Pharmacovigilance study of ramucirumab: A safety analysis based on the FDA adverse event reporting system.

Background: This study analyzes adverse event (AE) signals associated with ramucirumab using data from the FDA Adverse Event Reporting System (FAERS) to provide evidence supporting the safety of the drug for clinical use.

Methods: Data were extracted from the FAERS database using Open Vigil 2.1.

Electrocatalytic Hydrogen Peroxide Production: Advances, Challenges, and Future Perspectives.

Electrocatalytic hydrogen peroxide (HO) production has attracted considerable interest in recent years as an eco-friendly and sustainable oxidizing agent. Its versatile applications span environmental protection, energy conversion, and chemical synthesis. Traditional industrial methods for HO production, primarily based on the anthraquinone process, are highly complex and energy-demanding.

Impact of Acute High-Altitude Exposure on the Timing of Tranexamic Acid Administration in Rabbits with Traumatic Hemorrhagic Shock.

Liu, Zhen, Chao Nie, Lijia Yuan, Hui Jiang, Chuanchuan Liu, Yi Zhang, and Minghua Liu.Impact of Acute High-Altitude Exposure on the Timing of Tranexamic Acid Administration in Rabbits with Traumatic Hemorrhagic Shock. 00:00-00, 2025.

Ab Initio DFT Study of the Interactions of Americium and Curium Ions with Graphene Oxide.

One of the most critical steps in the treatment of spent nuclear fuel is the removal of americium (Am) and curium (Cm) ions from radioactive wastewater. The use of new materials with high surface areas, such as graphene, has been considered a promising solution to this issue. Therefore, understanding the mechanism by which Am and Cm ions are adsorbed onto the graphene surface in aqueous solutions is of paramount importance.

High entropy metal organic framework nanozyme with cocktail effect for efficient extraction and colorimetric detection of tetracycline in food and water environment.

Widespread misuse of tetracycline antibiotics (TCs) poses a serious risk to ecological stability and public health, and advanced methods are needed for monitoring of TCs in food and water environments. Here, a high entropy metal organic framework (HE-MOF) was constructed for simultaneous TC extraction and visual detection. The multimetallic-coordinated HE-MOF featured a unique microporous architecture and high surface area, providing abundant binding sites for TC.

CCL2-Driven Inflammation Links Periodontitis to Anxiety.

Aim: This study investigates the association between periodontitis and anxiety, focusing on the role of the chemokine CCL2 in mediating this relationship.

Materials And Methods: This study comprises an analytical cross-sectional study and a preclinical in vivo study. In the analytical cross-sectional study, anxiety levels were assessed in individuals with periodontitis and healthy controls using the Hamilton Anxiety Rating Scale (HAMA).

Automated exo-glycosidase-based glycan sequencing on a digital microfluidic system with integrated electrochemical detection of monosaccharides.

Glycans are one of the most important biomacromolecules and are essential to nearly all known life forms. However, their structural complexity makes structural analysis more challenging than nucleic acids or proteins, significantly limiting the opportunities for investigating their structure-function relationship. Here, we proposed a novel glycan sequencing strategy in which a suite of specific non-reducing-end exoglycosidases was integrated with electrochemical detection of monosaccharides in a digital microfluidic (DMF) chip.

The impact of mixed reality training method on novice trainees of dental implants: an in vitro study.

Objectives: A novel dental implant training method based on mixed reality (MR) navigation technology was developed. Therefore, the aim of this study was to evaluate the learning effect of this method in novices.

Methods: We designed and developed an MR-based training method that provides real-time supervision, teaching, and guidance.

2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part II: Recommendations for Patients With Common Comorbidities.

Objective: The aim of this updated guideline is to provide comprehensive recommendations for the management of gout in patients with common comorbidities, such as chronic kidney disease (CKD), cardiovascular disease (CVD), diabetes, osteoarthritis (OA), and gastrointestinal disorders.

Methods: This guideline was developed by a multidisciplinary expert panel consisting of specialists in endocrinology, rheumatology, nephrology, cardiology, gastroenterology, and methodology. The development process adhered to standard methodologies, including PICO (population, intervention, comparator, and outcomes) question deconstruction, systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) for evidence and recommendation evaluation, Delphi voting, and expert consensus.

Transcriptomic and microenvironment characteristics of triple-negative breast cancer under three different neoadjuvant treatment regimens.

Background: Adding immunotherapy to chemotherapy can modestly improve the pathological complete response (pCR) rate in triple-negative breast cancer (TNBC), while our previous NeoSAC study demonstrated that combining anti-angiogenic therapy can further enhance pCR. However, research on the mechanisms underlying the efficacy differences and biomarker comparisons across these treatment regimens remains insufficient.

Patients And Methods: Female TNBC patients were consecutively enrolled into three groups: chemotherapy (chemo), chemo-immunotherapy (chemo-ICI), and chemo-immunotherapy-anti-angiogenesis (chemo-ICI-AA, from our NeoSAC study, NCT04722718).

