Mobile App-Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial.

Importance: Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message-based intervention strategies could address this gap but lack evidence of benefit on multiple risk factors.

Objective: To evaluate the effectiveness of a mobile message-based intervention in controlling cardiovascular risk factors in patients with T2D.

Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging.

Background: Serum vitamins A and B12, as essential micronutrients, play pivotal roles in maintaining physiological homeostasis; however, the association between these vitamins and aging remains unclear. Therefore, this study aims to investigate potential threshold effects of these nutrients on accelerated biological aging using multidimensional DNA methylation biomarkers.

Methods: This study included 2,530 participants with DNA methylation data from the National Health and Nutrition Examination Survey 1999-2000 and 2001-2002.

Precise Excited-State Engineering in Benzimidazole Derivatives via Donor-Acceptor Architecture for Organic Temperature-Responsive Phosphorescence.

Herein, we report precise excited-state engineering in benzimidazole (NBd) derivatives via a donor-acceptor (D-A) architecture for organic temperature-responsive phosphorescence (RTP). Four NBd derivatives (1-NBdCN, 1-NBdBrCN, 2-NBdCN, and 2-NBdBrCN) with an electron acceptor at position 1 and position 2 were designed and synthesized. The position of the electron acceptor enables 1-NBdCN and 1-NBdBrCN with temperature-responsive phosphorescence and endows 2-NBdCN and 2-NBdBrCN with red-shifted phosphorescence, showing a remarkable site effect.

Joint Effect of Central Obesity and Family History on Hypertension in Type 2 Diabetes: A Cross-Sectional Study in China.

Purpose: This study aimed to examine the joint effect of central obesity (CO) and family history of hypertension (FHH) on hypertension in Chinese patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 1756 T2DM patients were enrolled from a cross-sectional study conducted in Zhejiang Province, China (March - November 2018). Multivariate logistic regression models were used to analyze factors associated with hypertension and to assess CO-FHH interactions on both additive and multiplicative scales.

Associations of Serum Thiamine Levels with Blood Pressure Among Middle-Aged and Elderly Women in Eastern China.

: Although B vitamins are implicated in cardiovascular regulation, the associations between serum thiamine (vitamin B1) and blood pressure (BP) remain unclear, particularly among women who are at high risk for hypertension-related complications. This study aimed to investigate relationships between serum thiamine levels and BP outcomes among middle-aged and elderly women in eastern China. : A community-based cross-sectional study was conducted among 2015 women aged 45-69 years in Zhejiang Province, China.

Tunable Ultralong Organic Room-Temperature Phosphorescence of Dinaphthylamine Skeleton via Molecular Modification and Conformational Change in a Flexible Cross-Linked Polymer Network.

Herein, we developed a simple cross-linking strategy to fabricate a flexible PETA/MA polymer network featuring tunable ultralong organic room-temperature phosphorescence (UORTP). Three dinaphthylamine-structured phosphorescence molecules (NQA-1, NQA-2, and NQA-3), modified with an (iso)quinoline ring, were synthesized, and the tiny structural change made a great difference to their UORTP properties by controlling T excited states and intersystem crossing (ISC) efficiency. We thoroughly studied the UORTP performance in toluene solution, in PMMA film, in non-cross-linked copolymerized films, and in cross-linked films with three different cross-linkers.

Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.

Objectives: To examine the association between uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients in China.

Methods: The investigation stems from a survey conducted in the eastern Chinese province of Zhejiang, spanning from March to November 2018. A multivariable logistic regression model was employed to assess the relationship between UHR and CKD, while restricted cubic spline (RCS) analysis was used to evaluate the dose-response relationship.

Through-Space Electron Effect Regulated Selective Expression of Ultralong Organic Room Temperature Phosphorescence and Photochromism.

