a growing demand for alternative solutions that can better fulfill these requirements. Visible light communication (VLC) has recently gained increasing research interest as a potential complementary technology for beyond-5 G communication, offering advantages such as unlicensed and abundant spectrum, high bandwidth and cost-efficiency.

Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments.

Iminosugars, a class of polyhydroxylated cyclic alkaloids with intriguing properties, hold promising therapeutic potentials against a broad spectrum of enveloped viruses, including DENV, HCV, HIV, and influenza viruses. Mechanistically, iminosugars act as the competitive inhibitors of host endoplasmic reticular α-glucosidases I and II to  disrupt the proper folding of viral nascent glycoproteins, which thereby exerts antiviral effects. Remarkably, the glycoproteins of many enveloped viruses are significantly more dependent on the calnexin pathway of the protein folding than most host glycoproteins.