Significance: Spatial frequency domain imaging (SFDI) is an emerging optical imaging modality for visualizing tissue absorption and scattering properties. This approach is promising for noninvasive wide field-of-view (FOV) monitoring of biophysiological processes .
Aim: We aim to develop deep-learning-enabled spatial frequency domain imaging (SFDI-net) for real-time large FOV imaging of the optical, structural, and physiological properties and demonstrate its application for probing the spatiotemporal dynamics of skin physiology.