Comprehensive evaluation of Xuezhikang by four-dimensional fingerprint combined with antioxidant.

It is reported that XZK has the ability to modulate blood lipid levels, thereby decreasing the likelihood of cardiovascular incidents and overall mortality among patients suffering from hypertension and dyslipidemia. To ensure the overall quality of XZK, strict quality control measures are essential. In this study, the quality consistency of XZK capsules was investigated using a five-wavelength fusion fingerprint (FWFFT) method, complemented by all-ultraviolet spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorimeter (DSC) analysis.

FF Swin-Unet: a strategy for automated segmentation and severity scoring of NAFLD.

Background: Non-alcoholic fatty liver disease (NAFLD) is a significant risk factor for liver cancer and cardiovascular diseases, imposing substantial social and economic burdens. Computed tomography (CT) scans are crucial for diagnosing NAFLD and assessing its severity. However, current manual measurement techniques require considerable human effort and resources from radiologists, and there is a lack of standardized methods for classifying the severity of NAFLD in existing research.

Structural Evolution and Electrochemical Performance of NiP-FeP Catalysts for Oxygen Evolution Reaction in Alkaline Water/Seawater.

Low voltage driven overall water splitting remains a significant challenge for practical hydrogen production. The unique interface and interaction between different components in heterostructures endow them with extraordinary properties that are not achievable in single-component materials. In this study, we introduce the NiP-FeP heterostructure as a catalyst for the oxygen evolution reaction (OER) to enable efficient overall water splitting.

Comprehensive quality assessment of Xiaoer Chiqiao Qingre granules by fingerprinting technology combined with multi-component quantitative methods.

To enhance the safety, efficacy, and quality consistency of herbal compound preparation (HCP), 20 batches of Xiaoer Chiqiao Qingre granules (XCQG) were selected as the research subject, and established a comprehensive evaluation strategy for the quality of XCQG. Firstly, the fingerprint peaks of XCQG at two wavelengths were recorded, and the purity of the fingerprint peaks was analyzed by dual-wavelength absorbance coefficient ratio spectrum (DWAR). Subsequently, quantitative analysis of multi-components by single marker (QAMS) and multi-markers assay by monolinear method (MAML) were employed to determine the content of the four major compounds of XCQG and fit the obtained results.

Mendelian Randomization Identifies Putative Aging-Related Causal Genes With Diagnostic Potential in Ulcerative Colitis.

Background: Aging-related immunosenescence increases the risk of ulcerative colitis (UC), and investigating aging-related causal genes in UC patients may aid in deciphering the molecular pathophysiology of UC. This study aims to identify aging-related causal genes and explore their diagnostic value and underlying mechanisms in UC.

Methods And Materials: Colonic transcriptome data, aging-related genes, genome-wide association studies (GWAS) data, and cis-expression quantitative trait loci (cis-eQTL) data were collected from databases.

Predictive Value of Preoperative Maximum Standardized Uptake Value (SUVmax) in Patients with Advanced Gastric Cancer.

This study aimed to investigate the clinical and prognostic significance of preoperative maximum standardized uptake value (SUVmax) and GLUT-1 expression in patients with advanced gastric cancer (AGC). Medical records of patients who were diagnosed with AGC between 2018 and 2020 at Zhongshan Hospital of Fudan University (Shanghai, China) were retrospectively analyzed. Finally, 182 patients were enrolled, and for each patient, SUVmax was calculated for the primary lesion on PET/CT prior to curative surgery.

Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in China.

Insulin resistance (IR) has emerged as a risk factor for coronary artery disease (CAD), but there are currently insufficient data on the association of non-insulin-based IR indexes [triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride and glucose (TyG) index, and metabolic score for IR (METS-IR)] with the postoperative prognosis in patients undergoing coronary artery bypass grafting (CABG). Therefore, the present study aimed to examine the predictive power of the above non-insulin-based IR indexes for postoperative prognosis of CABG patients, and to further compare the predictive power of the three indexes. This study included 1472 consecutive CABG patients from June 2014 to January 2019.

Safety, effectiveness and the optimal duration of preoperative imatinib in locally advanced gastric gastrointestinal stromal tumors: A retrospective cohort study.

