Association between prone position ventilation and tracheal injury score in intensive care unit patients with invasive ventilation: a secondary analysis of a prospective cohort study in China.

Objectives: At present, the available evidence regarding the relationship between prone position ventilation (PPV) and tracheal injury score remains inadequate. This study seeks to gain deeper insights into the relationship between PPV and tracheal injury score in intensive care unit (ICU) patients with invasive ventilation.

Design: A secondary analysis of a prospective cohort study.

Association of obesity-related anthropometric indicators with chronic constipation and diarrhea among U.S. adults: a cross-sectional study.

Aim: Prior studies have linked obesity indicators to constipation/diarrhea, but multi-measure comparisons remain limited. We analyzed these associations in U.S.

BioFuse: A programmable timer switch of gene expression.

Current gene circuits designed to time gene expression depend on the intricate interactions among various regulators and their targets, which confines them to a limited range of temporal tunability. Here, we report a programmable timer switch of gene expression termed BioFuse, which allows the reaction time ranging from hours to days. BioFuse comprises a series of fuse-like tandem DNA cassettes that can be sequentially edited by the adenine base editors (ABEs), resulting in either the activation or deactivation of a downstream gene once the editing is complete.

Negative Modulation of Maternal Iodine Deficiency and Excess on Milk Lipid Synthesis and Secretion in Lactating Rats.

Iodine is an essential micronutrient for developmental processes in the early stages; however, data on the effect of maternal iodine nutrition on milk lipids are limited. We aimed to explore the effect of inadequate and excessive iodine intake on milk lipid metabolism and its mechanisms preliminarily. Rats were treated with different concentrations of potassium iodide water to construct animal models of iodine deficiency and excess.

The interaction between McMLO7b and McCASPL22 regulating the susceptibility to powdery mildews in balsam pear.

Powdery mildew (PM) is one of the most serious diseases in balsam pear. MLO (Mildew Resistance Locus O) is a key factor in the response of plants to PM infection, but its regulation mechanism remains poorly understood. In this study, overexpression of McMLO7b (MLO7b in Momordica charantia L) was found to potentially enhance Arabidopsis susceptibility to PM, confirming that McMLO7b acts as a susceptibility factor during PM infection.

An Ultra-Robust, Highly Compressible Silk/Silver Nanowire Sponge-Based Wearable Pressure Sensor for Health Monitoring.

Wearable pressure sensors have emerged as vital tools in personalized monitoring, promising transformative advances in patient care and diagnostics. Nevertheless, conventional devices frequently suffer from limited sensitivity, inadequate flexibility, and concerns regarding biocompatibility. Herein, we introduce silk fibroin, a naturally occurring protein extracted from silkworm cocoons, as a promising material platform for next-generation wearable sensors.

Secure wireless communication of brain-computer interface and mind control of smart devices enabled by space-time-coding metasurface.

Brain-computer interface (BCI) provides an interconnected pathway between the human brain and external devices and paves a potential route for mind manipulations. However, most existing BCI technologies are based on simple signal transmission and are independent of other interface devices, with limited consideration for the reliability and security of the human brain's information interaction in complicated wireless environments. Here, we propose a deep fusion coding scheme that combines the BCI visual stimulation coding with metasurface space-time coding at the physical layer, enabling reliable and secure information transfers between the human brain and external devices.

Predicting Anti-Cancer Drug Response Based on Hypergraph Representation Learning.

Accurate prediction of drug responses is critical for advancing personalized cancer therapies. Although current graph neural network (GNN)-based approaches predominantly focus on pairwise interactions between cell lines and drugs, they often neglect the potential of higher-order interactions. In this study, we present HRLCDR, a novel computational framework that utilizes Hypergraph Representation Learning to predict Cancer Drug Responses.

Electronic Cloud Topology-Driven Electrostatic Decoupling: To Suppress High-Voltage Parasitic Reactions of Phosphate Cathode in Sodium-Ion Batteries.

