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Article Abstract
Peroxynitrite (ONOO) is an important reactive oxygen species (ROS), which can react with a variety of biologically active species and cause many diseases, such as cancer, neurodegenerative disorders. Herein, we develop a novel far-red fluorescent probe DCM-KA, which is equipping with α-ketoamide moiety caged DCM-NH. The probe exhibits fluorescence off-on response to ONOO over other biological interfering analytes by ONOO-induced α-ketoamide deprotection reaction. More importantly, the probe is biocompatible and has been successfully utilized to visualize endogenous ONOO production in macrophage cell line J774A.1.
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| http://dx.doi.org/10.1016/j.talanta.2019.01.065 | DOI Listing |
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