Detection of serum anti-candidalysin IgG by indirect ELISA: a novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study.

Invasive candidiasis (IC) is the most common fungal infection in clinical settings, yet early diagnosis remains challenging. Candidalysin, a key virulence factor in invasive infections, exhibits site-specific pathogenicity. Our study identifies candidalysin as a serodominant antigenic peptide and reveals significantly elevated serum anti-candidalysin IgG levels in IC across diverse anatomical sites, suggesting its potential as a novel diagnostic biomarker.

AlTPS6 from Is a Crucial Regulatory Target for Root-Knot Nematode Infestation.

Root-knot nematodes (RKNs) are widespread parasites that damage crops by weakening the plant immune system, causing root galls and stunting growth. However, the molecular mechanisms behind how RKNs regulate host plant defenses remain largely unknown. The medicinal plant frequently suffers losses from RKNs.

The effect of integrated care interventions on cognitive decline among older adults: A systematic review and meta-analysis.

Objective: To pool existing studies to determine the efficacy of integrated care interventions on mitigating cognitive decline among older adults.

Design: Systematic review with a meta-analysis of randomized controlled trials (RCTs).

Methods: Ten databases were searched from their inception to June 18th, 2024, with an update on November 10th, 2024.

Wood-inspired aerogels with directional ordered pathways for rapid atmospheric water harvesting.

Sorption-based atmospheric water harvesters (SAWH) provide a promising solution to the world's freshwater shortage problems. Inspired by the transpiration of wood, photothermal aerogels with directional ordered pathways were prepared using directional freezing technology. More importantly, the ultra-hygroscopic lithium composite (LC) converted from lithium chloride (LiCl) was loaded on these aerogels to perfectly solve the deliquescence and agglomeration problems after desorption, resulting in developing pectin/carbon nanotubes/ultra hygroscopic lithium composite (P/CNTs/LC) aerogels.

Integrating narrative care into the reform of long-term geriatric care practice: An exploration.

Objective: To explore the integration of narrative care into a geriatric long-term care practice curriculum and to provide a reference for further incorporation of narrative care into similar curricula.

Methods: The curriculum design for geriatric long-term care practice was reformed by incorporating narrative care elements. The study focused on undergraduate nursing students from the 2023 cohort at a tertiary hospital in Nanjing.

Data-driven trends in critical care informatics: a bibliometric analysis of global collaborations using the MIMIC database (2004-2024).

Background: The Medical Information Mart for Intensive Care (MIMIC) database has become a cornerstone resource for critical care research, enabling advances in outcome prediction, machine learning, and patient management. However, comprehensive bibliometric understanding of MIMIC-related research evolution, global collaboration, and thematic trends remains limited.

Objective: This study aimed to perform a comprehensive bibliometric analysis of MIMIC-related publications (2004-2024), identifying thematic evolution, global research trends, and emerging areas, to guide future research directions.

Two distinct cell types of the medial mammillary body forming segregated subcircuits.

The medial mammillary body (MM) is an integral component of the Papez circuit and the extended hippocampal system essential for cognitive and emotional functions. However, whether MM contains morpho-electrophysiologically distinguishable, genetically identifiable neuron types, and how they interact to process information underlying diverse MM functions, has remained largely unexplored. Here we employed a multidisciplinary approach in mice, combing genetic labeling, electrophysiological recording, morphological reconstruction, viral tracing, activity monitoring and manipulation, and behavioral testing to perform an integrative analysis of MM.

Prognostic factors of invasive fungal infections in pediatric intensive care units and changes in treatment outcomes before and after the COVID-19 pandemic: a multicenter retrospective study.

Objective: To investigate the prognostic factors influencing the outcomes of children with invasive fungal infection in pediatric intensive care unit (PICU) and explore the effects of changes in clinical characteristics before and after the COVID-19 pandemic on treatment outcomes.

Methods: In total, 665 children with invasive fungal infections from the PICUs of four hospitals in China were retrospectively enrolled from January 2017 to December 2021. These children were categorized into an effective treatment group (336 cases) and a failure group (329 cases, including treatment abandonment and death) based on prognosis.

Epigallocatechin-3-gallate mitigates postovulatory oocyte aging by reducing oxidative stress and promoting embryonic development.

In Brief: Postovulatory oocyte aging significantly compromises oocyte quality, resulting in fertilization failure, abnormal embryonic development, and unfavorable outcomes in assisted reproductive technology (ART). Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, demonstrates the ability to effectively reduce excessive oxidative stress in oocytes and improve the quality of aged oocytes both in vitro and in vivo, offering promising potential for enhancing the success of ART and efficiency in livestock breeding.

Abstract: Oxidative stress-mediated postovulatory aging (POA) significantly compromises oocyte quality and impairs subsequent embryonic developmental competence, thereby reducing the efficiency of assisted reproductive technologies (ART) and livestock breeding.

A novel-miR-164 from Atractylodes lancea targets AlNAC1 regulating leaf senescence.

A novel miR164-AlNAC1 module adjusting the expression of genes related to chlorophyll synthesis and ROS synthesis, and regulating leaf senescence in Atractylodes lancea. Leaf senescence is a critical developmental process regulated by complex genetic networks. In this study, a novel miRNA belonging to the MIR164 family was identified as a key regulator of leaf senescence in A.

