Chromatin-associated circRNA ciCRLF3(2) regulates cell differentiation blockage via activating non-homologous end joining-based DNA repair.

DNA damage response (DDR) is a complicated network that responds to DNA lesions to prevent their accumulation; a defective DDR is one hallmark of cancer. Although targeting DDR pathways has been considered as a therapeutic approach, DDR inhibitors have also been reported ineffective for treating some low mutation burden cancers, such as Mixed-lineage leukemia (MLL)-rearranged (MLL-r) leukemia, a clinically fatal and refractory malignancy. Exploring the roles and mechanisms of DDR pathways in these low mutation burden cancers may help understand the chromatin biology and develop therapeutic strategies.

Panoramic laser communication optical systems for low Earth orbit satellite networking.

Laser communication, which is known for its high data rate and large capacity, is a promising solution for future large-scale satellite constellation networking. However, the limited field of view (FOV) of current communication terminals makes establishing inter-satellite links challenging. This paper presents a wide-field optical system for laser communication that addresses the challenge of the limited field of view (FOV) in current satellite terminals.

Nanoscale displacement measurement and motion status monitoring by a Michelson interferometer with conjugated vortex beams.

The Michelson interferometer with conjugate vortex beams has been modified for the precise detection of nanoscale displacements. In this system, linear mechanical displacements in one of the interferometer arms are converted into rotational motion of flower-like interference patterns. The rotation angle relative to the displacement is determined by the topological charge of vortex beams.

Toltrazuril inhibits Toxoplasma gondii by potentially targeting pyrimidine metabolism.

Toxoplasma gondii is a significant zoonotic pathogen that infects nearly all warm-blooded animals. Available drugs for clinical treatment of toxoplasmosis are limited, creating an urgent need for development of new compounds. Toltrazuril (TOL) is a highly effective and broad-spectrum drug against parasites in Apicomplexa.

All-inside physeal bar resection for partial physeal arrest of the distal radius with the aid of an arthroscope and patient-specific instrument.

Purpose: The premature closure of the epiphysis of the distal radius is an infrequent condition in pediatric patients, often resulting in distal radius deformity. Currently, there is limited literature on its treatment, and controversy exists. This study aimed to evaluate the clinical efficacy of all-inside physeal bar resection with the aid of an arthroscope and patient-specific instrument.

Nucleus pulposus cell-associated PLAU promotes intervertebral disc degeneration through HIPPO pathway.

Intervertebral disc degeneration (IDD) is the most common and critical pathological basis for various spinal disorders. In this study, we investigated how plasminogen activator urokinase (PLAU) promotes IDD progression through the HIPPO pathway. Bioinformatics analysis showed that PLAU is a hub gene in IDD.

Seamless optical cloud computing across edge-metro network for generative AI.

The rapid advancement of generative artificial intelligence (AI) in recent years has profoundly reshaped modern lifestyles, necessitating a revolutionary architecture to support the growing demands for computational power. Cloud computing has become the driving force behind this transformation. However, it consumes significant power and faces computation security risks due to the reliance on extensive data centers and servers in the cloud.

Capsaicin inhibits the biofilm of Klebsiella pneumoniae by targeting the transcriptional regulator SdiA.

Pneumonia, particularly when caused by the bacterium Klebsiella pneumoniae, presents a major global health challenge. This gram-negative bacterium is a notable pathogen in healthcare-associated infections, leading to severe conditions such as urinary tract infections, pneumonia, and the bloodstream infections, mainly in immunocompromised subjects. The bacterium's ability to resist multiple antibiotics complicates the treatment, posing a major concern in hospital settings.

How to promote green transformation of mariculture industry under the influence of financial constraints? A policy simulation based on peer incentive perspective.

The green transformation of mariculture is a crucial aspect for promoting the sustainable development of the marine environment. To address financial constraints such as the high financial pressure on local governments and the difficulty of traditional fishing enterprises in meeting green credit conditions due to technical resource limitations, the paper proposes a peer incentive mechanism. Then, this paper focuses on the impact of peer incentive policy on the green transition of the mariculture industry by constructing a four-party evolutionary game model among local governments, financial institutions, green mariculture enterprises and traditional mariculture enterprises.

Dietary supplementation with isochlorogenic acid improves growth performance and intestinal health of broilers.

This study evaluated the effects of dietary supplementation with isochlorogenic acid (ICA) on growth performance and intestinal health of broilers. A total of 400 Cobb broilers (44.20 ± 0.

ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia-derived mesenchymal stem cells.

Osteogenic differentiation of mesenchymal stem cells (MSCs) was strongly correlated with the progression of congenital tibial pseudoarthrosis (CPT). Activation of ferroptosis inhibited osteogenic differentiation of MSCs. ELAV-like RNA binding protein 1 (ELAVL1) is a key factor in promoting ferroptosis.

C3-H Trifluoroacetylation of Quinolines and Pyridines: Access to Heteroaryl Ketones, Carboxylic Acids, and Amides.

Despite extensive synthetic endeavors, achieving direct C3-H trifluoroacetylation in quinolines/pyridines continues to pose significant challenges. We report a protocol for direct C3-H trifluoroacetylation of quinolines and pyridines under transition-metal-free conditions. Readily accessible quinolines or pyridines serve as starting materials and undergo a dearomatization process to generate dihydroquinoline or dihydropyridine intermediates, which readily react with trifluoracetic anhydride.

Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies.

