Homo-layer flexible BiTe-based films with high thermoelectric performance.

Here, we demonstrate unconventional scalable and sustainable manufacturing of flexible n-type BiTe films via physical vapor deposition and homo-layer fusion engineering. The achieved ultrahigh power factor of up to 30.0 microwatts per centimeter per square kelvin and ultralow lattice thermal conductivity of 0.

Epidemiological characteristics and environmental contamination of monkeypox in Beijing's Chaoyang district: Field evidence from 2023 to 2024.

Objectives: The mpox outbreak in Beijing's Chaoyang District after late May 2023, this study aims to evaluate the epidemiological characteristics and environmental contamination of this outbreak.

Methods: A field investigation was conducted to evaluate the epidemiological characteristics of mpox cases and their living environments in Chaoyang District, Beijing, between May 2023 and May 2024. Laboratory testing, epidemiological description, and statistical analysis were conducted subsequently.

Study on Compression Properties and Construction Applications of Loess Filling Materials for High Embankments Along G85 Expressway in Eastern Gansu Province.

Based on the G85 high-fill subgrade project in east Gansu Province, this study conducts one-dimensional compression tests in the laboratory on both disturbed and in situ-compacted loess. Through the combination of the test results of remolded soil, compaction standards for each layer of the subgrade fill are established, and quality inspections of the compacted subgrade are performed. The experimental results demonstrate that the compression deformation of remolded loess exhibits a positive correlation with compaction degree and a negative correlation with moisture content.

Dysbiosis of gut and urinary microbiota in urolithiasis patients and post-surgical cases.

Background: Research on the microbial roles in urolithiasis primarily focuses on the intestinal microbiota. This study analyzed urine and fecal samples from three cohorts: healthy controls (Control), patients with urinary stones (US), and postoperative patients (PS). We conducted 16S rRNA sequencing analysis to evaluate the variations in microbial communities among these groups during urinary stone production and therapy processes.

Comprehensive single-cell sequencing reveals the tumor microenvironment and tumor-specific characteristics in trachea squamous cell carcinoma.

Trachea squamous cell carcinoma (TSCC) is a subtype of lung cancer. A thorough investigation of the tumor microenvironment of TSCC is crucial for the development of cancer therapeutics and predicting clinical responses. In this study, we utilized single-cell RNA sequencing to analyze seven TSCC samples (including five malignant and two non-malignant samples) and obtained 70,682 high-quality cells.

Attosecond control and measurement of chiral photoionization dynamics.

Many chirality-sensitive light-matter interactions are governed by chiral electron dynamics. Therefore, the development of advanced technologies making use of chiral phenomena would critically benefit from measuring and controlling chiral electron dynamics on their natural attosecond timescales. Such endeavours have so far been hampered by the lack of characterized circularly polarized attosecond pulses, an obstacle that has recently been overcome.

Characteristics of Japanese encephalitis virus infection in NCG-hSTAT2+/+ mice: a novel model for studying neurological symptoms and immune response.

Japanese encephalitis virus (JEV), a leading cause of viral encephalitis in Asia and the Western Pacific, is regulated by type I interferon (IFN) signaling pathway, in which STAT2 is critical. However, STAT2's exact role in JEV-mediated IFN evasion remains unclear. Existing murine models of JEV infection predominantly employ high viral titers to induce encephalitis and primarily use immunocompetent or IFN receptor-deficient mice, limiting their utility for studying JEV's IFN evasion mechanisms.

Asymmetric Stress Engineering of Dense Dislocations in Brittle Superconductors for Strong Vortex Pinning.

Large lossless currents in high-temperature superconductors (HTS) critically rely on dense defects with suitable size and dimensionality to pin vortices, with dislocations being particularly effective due to their 1D geometry to interact extensively with vortex lines. However, in non-metallic compounds such as HTS with rigid lattices, conventional deformation methods typically lead to catastrophic fracture rather than dislocation-mediated plasticity, making it a persistent challenge to introduce dislocations at high density. Here, an asymmetric stress field strategy is proposed using extrusion to directly nucleate a high density of dislocations in HTS by activating shear-driven lattice slip and twisting under superimposed hydrostatic compression.