The polyanionic structure cathodes with synergistic Mn/V redox couples enables high-voltage platform and delivers considerable theoretical energy density in sodium-ion battery. However, achieving stable and reversible high-voltage redox reactions remain challenging due to the inactivation of redox couples during discharge. Herein, we found that coupled redox behavior triggered by orbitals with similar energy levels leads to high-voltage irreversibility and parasitic reactions.

Multi-biosensing hairband for emergency health assessment.

Blood analysis is regarded as the gold standard for monitoring analytes in clinical diagnostics. However, the time-consuming and site-limited nature often delays medical interventions that are crucial for patients in emergency scenarios. Herein, a weavable multi-biosensor array is developed through coaxial wet spinning for real-time multiplex detection of sweat biomarkers (pH, Na, K, and Ca) and body temperature.

Integrating Time and Frequency Domain Features of fMRI Time Series for Alzheimer's Disease Classification Using Graph Neural Networks.

Accurate and early diagnosis of Alzheimer's Disease (AD) is crucial for timely interventions and treatment advancement. Functional Magnetic Resonance Imaging (fMRI), measuring brain blood-oxygen level changes over time, is a powerful AD-diagnosis tool. However, current fMRI-based AD diagnosis methods rely on noise-susceptible time-domain features and focus only on synchronous brain-region interactions in the same time phase, neglecting asynchronous ones.

Deciphering photocurrent mechanisms at the nanoscale in van der Waals interfaces for enhanced optoelectronic applications.

Integrated photodetectors are vital for their high speed, sensitivity, and low power consumption, with photocurrent driven by the photovoltaic and photothermoelectric (PTE) effects. At the nanoscale, these mechanisms overlap, complicating their separate evaluation. We introduce a 3D photocurrent nanoimaging technique to map these effects in a MoS-Au Schottky photodiode, revealing a PTE-dominated region extending hundreds of nanometers from the electrode edge, enabled by weak electrostatic forces in two-dimensional materials.

Hemoadhican-based self-leveling Janus patch for comprehensive prevention of postoperative adhesions.

Postoperative anti-adhesion materials face significant challenges, including dislocation, the induction of nonspecific tissue adhesions, and secondary fibrinolytic disorders. In this study, we developed a self-leveling, transient, unilaterally bonded Janus patch (J-HD) based on hemoadhican (HD). This patch consists of three distinct functional layers: an anti-adhesion layer, a reinforcement layer, and a wet tissue adhesion layer.

Deterioration mechanism and stochastic damage modeling of tunnel lining concrete in hydrothermal corrosive environments.

Corrosion caused by geothermal water and thermal damage due to high temperature are the critical causes of lining material cracking and structural instability in hydrotherm al high-geothermal tunnels. In order to investigate the coupled effect of high temperature and corrosion on the macroscopic mechanical properties and microstructure of lining concrete, a series of experiments have been conducted, and a new thermal-corrosion damage model has been proposed that can describe the evolution of the mechanical properties of concrete in this particular environment. The study results indicate that the mass loss rate exhibits a trend of decreasing and then increasing as the degree of corrosion increases.

Timing selection for sedated gastroscopy after SARS-CoV-2 infection: a retrospective cohort study.

Background: Sedated gastroscopy poses risks for patients with upper respiratory infections. The optimal timing for performing sedated gastroscopy in patients with acute SARS-CoV-2 infection is uncertain.

Methods: We retrospectively collected data from patients who underwent sedated gastroscopy at the Affiliated Hospital of Qingdao University between December 19th 2022 and January 20th 2023.

Validation of Experimental Cooling Performance of Multi-Stage Thin-Film Thermoelectric Devices via Numerical Simulation.

In-plane thermoelectric thin-film cooling devices are considered a promising solution for thermal management in electronic systems. However, the actual cooling performance is far below that of regular bulk cooling devices, making the design of thin-film devices much more difficult. In this work, a numerical analysis of the cooling performance of single-leg thin-film devices and multi-stage cascaded thin-film devices was conducted to understand the depressed cooling performance.

