Association of dietary index for gut microbiota and sarcopenia: the mediation effect of body roundness index.

Background And Objectives: The complex interplay between diet, gut microbiota, and metabolic health has gained increasing recognition as a key factor in the development of obesity and related conditions, such as sarcopenia. This study examines the relationship between the dietary index for gut microbiota (DI-GM) and sarcopenia, while exploring the potential mediating role of the body roundness index (BRI) in this association. By integrating these factors, our findings aim to shed light on the diet-gut microbiota-sarcopenia interaction and its implications for personalized dietary interventions.

Dextran sulfate-containing thermosensitive hydrogel improves tendon healing by modulating macrophage polarization.

Direct tendon repair is a prevailing management strategy for tendon rupture. However, healing is impeded by the relatively low metabolic activity of tendon cells and chronic inflammation following the initial injury and subsequent surgery. To address this challenge, we developed a thermosensitive Pluronic-dextran sulfate (PDS) hydrogel to mitigate chronic inflammation by modulating macrophage phenotypes and facilitating extracellular matrix deposition through the sulfated residue of the hydrogel.

Influence of eHealth literacy on acceptance of healthcare services with risks in China: chain-mediating effect of general risk propensity and self-efficacy.

Objectives: To investigate factors associated with the acceptance of healthcare services with risks among Chinese public.

Study Design: This national cross-sectional study used data from the 2023 Psychology and Behavior Investigation of Chinese Residents.

Methods: Structural equation modelling was used to analyse the chain-mediated pathways of e-health literacy acting through general risk propensity and self-efficacy on the acceptability of five risky healthcare services (COVID-19 vaccine booster shots, mixed vaccination with COVID-19 vaccine, telemedicine, internet-based home care, and brain-computer interface technology).

The Intervention of Medical Social Workers: Humanistic Care of Cardiovascular Disease Patients.

Aim: To explore the implementation pathway and effectiveness of medical social workers and nurses in humanistic care nursing and to evaluate the impact of this collaborative model on patient satisfaction and healthcare resource utilization efficiency in cardiovascular wards.

Methods: This study adopted a quasi-experimental pre- and post-test design to implement humanistic care intervention in the cardiovascular ward of a tertiary care hospital in Zhuhai, China, from September to November 2023. A collaborative team consisting of two medical social workers and four charge nurses, based on the three-stage service process of "pre-hospital assessment-hospital care-discharge follow-up", systematically provided four core humanistic care services of "case management, group support, humanistic environment creation, and social resource connection".

The Efficacy and Safety of Intrapancreatic Bile Duct Resection Applied in Type I of Congenital Bile Duct Dilation: A Multi-center Control Cohort Study.

Objective: To compare the efficacy and safety of radical extrahepatic cyst excision including the intrapancreatic bile duct (REC) and subtotal extrahepatic cyst excision preserving the intrapancreatic bile duct (SEC) in treating Todani type I congenital bile duct dilation (CBD) with intrapancreatic bile duct involvement (I-IPBD).

Background: The application of REC and SEC in I-IPBD remains debated.

Methods: The multicenter study recruited I-IPBDs who underwent REC or SEC from 5 centers between 2006 and 2024.

Exploring the Prevention of Lipid Deposition Caused by High-Fat Diet and Its Mechanism of Action of Fermented Juice Based on Liver Metabolomics and Gut Microbiota.

Hyperlipidemia has become a prevalent disease in the global epidemic, posing a threat to human health. This study aims to investigate the mechanism by which fermented juice (RRFJ) can prevent lipid deposition induced by a high-fat diet in mice. The results showed that mice in the RRFJ intervention group had significantly reduced body weight as well as lower levels of serum and liver lipid indicators compared to the high-fat diet group.

Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.

Uterine scarring is a common complication following uterine injury, characterized by abnormal wound healing in the endometrial or myometrial tissue. However, the underlying mechanisms contributing to scar formation remain unclear, impeding the development of effective drugs for uterine scarring. Here, we identify that secreted frizzled-related protein 2 (sFRP2) is highly expressed in human and mouse uterine tissues with uterine scarring, particularly in uterine fibroblasts.

