First synergistic application of nanocarrier-loaded metaflumizone and parasitic wasps: A high-efficiency green pest control strategy.

The improper use of chemical pesticides threatens ecosystems and human health, highlighting the need for sustainable alternatives. Nano-pesticides and biological control agents offer a solution, and their combination can reduce pesticide usage and improve pest control efficacy. This study utilized a star polycation (SPc) to prepare a metaflumizone nano-pesticide and combined it with the egg parasitoid (Telenomus remus) for synergistic pest management.

Calix[]azanediyldibenzoate: Intramolecular Hydrogen Bond-Assisted Synthesis, Acidichromism, and Oriented Self-Assembly.

Here, intramolecular hydrogen bond (IMHBs)-induced rigidity is used for the first time to synthesize macrocyclic arenes. Calix[]azanediyldibenzoates (C[]A, where = 3, 4, or 5) are synthesized through a one-step condensation reaction between dimethyl 2,2'-azanediyldibenzoate and paraformaldehyde. Compared to the monomer, the macrocycles exhibit a fast and significant acidochromic response due to the intramolecular charge transfer that is boosted by the synergistic effect of their adsorption and protonation.

Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis.

Introduction: Cadmium, a major environmental contaminant, induces progressive intestinal damage through bioaccumulation . Elucidating its pathogenic mechanisms is crucial for developing therapeutic interventions.

Methods: This study employed multi-omics approaches to systematically investigated cadmium-induced ileal dysfunction in Hu sheep and the intervention mechanisms of sodium octanoate.

Quantifying the impact of urban sprawl on vegetation productivity through neighborhood substitution considering environmental similarity.

Urban sprawl can reduce vegetation cover and degrade vegetation net primary productivity (NPP), which plays a crucial role in urban ecosystems. However, large uncertainties remain in quantifying the impact of urban sprawl on NPP caused by models and available data. This paper proposed a newly model, i.

Epiberberine alleviates cadmium-induced duodenal inflammation in Hu sheep by inhibiting HIF-1 signaling pathway.

Environmental cadmium (Cd) exposure not only poses a significant threat to livestock health but also induces intestinal disorders in sheep. As a critical region for digestion and absorption, damage to the duodenum directly impairs systemic health. To elucidate the key mechanisms underlying Cd-induced duodenal injury and identify preventive and therapeutic strategies, this study utilized Cd-exposed Hu sheep as experimental models and applied multi-omics technologies, including non-targeted metabolomics, proteomics, and transcriptomics.

Comparative Analysis of Histological Tools for Myelin.

Myelin is an essential structure that facilitates rapid saltatory conduction in the nervous system. Discrepancies in myelin microstructure are a hallmark of numerous neurological disorders, rendering the assessment of myelin integrity and content an indispensable tool in clinical diagnostics and neuroscience research. Extensive research has been dedicated to scrutinizing its biochemical makeup and morphology under normal, pathological, and experimental conditions over the years.

Differential ecotoxicity of nanoencapsulated metamifop and its active ingredient in zebrafish (Danio rerio): Insights from transcriptome and metabolome analysis.

Nanopesticides have gained increasing attention for their enhanced control efficacy. However, their potential toxicity to environmental and public health remains largely unexplored, and their toxicological mechanism at molecular level is poorly understood. To this context, a hydrophilic and lipophilic diblock polymer (HLDP) was designed and synthesized to develop a novel nanoherbicide metamifop (MP)@HLDP with high herbicidal activity against barnyard grasses (Echinochloa crusgalli).

HLDP nano-assembly boosts monosultap insecticidal activity against Asian corn borers through enhanced neurotoxicity and energy depletion.

The incorporation of nanotechnology presents an innovative strategy to overcome the limitations of conventional pesticides for efficient utilization. Herein, a hydrophilic and lipophilic diblock polymer (HLDP) nanocarrier was successfully synthesized and employed to encapsulate monosultap (Mon), yielding a highly-effective nanoformulation. HLDP exhibited a drug loading capacity of approximately 16.

Integrin-Alpha-6+ Cells Are Responsible for Blastema Formation During Oral Siphon Regeneration in Ciona robusta.