Preoperative embolization of head and neck tumors: a systematic review and meta-analysis.

Purpose: Preoperative embolization is a widely recognized adjunctive treatment for highly vascular head and neck tumors; however, there is still no consensus regarding its efficacy and safety. Our study aims to address this issue through a meta-analysis.

Methods: A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane databases to identify relevant literature on preoperative embolization for head and neck tumors up to March 2025.

ATP-gated P2x7 receptors express at type II auditory nerves and required for efferent hearing control and noise protection.

Negative feedback of the cochlear efferent system plays a critical role in control of hearing sensitivity and protection from noise trauma. Type II auditory nerves (ANs) innervate outer hair cells (OHCs) in the cochlea and provide an input to the cochlear efferent system to achieve hearing sensitivity controlling and protection; in particular, medial olivocochlear efferent nerves innervate OHCs to control OHC electromotility, which is an active cochlear amplifier in mammals. However, little is known about channel information underlying type II AN activity and consequent function.

Identification of a p21-activated kinase 1 (PAK1) inhibitor with 10-fold selectivity against PAK2.

The p21-activated kinases (PAKs) are noted for their role in cytoskeletal organization, cellular morphogenesis, and pro-survival signaling. PAK1 is of particular interest due to its role in tumorigenesis, being amplified in multiple cancers (the most prevalent being breast, ovarian, and melanoma cancers). PAK2 is closely related to PAK1 in structure but is associated with cardiotoxicity.

Lipidomic characteristics of eight major legumes and alterations of lipid profiles in legumes in response to soaking and cooking.

Legumes are important sources of dietary lipids, and lipidomic analysis of legumes using UPLC-QTOF-MS is crucial for human health. This study characterized and compared the lipid profiles of black soybean, mung beans, chickpeas, peas, fava beans, cowpeas, adzuki beans, and kidney beans, and investigated the effects of soaking and cooking. Sixteen subclasses comprising 520 lipids were identified, with 170 differential lipids among the eight legume types.

Mowing mitigates the enhancement of nitrogen enrichment on grassland insect herbivory.

Insect herbivory influences ecosystem nutrient cycling and energy flow, and is sensitive to global change drivers. Nitrogen (N) enrichment would stimulate grassland insect herbivory by increasing insect abundance and changing plant community. However, it remains unknown whether such impacts of N enrichment would depend on grassland management practices, such as mowing.

Cellulose nanocrystal-modified hydrogel wearable sensor with self-healing function from dynamic bond and controllable dual hydrogen-bond crosslinking.

Multi‑hydrogen bond networks have been introduced into hydrogels to enhance responsiveness, self-healing, and processability, but low interaction density and weak bond force limit their strength and tear resistance. In this study, we construct a multiple-crosslinked interpenetrating network system of dynamic covalent bond, dual‑hydrogen bond, and percolation around cellulose nanocrystals (CNCs) to resolve the function-plasticity trade-off. This design enhances strength and toughness without sacrificing the hydrogel's electromechanical sensing and self-healing performance.

Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis.

The role of modification by ubiquitin-fold modifier ('UFMylation') in regulating metastasis has remained enigmatic. Cell migration, a critical step in metastasis, is driven by actin polymerization mediated by actin-related proteins 2 and 3 (Arp2/3) at the leading edge of lamellipodia. Here, we report that UFM1-specific E3 ligase 1 (UFL1) interacts with and catalyzes the UFMylation of ArpC4, a core subunit of the Arp2/3 complex.

Chromosome-level genome assembly for clubrush (Scirpus × mariqueter) endemic to China.

Scirpus × mariqueter (Tang & F.T.Wang) Tatanov, which is endemic to eastern estuaries in China, is a tidal zone-engineering species with great promise for managing greenhouse gases and enhancing ecosystem resilience against invasive species.