China's macro environment and LGBTQ+ rights: The benefits of an online support community to promote marriage equality.

Many LGBTQ+ communities have been actively campaigning to influence their countries to promote equality and protect human rights, including the right to same-sex marriage. However, the macro environment in China, including public policy and social attitudes, heavily influences such activism, which is progressing almost silently. The social environment shaped by traditional values still discriminates against and marginalizes sexual minorities, making it challenging to establish marriage equality.

Combination of LowDose Epigenetic Modifiers and TIC10 for the Activation of Antitumor Immunity and Inhibition of Tumor Growth in Gastrointestinal Cancer.

Background: Cytotoxic agents remain the mainstay treatment for advanced gastrointestinal cancer. However, the number of cytotoxic agents is limited, and the treatment effect is not satisfactory. Therefore, new agent and combination strategies are to be explored.

Integrated transcriptomic, proteomic, and metabolomic analysis unveils key roles of protein and nucleic acid interactions in diabetic ulcer pathogenesis.

Background: Diabetes mellitus significantly increases the risk of complications, particularly diabetic foot ulcers (DFUs). However, the underlying mechanism remains unclear. This study aimed to assess the overall therapeutic approach in diabetic ulcers.

Nurses' Experience Regarding Barriers to Providing Internet Plus Continuous Nursing: Mixed Methods Study.

Background: The novel medical model of "Internet Plus continuous nursing" has received much attention under the dual background of aging and digitalization in China. However, there is a scarcity of studies that report on the potential barriers and challenges associated with the implementation of this practice.

Objective: This study aimed to investigate and understand nurses' experience regarding barriers to providing Internet Plus continuous nursing.

A surveillance-based epidemiological study of renal agenesis in 25 million births in china, 2007-2020.

Background: Renal agenesis (RA), a rare congenital kidney defect, varies in clinical severity. Unilateral renal agenesis (URA) is more prevalent and may cause long-term renal complications, whereas bilateral renal agenesis (BRA) is typically fatal. While epidemiological data on RA is limited in China, understanding its prevalence and associated factors is crucial for public health interventions.

Phytochemicals, Extraction Methods, Health Benefits, and Applications of Loquat ( Lindl.) and Its By-Products: A Comprehensive Review.

Loquat (), a plant native to China and having extensive medicinal values, has recently drawn considerable attention. The current research on loquat mainly centers on its preservation, processing, and extraction of bioactive compounds. Nevertheless, there are still challenges and problems in the medical research and application of loquat and its byproducts.

Epidemiology of hypospadias in China: A nationwide surveillance-based study, 2010-2020.

Background: The prevalence of hypospadias varied internationally. However, epidemiological data on hypospadias in contemporary China remain limited.

Objectives: We aim to examine the epidemiological characteristics of hypospadias in Chinese population.

Erratum: Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1.

[This corrects the article DOI: 10.1016/j.isci.

Atractylodes lancea (Thunb.) DC polysaccharide structural properties and its protective impact on cisplatin-induced gastrointestinal harm by restoring the intestinal barrier and gut flora.

Atractylodes lancea (Thunb.) DC (AL) has been extensively used in dietary health and clinical treatments due to its beneficial therapeutic effects on the gastrointestinal tract. In this study, we isolated and purified AL polysaccharide (ALP) and investigated its therapeutic efficacy in chemotherapy-associated gastrointestinal damage.

InP optical phased array for high-speed wavefront shaping through scattering media.

By spatially modulating the wavefront, light can be controlled to focus through scattering media, enabling applications in biological sensing, non-line-of-sight (NLOS) imaging, and optical wireless communication. However, conventional liquid crystal-based spatial light modulators (LC-SLMs) and digital micromirror devices (DMDs) operate at refresh rates of at most tens of kilohertz, limiting their practicality for real-time manipulation of a large number of controlled channels. Here, we demonstrate wavefront shaping (WFS) through scattering media using an InP optical phased array (OPA).

