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Laser ablation is widely recognized as a non-contact and contamination-free processing technology for fabricating fused silica optics. However, when machining curved optics, the introduction of incidence and path angles inevitably alters laser beam characteristics and complicates path planning. Due to the complex coupling interactions and unique properties of fused silica, the unclear influence mechanism of these angles on laser ablation has become a bottleneck hindering further advancements. In this study, a three-dimensional multi-physics model was developed to elucidate the underlying influence mechanism. Through comprehensive theoretical simulations, the effects of different incidence and path angles on surface morphology, temperature field, heat-affected zone (HAZ), and thermal stress were systematically investigated. The results demonstrate that the incidence angle modulates ablation quality and thermo-mechanical properties by reducing power density, inducing spot distortion, and lowering material reflectivity. Meanwhile, the path angle influences machining morphology, temperature and HAZ distribution by altering the direction of spot distortion. Additionally, experimental measurements validated the simulation results, demonstrating an average error of 4.81% in ablation depth across incidence angles from 0° to 20°. This work not only deepens the understanding of the laser ablation process but also provides a theoretical foundation for achieving high-quality fabrication of curved fused silica optics.
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http://dx.doi.org/10.1364/OE.559968 | DOI Listing |
Lasers Med Sci
September 2025
Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, 71 Hexi Street, Nanjing 210019, Jiangsu, China.
To evaluated the efficacy of photodynamic therapy (PDT) in improving laryngeal mucosal wound scar healing in vivo and investigated its underlying mechanisms. Laryngeal mucosal wounds were induced in Sprague-Dawley rats. Two weeks post-injury, PDT was administered via intraperitoneal injection of 100 mg/kg 5-aminolevulinic acid (5-ALA) and 635-nm red laser irradiation at varying energy doses (15, 30, and 45 J/cm²).
View Article and Find Full Text PDFJ Thromb Thrombolysis
September 2025
Central Laboratory of Yongchuan Hospital, Chongqing Medical University, No. 439, Xuanhua Road, Yongchuan District, Chongqing, 402160, China.
In vitro assessment of the inhibitory effect of antiplatelet drugs on platelet aggregation is frequently employed to guide personalized antiplatelet therapy in clinical practice. However, existing methods for detecting platelet aggregation rely heavily on high concentrations of exogenous agonists, which may obscure part of the inhibitory effect of antiplatelet drugs and lead to an underestimation of their effects. This study validates a novel analytical strategy for evaluating the effects of antiplatelet drugs by quantifying the microscopic three-dimensional morphological parameters of platelet aggregates formed through spontaneous aggregation on a glass surface.
View Article and Find Full Text PDFBackground: Actinomyces graevenitzii is a relatively uncommon Actinomyces species, which is an oral species and predominantly recovered from respiratory locations [1,2]. It is a gram-positive anaerobic bacteria or microaerobic filamentation bacteria, which can induce pyogenic and granulomatous inflammation characterized by swelling and concomitant pus, sinus formation, and the formation of yellow sulfur granules. All tissues and organs can be infected; the most common type involves the neck and face (55%), followed by the abdominal and pelvic cavities (20%).
View Article and Find Full Text PDFJ Refract Surg
September 2025
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
Purpose: To report a case of acute and transient accommodative insufficiency after laser in situ keratomileusis (LASIK) due to coronavirus disease 2019 (COVID-19).
Methods: Case report and literature review.
Results: A 36-year-old man complained of acute blurred near vision 7 days after uneventful bilateral hyperopic LASIK, concurrent with the onset of COVID-19 infection.
J Refract Surg
September 2025
Department of Refractive Surgery, Shanghai Aier Eye Hospital, Shanghai.
Purpose: To analyze the effects of ablation interruption on ablation depths and clinical refractive outcomes to characterize the impact of ambient temperature changes and ablation interruption on ocular surface temperature (OST) during excimer laser ablation.
Methods: This prospective study was conducted on laser ablations in polymethylmethacrylate (PMMA) plates and porcine corneas to simulate laser in situ keratomileusis (LASIK) treatments using the EX500 laser (Alcon Laboratories, Inc) at ambient temperatures of 18, 20, and 22 °C. Ablation interruption was performed for 1, 2, 3, 4, and 5 seconds at the 10th second of the treatment of -9.