The efficacy of virtual reality in adults during puncture biopsy: A systematic review and meta-analysis of randomized controlled trials.

Background: Virtual reality, as a nascent technology, possesses the potential to enhance patient comfort by mitigating pain and anxiety during medical procedures. This study aimed to evaluate the efficacy of virtual reality intervention in managing pain for adults undergoing puncture biopsy procedures.

Methods: From the outset of the development of databases until October 8, 2024, a comprehensive search of the published literature was performed across eight electronic databases.

The Efficacy of Aromatherapy on Pain and Anxiety During Needle-Related Procedures in Adults: A Systematic Review and Meta-Analysis.

Background: Pain and anxiety resulting from needle-related manipulation are major causes of patient refusal and missed optimal treatment. This study focuses on assessing the effectiveness and benefits of aromatherapy in adult patients undergoing needle-related manipulation for pain and anxiety.

Methods: The researchers conducted detailed searches of a total of five databases, the Cochrane Library, Web of Science, Embase Databases, and Scopus, from the period of the library's construction until November 23, 2024.

The Learning Outcomes of Smoking Cessation Education and Training for Dental Students: A Systematic Review.

Objectives: The aim of this systematic review was to assess the effectiveness of smoking cessation education and training on the learning outcomes of dental students.

Methods: A thorough literature search was conducted using the PubMed, Web of Science, EMBASE, SCOPUS, Cochrane Library, CINAHL, and APA PsycINFO databases, covering publications up to March 2025. The inclusion criteria comprised all randomized controlled trials and quasi-experimental studies, with the assessment of methodological quality performed using the Medical Education Research Study Quality Instrument.

Analgesia and sedative effects of a fixed nitrous oxide/oxygen mixture on supragingival scaling patients: a study protocol for a randomised controlled trial.

Introduction: Pain during supragingival scaling is often uncomfortable for patients, causing varying degrees of fear and anxiety, thus affecting patient comfort and compliance during treatment and reducing the effectiveness of treatment. Nitrous oxide/oxygen mixtures have the advantages of analgesic and sedative effects and are well tolerated. The purpose of this study is to explore the safety and effectiveness of a fixed inhaled nitrous oxide/oxygen mixture analgesia technology in the process of supragingival scaling and to provide empirical evidence for patients to reduce pain and reduce anxiety during supragingival scaling.

Oral health-related knowledge, attitudes and behaviors (KAB) of dental students: a systematic review and meta-analysis.

Background: Oral health is an essential component of overall health. However, it is frequently overlooked. As the main providers of oral health care, dental students play an important role in public education on oral health.

Analgesic effect of premixed nitrous oxide in postoperative rehabilitation for ankle fractures: study protocol for a randomized controlled trial.

Background: The prevalence of ankle fractures is increasing globally. Postoperative rehabilitation exercises constitutes an essential component of the surgical procedure. However, the severe pain in postoperative rehabilitation exercises remains a clinical problem.

Postoperative rehabilitation training adherence and influencing factors in adults with traumatic fractures in China: a cross-sectional study.

Objective: To explore rehabilitation training adherence as well as its related influencing factors among adult patients with traumatic limb fractures to provide a basis for clinical intervention strategies.

Design: Cross-sectional study.

Setting: Department of Rehabilitation Medicine.

Developing the core knowledge system of dental hygienists training in China: a modified Delphi study.

Background: Dental hygienists are professionals engaged in oral disease prevention, oral health care, and auxiliary diagnosis and treatment. Despite the continuous improvement of dental services, the current training model for dental hygienists in China may not be able to meet the needs of dental diagnosis and treatment in China in the next two to three decades. It is urgent to carry out continuing education training for dental nurses currently performing roles similar to those of dental hygienists so that they can truly address the public oral health needs during the transition period of dental hygienists cultivating in China.

Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.

Background: The role of the glymphatic system in occult cerebral palsy (CP) remains unclear. In this study, glymphatic system function and its association with motor impairment in occult CP patients was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).

Methods: This retrospective study used DTI to calculate the diffusivity values along the x-, y-, and z-axes in 27 occult CP patients and 27 matched controls.

Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics.

Telomeres and telomerase play crucial roles in the initiation and progression of cancer. As biomarkers, they aid in distinguishing benign from malignant tissues. Despite the promising therapeutic potential of targeting telomeres and telomerase for therapy, translating this concept from the laboratory to the clinic remains challenging.

Current and projected incidence rates of pancreatic cancer in 43 countries: an analysis of the Cancer Incidence in Five Continents database.

Objective: The aetiology of pancreatic cancer is complex, and there is limited research on its incidence. We aimed to investigate the incidence trends of pancreatic cancer in 43 countries and predict trends up to 2030.

Methods: The annual incidence of pancreatic cancer was obtained from the Cancer Incidence in Five Continents database, which comprises 108 cancer registries from 43 countries.

Nitrous oxide analgesia for rehabilitation after anterior cruciate ligament reconstruction: A randomized controlled trial.

Background: Although there is increasing emphasis on rehabilitation training after ligament reconstruction, little is known about the pain induced by the procedure itself. Procedural success may be limited by pain and anxiety. Nitrous oxide is widely used to alleviate procedural pain.