Background: The optimal duration of preoperative imatinib (IM) remains controversial. This study aimed to evaluate the safety, therapeutic effectiveness, and optimal duration of preoperative IM in patients with locally advanced gastric gastrointestinal stromal tumors (GIST).

Methods: The clinicopathologic data of 41 patients with locally advanced gastric GIST who received preoperative IM and underwent surgical resection from January 2014 and December 2021 were retrospectively analyzed.

FUS-stabilized USP35 promotes growth, invasion and angiogenesis in NSCLC through deubiquitinating VEGFA.

Vascular endothelial growth factor A (VEGFA) is an important regulator for non-small cell lung cancer (NSCLC). Our study aimed to reveal its upstream pathway to provide new ideas for developing the therapeutic targets of NSCLC. The mRNA and protein levels of VEGFA, ubiquitin-specific peptidase 35 (USP35), and FUS were determined by quantitative real-time PCR and Western blot.

Calcite carbonate sinks low-density plastic debris in open oceans.

The vertical settling of plastic debris in oceans is poorly understood. A large share of low-density microplastics (LDMPs) are largely absent from sea surfaces. The present study employs a model that considers the potential of an overlooked microbially induced calcium carbonate precipitation (MICP) process and new motion equations for irregular LDMPs.

Per- and polyfluoroalkyl substances (PFAS) exposure in plasma and their blood-brain barrier transmission efficiency-A pilot study.

Per- and polyfluoroalkyl substances (PFAS) have been shown to penetrate the blood-brain barrier (BBB) and accumulate in human brain. The BBB transmission and accumulation efficiency of PFAS, as well as the potential health risks from human co-exposure to legacy and emerging PFAS due to differences in transport efficiency, need to be further elucidated. In the present pilot study, 23 plasma samples from glioma patients were analyzed for 17 PFAS.

Modeled Pathways and Fluxes of PCB Dechlorination by Redox Potentials.

Dechlorination is one of the main processes for the natural degradation of polychlorinated biphenyls (PCBs) in an anaerobic environment. However, PCB dechlorination pathways and products vary with PCB congeners, types of functional dechlorinating bacteria, and environmental conditions. The present study develops a novel model for determining dechlorination pathways and fluxes by tracking redox potential variability, transforming the complex dechlorination process into a stepwise sequence.

Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells.

Objective: This study investigated the role of long non-coding RNAs (lncRNAs) FTX in vascular endothelial cells (ECs).

Methods: Transfection of FTX/Sh-FTX with lentivirus was used to construct gain and loss of function cell models in human umbilical vein endothelial cells (HUVECs). Liquid chromatography-mass spectrometry was used for quantitative proteomics analysis of differentially expressed proteins (DEPs).

COLEC12 Promotes Tumor Progression and Is Correlated With Poor Prognosis in Gastric Cancer.

Purpose: Collectin subfamily member 12, a transmembrane scavenger receptor C-type lectin, is aberrantly expressed in various cancers. However, its physiological role in gastric cancer remains somewhat unclear. This study aimed to investigate the Collectin subfamily member 12 expression pattern in human gastric cancer and its role in gastric cancer progression.

Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination.

Imatinib (IM) has significantly improved the prognosis of gastrointestinal stromal tumor (GIST) patients, but some patients still have primary resistance to IM, and approximately half of patients develop acquired drug resistance within 2 years of treatment, necessitating exploration of new treatment strategies. Targeting ferroptosis as a novel approach to tumor treatment has gained attention. Yet, there is limited research on ferroptosis in GIST, and the underlying mechanism remains unclear.

Triglyceride-glucose index in the prediction of adverse cardiovascular events in patients without diabetes mellitus after coronary artery bypass grafting: a multicenter retrospective cohort study.

Background: The triglyceride-glucose (TyG) index has been evaluated as a reliable surrogate for insulin resistance (IR) and has been proven to be a predictor of poor outcomes in patients with cardiovascular diseases. However, data are lacking on the relationship of the TyG index with prognosis in nondiabetic patients who underwent coronary artery bypass grafting (CABG). Thus, the purpose of our current study was to investigate the potential value of the TyG index as a prognostic indicator in patients without diabetes mellitus (DM) after CABG.