Clinical features and survival analysis of adult patients with severe lower respiratory tract infection positive for respiratory syncytial virus.

Background: The awareness and attention toward lower respiratory tract infections caused by respiratory syncytial virus (RSV) are lower in adults than in children. Moreover, the clinical data on severe RSV infections in adults are lacking. This study aimed to augment the clinical understanding of RSV infections.

Unraveling the molecular mechanisms underlying flat stem formation in Atractylodes lancea in response to phytoplasmas.

For centuries, the herb Atractylodes lancea (Thunb.) has been revered for its pharmacological properties, particularly its efficacy in combating spleen and stomach ailments. However, prolonged artificial cultivation of A.

Hunger Breeds Discontentment: The Relation of Organisational Atmosphere on Emotional Eating Among Nurses and Mediating Role of Workplace Loneliness.

Aims: This study aimed to investigate the interrelationship between organisational climate, workplace loneliness and emotional eating among nurses.

Design: A cross-sectional study Data collection involved several validated instruments: a general information questionnaire to capture demographic and professional details, an organisational climate scale to assess the work environment, a workplace loneliness scale to measure feelings of isolation and an emotional eating scale to evaluate the extent of eating behaviours driven by emotional distress.

Methods: The research was conducted in March 2024, involving 385 clinical nurses from a large comprehensive hospital in Nanjing, China.

Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop.

Purpose: The aim of this study was to investigate the therapeutic effect of API on UC via the regulation of PAMP-MRGPRX2-mediated mast cells (MCs) degranulation.

Background: The pro-inflammatory positive feedback loop mediated by Mas-related G-protein-coupled receptor X2 (MRGPRX2) and its endogenous ligand, PAMP-12, is associated with ulcerative colitis (UC) progression. However, the therapeutic strategies that target MRGPRX2 in the treatment of UC are less reported.

Correlation analysis on risk factors for cervical cancer in perimenopausal women.

Objective: To analyze the risk factors for cervical cancer in perimenopausal women.

Methods: The data of 380 cervical cancer patients and 380 healthy individuals undergoing physical examinations at the Health Management Center of West China Hospital, Sichuan University, between April 2022 and March 2023, were retrospectively analyzed. The baseline information, genetic characteristics, medical records (both past and present), menstrual cycles, healthy conditions of the reproductive system, and sexual activities of patients in the cervical cancer patient group and healthy control group were compared.

Eco-friendly and efficient flame retardant rigid polyurethane foam reinforced with lignin and silica aerogel.

With the continuous improvement of living standards, the development of eco-friendly rigid polyurethane foam (RPUF) materials with excellent flame retardancy, thermal insulation, and outstanding mechanical strength has become an urgent challenge. This study presented an innovative strategy using lignin as a mechanical reinforcement and flame-retardant synergist, combined with DMMP and EG as highly efficient flame retardants. Furthermore, the incorporation of a silica aerogel coating via surface post-treatment significantly enhanced the flame retardancy of the composite.

Thermal- and Rate-Regulated Fast Switchable Adhesion within Glass Transition Zone of an Epoxy Polymer.

Thermoresponsive shape memory polymer (SMP) adhesives have demonstrated a high adhesion strength and large switching ratios on different substrates. However, a long response time to switch adhesion on or off is generally encountered. This study provides a fast adhesion switching method based on the temperature and rate dependence of adhesion within the glass-transition zone of an epoxy polymer.

Color-induced changes in : an integrative transcriptomic and metabolomic analysis of petals and non-petals.

(CM), renowned for its diverse and vibrant varieties, holds significant ornamental and medicinal value. Despite this, the core regulatory mechanisms underlying its coloration, especially in non-petal tissues (i.e.

Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway.

Per- and polyfluoroalkyl substances (PFAS) are synthetic perfluorinated compounds known for their persistence in the environment and reproduction toxicity. PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been identified in the follicular fluid of infertile women. However, the specific of PFOA and PFOS mixture on oocyte quality and female fertility remain unclear.

Differential gene expression in PBMCs: Insights into the mechanism how pulmonary tuberculosis increases lung cancer risk.

Pre-existing of pulmonary tuberculosis (PTB) poses increased lung cancer risk, yet the molecular mechanisms remain inadequately understood. This study sought to elucidate the potential mechanisms by performing comprehensive analyses of differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) from patients with PTB, lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC). Microarray assays were employed to analyze the DEGs in PBMCs of these patients.

The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus.

Respiratory syncytial virus (RSV) is one of the most common respiratory pathogens, causing a significant disease burden in young children and the elderly. Up to now, there is no specific drug in the clinic. N6-methyladenosine (mA) is a ubiquitous RNA modification in eukaryotes that regulates disease processes caused by viral infections.

Pre-diagnostic trajectory of pediatric hemophagocytic lymphohistiocytosis: observations from hematological and hepatic parameters.

Understanding the early features and characteristics of hemophagocytic lymphohistiocytosis (HLH) is essential for identifying high-risk individuals and also providing valuable pathological insights. This study aims to investigate the characteristics and trends of blood and hepatic parameters before an HLH diagnosis was established. Longitudinal hematological and hepatic test results from pediatric patients with HLH and an age- and sex-matched control group were analyzed.