We report a through-space electron effect (TSEE) between two phosphorescent units that significantly modulates the selective expression of ultralong organic room-temperature phosphorescence (UORTP) and photochromism. A series of phosphorescent molecules (DNapTr, DNapBNT, DNapFL, and DNapPy), featuring two phosphorescent units connected by a nonconjugated spacer, were synthesized. Our findings reveal that both TSEE and the energy gap Δ (defined as - ) between the lowest triplet energy levels (T) of the phosphorescent units play crucial roles in determining UORTP and the photochromic behavior in PMMA films.

Earth greening and climate change reshaping the patterns of terrestrial water sinks and sources.

While vegetation brings positive benefits for climate mitigation and adaptation, the impact of ongoing global greening remains controversial due to its uncertain effects on hydrological cycle. Here, we quantitatively assess the impact of vegetation dynamics on global water availability by proposing a comprehensive framework to quantify the terrestrial water sink and source scores associated with vegetation dynamics. These scores serve as indicators of whether large alterations in water resources have occurred in the lands due to either the greening or degradation of surface vegetation.

Inhibitory effects of water-soluble hemicelluloses from corn bran with varying molecular weights on wheat starch digestibility.

This study examined effects of corn bran hemicellulose (CBH) with three molecular weight levels-CBH-H (M = 789 × 10), CBH-M (M = 15 × 10), and CBH-L (M = 1 × 10)-on wheat starch digestion and explored the underlying mechanism by investigating their interactions with starch and enzymatic activities. The results demonstrated that when heated at 100 °C and 130 °C, CBH-H exhibited the strongest inhibition on peak and setback viscosity, reducing them by 49.3 % and 44.

Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank.

Background: Polygenic risk scores (PRSs) have been extensively developed for cancer risk prediction in European populations, but their effectiveness in the Chinese population remains uncertain.

Methods And Findings: We constructed 80 PRSs for the 13 most common cancers using seven schemes and evaluated these PRSs in 100,219 participants from the China Kadoorie Biobank (CKB). The optimal PRSs with the highest discriminatory ability were used to define genetic risk, and their site-specific and cross-cancer associations were assessed.

Association between COPD and CKD: a systematic review and meta-analysis.

Objective: Chronic obstructive pulmonary disease (COPD) and chronic kidney disease (CKD) are significant global health issues with a well-established association between the two. This study aims to assess the risk of developing CKD in patients with COPD through systematic review and meta-analysis, and to explore the impact of CKD on the prognosis of COPD patients.

Methods: A total of 23 studies were included in the analysis, comprising 11 studies on the risk of CKD in patients with COPD, 6 studies on the impact of CKD on the short-term all-cause mortality risk of patients with acute exacerbation of COPD (AECOPD), and 6 studies on the impact of CKD on the long-term all-cause mortality risk of COPD patients.

SUZ12-Increased NRF2 Alleviates Cardiac Ischemia/Reperfusion Injury by Regulating Apoptosis, Inflammation, and Ferroptosis.

Nuclear factor erythroid 2-related factor 2 (NRF2) is a redox-sensitive transcriptional factor that enables cells to resist oxidant responses, ferroptosis and inflammation. Here, we set out to probe the effects of NRF2 on cardiomyocyte injury under acute myocardial infarction (AMI) condition and its potential mechanism. Human cardiomyocytes were exposed to hypoxia/reoxygenation (H/R) to induce cell injury.

[Immediate metatarsal lengthening for congenital brachymetatarsia].

Objective: To explore clinical efficacy of congenital brachymetatarsia with immediate metatarsal lengthening.

Methods: From March 2015 to December 2020, 7 patients with brachymetatarsia were treated, including 6 females and 1 male;aged range from 18 to 30 years old;there were 5 patients with metatarsal microsomia on one foot, 2 patients with metatarsal microsomia on the first and fourth right foot, and immediate extension of metatarsal microsomia on the first and fourth right foot;two patients were short metatarsal bones of both feet. The length of short metatarsal bone, length of normal metatarsal bone, distance of short metatarsal bone and healing of bone graft were observed before and 12 months after operation.