Combination of the triglyceride-glucose index and EuroSCORE II improves the prediction of long-term adverse outcomes in patients undergoing coronary artery bypass grafting.

Aims: We aimed to investigate the independent and combined association of the triglyceride-glucose (TyG) index and EuroSCORE II with major adverse cardiovascular event (MACE) after coronary artery bypass grafting (CABG), and examine whether the addition of the TyG index improves the predictive performance of the EuroSCORE II.

Materials And Methods: This study included 1013 patients who underwent CABG. The primary endpoint was MACE, which was defined as the composite of all-cause death, repeat coronary artery revascularisation, non-fatal myocardial infarction and non-fatal stroke.

The metabolic score for insulin resistance in the prediction of major adverse cardiovascular events in patients after coronary artery bypass surgery: a multicenter retrospective cohort study.

Background: The metabolic score for insulin resistance (METS-IR) is a simple, convenient, and reliable marker for resistance insulin (IR), which has been regarded as a predictor of cardiovascular disease (CVD) and cardiovascular events. However, few studies examined the relationship between METS-IR and prognosis after coronary artery bypass graft (CABG). This study aimed to investigate the potential value of METS-IR as a prognostic indicator for the major adverse cardiovascular events (MACE) in patients after CABG.

Omni-functional crystal: Advanced methods to characterize the composition and homogeneity of lithium niobate melts and crystals.

Lithium niobate (LN) is a type of multifunctional dielectric and ferroelectric crystal that is widely used in acoustic, optical, and optoelectronic devices. The performance of pure and doped LN strongly depends on various factors, including its composition, microstructure, defects, domain, and homogeneity. The structure and composition homogeneity can affect both the chemical and physical properties of LN crystals, including their density, Curie temperature, refractive index, and piezoelectric and mechanical properties.

Recalibrating polyparameter linear free energy relationships and reanalyzing mechanisms for partition of nonionic organic compounds to low-density polyethylene passive sampler.

Equilibrium passive sampling techniques based on the low-density polyethylene (LDPE) film are increasingly used for determining the concentration of contaminants in water and air. Reliable models capable of predicting LDPE-water and LDPE-air partition coefficients (K and K) would be very useful. In previous studies, polyparameter linear free energy relationships (PP-LFERs) based on Abraham's solute descriptors were calibrated for LDPE-water and LDPE-air systems.

The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study.

Background: Elevated serum uric acid (SUA) is regarded as a risk factor for the development of cardiovascular diseases. Triglyceride-glucose (TyG) index, a novel surrogate for insulin resistance (IR), has been proven to be an independent predictor for adverse cardiac events. However, no study has specifically focused on the interaction between the two metabolic risk factors.

New insight on the correlation of immune landscapes with immune markers expression in different risk classification of gastrointestinal stromal tumors.

Background: The immune landscapes of gastrointestinal stromal tumors (GISTs) are still unclear. We aimed to explore the immune status of GISTs with different recurrence risks and sought potential immunotherapeutic targets.

Methods: Immune cell infiltration and the expression of 93 tumor markers of 65 GISTs with different recurrence risks from public datasets were analyzed via bioinformatic methods.

Insufficient evidence to link human exposure to heavy metals with biomarkers of glioma.

Information on molecular mechanisms has implicated potential association between the concentrations of heavy metals and incidences of glioma, but experimental data on human brain tissue remain sparse. To address this data gap, 13 heavy metals were measured in 137 glioma and 35 non-glioma samples collected from 161 alive patients in Guangdong Province, China in 2019 - 2020. All target heavy metals were detected, suggesting they could cross the blood-brain barrier.

Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes.

Objective: This study aims to decode the proteomic signature of cardiomyocytes in response to lncRNA Ftx knockdown and overexpression via proteomic analysis, and to study the biological role of lncRNA Ftx in cardiomyocytes.  METHODS: The expression level of the lncRNA Ftx in cardiomyocytes cultured in vitro was intervened, and the changes in protein levels in cardiomyocytes were quantitatively detected by liquid chromatography-mass spectrometry. The key molecules and pathways of the lncRNA-Ftx response were further examined by GO, KEGG, and protein interaction analysis.