Subaerial oxidative uranium mobilization at the culmination of the Great Oxidation Event.

Redox-sensitive elements figure prominently in studies of the evolution of Earth's surface redox state, including the first major rise in atmospheric O, the Paleoproterozoic Great Oxidation Event. Most Precambrian rocks endured multistage tectonothermal histories, however, adding ambiguity to interpretation of their chemistry. Here, we apply U-Th-Pb isotope geochronology to the highly oxidized ~2.

The small nucleolar RNA NON-CODING RNA 1 negatively regulates drought tolerance in Arabidopsis thaliana.

Small nucleolar RNAs (snoRNAs) function in ribosome biogenesis, and many ribosome biogenesis-related genes were downregulated by osmotic stress, implying a negative role of snoRNAs in drought tolerance. A snoRNA, namely, the NON-CODING RNA 1 (NCR1) was studied for its roles in drought tolerance in Arabidopsis. In comparison with wild-type (WT) plants, the loss-of-function ncr1 mutant plants showed enhanced drought tolerance, which was restored in the NCR1-complemented plants, whereas the NCR1-overexpressing plants revealed a drought-sensitive phenotype.

Mechanistic roles of GmSWEET10a/b and GmSUT1 in the oil-protein balance in soybean mature seeds at transcriptional and metabolic levels.

Previous investigations indicated that the soybean (Glycine max) SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTER10a/b (GmSWEET10a/b) genes promote oil accumulation, while inhibiting protein accumulation in seeds. To clarify the mechanisms modulated by GmSWEET10a/b in mediating the oil and protein accumulations in soybean seeds, an integrated comparative multiomics was conducted using the double gmsweet10a,b mutant and wild-type (WT) embryos. Spatial metabolomic analysis revealed that gmsweet10a,b embryos were surrounded by a sugar-reduced seed coat and experienced a sugar-starvation state in embryonic tissues in vivo.

Intravenously injected hPSC-derived pericytes for Alzheimer's disease: neuroprotection and vascular repair via extracellular vesicles.

Intravenously injected human pluripotent stem cell (hPSC)-derived pericytes and their extracellular vesicles (EVs) represent promising therapeutic strategies for neurological diseases. Our study aimed to investigate the effects and mechanisms of intravenous transplantation for treating Alzheimer's disease (AD), with a focus on elucidating the critical role of EV-related mechanisms. We generated pericytes (hPSC-CNC PCs) from hPSC derived cranial neural crest (CNC) and employed 12-month-old 5xFAD mice as an advanced stage AD model.

Controls of reservoir quality for submarine fan of F4 Formation in the Z oilfield, Illizi Basin, Algeria.

Subaqueous fan reservoirs have emerged as a pivotal focus in recent deep-water oil and gas exploration. In the Illizi Basin of Algeria, a series of submarine fan reservoirs are developed within the Devonian F4 Formation of the Z oilfield. Understanding the genesis of high-quality reservoirs (defined as those with porosity exceeding 25% and permeability greater than 1000 mD) is crucial for pinpointing high-productivity wells in deep-water submarine fan settings.

Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury.

Testicular tissues are highly vulnerable to oxidative stress and external insults due to their unique physiological microenvironment; thus, developing protective interventions is critical. We reveal that preconditioning through short-term stress-induced sympathetic nervous system (SNS) activation effectively mitigates testicular ischemia-reperfusion injury (IRI) in mice. Pre-activation of the SNS via diverse stressors markedly reduced seminiferous tubular damage and oxidative biomarkers compared to untreated controls.

Effectiveness of a standardised and interactive intervention to prevent preschooler unintentional injury in rural China: a cluster randomised controlled trial.

Introduction: Previous interactive education interventions for child injury prevention are suboptimal for implementation in rural areas. This study evaluated the effectiveness of a standardised school-based interactive education intervention to prevent unintentional injury for rural preschoolers.

Methods: A 9-month single-blinded cluster randomised controlled trial was conducted in rural China, involving 12 preschools with 2518 preschoolers aged 3-6 years old.

Sensitivity of mass-independent Sn isotope fractionation to UV radiation and magnetic fields.

Mass-independent isotope fractionation (MIF) enables powerful geochemical tracers for various geological and planetary problems, yet the mechanisms driving MIF for tin (Sn) remain ambiguous. Here, we demonstrate that distinct Sn isotope fractionation signatures were produced during photolysis of organic Sn species (i.e.

