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Background: As China faces a rapidly aging population, older adults now account for nearly 40 % of emergency department (ED) visits, creating urgent demand for age-appropriate care models. Comprehensive Geriatric Assessment (CGA) has been internationally recommended to improve outcomes for older patients, yet its application in China's emergency settings remains limited. Within the country's tiered healthcare system, Community Health Service Centers (CHSCs) and General Hospitals (GHs) differ in resources and functions, affecting CGA feasibility. This study compares CGA-related practices, barriers, and training needs across CHSCs and GHs to inform context-sensitive implementation strategies.
Methods: A cross-sectional survey was conducted in August 2024 among 372 emergency healthcare providers from CHSCs and GHs in Wuhan. Descriptive and comparative analyses were used to examine differences in CGA awareness, application, and barriers among healthcare providers from different levels of institutions.
Results: CGA awareness was suboptimal in both settings (CHSCs: 51.9 %, GHs: 40.2 %), yet support for implementation exceeded 70 % across providers. GHs reported more frequent encounters with complex geriatric cases and broader CGA application, especially in domains such as delirium, anxiety, and pressure ulcer screening (p < 0.05). However, GHs faced acute barriers including time and staffing shortages. CHSCs, though less involved in CGA delivery, expressed strong motivation for training (91.0 % vs. 84.0 %) and cited lack of professional knowledge as the primary barrier (p = 0.018).
Conclusions: This is the first empirical study to compare CGA practices between CHSCs and GHs in China's emergency care system. Findings highlight institutional misalignments that constrain CGA delivery, while also revealing complementary strengths. A two-tiered model-initial risk screening in GHs followed by longitudinal CGA in CHSCs-may offer a pragmatic path forward. Scalable training programs and hub-and-spoke collaboration structures are needed to build CGA capacity and improve emergency care quality for older adults.
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http://dx.doi.org/10.1016/j.ajem.2025.08.032 | DOI Listing |
Nat Commun
September 2025
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Arch Cardiovasc Dis
September 2025
CIC INSERM 1410, 97410 Saint-Pierre, France; Department of Cardiology, La Réunion University Hospital, 97400 Saint-Denis, France. Electronic address:
Background: Artificial intelligence has emerged as a promising tool to optimize patient care in the field of cardiovascular medicine. However, data on its adoption and utilization by healthcare professionals are scarce.
Aim: To explore the factors that support or hinder the adoption of artificial intelligence in cardiology in France.
Am J Hum Genet
September 2025
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK. Electronic address:
Multiplex assays of variant effect (MAVEs) provide promising new sources of functional evidence, potentially empowering improved classification of germline genomic variants, particularly rare missense variants, which are commonly assigned as variants of uncertain significance (VUSs). However, paradoxically, quantification of clinically applicable evidence strengths for MAVEs requires construction of "truthsets" comprising missense variants already robustly classified as pathogenic and benign. In this study, we demonstrate how benign truthset size is the primary driver of applicable functional evidence toward pathogenicity (PS3).
View Article and Find Full Text PDFBlood Adv
September 2025
Alfred Health and Monash University, East Melbourne, Australia.
Zanubrutinib is a next-generation covalent Bruton tyrosine kinase (BTK) inhibitor designed to provide complete and sustained BTK occupancy for efficacy across disease-relevant tissues, with fewer off-target adverse events (AEs) than other covalent BTK inhibitors. In the phase 3 ASPEN study (BGB-3111-302), comparable efficacy and a favorable safety profile versus ibrutinib were demonstrated in patients with MYD88-mutated Waldenström macroglobulinemia (WM), leading to approval of zanubrutinib for patients with WM. BGB-3111-LTE1 (LTE1) is a long-term extension study to which eligible patients, including patients from comparator treatment arms, could enroll following participation in various parent studies of zanubrutinib to treat B-cell malignancies.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Department of Biostatistics, University of Florida Colleges of Medicine and Public Health and Health Professions, Gainesville, FL.
Objectives Background: Monocyte anisocytosis (monocyte distribution width [MDW]) has been previously validated to predict sepsis and outcome in patients presenting in the emergency department and mixed-population ICUs. Determining sepsis in a critically ill surgical/trauma population is often difficult due to concomitant inflammation and stress. We examined whether MDW could identify sepsis among patients admitted to a surgical/trauma ICU and predict clinical outcome.
View Article and Find Full Text PDF