ERRγ Promotes Multiple Myeloma Survival by Coordinating NF-κB Signaling and Mitochondrial Apoptosis Regulation.

Background: Multiple myeloma (MM) remains a formidable clinical challenge due to its high relapse rate and resistance to existing therapies. Estrogen-related receptor gamma (ERRγ), a nuclear receptor critical for cellular energy metabolism, has been implicated in various cancers. but its role in MM remains unclear.

A new D-π-A-type fluorescent probe for sensitive and quantitative monitoring and bioimaging of NH in various water/soil samples, living cells, plants and zebrafish.

Herein, a new carbazole-based fluorescent probe 3-methyl-2-(2-(9-propyl-9H-carbazol-3-yl)vinyl)benzo[d]thiazol-3-ium iodide (CTB) with a D-π-A structure was exploited for the colorimetric/fluorescent dual-signal detection of hydrazine (NH). CTB showed ultrashort reaction time (30 s), ultrahigh anti-interference, good specificity, outstanding sensitivity (low detection limit: 24.6 nM), and wide pH applicable range (4-11).

Visualization of Light-Impinging Geometry in Nonlinear Photocurrents of Vertical Optoelectronic Devices.

Nonlinear photocurrents (NPs) are electrical currents expected to be measured at the electrodes of a device consisting of an active area, sensitive to light, with a higher-order in-electric field where light-impinging geometry (LIG) is the determining factor in the experimental observation. Although the phenomenology of this light-matter interaction is clear for light directed on a lateral device plane with well-defined azimuthal and incidence angles, as well as light polarization angle, it can be quite complicated for a vertical device structure and reconsideration of the expected NP contributions is necessary in the latter case. In this study, we used a visual approach to describe the LIG for vertical device structures using a specific example of a photodiode, and showed that these angles must be redefined, namely, the interchangeability of azimuthal and incidence angles.

Management of adolescent scoliosis: a comprehensive review of etiology and rehabilitation.

Adolescent scoliosis (AS) is a complex spinal deformity characterized by a curvature exceeding 10 degrees, affecting 1%-3% of adolescents globally. Despite extensive research, its etiology remains multifactorial, involving genetic, biomechanical, neuromuscular, and environmental factors. This review synthesizes recent advances in understanding the pathogenesis of AS and explores the latest developments in non-surgical rehabilitation strategies, including physical therapy, bracing, exercise therapy, and psychological interventions.

Down-regulation of 14-3-3 genes suppress sugar metabolism in Bemisia tabaci MED and reduce transmission of tomato chlorosis virus.

Background: Tomato chlorosis virus (ToCV) is an RNA virus that seriously reduces tomato yield, mainly transmitted by whiteflies (Bemisia tabaci) in a semi-persistent manner. Currently, preventing ToCV transmission by selecting the target gene of whiteflies is an effective measure to control ToCV. Proteomic analysis revealed that 14-3-3 protein levels significantly increase in ToCV-infected B.

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication.

Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear. Here, we report that an evolutionarily conserved tandem Tudor domain (TTD) in BAHCC1 (BAHCC1) selectively reads H4K20me1 for facilitating replication origin activation and DNA replication.

Association between triglyceride glucose-waist to height ratio (TyG-WHtR) and hypertension in adults aged 18-60: a cross-sectional study.

Background: This study aimed to explore the association between TyG and the prevalence of hypertension in US adults aged 18-60.

Method: Data was obtained from the National Health and Nutrition Examination Survey (NHANES) covering the circles from 2009 to 2018, involving 12,309 adults aged 18 to 60. The biomarkers studied in this article included weight, body mass index (BMI), waist circumference (WC), weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-weight (TyG-Weight), and triglyceride glucose-waist to height ratio (TyG-WHtR).

Injectable Hydrogel Technologies for Bone Disease Treatment.

