Research progress of mRNA vaccines for infectious diseases.

mRNA vaccines for infectious diseases prevent diseases by stimulating the body to produce specific immune responses through mRNA molecules encoding pathogenic proteins. Compared to traditional vaccines (e.g.

Hydrogel-Based Continuum Soft Robots.

This paper comprehensively reviews the latest advances in hydrogel-based continuum soft robots. Hydrogels exhibit exceptional flexibility and adaptability compared to traditional robots reliant on rigid structures, making them ideal as biomimetic robotic skins and platforms for constructing highly accurate, real-time responsive sensory interfaces. The article systematically summarizes recent research developments across several key dimensions, including application domains, fabrication methods, actuator technologies, and sensing mechanisms.

Cosserat Rod-Based Tendon Friction Modeling, Simulation, and Experiments for Tendon-Driven Continuum Robots.

Traditional tendon-driven continuum robot (TDCR) models based on Cosserat rod theory often assume that tendon tension is a continuous wrench along the backbone. However, this assumption overlooks critical factors, including the discrete arrangement of disks, the segmented configuration of tensioned tendons, and the friction between tendons and guide holes. Additionally, tendon forces are not continuous but discrete, concentrated wrenches, with the frictional force magnitude and direction varying based on the TDCR's bending configuration.

Continuum Robots and Magnetic Soft Robots: From Models to Interdisciplinary Challenges for Medical Applications.

This article explores the challenges of continuum and magnetic soft robotics for medical applications, extending from model development to an interdisciplinary perspective. First, we established a unified model framework based on algebra and geometry. The research progress and challenges in principle models, data-driven, and hybrid modeling were then analyzed in depth.

Global prevalence, burden and trend in HIV and drug-susceptible tuberculosis co-infection from 1990 to 2019 and prediction to 2040.

Objectives: The purpose of this study is to describe the current situation and forecast the trends of co-infection between the human immunodeficiency virus (HIV) and drug-susceptible tuberculosis (DS-TB) in different countries, across various age groups and genders.

Methods: We obtained data on the number of cases, age-standardized incidence rate, age-standardized prevalence rate, age-standardized rate of disability-adjusted life years (DALYs), and age-standardized death rate from the Global Burden of Disease (GBD) 2019 database. These data were used to describe the distribution and burden of co-infection between the human immunodeficiency virus (HIV) and DS-TB in different regions, genders, and age groups.

The expression and function of long noncoding RNAs in hepatocellular carcinoma.

With the deepening of the genome project study, attention on noncoding RNAs is increasing. Long noncoding RNAs (lncRNAs) have become a new research hotspot. A growing number of studies have revealed that lncRNAs are involved in tumorigenesis and tumor suppressor pathways.

Excluding Participants With Mycobacteria Infections From Clinical Trials: A Critical Consideration in Evaluating the Efficacy of BCG Against COVID-19.

In the context of the coronavirus disease 2019 (COVID-19) pandemic, Bacillus Calmette-Guérin (BCG), a tuberculosis (TB) vaccine, has been investigated for its potential to prevent COVID-19 with conflicting outcomes. Currently, over 50 clinical trials have been conducted to assess the effectiveness of BCG in preventing COVID-19, but the results have shown considerable variations. After scrutinizing the data, it was discovered that some trials had enrolled individuals with active TB, latent TB infection, or a history of TB.

Building a model for the differential diagnosis of non-tuberculous mycobacterial lung disease and pulmonary tuberculosis: A case-control study based on immunological and radiological features.

Background: Although the incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing annually, it is easily misdiagnosed as pulmonary tuberculosis (PTB). This study aimed to screen and identify the immunological and radiological characteristics that differentiate NTM-PD from PTB and to construct a discriminatory diagnostic model for NTM-PD, providing new tools for its differential diagnosis.

Methods: Hospitalised patients diagnosed with NTM-PD or PTB between January 2019 and June 2023 were included in the study.

LTBI-negative close contacts of tuberculosis are more likely to develop the disease: enlightenment and lessons from a cluster outbreak.

Background: Tuberculosis (TB) prevention and control among groups living together, such as students, workers, older adults in nursing homes, and prisoners, present many challenges due to their particular age and environmental factors, which can make them more susceptible to TB clusters with significant societal impact. This study aimed to evaluate a TB cluster outbreak epidemic in a university and provide suggestions for improving TB control strategies for groups living together.

Methods: Pulmonary TB screening and close-contact investigation were conducted using acid-fast staining, sputum culture, GeneXpert testing, tuberculin skin testing (TST), interferon-gamma release assay (IGRA), and chest computed tomography (CT).

Clinical characteristics of patients with non-tuberculous mycobacterial pulmonary disease: a seven-year follow-up study conducted in a certain tertiary hospital in Beijing.

Background: The incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) has increased in recent years. However, the clinical and immunologic characteristics of NTM-PD patients have received little attention.

Methods: NTM strains, clinical symptoms, underlying diseases, lung CT findings, lymphocyte subsets, and drug susceptibility tests (DSTs) of NTM-PD patients were investigated.

Shape Adjustment and Experimental Study of a Shape Memory Cable (SMC) Structure.

Large deployable cable net antennas have attracted extensive attention worldwide because of their simple structure and high storage ratio. The cable net structure is affected by long exposure in a harsh space environment during satellite operation, resulting in large thermal deformation and stress relaxation, which leads to a degradation of antenna performance. To address the thermal deformation of the cable net structure, a shape memory cable (SMC) net structure model was proposed with surface accuracy as the research objective.

