Synthesis and cytotoxicity evaluation of yunnancoronarin A derivatives.

Yunnancoronarin A, a prominent natural labdane diterpene, has a range of pharmacological characteristics. In this study, 11 compounds (-) were synthesised using an acylation procedure and subsequent photooxidation, with yunnancoronarin A serving as the starting material. The structures of the eleven novel compounds were determined using H NMR,C NMR, and HR-ESI-MS.

Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis.

The role of modification by ubiquitin-fold modifier ('UFMylation') in regulating metastasis has remained enigmatic. Cell migration, a critical step in metastasis, is driven by actin polymerization mediated by actin-related proteins 2 and 3 (Arp2/3) at the leading edge of lamellipodia. Here, we report that UFM1-specific E3 ligase 1 (UFL1) interacts with and catalyzes the UFMylation of ArpC4, a core subunit of the Arp2/3 complex.

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis.

Inactivation of the p53 pathway is linked to a variety of human cancers. As a critical component of the p53 pathway, ubiquitin-specific protease 7 (USP7) acts as a deubiquitinase for both p53 and its ubiquitin E3 ligase mouse double minute 2 homolog. Here, myeloid leukemia factor 2 (MLF2) is reported as a new negative regulator of p53.

The mediating role of gaze patterns in the association of child sleep disturbances and core symptoms of autism spectrum disorder.

Children with autism spectrum disorder (ASD) are at high risk for sleep disturbances, but the mechanism underlying the association between sleep disturbances and ASD core symptoms is largely unknown. This study examined the relationship between sleep disturbances and ASD core symptoms, and the mediating role of gaze patterns during the facial emotion recognition (FER) task. The study included 57 children with ASD and 59 age- and intelligence-matched typically developing (TD) controls aged 3-7 years.