Homo-layer flexible BiTe-based films with high thermoelectric performance.

Here, we demonstrate unconventional scalable and sustainable manufacturing of flexible n-type BiTe films via physical vapor deposition and homo-layer fusion engineering. The achieved ultrahigh power factor of up to 30.0 microwatts per centimeter per square kelvin and ultralow lattice thermal conductivity of 0.

Injectable chitosan-based thermosensitive hydrogel loaded with adipose-derived mesenchymal stem cells promotes pressure ulcer healing.

Pressure ulcers, resulting from prolonged external pressure or shear forces on skin and underlying tissues over bony prominences, lead to tissue ischemia and impaired lymphatic drainage. Without timely intervention, these wounds can progress to severe complications including cellulitis, chronic infections, and osteomyelitis. In this study, we developed a chitosan/sodium β-glycerophosphate/gelatin (CS/β-GP/GEL) thermosensitive hydrogel system to enhance the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADSCs) in pressure ulcer healing.

production of CAR T cell: Opportunities and challenges.

Chimeric antigen receptor T (CAR T) cell therapy has achieved remarkable efficacy for patients with hematological malignancies. However, viral vector-mediated production of CAR T cells is time-consuming and expensive and impairs T cell function. On one hand, an elaborate manufacturing process not only impairs the function of CAR T cells but also limits its usage in patients with rapidly progressing diseases.

Comparison of Coronary Angiographic-Derived and Intracoronary Imaging-Based Fractional Flow Reserve in Assessing Coronary Artery Stenosis Severity: A Systematic Review and Network Meta-Analysis.

Objective: This systematic review and network meta-analysis aimed to compare the accuracy of coronary angiographic-derived fractional flow reserve (Angio-FFR), optical coherence tomography (OCT)-FFR, and intravascular ultrasound (IVUS)-FFR in evaluating the severity of coronary artery stenosis.

Methods: PubMed, Embase, and Cochrane Library were searched from January 1, 2010 to April 1, 2024 for studies on the accuracy assessment of Angio-FFR, OCT-FFR, and IVUS-FFR. A network meta-analysis was performed with accuracy and analysis of variance models.

Canadian 2021 H-type Bovine Spongiform Encephalopathy case associated with a novel E211K polymorphism in prion protein gene.

Bovine Spongiform Encephalopathy (BSE) is a fatal neurodegenerative disease in cattle which can be either classical BSE (C-BSE) or atypical BSE (including H-BSE and L-BSE). Here, we report the results of our analyses of an H-BSE case found in Canada in 2021, indicating restriction of the pathological agent (PrP) mainly to the central nervous system with no or occasional weak involvement of peripheral tissues. Importantly, a non-synonymous mutation at codon 211 of the gene was detected and confirmed to be present as a germline mutation.

Metabolic Alterations in Crassostrea Gigas After Feeding Selenium-Enriched Yeast Based on Transcriptomic Analysis.

This study explores the effects of selenium-enriched yeast supplementation on growth-related and immune-related gene expression in , aiming to support feed optimization in oyster aquaculture. Selenium, an essential trace element, is vital for growth, immune function, and metabolism in animals. Selenium-enriched yeast, an organic form, offers superior bioavailability, enabling efficient absorption and utilization.

Predicting :: genetic abnormalities in acute myeloid leukemia from bone marrow smears: Can artificial intelligence do better?

The presence of the :: fusion gene in acute myeloid leukemia (AML) is associated with distinct morphological characteristics of myeloblasts. This study aims to assess the capability of artificial intelligence (AI) in identifying genetic abnormalities based on cell morphology. This multicenter trial included 205 patients diagnosed with AML, of which 75 were AML with ::.

Rapid and accurate detection of urinary iodine by single crystal silver iodide sensor.

Iodine deficiency or excess impacts thyroid health, necessitating accurate urinary iodine monitoring. However, existing detection methods face challenges including complicated sample handling, poor anti-interference ability, and the detection range does not cover the range of human urinary iodine concentration. Conventional iodide ion-selective electrode is based on polycrystalline membranes, which has high detection limit and is susceptible to chloride ion interference.

