MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances.

Background: Anthracycline-based chemotherapy is a highly effective treatment for numerous cancers, yet its clinical use is severely limited by cumulative, dose-dependent cardiotoxicity. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in the pathophysiology of cardiovascular disease, but their specific functions in anthracycline-induced cardiotoxicity (AIC) require systematic elucidation.

Purpose: This review aims to systematically summarize current research on the key miRNAs, their molecular targets, and associated signaling pathways that regulate AIC, while also exploring their potential as biomarkers for early diagnosis and as therapeutic targets for intervention.

Association of HARMS-AF score with atrial tachyarrhythmia recurrence after radiofrequency catheter ablation: a retrospective observational study.

Background And Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia, with high recurrence rates following radiofrequency catheter ablation (RFCA). Identifying predictors of atrial tachyarrhythmia (Ata) recurrence is crucial for risk stratification and personalized management. The HARMS-AF score, a novel lifestyle-based risk score comprising hypertension, age, BMI ≥ 30 kg/m², male sex, sleep apnea, smoking, and alcohol consumption, has emerged as a potential predictor for Ata recurrence.

Natural variation and functional analysis of TaSD6 genes regulating seed dormancy in common wheat.

Background: The bHLH transcription factor SD6 regulates rice seed dormancy. However, sequence variants of wheat SD6 homologs and their roles in seed dormancy remain unknown.

Results: Here, we cloned three wheat homologous genes of SD6 (named TaSD6-7A, TaSD6-7B, and TaSD6-7D), and found that TaSD6-7A had abundant sequence variations, while TaSD6-7B and TaSD6-7D had no variation.

Through Network Pharmacology Combined with Artificial Intelligence Techniques, Potential Targets of Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia were Identified and Validated.

Background: Banxia Xiexin Decoction (BXD) has been shown to exert therapeutic effects on Functional dyspepsia (FD). This study aims to investigate the therapeutic mechanisms of BXD in treating FD.

Methods: Network pharmacology was employed to explore the potential targets of BXD in the treatment of FD.

Efficacy and safety of Shexiang Baoxin Pill combined with Baduanjin in the treatment of acute myocardial infarction: A prospective randomized study.

Background: To evaluate the efficacy and safety of the Shexiang Baoxin Pill (SBP) combined with Baduanjin exercise in the treatment of patients with acute myocardial infarction (AMI).

Methods: A total of 150 AMI patients who underwent percutaneous coronary intervention (PCI) were randomly assigned to 3 groups: Group A received conventional therapy combined with SBP and Baduanjin, Group B received conventional therapy with Baduanjin, and Group C received only conventional therapy. The study was conducted over 6 months, with primary outcomes measured using left ventricular ejection fraction (LVEF) for cardiac function, Hamilton Anxiety Scale (HAMA) for anxiety, Hamilton Depression Rating Scale (HAMD) for depression, and Myocardial Infarction Dimensional Assessment Scale (MIDAS) for quality of life.

Wheat Chromatin Assembly Factor-1 Negatively Regulates the Biosynthesis of Cuticular Wax and Salicylic Acid to Fine-Tune Powdery Mildew Susceptibility.

Powdery mildew caused by phytopathogen f. sp. () negatively impacts wheat production.

The coming era of proteomics-driven precision medicine.

The concept of 'proteomics-driven precision medicine' highlighted in 2019 emphasized the potential of proteomics to transform precision medicine by offering deeper insights into dynamic biological processes. Since then, this field has seen remarkable advancements, interlinking with key pillars such as protein expression profiling, post-translational modifications, protein-protein interactions and spatial proteomics to transform healthcare. Technological progress has led to the creation of comprehensive reference maps of proteomes, identification of over 90% of human protein-coding genes, and detailed cellular and molecular landscapes within organs.

The pathogenesis of benign prostatic hyperplasia and the roles of Prdx3, oxidative stress, pyroptosis and autophagy:a review.

Benign prostatic hyperplasia (BPH) is driven by hormonal and inflammatory mechanisms, yet emerging factors such as peroxiredoxin 3 (Prdx3), oxidative stress (OS), pyroptosis, and autophagy remain understudied. This review synthesizes their roles in BPH pathogenesis. We demonstrate that Prdx3 inhibits autophagy, exacerbates OS, and induces pyroptosis, ultimately promoting prostate cell proliferation.

