Vegetation restoration improves phosphorus content and availability in tailings slag.

Phosphorus (P) is the primary limiting nutrient for plant growth, and enhancing soil P content and availability is a core goal of vegetation restoration in degraded ecosystems. However, the effect of vegetation restoration on soil P fractions and availability, and the driving factors, remain poorly understood in mining areas. Hence, this study collected soilsfrom unrestored mine tailings (S) and three restoration treatments planted with Lespedeza cuneata (LC), Juniperus chinensis (JC) or Koelreuteria paniculata (KP) in the Xiangtan manganese mining area, Hunan Province, China.

Natural variation and functional analysis of TaSD6 genes regulating seed dormancy in common wheat.

Background: The bHLH transcription factor SD6 regulates rice seed dormancy. However, sequence variants of wheat SD6 homologs and their roles in seed dormancy remain unknown.

Results: Here, we cloned three wheat homologous genes of SD6 (named TaSD6-7A, TaSD6-7B, and TaSD6-7D), and found that TaSD6-7A had abundant sequence variations, while TaSD6-7B and TaSD6-7D had no variation.

Trans-Sodium Crocetinate Ameliorates High-Altitude Acute Lung Injury via Modulating EGFR/PI3K/AKT/NF-κB Signaling Axis.

Objectives: , a traditional Chinese medicine, is renowned for its pharmacological effects in promoting blood circulation, resolving blood stasis, regulating menstruation, detoxification, and alleviating mental disturbances. Trans-crocetin, its principal bioactive component, exhibits significant anti-hypoxic activity. The clinical development and therapeutic efficacy of trans-crocetin are limited by its instability, poor solubility, and low bioavailability.

Chiral BN-Heteroacenes Embedded with B←N Coordination: Acid-Triggered Reversible Bond Switching and Optical Limiting Behavior.

Boron-nitrogen coordination (B←N) bonds have emerged as a versatile motif for engineering π-conjugated systems with tunable optoelectronic properties. Herein, we report the synthesis, structures, and properties of chiral heteroacenes (-) featuring B←N coordination within highly twisted π-frameworks. - were synthesized via a four-step approach, where the final cyclization simultaneously forged six- and five-membered rings bearing both B-N covalent and B←N dative bonds.

Microbiome and Gartynecologic Cancer.

In recent years more and more studies have pointed out that the microbiota plays an important role in the development of gynecological tumors. A healthy female reproductive tract microbiota is dominated by lactobacilli, which can produce lactic acid and other metabolites to protect the normal reproductive tract microenvironment. If the microflora is out of balance, the abnormally increased flora may contribute to inflammation and even cancer in the reproductive system by activating the immune response, regulating metabolites and hormone levels.

Temperature-related hospitalization burden under climate change.

Climate change has markedly increased adverse effects on human health and economic growth. However, few studies have differentiated the impacts of extreme temperatures at the city level and analysed the future implications for human health under various climate change scenarios. Here we leverage data on historical relationships among six kinds of climate-sensitive diseases (CSDs) and associated hospitalizations and temperatures across 301 cities (more than 90% of all cities) and more than 7,000 hospitals in China, and use a nonlinear distributed lag model.

Effect of Platelet-Rich Plasma Injection in Hamstring Injury: A Systematic Review and Meta-Analysis.

Context: Hamstring injury is a common sports trauma that severely affects patients' daily life and function. Platelet-rich plasma (PRP), an effective therapeutic strategy for musculoskeletal injuries, may be beneficial in promoting recovery from hamstring injury.

Objective: The aim of this study was to compare the prognosis of patients with hamstring injuries who were treated with injections of PRP.

Exploring the mechanism of TLR4/NF-κB signaling pathway in hypoxic myocardial injury: Implications for traditional Chinese medicine therapy.

Hypoxic myocardial injury is the core mechanism of many cardiovascular diseases and poses a serious threat to global public health. Its pathogenesis involves energy metabolism disorder, oxidative stress, inflammatory response, apoptosis regulation imbalance, and other links, resulting in myocardial dysfunction and damage. In recent years, a large number of studies have confirmed that the Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling network can regulate hypoxic myocardial injury by mediating HMGB1, MyD88, Caspase-3, HIF-1α, TNF-α, NLRP3, HSP70, etc.

[Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia].

Objective: To explore the effects of the Otago Exercise Program (OEP) on activities of daily living, muscle strength, balance, and physical function in older adults with sarcopenia, to compare OEP with conventional exercise training, and to provide a basis for clinical rehabilitation programs for older adults with sarcopenia.

Methods: In this randomized controlled trial, 120 older adults clinically diagnosed with sarcopenia were enrolled. The participants were randomly assigned to the OEP intervention group (experimental group) and the conventional exercise intervention group (control group), with 60 in each group.

Complex papillary hyperplasia of the endometrium: an uncommon case report with cytopathological features and diagnostic implications.

Background: Complex papillary hyperplasia of the endometrium (CPHE) is a rare benign lesion with overlapping features of malignancy, posing significant diagnostic challenges. This case highlights the importance of multidisciplinary evaluation to avoid misdiagnosis and overtreatment.

Case Presentation: A 49-year-old premenopausal woman presented with irregular vaginal bleeding.

The ethylene responsive factor TaERF-2 A activates gibberellin 2-oxidase gene TaGA2ox2-3B expression to enhance seed dormancy in wheat.

The plant hormone gibberellin (GA) plays a key role in breaking seed dormancy, but the underlying regulatory mechanism is not fully understood. Here, we reported TraesCS3B02G166100 (named TaGA2ox2-3B), encoding a GA metabolism enzyme GA2ox family member, to be differentially expressed in strong- and weak-dormancy wheat seeds during germination. We confirmed that the ERF transcription factor TaERF-2 A directly bound to the TaGA2ox2-3B promoter and enhanced its transcription.

Elucidation of the antipyretic and anti-inflammatory effect of 8--Acetyl Shanzhiside methyl ester based on intestinal flora and metabolomics analysis.

Introduction: (Benth. ex Hook.f.

Research trends and hotspots of single nucleotide polymorphisms in endometrial cancer: a bibliometric analysis.

Background: Endometrial cancer (EC) is a common gynecological malignancy with increasing incidence, especially in developed nations. Understanding genetic variations, particularly single nucleotide polymorphisms (SNPs), is crucial for uncovering the disease's pathogenesis, progression, and treatment responses. This study explores the global research landscape of SNPs in EC, focusing on field evolution, key contributors, and emerging trends.

Exosomes derived from human umbilical cord mesenchymal stem cells can reverse ventricular remodeling and improve long-term cardiac function after acute myocardial infarction.

Background: Acute myocardial infarction (AMI) is the most common ischemic heart disease with high morbidity and high mortality. Although the treatment of AMI is constantly developing, ischemia-reperfusion (I/R) injury remains a complex problem. In recent years, human umbilical cord-derived mesenchymal stem cell-derived exosomes (hUC-MSC-EXO) have been shown to alleviate related damages.

Molecular and functional characterization of peptidoglycan recognition protein-L2 from Hexagrammos otakii (Ho-PGRP-L2) involved in innate immune response.

Peptidoglycan recognition proteins (PGRPs), a family of pattern recognition receptors, play diverse roles in antimicrobial defense. This study investigated the role of a long-type peptidoglycan recognition protein designated as Ho-PGRP-L2 in the antibacterial immune response of the economically important fish species Hexagrammos otakii. Ho-PGRP-L2 was successfully cloned and characterized, which possesses a signal peptide, a typical PGRP domain, and a Zn binding domain including four specific amino acid residues which were required for amidase activity.

A deep-learning model to predict the completeness of cytoreductive surgery in colorectal cancer with peritoneal metastasis☆.

Background: Colorectal cancer (CRC) with peritoneal metastasis (PM) is associated with poor prognosis. The Peritoneal Cancer Index (PCI) is used to evaluate the extent of PM and to select Cytoreductive Surgery (CRS). However, PCI score is not accurate to guide patient's selection for CRS.

Stable and Efficient Indoor Photovoltaics Through Novel Dual-Phase 2D Perovskite Heterostructures.