Dual Scaffold Construction via Self-Assembled Chiral Ni(II)-Diamine Catalysts: Enantioselective Addition and Dieckmann Cyclization of Ynones with 3-Substituted Oxindoles.

A novel chiral Ni(II)-diamine combinatorial catalyst has been developed for the asymmetric conjugate addition and cascade Dieckmann cyclization of ynones with 3-substituted oxindoles. This reaction offers rapid and convenient access to a wide array of enantiomerically enriched 3,3'-disubstituted oxindoles and synthetically valuable spirocyclopentenone oxindoles, employing a low catalyst loading under mild conditions. Control experiments reveal that precise chiral matching between the two diamine ligands is critical for achieving high chemo- and enantioselectivity.

Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort.

Background: The triglyceride-glucose (TyG) index serves as an alternative index for assessing insulin resistance (IR). The relationship between the TyG index and its combined indicators and sarcopenia remains insufficiently explored.

Aim: To investigate the association between the TyG index and its combined parameters and sarcopenia.

Antibacterial reuterin as a multifunctional crosslinker for constructing chitosan-based hydrogels to promote infected wound healing.

Compared to traditional antibiotics, which often contribute to antibiotic resistance, probiotics and their metabolites have garnered increasing attention for their potential to improve the wound microenvironment. Among these, reuterin, a metabolite produced by Limosilactobacillus reuteri, exhibits notable antioxidant and antimicrobial activities, making it particularly advantageous for medical applications. Inspired by the structural similarity of reuterin to conventional chemical crosslinkers, we explored its dual role for the first time-as both a bioactive component and a crosslinking agent-by combining it with chitosan to develop a novel therapeutic hydrogel, eliminating the need for additional drug loading.

Case report: Analysis of the efficacy and safety of anti-infectious treatment for brain abscess caused by oral anaerobes.

Anaerobic meningitis is relatively rare, and the positivity rate of cerebrospinal fluid (CSF) cultures is exceedingly low, particularly in light of the limited research data regarding bacterial meningitis caused by oral anaerobes. This report presents a case involving a 24-year-old woman who developed fever and headache 32 days after undergoing a cesarean section. The symptoms persisted for 2 weeks, and enhanced nuclear magnetic resonance (NMR) scanning confirmed the suspicion of a brain abscess.

Toripalimab plus bevacizumab versus sorafenib as first-line treatment for advanced hepatocellular carcinoma (HEPATORCH): a randomised, open-label, phase 3 trial.

Background: Although several PD-1 or PD-L1 inhibitors combined with antiangiogenic agents have been approved as first-line treatment of advanced hepatocellular carcinoma, treatment needs remain unmet given the high incidence and mortality of hepatocellular carcinoma and due to factors such as regional approval status, medical insurance restrictions, and cost considerations. In this phase 3 HEPATORCH study, we aimed to compare the efficacy and safety of toripalimab plus bevacizumab versus sorafenib in patients with previously untreated advanced hepatocellular carcinoma.

Methods: We did a randomised, open-label, phase 3 study in 57 hospitals across mainland China, Taiwan, and Singapore.

Stabilizing Residual Monomers within Polymerized Electrolytes for High-Voltage Lithium Metal Batteries.

Poly(1,3-dioxolane) (PDOL)-based electrolyte has gained wide attention due to its high compatibility with the lithium metal anode, intimate contact with electrodes, and high ionic conductivity. However, its application in high-voltage batteries is limited because the residual DOL monomers are prone to oxidation at high voltage. Here, we report that LiDFOB-initiated polymerization stabilizes these residual monomers, thus overcoming the oxidation-related limitations of PDOL-based electrolytes.

Geographical characteristics and formation mechanisms of smallpox epidemics in Hubei Province, China, 1488-1949.

Smallpox is a highly contagious and ancient disease influenced by natural and social factors. These factors led to the wide spread of smallpox in Hubei Province of China during the historical period. We conducted the spatial and temporal distribution patterns of smallpox epidemics and their formation mechanism in Hubei Province of China during 1488-1949.