Integrating network pharmacology and molecular modeling to decipher the anti-esophageal squamous cell carcinoma mechanisms of Bidens pilosa L.

Unlabelled: (BL), known for its anti-inflammatory, antioxidant, and anticancer properties across multiple malignancies, was investigated for its potential therapeutic effects against esophageal squamous cell carcinoma (ESCC). Through integrative network pharmacology and computational approaches, 10 bioactive compounds from BL were identified from HERB 2.0, symMap, BATMAN-TCM (target prediction score cutoff = 20, adjusted -value = 0.

Integrative Omics Reveals Glutamine Catabolism-Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading.

Osteoclasts derived bone marrow monocytes have been documented to modulate bone quality by directly sensing mechanical forces. However, the mechanisms by which osteoclasts perceive and respond to mechanical disturbances remain unclear. Through integrating multi-omics data of bone tissues from hindlimb unloading (HLU) and control mice, it is revealed that glutamine (Gln) catabolism-induced suppression of apoptosis is critical for monocytes sensing and responding to mechanical unloading.

Bioinspired slippery dressing with minimal adhesion and moisturizing for burn wound healing.

Burn wound healing, which is accompanied by excessive seepage, seriously delays patients' quality of life. However, most reported dressings focus on the management of effusion, often ignoring problems such as secondary injury and scars after healing. Herein, we reported a bio-inspired lubricating dressing with silicone oil stored in a polydimethylsiloxane (PDMS) network.

Polyadenylation Complex CFII Recognizes Downstream Cis-element for Pre-mRNA Polyadenylation Through Interaction with an RNA-Binding Protein in Arabidopsis.

Alternative polyadenylation of pre-mRNA generates mRNAs with alternative 3' ends, thereby increasing the complexity of the transcriptome and proteome. This process is carried out by pre-mRNA 3' end processing complexes, with the specificity and site selection of polyadenylation primarily defined by the interaction between these complexes and conserved pre-mRNA cis-elements. However, the cis-element recognized by the polyadenylation CFII complex and the downstream cis-element of the poly(A) site remain unknown.

Role of T cell exhaustion and tissue-resident memory T cells in the expression and prognosis of colorectal cancer.

The tumour microenvironment (TME) is complex and dynamic, and changes significantly with tumour progression. Studying the evolving state of T cells, especially tumour-specific subsets, has become feasible. However, the roles of exhausted T cells (Tex) and pre-exhausted tissue-resident memory T cells (pf-Trm), which emerge after prolonged antigen stimulation, remain unclear.

HISTONE DEACETYLASE 19 interacts with ELONGATED HYPOCOTYL5 to regulate wheat cuticular wax biosynthesis in response to ultraviolet B radiation.

Ultraviolet B (UV-B) radiation negatively affects crop production and threatens food security. The waxy cuticle coats the above-ground organs of terrestrial plants and contributes to plant adaptation to UV-B radiation. However, the molecular mechanism underlying the response of plant cuticular wax biosynthesis to UV-B radiation remains poorly understood.

Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing.

Alcohol use disorder is closely related to genetic and environmental factors. However, the contribution of coding variation to alcohol use disorder susceptibility remains poorly understood. We aimed to identify genetic mutations in alcohol use disorder by whole exon sequencing.

Real-world experience of hetrombopag in immune thrombocytopenia treatment: a retrospective cohort study.

Background: Clinical data on hetrombopag, a novel thrombopoietin receptor agonist (TPO-RA) developed in China, remain limited for the treatment of immune thrombocytopenia (ITP). This retrospective study aimed to investigate the efficacy and safety of hetrombopag for ITP patients in the real-world setting.

Methods: Patients with ITP received hetrombopag monotherapy at an initial dose of 2.

Network pharmacology and experimental verification: Rosmarinic acid alleviates doxorubicin-induced cardiomyocyte apoptosis by regulating BCL2L1.

PurposeThis study investigated the mechanism by which Rosmarinic acid (RA) may alleviate doxorubicin (DOX)- induced cardiomyocyte apoptosis.MethodsThe target genes of RA, DOX-related differentially expressed genes, and GEO database related genes were retrieved by bioinformatics analyses. The results of these analyses were further intersected to identify candidate genes.

Surface Grafted Design of Self-Cleaning and Highly Transparent Reversible Coatings.