Ascidians exhibit remarkable regenerative capacity through epimorphosis regeneration, a process characterized by blastema formation containing highly proliferative progenitor cells. Characterization of blastemal cell types offers potential advantages for further exploration of cell origin, migration, and differentiation during regeneration. Here, we systematically delineated four morphologically distinct regeneration phases, with particular focus on blastemal morphogenesis using the oral siphon (OS) regenerative model in Ciona robusta.

The daily interplay between sleep and emotional dysregulation in emerging adults with heavy alcohol use patterns.

Objectives: This study aimed to examine within-person, bidirectional associations between sleep disturbances and emotional dysregulation among emerging adults with high alcohol use patterns, with particular attention to within-day fluctuations in emotional dysregulation and the potential moderating role of anxiety symptoms.

Methods: Data are from a longitudinal study of heavy drinkers (N = 300, 65.4% women, Mage 24.

Nano-Enabled Insecticides for Efficient Pest Management: Definition, Classification, Synergistic Mechanism, and Safety Assessment.

The widespread use of pesticides plays a vital role in safeguarding crop yields and ensuring global food security. However, their improper application has led to serious challenges, including environmental pollution, pesticide residues, and increasing insect resistance. Traditional chemical pesticides are no longer sufficient to meet the demands for sustainable modern agriculture.

Down-regulation of 14-3-3 genes suppress sugar metabolism in Bemisia tabaci MED and reduce transmission of tomato chlorosis virus.

Background: Tomato chlorosis virus (ToCV) is an RNA virus that seriously reduces tomato yield, mainly transmitted by whiteflies (Bemisia tabaci) in a semi-persistent manner. Currently, preventing ToCV transmission by selecting the target gene of whiteflies is an effective measure to control ToCV. Proteomic analysis revealed that 14-3-3 protein levels significantly increase in ToCV-infected B.

Microglia-mediated neurogenesis is linked to cognitive deficits in a two-hit model of maternal immune activation and juvenile stress.

Maternal immune activation (MIA), combined with exposure to a second environmental stressor, contributes to neurodevelopmental disorders in offspring. Immune-challenged microglial cells play a crucial role in the pathogenesis of these disorders. However, the mechanisms through which microglia mediate cognitive impairments in individuals exposed to dual stresses remain poorly understood.

Copper and Zinc Sulfates Suppress spp. and Enhance Potato Resistance via Thaxtomin A Inhibition and Defense Gene Regulation.

Potato ( L.) is a major staple crop globally, yet its production is severely impacted by common scab, a disease caused by spp., leading to substantial economic losses.

Effect of low-dose supplemental esketamine infusion on the intraoperative frontal electroencephalography dynamics and postoperative sleep disturbance during gynecological laparoscopic surgery: a double-blind, randomized clinical trial.

Background: Recent studies have shown that intraoperative administration of subanesthetic esketamine not only induced an active prefrontal electroencephalogram (EEG) pattern during sevoflurane anesthesia, but also improve the sleep quality in women after laparoscopic surgery, but the latter regarding the specific mechanism of the EEG frontal power band activity remains unknown. Our research aimed to investigate the impact of low-dose supplemental esketamine infusion on the incidence of postoperative sleep disturbance and the intraoperative frontal EEG characteristics in patients undergoing gynecologic laparoscopic surgery under general anesthesia.

Methods: Ninety-eight patients scheduled for gynecological laparoscopic surgery under general anesthesia were randomly assigned to receive either a continuous infusion of 1 mg · kg-1 · h-1 esketamine or an equivalent volume of normal saline for 30 minutes.

Theoretical and experimental investigations of angular effects in pulsed CO laser ablation with fused silica.

Laser ablation is widely recognized as a non-contact and contamination-free processing technology for fabricating fused silica optics. However, when machining curved optics, the introduction of incidence and path angles inevitably alters laser beam characteristics and complicates path planning. Due to the complex coupling interactions and unique properties of fused silica, the unclear influence mechanism of these angles on laser ablation has become a bottleneck hindering further advancements.

Suitable Planting Area Prediction for Two Species: An Analysis Based on Habitat and Phytochemical Suitability.

The distribution of suitable habitats for medicinal plants is affected by climate, soil, land use, and other factors. , an important traditional Chinese medicinal resource in Xinjiang, includes (Royle) I. M.

Hydrophilic and lipophilic diblock polymer-based nanoplatform improves the bioactivity of insect growth regulator via inhibiting chitin synthesis.

