Publications by authors named "Xiao-Lin Yan"
Development prospects of "Internet + medical and health services" in Shandong: application status and public acceptance.
Front Public Health
August 2025
Background: The integration of Internet technology into healthcare has led to the birth of the "Internet + medical and health services" model-a transformative approach to improving accessibility and efficiency in healthcare delivery.
Objective: This study aims to assess the current status, challenges, and user perceptions of the "Internet + medical and health" services platform among individuals in Shandong, China.
Methods: The cross-sectional survey was conducted between September 2023 and October 2023 on patients from public medical institutions in Shandong Province.
Background: The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.
Aim: To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.
Methods: Overall, 98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study (50 patients) and control groups (48 patients).
Exogenous autoinducer-2 alleviates intestinal damage in necrotizing enterocolitis via PAR2/MMP3 signaling pathway.
Int Immunopharmacol
September 2024
Article Synopsis
- * Researchers performed experiments on both neonatal mice with NEC and cultured intestinal cells exposed to a damaging agent, measuring various biological markers and proteins involved in inflammation and tissue repair.
- * Results showed that AI-2 significantly improved intestinal damage by enhancing tight junction proteins (ZO-1 and occludin) while decreasing harmful inflammatory markers (IL-1β and IL-6), suggesting AI-2 could be a potential protective treatment for NEC.
Succinate aggravates intestinal injury in mice with necrotizing enterocolitis.
Front Cell Infect Microbiol
October 2023
Article Synopsis
- Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition mainly affecting premature infants, and the study focuses on the role of succinate, a metabolite, in its pathogenesis.
- Through analysis of fecal samples from neonates and mouse models, the study found that succinate levels were significantly higher in NEC cases compared to non-NEC cases, indicating a potential link between succinate and changes in gut bacteria.
- Increased levels of succinate were shown to worsen weight gain, intestinal damage, and mortality in mice, along with notable shifts in inflammatory cytokine gene expression, suggesting that succinate may play a detrimental role in NEC development.
[Vinegar processing attenuates toxicity on IEC-6 cells caused by chloroform extraction of Daphne genkwa].
Zhongguo Zhong Yao Za Zhi
June 2018
To screen the toxic polar fractions of Daphne genkwa, compare the toxicity of D. genkwa on crypts epithelial cells IEC-6 before and after vinegar processing, and preliminarily investigate the mechanism of D. genkwa vinegar processing on toxicity reducing.
View Article and Find Full Text PDF[Protective effect of different polar fractions of Carbonized Rubiae Radix et Rhizoma (cRRR) against oxidative injury].
Zhongguo Zhong Yao Za Zhi
December 2017
The protective effect of different polar fractions of Carbonized Rubiae Radix et Rhizoma (cRRR) against ox-LDL-induced damage to human umbilical vein endothelial cells (HUVECs) was investigated by MTT assay, and the components were identified by using UPLC-Q-TOF-MS. According to the study, ethyl acetate extract and n-butanol extract could increase cell viability (P<0.01), while petroleum ether extract had no influence, and water extract could even inhibit the cell viability to some degree.
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