Publications by authors named "XiaoLin Yan"
Development prospects of "Internet + medical and health services" in Shandong: application status and public acceptance.
Front Public Health
August 2025
Background: The integration of Internet technology into healthcare has led to the birth of the "Internet + medical and health services" model-a transformative approach to improving accessibility and efficiency in healthcare delivery.
Objective: This study aims to assess the current status, challenges, and user perceptions of the "Internet + medical and health" services platform among individuals in Shandong, China.
Methods: The cross-sectional survey was conducted between September 2023 and October 2023 on patients from public medical institutions in Shandong Province.
Thin-film encapsulation has been a critical method to realize small-size OLED displays. However, the manufacturing of large-size flexible OLED is still in the preparatory phase prior to commercialization, which entails more rigorous demands for reliability and flexibility with regard to thin-film encapsulation. This review, from the perspective of engineering for mass production, addresses the development of thin-film encapsulation and its three core properties for comprehensive validation while engineering, including basic properties, reliability, and compatibility.
View Article and Find Full Text PDFPredictive value of lactate levels for mortality in pneumonia: a systematic review and meta-analysis.
J Infect Dev Ctries
June 2025
Introduction: Lactate levels, a marker of tissue hypoxia and metabolic acidosis, have been suggested as a prognostic indicator for patient outcomes in pneumonia. This systematic review and meta-analysis aim to determine the predictive value of lactate levels for mortality in patients with pneumonia.
Methods: A systematic literature search was done using CINAHL, SCOPUS, EMBASE, MEDLINE, Cochrane, Google Scholar, and ScienceDirect databases.
Unwanted side reactions occurring at electrode|electrolyte interfaces significantly impact the cycling life of lithium metal batteries. However, a comprehensive view that rationalizes these interfacial reactions and assesses them both qualitatively and quantitatively is not yet established. Here, by combining multiple analytical techniques, we systematically investigate the interfacial reactions in lithium metal batteries containing ether-based non-aqueous electrolyte solutions.
View Article and Find Full Text PDFBackground: The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.
Aim: To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.
Methods: Overall, 98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study (50 patients) and control groups (48 patients).
Xylose utilization promotes replication within macrophages and systemic infection in mice.
Virulence
December 2024
Article Synopsis
- An intracellular pathogen can survive and replicate in host macrophages, potentially causing systemic diseases.
- The study found that xylose, a common sugar, increased in concentration during infection, and specific genes responsible for xylose metabolism were more active in macrophages.
- Mutations in xylose catabolic genes reduced the pathogen's replication and colonization in mouse organs, suggesting that utilizing xylose is crucial for its growth and virulence in an infected host.
Exogenous autoinducer-2 alleviates intestinal damage in necrotizing enterocolitis via PAR2/MMP3 signaling pathway.
Int Immunopharmacol
September 2024
Article Synopsis
- * Researchers performed experiments on both neonatal mice with NEC and cultured intestinal cells exposed to a damaging agent, measuring various biological markers and proteins involved in inflammation and tissue repair.
- * Results showed that AI-2 significantly improved intestinal damage by enhancing tight junction proteins (ZO-1 and occludin) while decreasing harmful inflammatory markers (IL-1β and IL-6), suggesting AI-2 could be a potential protective treatment for NEC.
Article Synopsis
- * This research presents a new electrophoretic deposition (EPD) method that enables high-resolution and efficient assembly of these nanoparticles into controlled patterns.
- * The study shows that using silicon oxide and titanium oxide nanoparticles together improves the emission efficiency of quantum dots and suggests potential applications in high-resolution display technology.
Article Synopsis
- * A meta-analysis of 16 studies found that TWP improves outcomes in patients with primary membranous nephropathy (PMN), type 2 diabetic kidney disease (DKD), and severe Henoch-Schönlein purpura nephritis (HSPN), with results comparable to glucocorticoids and valsartan.
- * The addition of TWP led to improved remission rates and reduced urine protein levels without significantly increasing adverse reactions, suggesting it may be a safe therapeutic option for these conditions.
High-Resolution Quantum Dot Light-Emitting Diodes by Electrohydrodynamic Printing.