The efficacy of virtual reality in adults during puncture biopsy: A protocol of a systematic review and meta-analysis.

Background: Puncture biopsy is a primary method for obtaining tissue or cell samples from tumors for histopathological diagnosis. However, patients often experience pain, anxiety, and discomfort during the procedure. Virtual reality is a novel technology developed through advancements in computer skill, and it is utilized in healthcare as a cognitive approach to relieve pain and relaxation.

Dentists' views on the role orientation of dental hygienists in China: A qualitative content analysis.

Background: A dental hygienist is an indispensable auxiliary staff in stomatology who assists people in achieving an optimum level of oral health. Despite advancements in dental medical services, our country has not yet established the position of dental hygienists. The current imbalance in the allocation of dental human resources has created a significant disparity between the demand for and supply of dental auxiliaries.

A nanoscale natural drug delivery system for targeted drug delivery against ovarian cancer: action mechanism, application enlightenment and future potential.

Ovarian cancer (OC) is one of the deadliest gynecological malignancies in the world and is the leading cause of cancer-related death in women. The complexity and difficult-to-treat nature of OC pose a huge challenge to the treatment of the disease, Therefore, it is critical to find green and sustainable drug treatment options. Natural drugs have wide sources, many targets, and high safety, and are currently recognized as ideal drugs for tumor treatment, has previously been found to have a good effect on controlling tumor progression and reducing the burden of metastasis.

Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase.

Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while in precancerous lesions of cancer, telomeres in cells are usually significantly shortened.

Nitrous Oxide to Reduce Wound Care-Related Pain in Adults: A Systematic Review and Meta-Analysis.

As an essential procedure, wound care comes with acute pain, which is short but high in intensity, causing patients to fear and affecting subsequent treatment. Nitrous oxide (NO) is used to relieve pain related to wound care; however, evidence regarding its application is conflicting. Thus, this systematic review and meta-analysis was performed to evaluate the efficacy of NO in wound care-related pain.

Perspectives and Practice in Eastern and Western Medicine for Pain Management in Rehabilitation Training after Orthopedic Trauma Surgery: A Qualitative Study.

Background: Despite the increasing emphasis on rehabilitation training after orthopedic surgery, little is known about the pain caused by the procedure itself. Clinical practice is driven by beliefs in pain management.

Aims: This study aimed to explore the perspective of pain management during rehabilitation training after orthopedic trauma in China and its influencing factors from different perspectives in traditional Chinese medicine and Western medicine, respectively.

KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway.

Colon adenocarcinoma (COAD) is the most common malignancy of the digestive tract, which is characterized by a dismal prognosis. No effective treatment has been established presently, thus there is an urgent need to understand the mechanisms driving COAD progression in order to develop effective therapeutic approaches and enhance clinical outcomes. In this study, we found that KLF7 is overexpressed in COAD tissues and correlated with clinicopathological features of COAD.

Analgesic effect of nitrous oxide during manual therapy after anterior cruciate ligament reconstruction: a study protocol for a randomized controlled trial.

Background: Many patients during manual therapy after anterior ligament reconstruction will experience severe pain, which has a negative impact on their rehabilitation. However, there is rarely an analgesic method for these patients during rehabilitation. Nitrous oxide with rapid analgesic and sedative effects is often used to relieve pain in minor procedures.

Potential chemoprotective effects of active ingredients in on doxorubicin-induced cardiotoxicity: a systematic review of and studies.

Background: Recently, attention has been paid to the protective properties of active ingredients in (AISM) against organ toxicity induced by chemotherapy drugs. Purpose of the present systematic review is to evaluate the chemoprotective effects and mechanisms of AISM on models of doxorubicin-induced cardiotoxicity (DIC).

Methods: According to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to collect all relevant studies on "the role of AISM on DIC" published up until May 2023.

SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.

The existing biomarkers are insufficient for predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). Intraductal papillary mucinous neoplasm (IPMN) is a precursor to PDAC; therefore, identifying biomarkers from differentially expressed genes (DEGs) of PDAC and IPMN is a new and reliable strategy for predicting the prognosis of PDAC. In this study, four datasets were downloaded from the Gene Expression Omnibus database and standardized using the R package 'limma.

Lysosomes, curcumin, and anti-tumor effects: how are they linked?

Curcumin is a natural active ingredient from traditional Chinese medicine (TCM) that has multi-target characteristics to exert extensive pharmacological activities and thus has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. As an important class of membranous organelles in the intracellular membrane system, lysosomes are involved in biological processes such as programmed cell death, cell metabolism, and immune regulation, thus affecting tumor initiation and progression. It has been shown that curcumin can modulate lysosomal function through the aforementioned pathways, thereby affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function.

Application of natural polysaccharides and their novel dosage forms in gynecological cancers: therapeutic implications from the diversity potential of natural compounds.

Cancer is one of the most lethal diseases. Globally, the number of cancers is nearly 10 million per year. Gynecological cancers (for instance, ovarian, cervical, and endometrial), relying on hidden diseases, misdiagnoses, and high recurrence rates, have seriously affected women's health.