PER1 Serves as a Tumor Suppressor in Breast Cancer by Regulating MEK5/ERK5 Signaling Pathway.

Background: Breast cancer (BC) is one of the most frequently diagnosed malignant tumors worldwide. Period circadian protein homolog 1 (PER1) is a primary component of the biorhythm molecular oscillation system. The objective of this study was to elucidate the association between PER1 and clinical BC outcomes and determine the potential effect of PER1 on BC tumor development.

Functional mechanism and clinical implications of lncRNA NEAT1 in traumatic fractures and their correlation with delayed healing.

Background: The clinical diagnosis of delayed fracture healing currently lacks molecular markers that exhibit both high sensitivity and robust dynamic detection capabilities. To evaluate the value of lncRNA NEAT1 for diagnosing delayed fracture healing and its potential mechanism of action.

Methods: 122 traumatic fractures patients were collected, including 61 normal fracture healing (NFH) patients and 61 delayed fracture healing (DFH) patients.

Clinical Characteristics of Patients With Respiratory Infections After Nonpharmacological Interventions for COVID-19 in China Have Ended: Using Machine Learning Approaches to Support Pathogen Prediction at Admission.

Objectives: In the aftermath of the COVID-19 pandemic, China witnessed a surge in respiratory virus infections, which presented considerable challenges to primary health care systems. This study developed an interpretable prediction model using complete blood count (CBC) test data. This model aims to identify common respiratory virus infections in patients.

Optimal Visualization and Measurement of the Extracranial Middle Meningeal Artery in CTA.

Background: This study aimed to optimize the visualization and measurement of the extracranial middle meningeal artery (exMMA) using head and neck CT angiography (CTA) to enhance trans-exMMA embolization therapy.

Methods: CTA images from 80 patients (40 males, 40 females; aged 21-80 y) were analyzed. Imaging postprocessing techniques, including plain view, multiplanar reconstruction (MPR), and 3D volume rendering (3DVR), were used to optimize exMMA visualization.

Tumor-expressing PD-L1 regulates NT5E expression through MAPK/ERK pathway in triple-negative breast cancer.

Objectives: While programmed cell death 1 (PD-1) inhibitors have improved cancer treatment, the function and mechanisms of programmed cell death ligand 1 (PD-L1), particularly when expressed by cancer cells, remain unclear. This study aims to explore the role of PD-L1 within breast cancer cells and identify key targets for future immunotherapy.

Methods: RNA-seq was performed on breast cancer cells with silenced PD-L1 to screen for differentially expressed genes, followed by bioinformatics analysis.

Seismic performance of multistory frames with novel self-centering friction SMA dampers.

Owing to their advantageous properties of super-elasticity and shape memory effect, shape memory alloys (SMAs) can dissipate seismic energy and minimize post-earthquake structural damage. In this study, an improved SMA multi-linear constitutive model is proposed first, and a new material model based on OpenSees platform is developed. Secondly, a new self-centering friction damper (SCFD) is proposed by combining SMA and friction material, and a numerical model is established and validated by damper tests.

Neutrophil-to-High density lipoprotein cholesterol ratio predicts early hematoma expansion in patients with spontaneous intracerebral hemorrhage.

Background: The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is a novel inflammatory-metabolic biomarker that reflects the dynamic interplay between systemic inflammation and lipid-mediated vascular protection. While elevated NHR has been linked to the incidence and prognosis of acute ischemic stroke, its association with early hematoma expansion (HE) in spontaneous intracerebral hemorrhage (sICH) remains unclear.

Methods: Demographic data, clinical characteristics, laboratory values, and functional outcomes of patients diagnosed with sICH were retrospectively collected and analyzed.

Ultrasonically assisted synthesis of Co-Ni bimetallic oxides for simultaneous detection of furazolidone and metronidazole.