Medicine Usage for Hypertension Management in Type 2 Diabetes Patients in the Rural-Urban Fringe Zone, Suzhou City, Jiangsu Province, China.

Objective: Medicine is critical for blood-pressure control in patients with type 2 diabetes mellitus (T2DM), for evaluation of treatment patterns and effects would offer baselines for future health services.

Methods: A cross-sectional study was conducted from August 2018 to January 2021 in the urban-rural fringe zone of Suzhou City, Jiangsu Province, China. Blood pressure and antihypertensive medication use were collected from T2DM patients combined with hypertension (HTN).

Site Effect of Electron Acceptors on Ultralong Organic Room-Temperature Phosphorescence.

Herein, we successfully observe the site effect of electron acceptors on ultralong organic room-temperature phosphorescence (UORTP) in the case of 7-benzo[]carbazole (BCz) derivatives: cyanophenyl on the nitrogen site can promote intersystem crossing (ISC) efficiency and enhance phosphorescence intensity by facilitating -π* transitions but make a slight change to the phosphorescence wavelength; cyanophenyl on the naphthalene site can cause a remarkable red shift of phosphorescence wavelength by reducing the T energy level of BCz derivatives and also enhance phosphorescence intensity by promoting ISC but weaken phosphorescence intensity by lowering the molecular symmetry. Three BCz derivatives (1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN) with the electron acceptor cyanophenyl at different sites (nitrogen site and naphthalene site) were synthesized through a combination of the nucleophilic substitution reaction and the Suzuki coupling reaction. The phosphorescence properties of 1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN in toluene solution, in a copolymerized MMA film, and in a PVA film were measured and analyzed.

Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study.

Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow-up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence-weighted overall cancer PRS (CPRS).

An artificial intelligence-enabled electrocardiogram algorithm for the prediction of left atrial low-voltage areas in persistent atrial fibrillation.

Objectives: We aimed to construct an artificial intelligence-enabled electrocardiogram (ECG) algorithm that can accurately predict the presence of left atrial low-voltage areas (LVAs) in patients with persistent atrial fibrillation.

Methods: The study included 587 patients with persistent atrial fibrillation who underwent catheter ablation procedures between March 2012 and December 2023 and 942 scanned images of 12-lead ECGs obtained before the ablation procedures were performed. Artificial intelligence-based algorithms were used to construct models for predicting the presence of LVAs.

Study on preparation and properties of antifreeze compound road dust suppressant.

Open-pit mine pavement dust dries and breaks easily. As such, a composite pavement dust suppressant with good wettability, moisturizing, coagulation, and antifreezing properties in winter was investigated. Monomer screening and orthogonal experiments were conducted, using evaporation rate, permeability rate, viscosity, and freezing point as evaluation indexes.

A molecular subtyping associated with the cGAS-STING pathway provides novel perspectives on the treatment of ulcerative colitis.

Ulcerative colitis (UC) is characterized by an abnormal immune response, and the pathogenesis lacks clear understanding. The cGAS-STING pathway is an innate immune signaling pathway that plays a significant role in various pathophysiological processes. However, the role of the cGAS-STING pathway in UC remains largely unclear.

MYC phase separation selectively modulates the transcriptome.

Dysregulation and enhanced expression of MYC transcription factors (TFs) including MYC and MYCN contribute to the majority of human cancers. For example, MYCN is amplified up to several hundredfold in high-risk neuroblastoma. The resulting overexpression of N-myc aberrantly activates genes that are not activated at low N-myc levels and drives cell proliferation.

A novel mutation in ANOS1 in a Chinese family with Kallmann syndrome: Case report.

We reported a novel variant in Kallmann syndrome. It not only determines the clinical importance of whole exome sequencing for identification of genetic pathogenic variants, but also enriches the ANOS1 genetic spectrum of CHH patients in Chinese population.