Dioscin induces ferroptosis to suppress the metastasis of gastric cancer through the SLC7A11/GPX4 axis.

The prognosis of gastric cancer (GC) remains poor due to metastases and resistance to chemotherapy. Ferroptosis is a novel cell death regulation mode characterized by iron dependence and lipid peroxidation. Dioscin, a compound extracted from the Paris polyphylla rhizomes roots, has been shown to have an inhibitory effect on cancers.

Precise modulation of bioactive gibberellin homeostasis: A promising strategy for enhancing abiotic stress tolerance.

This commentary discusses studies identifying three elite loci, ATT2, wrky53 and CTB5, which enhance abiotic stress tolerance and maximize grain yield under challenging environmental conditions by modulating gibberellin content. These loci could be valuable tools for developing new varieties for agricultural sustainability.

Invasion Status, Mechanisms, and Future Distribution Prediction of in the Trade Port Region: A Case Study of Ningbo Port, China.

Trade ports are the first places where alien species invade and the source of their spread to other areas. Controlling invasions in these regions can effectively reduce invasion pressure and disrupt the spread pathways of invasive species, thereby significantly reducing their threat to local ecosystems and biodiversity loss. Based on 595 field survey plots, the Generalized Linear Model (GLM) and Species Distribution Model (MaxEnt) were employed to analyze and predict the invasion mechanisms and future possible distribution of in the Ningbo Port, China.

Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltration.

Calreticulin (CALR) supports the induction of dendritic cell maturation, which makes it a key target for effective esophageal squamous cell carcinoma (ESCC) immunotherapy. The mechanism of CALR in the immunotherapy of ESCC is not fully studied. The aim of the present study was to explore the contributing role of CALR in ESCC progression.

Phytoparasite avoidance: Manipulation of strigolactone exudation, not biosynthesis.

Strigolactones exuded from host plants induce the germination of phytoparasites. Recent studies demonstrate that knocking out ABCG transporter genes decreases strigolactone exudation and represses parasite seed germination with fewer negative impact on crop growth and yield compared with manipulating strigolactone biosynthesis, providing a novel approach to control parasitic plants.

The Median Effective Concentration (EC50) of Alfentanil Combined with Propofol Closed-Loop Targeted Infusion in Super-Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP).

Purpose: To investigate the median effective concentration (EC50) of alfentanil combined with propofol closed-loop targeted infusion when used for sedation in super-elderly endoscopic retrograde cholangiopancreatography (ERCP) patients.

Patients And Methods: A total of 28 super-elderly patients (>85 years old) undergoing elective ERCP from April to September 2024 were enrolled to receive target-controlled continuous infusion of alfentanil with an initial infusion concentration of 50ng/mL, and the continuous infusion concentration was determined according to the Dixon up and down method, and the incremental/decremental gradient of alfentanil was set at 10ng/mL. The observation was terminated after 8 reflexes.

Knockdown NEK7 stimulates anti-tumor immune responses by NLRP3/PD-L1 signaling in esophageal cancer.

Background: Esophageal cancer is a prevalent malignancy with limited treatment options. The study aimed to understand the role and mechanism of NEK7 in esophageal cancer development.

Methods: RNA sequencing compared esophageal cancer tissues with adjacent tissues, and real-time PCR validated NEK7 expression.

Impaired ketogenesis in Leydig Cells drives testicular aging.

Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we show that Leydig cells are particularly vulnerable to aging processes in testis. Single-cell RNA sequencing identifies the expression of Hmgcs2, the gene encoding rate-limiting enzyme of ketogenesis, decreases significantly in Leydig cells from aged mice.

Genome-Wide Identification of the Gene Family in (L.) and Expression Pattern Analysis of .

Flowers are one of the most important organs in plants. Their development serves as a key indicator of the transition from vegetative to reproductive growth and is regulated by various internal signals and environmental factors. NAC (NAM, ATAF, CUC) transcription factors (TFs) play a crucial regulatory role in floral organ development; however, research on the analysis and identification of the NAC TF family in Chinese cabbage ( L.

Elbow medial approach open reduction and internal fixation with absorbable cannulated screws for the treatment of Kilfoyle II and III type medial condyle fractures of the humerus in children.

