A Tetradentate Chelator for Reducing Damage Caused by Uranium.

The rapid advancement of the nuclear industry has precipitated significant challenges in nuclear pollution, with radionuclide uranium emerging as a formidable threat to human safety due to its potent chemical toxicity and radioactivity. The development of uranium chelators represents a pivotal strategy in mitigating the internal damage caused by nuclear exposure. While the US Food and Drug Administration has approved certain drugs for this purpose, issues such as low selectivity and high toxicity remain unresolved.

A N^N-bidentate ligand modified with tetraphenylethylene derivative for uranium detection and decorporation in vitro and in vivo.

Uranium, once introduced into the human body, tends to accumulate in the kidneys and femurs. Its potent chemical toxicity and radioactivity can lead to severe damage, posing significant health risks. Consequently, there is an urgent need to develop low-toxicity materials capable of effectively detecting and removing uranium.

Red-emitting aggregation-induced emission fluorescent probe for monitoring fluctuation of HClO in mitochondria during ferroptosis.

Background: Ferroptosis is an iron-dependent programmed cell death pathway driven by lipid peroxidation that involves various inflammation-related diseases and even cancer, which is often accompanied by the accumulation of mitochondrial ROS. HClO, as one of the vital ROS in organisms, is mainly derived from the mitochondria of cells. And abnormal levels of HClO can disrupt redox homeostasis in cells and lead to various diseases.

A turn-on response fluorescent probe based on triphenylamine derivative for detection of AsO in water samples and cells.

Arsenic is a highly toxic substance, which has a serious threat to human health and environmental pollution. Therefore, it is of great significance to develop an analytical method for detection of arsenic. Here, a novel arsenic fluorescent probe TPA-As-FP based on triphenylamine fluorophore was synthesized by Schiff base reaction.

Selective Crystallization Separation of Uranium(VI) Complexes from Lanthanides.

The limited availability of uranium (U) resources poses significant challenges to the advancement of nuclear energy. Recycling uranium from spent fuel is critical, but the coexistence of lanthanides (Ln) complicates the extraction process significantly. Here, we present an N/O ligand, ()-'-(pyridin-2-ylmethylene) picolinohydrazide (), designed for the selective recovery of U(VI) over Ln(III/IV) in acidic environments.

Dual-Channel/Localization Single-Molecule Fluorescence Probe for Monitoring ATP and HOCl in Early Diagnosis and Therapy of Rheumatoid Arthritis.

Rheumatoid arthritis (RA), a common chronic inflammatory illness, is still incurable, reducing the sufferers' quality of life significantly. Adenosine 5'-triphosphate (ATP) and hypochlorous acid (HOCl) are key indicators in RA, but their precise mechanisms in RA pathophysiology are unknown. As a result, in order to detect ATP and HOCl simultaneously, we created two new dual-channel/localization single-molecule fluorescence probes, and .

Mitochondrial-Targeted AIE-Active Fluorescent Probe Based on Tetraphenylethylene Fluorophore with Dual Positive Charge Recognition Sites for Monitoring ATP in Cells.

Adenosine triphosphate (ATP), as an important intracellular energy currency produced in mitochondria, is closely related to various diseases in living organisms. Currently, the biological application of AIE fluorophore as a fluorescent probe for ATP detection in mitochondria is rarely reported. Herein, D-π-A and D-A structure-based tetraphenylethylene (TPE) fluorophores were employed to synthesize six different ATP probes (P1-P6), and the phenylboronic acid groups and dual positive charge sites of probes could interact with the vicinal diol of ribose and negatively charged triphosphate structure of ATP, respectively.

A dual-response mitochondria-targeted NIR fluorescent probe with large Stokes shift for monitoring viscosity and HOCl in living cells and zebrafish.

Mitochondria are important subcellular organelles involved in many cellular activities. Therefore, it is very important to monitor the concentration of various substances in mitochondria. In this work, we constructed a dual-response mitochondria-targeted fluorescent probe HBTN for the detection of viscosity and HOCl and .

Tracking HOCl by an incredibly simple fluorescent probe with AIE plus ESIPT in vitro and in vivo.

Hypochlorous acid is an important active substance involved in a variety of physiological processes in living organisms, while abnormal concentrations of HOCl are strongly associated with a variety of diseases such as cancer, inflammation, atherosclerosis, and Alzheimer's disease. As a result, it's crucial to establish a reliable method for tracking HOCl in vivo in order to investigate its physiological consequences. In this work, we developed a fluorescent probe DFSN with both AIE and ESIPT for imaging HOCl in vivo.

Red and Near-Infrared Fluorescent Probe for Distinguishing Cysteine and Homocysteine through Single-Wavelength Excitation with Distinctly Dual Emissions.

Small-molecule biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), participate in various pathological and physiological processes. It is still a challenge to simultaneously distinguish Cys and Hcy because of their similar structures and reactivities, as well as the interference from the high intramolecular concentration of GSH. Herein, a novel fluorescent probe, , based on cyanine and thioester was developed to differentiate Cys and Hcy through a single-wavelength excitation and two distinctly separated emission channels.

Visualizing hydrogen sulfide in living cells and zebrafish using a red-emitting fluorescent probe via selenium-sulfur exchange reaction.

Hydrogen sulfide (HS) is an important endogenous gasotransmitter and has been implicated with a variety of biological processes. The development of an efficient method for monitor HS fluctuations in biological systems is of great significance to understand its roles in physiological and pathological conditions. In this work, two red-emitting fluorescent probes SNARF-SSPy and SNARF-SeSPy for HS detection with turn-on fluorescence signals were reported.

A novel near-infrared fluorescent probe for detection of hypobromous acid and its bioimaging applications.

Hypobromous acid (HOBr) is an important reactive oxygen species and has been recently found to be associated with a variety of diseases. However, owing to a lack of effective analytical tools, there is still limited understanding of its roles in living systems. Here, we present a new type of near-infrared fluorescent probe DCSN for HOBr detection.

Construction of a novel far-red fluorescence light-up probe for visualizing intracellular peroxynitrite.

Peroxynitrite (ONOO) is an important reactive oxygen species (ROS), which can react with a variety of biologically active species and cause many diseases, such as cancer, neurodegenerative disorders. Herein, we develop a novel far-red fluorescent probe DCM-KA, which is equipping with α-ketoamide moiety caged DCM-NH. The probe exhibits fluorescence off-on response to ONOO over other biological interfering analytes by ONOO-induced α-ketoamide deprotection reaction.

A colorimetric/fluorescence dual-channel probe for highly discriminating detection of cysteine.

In this work, a novel fluorescence (FL) probe for selective and sensitive detection of Cys with colorimetric and FL dual signal changes was reported. The probe was synthesized by two step of sulfonamide reaction coupling between a sulfonyl benzoxadiazole (SBD) dye and dansyl chloride linked with rigid piperazine group. The probe showed a specific off-on response to Cys in aqueous solution with nanomolar LOD, and without interference by a range of amino acids and several competing analytes.