Insect growth regulators (IGRs) have shown great potential in green pest management, but their low control efficacy and delayed action limit their widespread application. In recent years, various nanodelivery systems have revolutionized pesticides by enhancing bioavailability, reducing dosage requirements, improving environmental compatibility, etc. Herein, a hydrophilic and lipophilic diblock polymer (HLDP) was designed and developed to construct an efficient nanoplatform for an IGR diflubenzuron (DFB).

AMPK Signaling Axis-Mediated Regulation of Lipid Metabolism: Ameliorative Effects of Sodium Octanoate on Intestinal Dysfunction in Hu Sheep.

At the present stage, heavy metal pollution, led by environmental exposure to cadmium (Cd), has caused incalculable losses in animal husbandry. The potential value of caprylic acid as a medium- and long-chain fatty acid with a unique role in regulating lipid metabolism has attracted much attention. Our previous study found that octanoic acid levels were significantly reduced under Cd-exposed conditions in Hu Sheep, on the basis of which we investigated the protective effect of sodium octanoate, a derivative of octanoic acid, against Cd exposure in Hu Sheep in the present study.

A self-assembled multicomponent RNA nano-biopesticide for increasing the susceptibility of destructive bean flower thrips to insecticides via dsNrf2.

High resistance of bean flower thrips (BFT, Megalurothrips usitatus) has led to the unscientific application of insecticides to cause famous "toxic cowpea" incidents in China. Nuclear factor erythroid 2-related factor 2 (Nrf2) plays an important role in inducing antioxidant responses and drug detoxification. Therefore, the detoxification genes may be suppressed to control insecticide resistance via Nrf2.

Discrepancies in the rumen microbiome, metabolome, and serum metabolome among Hu sheep, East Friesian sheep, and East Friesian × Hu crossbred sheep.

Crossbreeding has emerged as a strategy to combine desirable traits from different sheep breeds, with the goal of enhancing productivity, disease resistance, and growth rates. This study compares the immune responses, rumen microbiomes, and serum metabolites of Hu sheep, East Friesian (EF) sheep, and crossbred Hu × EF (DH) sheep to explore the effects of crossbreeding on productivity and disease resistance. Hu sheep exhibited significantly higher lymphocyte counts ( < 0.

Effects of Safety Attitudes on Crossing Behaviours of Students Aged 10-18 Years: The Moderating Effects of Family Climate and Social Norms.

This study focused on the effects of safety attitudes on young pedestrians' risky and positive crossing behaviours, with an emphasis on the moderating role of social norms and the family climate. Four hundred young pedestrians aged 10~18 years agreed to participate in this study and were required to complete the survey, which included items related to risky and positive pedestrian crossing behaviours, social norms, safety attitudes and the family climate. Safety attitudes, social norms and the family climate had direct effects on pedestrians' risky behaviours (aggressive, lapses and transgression), whereas only social norms could predict positive behaviours.

IL-1β Induced Intestinal Inflammation Pathogenesis in East Friesian Sheep: Insights from Organoid Modeling.

Establishing an appropriate model of intestinal inflammation in vitro is crucial for studying the pathogenesis of inflammatory bowel disease (IBD). While immortalized cell lines have long been employed to investigate intestinal cell functions and host-pathogen interactions in sheep, they inadequately mimic the physiological characteristics of ovine intestinal inflammation and may lose critical genetic features. The emergence of organoids has revolutionized in vitro intestinal inflammation modeling by offering superior structural and functional fidelity to native tissues.

Comprehensive evaluation of methods for identifying tissues or cell types of origin of the plasma cell-free transcriptome.

Plasma cell-free RNA (cfRNA) is derived from cells in various tissues and organs throughout the body and reflects the physiological and pathological conditions. Identifying the origins of cfRNA is essential for comprehending its variations. Only a few tools are designed for cfRNA deconvolution, and most studies have relied on traditional bulk RNA methods.

Oral Sheep Milk-Derived Exosome Therapeutics for -Induced Inflammatory Bowel Disease.

Cadmium (Cd) contamination in plants and soil poses significant risks to livestock, particularly sheep. Cd exposure often leads to severe gastrointestinal diseases in sheep that are difficult to treat. Milk-derived exosomes, particularly those from sheep milk (SM-Exo), have shown potential in treating gastrointestinal disorders, though their efficacy in Cd-induced colitis remains unclear.