Objective: This study aims to investigate the clinical efficacy of elbow medial approach open reduction and internal fixation with absorbable cannulated screws for the treatment of Kilfoyle II and III type medial condyle fractures of the humerus in children.

Methods: A retrospective analysis was conducted on 23 pediatric patients with medial condyle fractures of the humerus who underwent surgical treatment at the Department of Pediatric Orthopedics, Foshan Traditional Chinese Medicine Hospital, from June 2018 to December 2023. Among the patients, 15 were male and 8 were female, with ages ranging from 5 to 12 years (mean age: 9.

In vitro experiments and network pharmacology-based investigation of the molecular mechanism of neferine in the treatment of gastric cancer.

Background Gastric cancer is the world's leading tumor disease in terms of morbidity and mortality and is currently treated clinically with a comprehensive approach based on surgery. Studies have demonstrated the antitumor effects of neferine, but the anti-cancer mechanism for gastric cancer is not yet clear. Methods The Pubchem and Swiss TargetPrediction databases were searched to retrieve the targets of action of neferine.

Nanopore sequencing of MiniHap biomarkers for forensic DNA mixture deconvolution: A proof-of-principle study.

Mixture deconvolution remains one of the major challenges in the field of forensic science. Currently, genetic markers are used and studied in the field of forensic genetics, including short tandem repeat (STR), insertion/deletion polymorphism (InDel), single nucleotide polymorphism (SNP), InDel closely linked to STR (DIP-STR), SNP closely linked to STR (SNP-STR), InDel closely linked to SNP (DIP-SNP) and microhaplotype (MH), all of which have been studied for DNA mixture analysis and have their own advantages and disadvantages. Mini-haplotype (MiniHap), as a novel haplotype genetic marker, contains 5 or more SNPs.

Research progress on molecular mechanism of liver metastasis of gastric cancer and treatment with traditional Chinese medicine.

Gastric cancer liver metastasis (GCLM) refers to the process of cancer cells from the stomach spreading to the liver, which is an important sign of the deterioration of gastric cancer (GC) and has a profound influence on the treatment and prognosis of patients. Once GC has liver metastasis, the treatment becomes more complex and challenging, which seriously affects the survival rate of patients with GC. Therefore, studying the mechanism and treatment of GCLM is extremely necessary.

Strigolactone and karrikin receptors regulate phytohormone biosynthetic and catabolic processes.

Karrikin plays a more critical role in affecting the homeostasis of ABA and cytokinins, while strigolactones play a more critical role in influencing the homeostasis of jasmonic acid and gibberellins. Strigolactones (SLs) and karrikins (KARs) regulate plant growth and development through their crosstalk, and through the crosstalk between them and other phytohormones, such as abscisic acid (ABA) and auxin. However, how SL and KAR signaling pathways influence the levels of other phytohormones is still unknown.

Behavior changes influence mpox transmission in the United States, 2022-2023: Insights from homogeneous and heterogeneous models.

In 2022, an unprecedented mpox epidemic rapidly swept the globe, primarily transmitted through sexual contact among men who have sex with men (MSM). However, our understanding of how changes in human behavior influence this outbreak remains incomplete. In this study, we introduce a two-layer network model to investigate the impact of human behavior on mpox transmission within the United States during 2022-2023, leveraging surveillance data.

Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d]pyrimidines as potent HPK1 kinase inhibitors.

Hematopoietic progenitor kinase 1 (HPK1) has emerged as a promising target for cancer immunotherapy due to its critical role as a negative regulator of T cell receptor (TCR) signaling. Despite this potential, no HPK1 inhibitors have been approved for cancer treatment, underscoring the need for structurally novel inhibitors. Herein, we describe the design, synthesis and biological evaluation of a series of potent HPK1 inhibitors based on our previously identified hit 9.

Radix Codonopsis: a review of anticancer pharmacological activities.

Radix Codonopsis (Dangshen), derived from the dried root of plants in the Campanulaceae family, is a widely used Chinese herbal medicine. It is renowned for its pharmacological effects, including tonifying the middle qi, invigorating the spleen, benefiting the lungs, enhancing immunity, and nourishing the blood. Codonopsis extract is frequently incorporated into health products such as tablets and capsules, making it accessible for daily health maintenance.