Smooth muscle-specific HuR knockout attenuates vascular calcification.

Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury and aging. Human antigen R (HuR), a widely expressed RNA-binding protein, plays a key role in the regulation of homeostasis and pathological conditions such as cancer and cardiovascular disease, but its role in vascular calcification remains unclear. In this study, we generated smooth muscle-specific HuR knockout (HuR) mice to investigate the function of HuR in vascular calcification.

Integrated analysis of CD30 detection methodologies and synergistic drug combinations for optimizing brentuximab vedotin therapy in lymphoma.

Brentuximab vedotin (BV), a CD30-targeted antibody-drug conjugate, has shown significant efficacy in CD30-positive lymphoma. However, the relationships between CD30 expression levels and BV efficacy remains unclear. In this study, we first evaluated the reliability of CD30 detection by immunohistochemistry (IHC) and found that flow cytometry (FCM) offers higher sensitivity and accuracy in assessing CD30 expression.

Association between the atherogenic index of plasma and major adverse cardiovascular events in patients with premature coronary artery disease.

Background: The atherogenic index of plasma (AIP) as a novel lipid biomarker has been shown to be an important predictor of atherosclerosis and coronary artery disease. However, it remains unclear whether AIP has prognostic value for patients with premature coronary artery disease (PCAD). Therefore, the present investigation aims to explore the relationship between AIP and major adverse cardiovascular events (MACE) in the PCAD population.

Chitosan-based hemostatic bandage with in-situ formed silica nanoparticles for rapid bleeding control and wound healing promotion.

Conventional cotton fiber hemostatic bandages need to passively absorb a large amount of blood due to their high hydrophilicity, resulting in prolonged hemostasis time and increased susceptibility to infection, thereby impeding wound healing. Hence, it is imperative to develop novel hemostatic bandages that can promptly blood clotting while facilitating wound healing. Here a multifunctional composite hemostatic bandage (PSPC) was prepared through in-situ growth technology to anchor silica nanoparticles (SNP) on the polydopamine (PDA) coated chitosan non-woven fabric (CSNF) and combined with polyphosphate (PP).

Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank.

Background: Despite established associations between insulin resistance (IR)-related indices and cardiometabolic diseases (CMDs), most studies are limited to single CMD outcomes. The study aimed to examine the influence of IR-related indices on the incidence, predictive value, and progression trajectory of cardiometabolic multimorbidity (CMM), as well as potential biological mechanisms.

Methods: This prospective study included 374,274 individuals from the UK Biobank who were free of CMDs at baseline.

Comparison of outcomes between haploidentical and matched related donors for chronic myelomonocytic leukemia: A multicenter real-world study.

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative strategy for patients with chronic myelomonocytic leukemia (CMML). However, few reports have investigated the outcomes of patients receiving haploidentical HSCT. To this end, we included 117 patients with haploidentical donors (HID) and 75 patients with matched related donors (MRD) from 28 centers across China to explore the prognostic impact of different transplantation modalities.

Malignant transformation of sinonasal inverted papilloma invading the external nose: A case report and literature review.

Sinonasal inverted papilloma (SIP) is a benign neoplasm of the nasal cavity and sinuses, with a certain risk of malignant transformation. The malignant transformation of SIP is uncommon, and the invasion of malignant tumors into the facial skin is even rarer. This report describes the case of a male patient in his 20 s who underwent two endoscopic resections for SIP in the nasal cavity within a 6-year period.

Mechanism of miR-143 regulating ERK5 signaling pathway-mediated manganese-induced striatal neuronal apoptosis.

Overexposure manganese can induce neurotoxicity and apoptosis, in addition, miRNAs are widely involved in the apoptotic process of neurons. Therefore, it is crucial to explore the mechanism of miRNAs in manganese-induced neuronal apoptosis and then to find potential targets. Our present study showed that miR-143 expression was increased in striatum after exposure high doses of manganese.

Deep-learning-enabled spatial frequency domain imaging of the spatiotemporal dynamics of skin physiology.