Self-cleaning coatings have attracted attention for their ability to reduce surface contamination by repelling liquids. However, the development of a self-cleaning coating that maintains both high transparency and sustainable application still faces challenges. Here, a reversible coating (STRC) is reported that can be simply grafted onto different medical plastics.

Comparative Genomic Analysis Across Multiple Species to Identify Candidate Genes Associated with Important Traits in Chickens.

As one of the most important poultry species worldwide, chickens provide substantial amounts of meat, eggs, and other products for human consumption. With continuous improvements in living standards, consumer demand for high-quality animal products is increasing, making it essential to understand the genetic basis of key traits such as egg production, meat quality, and disease resistance for targeted genetic improvement. In this study, a number of the candidate genes associated with important traits in chickens were screened by various comparative genomics analysis methods.

Linking Ecological Stoichiometry to Biomass Allocation in Plants Under Cadmium and Petroleum Stress in the Yellow River Delta.

Cadmium and petroleum are the main pollutants in coastal wetland ecosystems that affect plant nutrient balance and growth. Scholars have discovered how saline plants adapt to single stresses. How plant ecology and physiology correspond to complex cadmium and petroleum pollution, especially regarding the pollution impacts on carbon (C), nitrogen (N), and phosphorus (P) stoichiometry and biomass allocation in coastal wetland plants, remains unclear, limiting their application in regard to pollution remediation.

SRPS: Survival Reinforced Transfer Learning for Multicentric Proteomic Subtyping and Biomarker Discovery.

Omics-based molecular subtyping in large-scale and multicentric cohort studies is a prerequisite for proteomics-driven precision medicine (PDPM). However, keeping the subtypes with robust molecular features and significant associations with prognosis across different cohorts is challenging due to the biological heterogeneity and technical inconsistency. Herein, we propose a subtyping algorithm, named Survival Reinforced Patient Stratification (SRPS), to adapt the known subtypes from a discovery cohort to another by simultaneously preserving the distinct prognosis and molecular characteristics of each subtype.

PEG Precipitation Followed by Albumin Depletion for Plasma Proteomics Analysis.

The mass spectrometry (MS)-based blood plasma or serum proteomic analysis is limited by interference from albumin, immunoglobins, and other highly abundant proteins. We have found that poly(ethylene glycol) (PEG) can efficiently precipitate some of these proteins except albumin. By PEG precipitation followed by albumin depletion, additional proteins and -glycoproteins can be identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the plasma.

Interface Optimization, Microstructural Characterization, and Mechanical Performance of CuCrZr/GH4169 Multi-Material Structures Manufactured via LPBF-LDED Integrated Additive Manufacturing.

CuCrZr/GH4169 multi-material structures combine the high thermal conductivity of copper alloys with the high strength of nickel-based superalloys, making them suitable for aerospace components that require efficient heat dissipation and high strength. However, additive manufacturing of such dissimilar metals faces challenges, with each laser powder bed fusion (LPBF) and laser directed energy deposition (LDED) process having its limitations. This study employed an LPBF-LDED integrated additive manufacturing (LLIAM) approach to fabricate CuCrZr/GH4169 components.

The ethylene responsive factor TaERF-2 A activates gibberellin 2-oxidase gene TaGA2ox2-3B expression to enhance seed dormancy in wheat.

The plant hormone gibberellin (GA) plays a key role in breaking seed dormancy, but the underlying regulatory mechanism is not fully understood. Here, we reported TraesCS3B02G166100 (named TaGA2ox2-3B), encoding a GA metabolism enzyme GA2ox family member, to be differentially expressed in strong- and weak-dormancy wheat seeds during germination. We confirmed that the ERF transcription factor TaERF-2 A directly bound to the TaGA2ox2-3B promoter and enhanced its transcription.

Baseline assessment of metal and microplastic pollution in sediments of a small-sized harbor in western Baltic Sea (Kalmar, Sweden).

This study provides a baseline analysis of sediment pollution in Kalmar Guest Harbor, Sweden, focusing on metals and microplastics. The study site, a bustling coastal area, was chosen to investigate the connections between anthropogenic activities, bioturbation, and environmental contaminants. The results revealed that the pollution extends beyond 30 cm of depth below the seafloor, with elevated levels of copper (Cu), tungsten (W), cadmium (Cd), zinc (Zn), lead (Pb), and microplastics.