Injectable hydrogels represent a highly promising approach for localized drug delivery systems (DDSs) in the management of bone-related conditions such as osteoporosis, osteonecrosis, osteoarthritis, osteomyelitis, and osteosarcoma. Their appeal lies in their biocompatibility, adjustable mechanical properties, and capacity to respond to external stimuli, including pH, temperature, light, redox potential, ionic strength, and enzymatic activity. These features enable enhanced targeted delivery of bioactive agents.

Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus-Vector-Plant Tripartite Interactions.

While interactions between viruses and their vectors, as well as between viruses and host plants, have been extensively studied, the genetic mechanisms underlying tripartite interactions remain largely unknown. In this study, phenotypic assays are integrated with molecular biology and functional genomic approaches to elucidate the tripartite interactions involving tomato chlorosis virus (ToCV), a major threat to tomato production worldwide, the whitefly, Bemisia tabaci, an insect vector, and host plants. ToCV infection induces the production of a chlorophyll degradation product that acts as a volatile attractant for whiteflies.

Modulating the electrocatalytic semihydrogenation selectivity of alkynes from water electrolysis using Pd-based sulfide and phosphide cathodes.

The electrocatalytic semihydrogenation of alkynes from water electrolysis is demonstrated using well-crystalized PdP, PdS, and PdP/PdS heterostructures. PdP exhibited a high conversion rate but poor selectivity for terminal alkynes, while PdS demonstrated a reduced conversion rate but relatively enhanced selectivity; and as expected the optimized PdP/PdS heterostructure can simultaneously achieve a high conversion rate and selectivity. As for internal alkynes, PdP showed a high conversion rate and selectivity, while PdS and PdP/PdS are unable to catalyze the transformation.

CKS2 Silencing Affects Proliferation and Apoptosis in Multiple Myeloma through the PTEN/ AKT/mTOR Pathway.

Multiple myeloma (MM), a prevalent plasma cell malignancy, represents a life-threatening hematological disorder with significant clinical morbidity. Despite its recognized impact on global health burdens, the precise molecular pathogenesis underlying disease progression remains incompletely elucidated. Transcriptomic profiling via RNA sequencing revealed significant upregulation of cyclin-dependent kinase regulatory subunit 2 (CKS2) in multiple myeloma.

Curcumin@ graphene oxide/chitosan/arginine hydrogel: A novel approach to treat Candida periprosthetic joint infections.

Candida albicans, responsible for nearly 70% of fungal infections, is a leading cause of life-threatening invasive infections, particularly in healthcare settings, with a mortality rate approaching 40% even after medical treatment. This study introduces a novel antifungal agent such as Curcumin@Graphene Oxide/Chitosan/Arginine nanocomposite hydrogel (Cur@GO/CS/Arg), targeting Candida albicans, a primary cause of periprosthetic joint infections (PJIs). The hydrogel exhibited remarkable antifungal efficacy, characterized by a 17 mm inhibition zone, a minimum inhibitory concentration (MIC) of 1.

A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma.

Background: Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in various types of cancer. However, the association between ferroptosis-related long noncoding RNAs (FRLs) and multiple myeloma (MM) remains unclear. This study aimed to develop an FRL-based predictive model to assess its potential role in predicting overall survival prognosis and evaluating immune cell infiltration and chemotherapy response in MM patients.

Dufulin Impacts Plant Defense Against Tomato Yellow Leaf Curl Virus Infecting Tomato.

(TYLCV) poses a significant threat to tomato production, leading to severe yield losses. The current control strategies primarily rely on the use of pesticides, which are often nonselective and costly. Therefore, there is an urgent need to identify more environmentally friendly alternatives.

Supramolecular engineering of cellulose-polyaniline composites using CuTA for superior energy storage applications.

Cellulose, the most abundant biomass, is highly appreciated for its robustness, biodegradability, and renewability, garnering significant interest for innovative applications in sustainable functional materials. Composites of cellulose and polyaniline (PANI) are particularly promising for flexible supercapacitors because of their ease of processing, excellent electrical conductivity, and high theoretical specific capacitance. However, challenges persist due to the tendency of PANI to agglomerate and the weak interfacial interactions between PANI and cellulose fibers (CFs).