ACS Appl Mater Interfaces
February 2024
Article Synopsis
- Quantum dot light-emitting diodes (QLEDs) are gaining popularity for their great light-emitting properties and ability to be manufactured using inkjet printing, but their low resolution limits their use in display applications.
- Researchers improved QLED resolution to 2540 pixels per inch (PPI) by using electrohydrodynamic (EHD) printing, achieving a maximum external quantum efficiency (EQE) of 20.29% and brightness of 35816 cd/m².
- The study highlighted that changing the QD layer fabrication process from spin-coating to EHD printing not only enhanced pixelation but also reduced leakage currents, yielding impressive results for potential high-resolution full-color displays.
Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen.
ChemistryOpen
June 2024
Article Synopsis
- Poorly soluble drugs like flurbiprofen, a nonsteroidal anti-inflammatory drug, have low absorption rates when taken orally, leading to low bioavailability.
- Researchers developed a new flurbiprofen-ethylenediamine salt (FLU-EDA) using solvent crystallization, which significantly improved its solubility and dissolution rate in water by 57-fold and 32-fold, respectively.
- This study contributes valuable data and theoretical insights for creating more effective flurbiprofen formulations.
Tailoring Li Deposition by Regulating Structural Connectivity of Electrochemical Li Reservoir in Li-metal Batteries.
Angew Chem Int Ed Engl
March 2024
Article Synopsis
- Irregular lithium (Li) deposition causes poor performance and safety risks in Li metal batteries, often linked to the traditional testing methods that dissolve Li entirely.
- The study reveals that maintaining structural connectivity in the electrochemical lithium reservoir is crucial for consistent lithium deposition and growth.
- Adjusting the shape of the lithium reservoir can enhance battery efficiency and longevity by improving how lithium is deposited during battery operation.
Urban noise exposure assessment based on principal component analysis of points of interest.
Environ Pollut
February 2024
Article Synopsis
- * An automatic data collection process gathers geospatial information and population data related to Points of Interest (POIs), which are then analyzed to understand how demographic factors influence noise distribution.
- * The research indicates that traffic noise exposure is significantly shaped by traffic conditions, building layouts, land-use types (NFR classes), and population density, leading to varying levels of noise impact and exposure in different areas.
Lactate promotes intracellular replication and systemic infection via driving macrophage M2 polarization.
Microbiol Spectr
December 2023
Article Synopsis
- An important enteropathogen can survive and replicate within host macrophages, potentially leading to severe systemic infections.
- Lactate, produced during bacterial infections, plays a key role in promoting macrophage M2 polarization, which supports the pathogen's growth.
- This research reveals the complex interactions between the pathogen and macrophages, enhancing our understanding of how metabolic processes influence host-pathogen dynamics.
Nitric oxide is a host cue for Salmonella Typhimurium systemic infection in mice.
Commun Biol
May 2023
Article Synopsis
- Nitric oxide (NO) is produced by the host's immune response to fight off microbial infections, but it also helps the bacteria Salmonella Typhimurium replicate during early infection in mice.
- The study found that NO activates a specific bacterial component known as Salmonella pathogenicity island-2 (SPI-2) through two proteins, Fnr and PhoP/Q.
- This activation leads to increased bacterial presence in various organs during the initial infection period, highlighting how host signaling can unexpectedly aid in the virulence of S. Typhimurium.
IONPs-Based Medical Imaging in Cancer Care: Moving Beyond Traditional Diagnosis and Therapeutic Assessment.
Int J Nanomedicine
April 2023
Article Synopsis
- The global incidence of cancer-related illness and death is rising, emphasizing the need for effective medical imaging in cancer management, such as diagnosis and treatment evaluation.
- Iron oxide nanoparticles (IONPs) are emerging as valuable contrast agents that improve the identification of cancerous tissues and facilitate advanced multimodal imaging techniques.
- This review covers recent advancements in IONPs-enhanced medical imaging, their applications in various cancer treatments, and the challenges facing their use, aiming to guide future developments in the field.
Rate-Dependent Failure Mechanisms and Mitigating Strategies of Anode-Free Lithium Metal Batteries.