2D perovskite materials are ideal candidates for indoor photovoltaic (IPV) applications due to their tunable bandgap, high absorption coefficients, and enhanced stability. However, attaining uniform crystallization and overcoming low carrier mobility remain key challenges for 2D perovskites, limiting their overall performance. In this study, a 2D perovskite light-absorbing layer is constructed using a Dion-Jacobson (DJ)-phase EDA(FA)PbI (n = 5) and introduced butylammonium iodide (BAI) for interface modification, thereby creating a novel DJ/Ruddlesden-Popper (RP) dual 2D perovskite heterostructure.

AIE luminogens based on 9, 10-dithienylanthracene with a D-A-D structure: Design, synthesis and application in cell imaging.

Three novel D-A-D-structured emitters derived from 9, 10-dithienylanthracene derivatives (DTAs) were synthesized and characterized. These DTAs consist of substituted 9-phenyl-9H-carbazole (BPCB-DTA), triphenylamine (BTPA-DTA) and N, N-dimethylaniline (BDMA-DTA) as donor units, with the phenylacetonitrile group serving as the acceptor. The impact of steric hindrance and electronic effect of the substituents on the optical properties has been thoroughly discussed.

Microbiome dysbiosis, neutrophil recruitment and mesenchymal transition of mesothelial cells promotes peritoneal metastasis of colorectal cancer.

Peritoneal metastasis (PM) is common in colorectal cancer (CRC), yet its underlying mechanisms are poorly understood. Here, we explored the transcriptional profile of CRC, PM and adjacent tissues revealing key players that facilitate PM. Single-cell analysis of 48 matched samples from 12 patients revealed that remodeling of malignant cells and the tumor microenvironment promotes CRC progression and metastasis.

Linear association between high-sensitivity C-reactive protein and postoperative delirium after general anesthesia: a cross-sectional study.

Objective: To investigate the association between high-sensitivity C-reactive protein (Hs-CRP) levels and the risk of postoperative delirium (POD) following general anesthesia.

Methods: This retrospective cross-sectional study included 644 patients who underwent general anesthesia. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between Hs-CRP and POD, with subgroup analyses used to assess stratified associations.

sp Carbon-Conjugated Covalent Organic Frameworks (spc-COFs): Synthesis and Application in Photocatalytic Water Splitting.

Preparation of irreversible sp carbon-conjugated covalent organic frameworks (spc-COFs) with specific porosity, easy structural functionalization, high chemical stability, and unique π-electron conjugation structure (especially the combination of π-π stacking interactions and conjugation system), can remove the barrier of electron transfer and provide a unique advantage for photocatalytic water splitting. Herein, based on three kinds of reactions (Aldol condensation reaction, Knoevenagel condensation reaction, and Horner-Wadsworth-Emmons reaction) and guided by the precise modulation of ligand structure and topology, this review summarizes the synthesis of spc-COFs and their applications in photoelectrocatalytic water splitting (hydrogen evolution and oxygen evolution reactions). Furthermore, challenges and possible research directions for spc-COFs in photocatalytic water splitting are also provided.

Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation.

Dysregulation of long non-coding RNAs (lncRNAs) is common in colorectal cancer liver metastasis (CRLM). Emerging evidence links lncRNAs to multiple stages of metastasis from initial migration to colonization of distant organs. In this study we investigated the role of lncRNAs in metabolic reprogramming during CRLM using patient-derived organoid (PDO) models.

Spectroscopic and calorimetric study of the interaction between Nile blue and double-stranded RNA.

Nile blue has been widely used in histological staining, fluorescence labeling, and DNA probing, with its intercalation behavior into the DNA helix being well documented. Here, we present a comprehensive investigation to address a current knowledge gap regarding the binding properties of Nile blue to two types of double-stranded RNA (dsRNA): poly(A·U) and poly(I·C), using various biophysical techniques. Absorption and fluorescence spectroscopic studies suggest a significant binding interaction between Nile blue and the two designated dsRNAs, specifically indicating an intercalation binding mode with poly(A·U) and demonstrating a noticeably higher binding affinity compared to poly(I·C).