Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590831 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2023.102279 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determinants of Antibody Reactivity in COVID-19: A Case-Control Study in a Middle Eastern Cohort.
Health Sci Rep
September 2025
Department of Science and Mathematics, School of Interdisciplinary Arts and Sciences University of Washington Tacoma Tacoma Washington USA.
Background And Aims: Understanding the determinants of humoral immunity following COVID-19 infection is essential for guiding vaccination and public health strategies. This study aimed to investigate the association between cycle threshold (Ct) values and SARS-CoV-2-specific antibody reactivity 1 month after recovery in a Middle Eastern cohort, and to identify other contributing factors.
Methods: A case-control study was conducted among COVID-19 patients registered in the Qatar Biobank between March and September 2020.
BCG-induced trained immunity potentiates TH17 responses in vitro.
J Leukoc Biol
August 2025
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Trained immunity amplifies innate immune responses in an antigen-independent manner. This study explored the ability of trained human primary macrophages to modulate the phenotype and function of T cells. Macrophages play an important role in antigen presentation, resulting in T-cell activation and antigen-specific clonal expansion; however, few studies have investigated whether trained immunity induction in macrophages modulates T cell activation.
View Article and Find Full Text PDFParents' perspectives of the new neonatal BCG vaccination pathway in England: a qualitative study.
BMC Public Health
August 2025
London School of Hygiene and Tropical Medicine, London, UK.
Background: The neonatal Bacillus Calmette-Guérin (BCG) selective vaccination pathway in England was revised in September 2021 due to the introduction of a national evaluation of newborn screening for Severe Combined Immunodeficiency (SCID). BCG is a live attenuated vaccine that is contraindicated in infants with SCID, hence BCG vaccination was moved from soon after birth to after SCID results were available, typically at 14-17 days. The transition also shifted vaccination delivery from maternity units to community clinics, raising concerns about potential barriers to access and lower vaccine uptake.
View Article and Find Full Text PDFBCG vaccination: historical role, modern applications, and future perspectives in tuberculosis and beyond.
Front Pediatr
July 2025
Department of Pharmacology, Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette and Camille Guérin, has a history spanning a century. This vaccine has been implemented in numerous countries, significantly reducing child mortality in regions heavily affected by TB.
View Article and Find Full Text PDFLong-term effects of BCG vaccination on telomere length and telomerase activity.
iScience
August 2025
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
This study explores the effects of Bacillus Calmette-Guérin (BCG) vaccination on telomere maintenance, an aging-related process, in immune cells. While BCG reduces systemic inflammation and enhances innate immune responsiveness by inducing trained immunity, its effects on other immune aging hallmarks, such as telomere shortening, are not fully understood. We assessed telomere length in two independent human cohorts before and three months after BCG vaccination.
View Article and Find Full Text PDF