ACS Appl Mater Interfaces
March 2023
Article Synopsis
- * A new method for calculating the real Coulombic efficiency (CE) during AFLMB cycling shows that lower discharge rates negatively impact Li CE, but higher rates improve its reversibility, suggesting AFLMBs are suited for high-power applications.
- * Despite improvements, AFLMBs still face rapid failures due to Li stripping overpotential; however, applying a zinc coating can enhance electron and ion transfer, indicating a need for focused strategies to optimize AFLMB commercialization.
Article Synopsis
- Salmonella Typhimurium, a harmful bacteria, can infect humans and animals, leading to gastrointestinal issues and severe infections, especially by replicating inside host immune cells called macrophages.
- In a study, the yhjC gene was discovered to be significantly increased when Salmonella entered macrophages, and its deletion hindered the bacteria's ability to replicate and colonize in mice, which improved the mice's survival rates.
- The research revealed that YhjC regulates various virulence genes, suggesting its role in enhancing S. Typhimurium's ability to cause systemic infections, making it a potential target for developing infection control strategies.
Blue light-emitting diodes based on colloidal quantum dots with reduced surface-bulk coupling.
Nat Commun
January 2023
Article Synopsis
- * The existing blue quantum dots achieve high efficiency but suffer from significant surface-bulk coupling, limiting their operational lifespan due to localized charges affecting performance.
- * A novel approach using blue quantum dots with a modified core-shell structure helps reduce this coupling, allowing for a range of emission colors and improved operational lifetimes of 75 to 227 hours, surpassing previous benchmarks.
Succinate aggravates intestinal injury in mice with necrotizing enterocolitis.
Front Cell Infect Microbiol
October 2023
Article Synopsis
- Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition mainly affecting premature infants, and the study focuses on the role of succinate, a metabolite, in its pathogenesis.
- Through analysis of fecal samples from neonates and mouse models, the study found that succinate levels were significantly higher in NEC cases compared to non-NEC cases, indicating a potential link between succinate and changes in gut bacteria.
- Increased levels of succinate were shown to worsen weight gain, intestinal damage, and mortality in mice, along with notable shifts in inflammatory cytokine gene expression, suggesting that succinate may play a detrimental role in NEC development.
Adjustable Mixed Conductive Interphase for Dendrite-Free Lithium Metal Batteries.
ACS Nano
August 2022
Article Synopsis
- Lithium metal batteries are promising for energy storage but face challenges like dendritic growth and unstable electrolyte interfaces.
- The study introduces a mixed ionic and electronic conductive interphase layer made from ZnO and Zn nanoparticles to improve battery performance.
- This new interphase enhances charge transfer and ion migration, resulting in impressive cycling stability for both symmetric cells (over 1200 hours) and full cells (2000 cycles with 91.5% capacity retention).
Article Synopsis
- Typhimurium is a harmful bacteria that causes gastroenteritis in humans and severe infections in mice, with its ability to use nitrate enhancing its growth during intestinal infections.
- In mice infected with Typhimurium, higher nitrate levels were detected in the liver and spleen, and mutations affecting nitrate transport reduced the bacteria's replication and systemic infection severity.
- The study suggests that utilizing nitrate boosts Typhimurium's virulence by acidifying its cytoplasm and activating virulence genes, particularly under low-oxygen conditions, indicating a complex interaction with the host.
Article Synopsis
- Constructing 3D skeletons with lithiophilic seeds helps create lithium metal anodes without dendrite formation, but common seeds often clump together during battery cycling.
- To improve performance, the study introduces intercalation-type lithiophilic seeds, which avoid aggregation due to their stable size and composition changes during use.
- The new 3D carbon-based host with embedded TiO seeds shows excellent efficiency and durability in lithium metal batteries, confirmed by various microscopical techniques demonstrating the seeds' stability throughout repeated charging and discharging cycles.
Article Synopsis
- * Microglia and astrocytes are activated by K1 and its outer membrane vesicles (OMVs), leading to the production of TNF-α and CXCL1, which are key players in recruiting neutrophils to the CNS.
- * Mice without microglia or TNF-α show reduced CXCL1 production and neutrophil recruitment, resulting in higher bacterial levels in the CNS, indicating the importance of these immune responses in combating K1 infection.