Engineering for Efficient Synthesis of Salidroside.

Salidroside is a high-value plant-derived glycoside with diverse biological activities, but the main industrial salidroside production method, extraction from plants, is insufficient to meet the growing market demand. The biosynthetic route via microbial fermentation is a sustainable and eco-friendly alternative method. synthesis of the precursor tyrosol was established by introducing the and genes.

Polydopamine modified carbon fiber to improve the comprehensive properties of carbon paper for proton exchange membrane fuel cell.

In this study, polydopamine (PDA) was used to modify functional groups on the surface of carbon fiber (CF), and the effects of different dopamine hydrochloride (DPH) concentrations on the surface morphology, functional groups, contact angle and dispersion stability of CF were studied. Subsequently, the raw carbon paper (RCP), hot-pressed carbon paper (HPCP) and carbon paper (CP) were prepared successively using the modified CF through wet forming, impregnation/hot-pressing, and carbonization methods. The surface morphology, tensile strength, flexural strength, electrical resistivity, air permeability and pore size distribution were analyzed for these materials.

Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe.

Maintaining tissue homeostasis necessitates the coordinated efforts of various cell types to regulate inflammation. Endoplasmic reticulum (ER) stress, a hallmark of inflammation, exacerbates tissue pathology in various human diseases. Glutathione (GSH), a pivotal regulator of cellular redox balance, controls disulfide bond formation in the ER, thereby shielding cells from oxidative stress.

Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study.

Objectives: Pre-eclampsia (PE) and gestational hypertension (GH) are two different categories of hypertensive disorders of pregnancy. Given earlier observational research, the relationship between sex hormone-binding globulin (SHBG) and a higher risk of GH/PE is still up for dispute. Hence, the present investigation aimed to examine the possible link between SHBG and the likelihood of GH/PE.

β-Caryophyllene wrapped by nanoliposomes efficiently increases the control effect on Bemisia tabaci MED.

Bemisia tabaci poses a severe threat to plants, and the control of B. tabaci mainly relies on pesticides, which causes more and more rapidly increasing resistance. β-Caryophyllene is a promising ingredient for agricultural pest control, but its feature of poor water solubility need to be improved in practical applications.

A C->T Variation in 3'-Untranslated Region Elevates MED12 Protein Level in Breast Cancer That Relates to Better Prognosis.

Mediator complex subunit 12 (MED12) is among the most frequently mutated genes in various types of human cancers. However, there is still a lack of understanding regarding the role of MED12 in breast cancer patient. Therefore, the aim of this study is to explore the roles of MED12 in breast cancer.

Ropivacaine combined with dexmedetomidine in ultrasound-guided axillary brachial plexus block in children, a randomized controlled trial.

Objective: In this study, we evaluated the efficacy and safety of 1 μg/kg dexmedetomidine as an adjuvant treatment to ropivacaine in children undergoing upper limb surgeries under ultrasound-guided axillary brachial plexus blocks and general anesthesia.

Methods: We enrolled 90 children (aged 1-8 years; ASA I-II) undergoing closed reduction and internal fixation for upper extremity fractures at the Xiamen Children's Hospital and randomly assigned them to one of two groups: L (injection with 0.25% ropivacaine) or D (injection with 0.

Strigolactones Negatively Regulate Tobacco Mosaic Virus Resistance in .

Strigolactones (SLs) are plant hormones that regulate diverse developmental processes and environmental responses in plants. It has been discovered that SLs play an important role in regulating plant immune resistance to pathogens but there are currently no reports on their role in the interaction between and the tobacco mosaic virus (TMV). In this study, the exogenous application of SLs weakened the resistance of to TMV, promoting TMV infection, whereas the exogenous application of Tis108, a SL inhibitor, resulted in the opposite effect.