Research progress on specific and non-specific immune effects of BCG and the possibility of BCG protection against COVID-19.

Bacille Calmette-Guérin (BCG) is the only approved vaccine for tuberculosis (TB) prevention worldwide. BCG has an excellent protective effect on miliary tuberculosis and tuberculous meningitis in children or infants. Interestingly, a growing number of studies have shown that BCG vaccination can induce nonspecific and specific immunity to fight against other respiratory disease pathogens, including SARS-CoV-2.

Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis.

Objective: Latent tuberculosis infection (LTBI) may be a risk of developing tuberculosis (TB) and thus a health hazard. The aim of this meta-analysis is to explore the association between vitamin D and LTBI.

Methods: Databases including PubMed, Embase, Scopus, and ProQuest were electronically searched to identify observational or interventional studies that reported the association between vitamin D and LTBI.

Two-Step Calibration Method for Inverse Finite Element with Small Sample Features.

When the inverse finite element method (inverse FEM) is used to reconstruct the deformation field of a multi-element structure with strain measurements, strain measurement errors can lower the reconstruction accuracy of the deformation field. Furthermore, the calibration ability of a self-structuring fuzzy network (SSFN) is weak when few strain samples are used to train the SSFN. To solve this problem, a novel two-step calibration method for improving the reconstruction accuracy of the inverse FEM method is proposed in this paper.

Simulation of the Evolution of Thermal Dynamics during Selective Laser Melting and Experimental Verification Using Online Monitoring.

The process parameters of selective laser melting (SLM) significantly influence molten pool formation. A comprehensive understanding and analysis, from a macroscopic viewpoint, of the mechanisms underlying these technological parameters and how they affect the evolution of molten pools are presently lacking. In this study, we established a dynamic finite element simulation method for the process of molten pool formation by SLM using a dynamic moving heat source.

Active Adjustment of Surface Accuracy for a Large Cable-Net Structure by Shape Memory Alloy.

The high surface accuracy design of a cable-net antenna structure under the disturbance of the extremely harsh space environment requires the antenna to have good in-orbit adjustment ability for surface accuracy. A shape memory cable-net (SMC) structure is proposed in this paper and believed to be able to improve the in-orbit surface accuracy of the cable-net antenna. Firstly, the incremental stiffness equation of a one-dimensional bar element of the shape memory alloy (SMA) to express the relationship between the force, temperature and deformation was effectively constructed.

Real-Time Monitoring of the Position and Orientation of a Radio Telescope Sub-Reflector with Fiber Bragg Grating Sensors.

Environmental loads linked with pointing errors, such as gravity, thermal gradients, and wind disturbances, are a serious concern for large-aperture high-frequency radio telescopes. For the purpose of maintaining the pointing performance of a telescope, a contact measurement scheme is proposed on basis of fiber Bragg grating (FBG) strain sensors that can monitor the sub-reflector shift in real time as the input data of the adjustment system. In this scheme, the relationship between the in situ strain measurement and the deformation of the supporting structure, which is the main cause of sub-reflector shift, is deduced using the inverse Finite Element Method (iFEM).

Finite Element Analysis for the Self-Loosening Behavior of the Bolted Joint with a Superelastic Shape Memory Alloy.

A macroscopic constitutive model is proposed in this research to reproduce the uniaxial transition ratcheting behaviors of the superelastic shape memory alloy (SMA) undergoing cyclic loading, based on the cosine-type phase transition equation with the initial martensite evolution coefficient that provides the predictive residual martensite accumulation evolution and the nonlinear feature of hysteresis loop. The calculated results are compared with the experimental results to show the validity of the present computational procedure in transition ratcheting. Finite element implementation for the self-loosening behavior of the superelastic SMA bolt is then carried out based on the proposed constitutive model to analyze the curves of stress-strain responses on the bolt bar, clamping force reduction law, dissipation energy change law of the bolted joint for different external loading cases, and preload force of the bolt.

Optimal Sensor Placement Based on Eigenvalues Analysis for Sensing Deformation of Wing Frame Using iFEM.

For real time monitoring of the wing state, in this paper, the inverse Finite Element Method (iFEM) is applied, which describes the displacement field of beam according to the Timoshenko theory, to sense the wing frame deformation. In order to maintain the accuracy and stability of frame deformation sensing with iFEM, an optimal placement model of strain sensors based on eigenvalue analysis is constructed. Through the model solution with the Particle Swarm Optimization (PSO) algorithm, two different optimal placement schemes of sensors are obtained.

miR-320a regulates high mobility group box 1 expression and inhibits invasion and metastasis in hepatocellular carcinoma.

Background & Aims: Several studies have shown that miR-320a induces apoptosis, inhibits cell proliferation, and affects cell cycle progression as a tumour suppressor in many cancers. However, the involvement of miR-320a in the invasion and metastasis of hepatocellular carcinoma (HCC) is still unknown.

Methods: Endogenous miR-320a and high mobility group box 1 (HMGB1) expressions were assayed by real-time PCR.

Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence.

The present study aimed to investigate the expression level of HOX transcript antisense RNA (HOTAIR) in hepatocellular carcinoma (HCC) and its association with various clinicopathological characteristics, and to further explore the molecular mechanisms of HOTAIR function in HCC. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression level of HOTAIR in 60 paired fresh HCC samples and adjacent normal liver tissue samples. The association between HOTAIR expression and clinicopathological parameters was analyzed.