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http://dx.doi.org/10.1016/j.jncc.2025.04.003 | DOI Listing |
Adv Sci (Weinh)
September 2025
State Key Laboratory of Advanced Medical Materials and Devices, Medical College, Tianjin University, Tianjin, 300072, China.
Recent breakthroughs in tumor biology have redefined the tumor microenvironment as a dynamic ecosystem in which the nervous system has emerged as a pivotal regulator of oncogenesis. In addition to their classical developmental roles, neural‒tumor interactions orchestrate a sophisticated network that drives cancer initiation, stemness maintenance, metabolic reprogramming, and therapeutic evasion. This crosstalk operates through multimodal mechanisms, including paracrine signaling, electrophysiological interactions, and structural innervation guided by axon-derived guidance molecules.
View Article and Find Full Text PDFInt J Hyperthermia
December 2025
Department of Radiation Oncology Physics, University of Maryland, Baltimore, MD, USA.
Objective: To develop a deep learning method for fast and accurate prediction of Specific Absorption Rate (SAR) distributions in the human head to support real-time hyperthermia treatment planning (HTP) of brain cancer patients.
Approach: We propose an encoder-decoder neural network with cross-attention blocks to predict SAR maps from brain electrical properties, tumor 3D isocenter coordinates and microwave antenna phase settings. A dataset of 201 simulations was generated using finite-element modeling by varying tissue properties, tumor positions, and antenna phases within a human head model equipped with a three-ring phased-array applicator.
IEEE J Biomed Health Inform
September 2025
Multi-modal brain tumors segmentation is a critical step for diagnosing and monitoring brain-related disease. Many studies have developed models for this task, but two challenges remain, i.e.
View Article and Find Full Text PDFPhytomedicine
August 2025
Cardiology Department, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. Electronic address:
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along with chronic inflammation; this leads to increased risk of heart disease and stroke, significantly impacting patients' health. Danxia Tiaoban Decoction (DXTB), a traditional Chinese medicine (TCM) formula, has demonstrated positive clinical effects in treating AS; however, its mechanisms of action remain unclear.
Objective: To explore the potential mechanisms of action of DXTB in treating AS through multi-omics integration and experimental validation.
Comput Biol Med
August 2025
The First People Hospital of Foshan, Foshan City CN, China. Electronic address:
Brain Tumor Segmentation (BTS) is crucial for accurate diagnosis and treatment planning, but existing CNN and Transformer-based methods often struggle with feature fusion and limited training data. While recent large-scale vision models like Segment Anything Model (SAM) and CLIP offer potential, SAM is trained on natural images, lacking medical domain knowledge, and its decoder struggles with accurate tumor segmentation. To address these challenges, we propose the Medical SAM-Clip Grafting Network (MSCG), which introduces a novel SC-grafting module.
View Article and Find Full Text PDF