Background: Gastrointestinal malignancies are a major public health concern worldwide, characterized by high incidence and mortality rates. Despite continuous advancements in existing treatment methods, overall survival rates remain low. Lipid metabolism plays a crucial role in the occurrence, progression, and treatment of gastrointestinal malignancies.

Diagnosis and treatment of lateral to medial diagonal injury of the elbow in children: concomitant lateral condyle and olecranon fractures.

Lateral condylar (LC) and olecranon (OC) fractures occurring concurrently on one side are rare phenomena with limited scientific literature. Our study aims to evaluate the radiologic, clinical, and functional consequences of lateral to medial injury of the elbow (LAMEINE) in pediatric patients, simultaneously comparing with lateral to medial diagonal injury of the elbow (MELAINE). Eighteen males and 10 females were diagnosed with LAMEINE.

Dynamic Cell Division and Growth During de Novo Meristem Formation in Epiphytic Fern Gametophytes.

Meristems in land plants serve conserved functions, maintaining undifferentiated cells and continuously producing new cells to support organ development and body formation. In seed plants, de novo meristem formation involves the initiation and assembly of new stem cell niches, promoting organogenesis and shaping plant architecture. However, the function and regulation of de novo meristem formation in seed-free vascular plants remains largely unknown.

SHP1 and its downstream p38/SP1/PI3K/YAP/Notch-1 signaling in trophoblast cells suppressed the progression of Preeclampsia via inhibiting proliferation of SMCs.

Preeclampsia leads to high fetal morbidity and pregnancy-induced mortality. However, the detailed molecular pathology of PE is currently unknown. shp1 has been shown to be critical to the pathogenesis of several diseases, but their role in PE requires further validation.

SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation.

Background: SLC7A11, a plasma membrane protein, has been implicated as an oncogene in various cancers, including hepatocellular carcinoma (HCC). Its role in HCC pathogenesis, particularly in relation to ferroptosis, is not well understood. This study aims to investigate the function of SLC7A11 with ferroptosis and its interaction in development of HCC.

Temporal trends in cross-country inequalities of early-onset pancreatic cancer: a comprehensive analysis for the global burden of disease study 2021.

By 2040, pancreatic cancer is expected to become the second leading cause of cancer-related deaths in the U.S., with early-onset pancreatic cancer (EOPC) cases rising among adolescents and young adults.

A just-in-time adaptive personalized mobile app intervention produces limited short-term reductions in heavy episodic drinking frequency in college students: A randomized control trial during the COVID-19 pandemic.

Background: High-risk drinking among college students is common, and alcohol expectancies and experienced consequences are proximal predictors of use. This study tested short- and long-term efficacy of a personalized just-in-time adaptive intervention with daily messages about alcohol use, alcohol expectancies, and consequences delivered via mobile app.

Methods: Participants were 408 students enrolled at a 2- or 4-year college (75% 4-year; 64% female) who completed twice-daily assessments for 21 days and follow-up surveys at 1-, 6-, and 12-months.

Single-cell transcriptomics reveals the interaction between fibroblasts and activated immune cells: an exploratory bioinformatics study of pro-inflammatory mechanisms in slow transit constipation.

Background: Slow transit constipateion (STC) is an intestinal disease characterized by colonic dyskinesia, which involves multiple factors such as neuroendocrine, substance metabolism, gut microbiota, ion channels, and aquaporin. Increasing evidence indicates that modulation of immune signaling, activation of immune cells, and secretion of cytokines impact oxidative stress, disruption of the intestinal mucosal barrier, and the subsequent intestinal dysfunction in STC. However, the landscape of the immune microenvironment (IME) and the disease-specific cell type in STC patients is unclear, and the detailed mechanism of how immune cells affect stromal cells during chronic inflammation is still lacking.

Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway.

Background: Lung cancer is the leading cause of cancer-related death in the worldwide. Although cisplatin and other platinum-based drugs are widely used as radiosensitizers in radiotherapy and considered the first-line treatment for advanced lung cancer, their clinical utility is often limited by drug resistance and severe cytotoxic side effects. In recent years, iridium-based complexes and other transition metal cation complexes with similar structural properties have garnered increasing research interest due to their potential anticancer properties.

Risk factors for hypothermia after transurethral holmium laser enucleation of the prostate and development of a nomogram model.

Objectives: Postoperative hypothermia is a common clinical complication with a high incidence rate, potentially adversely affecting postoperative recovery. Transurethral holmium laser enucleation of the prostate (HoLEP) is a minimally invasive procedure for benign prostatic hyperplasia (BPH). Offering advantages such as minimal bleeding, broad indications, and rapid postoperative recovery.

Ligand-Accelerated, Copper-Catalyzed Aerobic Oxidative Dehydrogenation of Primary Amines to Nitriles.

A highly efficient copper-catalyzed oxidative dehydrogenation of primary amines to access nitriles has been developed. We found that DMAP was an efficient ligand for copper-catalyzed oxidation and molecular oxygen was a green oxidizing agent. This reaction exhibited excellent functional group compatibility and a broad substrate scope.

Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis.

High lead (Pb) burden in humans disrupts bone homeostasis and can induce osteoporosis. Here, we report that osteoclast-derived exosomes (OC-Exos) were enriched in the plasma of patients with low bone mineral density and Pb exposure. Osteoclasts (OCs) secrete microRNA-enriched exosomes, through which miR-30a-3p is transferred to osteoblasts (OBs) to induce pyroptosis, leading to the aggravation of bone loss.