This work developed an ultrasonically assisted synthesis of nickel cobaltite (NiCoO) modified electrode for simultaneous detection of Furazolidone (FRZ) and Metronidazole (MTR) in biological samples. The structural and chemical properties of the as-prepared electrodes were systematically characterized through multiple analytical techniques. The NiCoO-modified glassy carbon electrode (NiCoO/GCE) demonstrated exceptional performance with wide linear ranges of 0.

Decoding coffee's chlorogenic acid: genetic-network pharmacology insights on kidney stones.

Chlorogenic acid, a principal bioactive component of coffee, has been proposed to reduce the risk of urinary tract stones, though its underlying mechanisms remain unclear. This study integrated Mendelian randomization and network pharmacology approaches to investigate its potential therapeutic role. A two-step Mendelian randomization analysis was conducted using genome-wide association data from the UK Biobank (coffee intake) and Finngen (upper urinary tract stones), focusing on European populations.

Fine mapping of a novel powdery mildew resistance gene PmDM8 derived from a cultivated emmer (Triticum dicoccum).

A novel powdery mildew resistance gene PmDM8, originated from cultivated emmer wheat accession JingDM8, was finely mapped to a 452.6-kb genomic interval on chromosome arm 6BL. Powdery mildew, caused by Blumeria graminis f.

Waveform-dependent air fluorescence from neutral and ionic nitrogen molecules.

Laser-induced air fluorescence in the ultraviolet regime is primarily attributed to transitions between the C and B states in excited neutral [Formula: see text] molecules and between the B and X states in [Formula: see text] ions. However, the mechanism underlying the former remains contentious, as direct population to the C state by light fields is forbidden by electron spin constraints. In this work, we investigate the mechanism of air fluorescence from excited neutral [Formula: see text] molecules by carrier-envelope phase-stabilized sub-4 femtosecond pulses.

Autochthonous DOM governs the occurrence and methylation of mercury-containing nanoparticles in urban river water: An integrated study of field investigations and laboratory experiments.

The methylation of mercury-containing nanoparticles (Hg-NPs) into neurotoxic methylmercury (MeHg) poses threats to wildlife and humans. However, how autochthonous dissolved organic matter (DOM) affects the occurrence and MeHg production of Hg-NPs remains poorly understood. In this study, the distribution of Hg-NPs and their interactions with autochthonous DOM in the Nanfei River, an urban river in eastern China, were systematically explored.

Synergistic Liquid Metal-Diamond-Reinforced Poly(ionic liquid) Composites for High Thermal Conductivity and Excellent Reliability.

This study presents a thermally conductive composite material that combines poly(ionic liquid) (PIL) poly(1-octyl-3-vinylimidazole)bis(trifluoromethanesulfonyl)imide (P[OVIm]NTf), liquid metal (LM), and diamond as dual fillers, totaling 85 vol % loading. The composite achieves a thermal conductivity of 14.2 W m K, a tensile elongation of 74%, and an interfacial adhesion strength of 0.

Associations between dietary index for gut microbiota and stroke, and the mediating role of inflammation: a prospective cohort study.

: There has been a growing focus on the link between diet, gut microbiota, and stroke. The dietary index for gut microbiota (DI-GM), a novel indicator reflecting the effect of diet on gut microbiota diversity, has not been extensively studied in relation to stroke. This study aimed to examine the association between DI-GM and stroke, and to explore the potential mediating role of inflammatory biomarkers.

LncRNA NEAT1 protects uremic toxin-induced intestinal epithelial barrier injury by regulating miR-122-5p/Occludin axis.

Background: Long non-coding RNA(LncRNA) has been reported to be associated with intestinal barrier damage. The aim of this study was to explore the mechanism of lncRNA Nuclear enriched abundant transcript 1 (NEAT1) in uremic toxin-induced intestinal epithelial barrier injury.

Methods: Human colon cancer cells (Caco-2) were used to establish intestinal epithelial injury models with the urea treatment in different conditions.

Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.

Background: The role of the glymphatic system in occult cerebral palsy (CP) remains unclear. In this study, glymphatic system function and its association with motor impairment in occult CP patients was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).

Methods: This retrospective study used DTI to calculate the diffusivity values along the x-, y-, and z-axes in 27 occult CP patients and 27 matched controls.