Significance: Spatial frequency domain imaging (SFDI) is an emerging optical imaging modality for visualizing tissue absorption and scattering properties. This approach is promising for noninvasive wide field-of-view (FOV) monitoring of biophysiological processes .

Aim: We aim to develop deep-learning-enabled spatial frequency domain imaging (SFDI-net) for real-time large FOV imaging of the optical, structural, and physiological properties and demonstrate its application for probing the spatiotemporal dynamics of skin physiology.

Temporal Muscles Thicken Compensatorily After Injection of Botulinum Neurotoxin A Into Masseter Muscles.

The masseter and temporal muscles are primary jaw muscles vital for chewing and speaking, which work in tandem for effective mastication. On the basis of the reported studies that masseter botulinum toxin A injection causes masseter muscle atrophy without impairing chewing function in most patients, this study explores whether the temporal muscle thickens compensatively after injection of botulinum toxin A into masseter muscle. In this prospective study, the authors analyzed data from 10 patients who were treated with botulinum toxin A injection into the masseter.

Integrated m6A RNA methylation and transcriptomic analysis of Apostichopus japonicus under combined high-temperature and hypoxia stress.

Background: Global climate change has significantly increased environmental stress in marine ecosystems, with rising sea surface temperatures and declining dissolved oxygen (DO) levels. These stressors pose critical challenges to aquaculture, particularly for Apostichopus japonicus, an economically significant species in China. A.

Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis.

Inflammation plays a crucial role in the progression of atherosclerosis. Junctional adhesion molecule-like protein (JAML), a type-I transmembrane glycoprotein, activates downstream signaling pathways. However, the precise role of macrophage-derived JAML in inflammation and atherosclerosis remains unclear.

Biomechanical and histological outcomes of a cervical expander capsule.

Background: An expander capsule is a fibrous membrane that forms around a tissue expander. However, its outcome is still unclear. Here we investigated the biomechanical and histological outcomes of cervical capsules that were left in vivo after expanders were removed.

Comparative transcriptome analysis reveals differences in immune responses to copper ions in Sepia esculenta under high-temperature conditions.

Sepia esculenta is one of the most abundant extant squid populations in Southeast Asia and is of interest due to its rapid reproductive rate and high commercial value. In recent years, with the rapid development of industrialization, issues such as global warming and heavy metal pollution in the oceans have emerged, posing a serious threat to the life activities of marine organisms. In this study, we used transcriptomic techniques to investigate the differences in Cu exposure immune responses in S.

Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in China.

Insulin resistance (IR) has emerged as a risk factor for coronary artery disease (CAD), but there are currently insufficient data on the association of non-insulin-based IR indexes [triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride and glucose (TyG) index, and metabolic score for IR (METS-IR)] with the postoperative prognosis in patients undergoing coronary artery bypass grafting (CABG). Therefore, the present study aimed to examine the predictive power of the above non-insulin-based IR indexes for postoperative prognosis of CABG patients, and to further compare the predictive power of the three indexes. This study included 1472 consecutive CABG patients from June 2014 to January 2019.

Targeting JAML promotes normalization of tumour blood vessels to antagonize tumour progression via FAK/SRC and VEGF/VEGFR2 signalling pathways.

Background: Angiogenesis is a crucial process in tumour growth and metastasis. Junctional adhesion molecule-like protein (JAML) plays an important role in cancer proliferation; however, its expression and role in tumour angiogenesis remains unexplored.

Methods: We collected colorectal cancer from Jinan Central Hospital, using immunofluorescence staining to confirm the expression of JAML in vascular endothelial cells of cancer and adjacent tissue.

A multiple linear regression model calculates the anterior neck skin surface area in Chinese individuals: Implications for neck resurfacing and reconstruction.

Background: The normal value of anterior neck skin surface area (ANSSA) before scar contracture is essential for designing a skin flap of appropriate size to reconstruct the neck. However, to our knowledge, no relevant research has been reported. This study aimed to explore the normal value of ANSSA and to establish ANSSA calculation models.