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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12347174 | PMC |
| http://dx.doi.org/10.3390/ijms26157442 | DOI Listing |
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Correction: Ashby et al. Femoral Structure and Biomechanical Characteristics in Sanfilippo Syndrome Type-B Mice. 2023, , 13988.
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In the original publication [...
View Article and Find Full Text PDFNegative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants.
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Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Adjustment for prognostic baseline variables can reduce bias due to covariate imbalance and increase efficiency in randomized trials. While the use of covariate adjustment in late-phase trials is justified by favorable large-sample properties, it is seldom used in small, early-phase studies, due to uncertainty in which variables are prognostic and the potential for precision loss, type I error rate inflation, and undercoverage of confidence intervals. To address this problem, we consider adjustment for a valid negative control outcome (NCO), or an auxiliary post-randomization outcome believed to be completely unaffected by treatment but more highly correlated with the primary outcome than baseline covariates.
View Article and Find Full Text PDFSex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques.
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View Article and Find Full Text PDFExercise intensity measurement using fractal analysis of heart rate variability: Reliability, agreement and influence of sex and cardiorespiratory fitness.
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Article Synopsis
- - The study evaluated the reliability of a method called detrended fluctuation analysis of heart rate variability (DFA-α1) for determining exercise intensity thresholds and compared it to traditional methods based on blood lactate and gas exchange for a group of 37 participants.
- - Test results showed that DFA-α1 had good reliability and moderate agreement with the other two methods, although the accuracy of thresholds varied depending on participants' cardiorespiratory fitness levels.
- - The findings indicated that male participants had a higher bias in threshold measurements compared to females, and to improve DFA-α1 accuracy, adjustments should be made based on both sex and fitness levels.