Diagonal paraspinal muscle degeneration and osteoporosis were associated with rotatory subluxation in degenerative lumbar scoliosis.

Purpose: This study aimed to investigate the potential association between paraspinal muscle (PSM) degeneration, osteoporosis, and vertebral rotatory subluxation (VRS) in patients with degenerative lumbar scoliosis (DLS).

Methods: This retrospective study analyzed standing anteroposterior radiographs to assess the coronal (Cobb angle, coronal balance distance, and lateral translation) and sagittal parameters (thoracic kyphosis, lumbar lordosis, and sagittal vertical axis). Patients were categorized into rotatory subluxation (RS, lateral translation ≥ 5 mm) and non-RS groups, with the RS group further subdivided into single- and double-level subgroups based on the frequency of RS occurrence.

Successful management of pneumopericardium in an extremely low birth weight preterm using a 22-gauge intravenous catheter as a pericardial drain.

Pneumopericardium is relatively rare but potentially fatal in premature babies. When a massive pneumopericardium leads to cardiac tamponade, emergent pericardiocentesis is often required to save lives. In some cases, the placement of a pericardial drain for continuous drainage may be necessary.

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment.

Efficient elimination of intestinal reactive oxygen species (ROS) and accelerated alleviation of proinflammatory microenvironment are considered as a direct approach for the management of inflammatory bowel disease (IBD). Although promising, current treatments focusing on the intestinal inflammation resolution are still unsatisfactory and far from their practical applications. To address these limitations, novel polydopamine nanodots (PDA NDs) are rationally designed and developed as an efficient oral formulation for the targeted IBD treatment by regulating intestinal oxidative stress and proinflammatory microenvironment.

Real-world drug safety study of somatostatin analogs based on the food and drug administration adverse event reporting system database.

Background: Somatostatin analogs (SSAs), synthetic peptides mimicking endogenous somatostatin, are widely used to treat neuroendocrine tumors and acromegaly. However, their use is often accompanied by adverse events (AEs) that may compromise patient safety. This study systematically evaluated AE signals associated with SSAs using the FDA Adverse Event Reporting System (FAERS) database to inform clinical practice.

Analysis of blood screening strategies and their efficacy among voluntary blood donors in a region of East China.

Objective: In this study, we aimed to analyze the blood screening detection strategies employed for voluntary blood donation in a specific region of East China and evaluate the efficacy of the blood safety detection system.

Donors And Methods: A total of 539,117 whole blood samples were collected from voluntary blood donors between January 2018 and July 2021, as well as in 2023 and 2024. The samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies, human immunodeficiency virus antibodies/antigen (HIV Ab/Ag), and Treponema pallidum (TP) antibodies using enzyme-linked immunosorbent assay (ELISA).

Clinical application of nanopore sequencing for haplotype linkage analysis in preimplantation genetic testing for Duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscular dystrophy, ultimately leading to paralysis and death from cardiac failure and/or respiratory insufficiency. Preimplantation genetic testing for monogenic disorders (PGT-M) has proven effective in helping families with complete pedigrees carrying DMD mutations to produce unaffected offspring. This study was designed to evaluate the feasibility of using nanopore sequencing as an effective PGT-M technique for DMD, particularly in cases involving de novo mutations or incomplete pedigrees that cannot be analyzed using second-generation sequencing (SGS) alone.

Worldwide antibiotic prescription practices in primary care and associated factors: A systematic review and meta-analysis.

Background: Antibiotic prescription is a major driver of antimicrobial resistance. However, evidence on antibiotic prescription practices is inadequate globally. This study aimed to assess antibiotic prescription practices and identify its associated factors in primary care worldwide.

Design and Preparation of Self-Adaptive and Robust Solid-State Elastomeric Electrolyte for Lithium Metal Battery Inspired by Rubber Tire.

The development of safe, high-performance solid-state electrolytes remains a central challenge for advancing lithium metal batteries (LMBs) toward practical deployment. Inspired by the durable, deformable nature of rubber tires, we report the design and preparation of a self-adaptive solid-state elastomeric electrolyte containing a deep eutectic electrolyte, termed PMEC, which integrates molecular-level plasticizer dispersion, mechanical flexibility, and interfacial adaptivity. The PMEC membrane exhibits high ionic conductivity (2.

Surgical Outcomes in Laparoscopic vs Open Diverting Colostomy for Radiation-Related Rectovaginal Fistula.

BACKGROUND Radiation-induced rectovaginal fistula (RI-RVF) is a debilitating condition occurring after radiotherapy for pelvic malignancies. Diverting colostomy is an effective procedure for improving quality of life. This study compared surgical outcomes of laparoscopic diverting colostomy with those of open surgery for RI-RVF.

Clinical significance of single channel dual-media spinal endoscopy in the treatment of lumbar spinal stenosis.

Background: To investigate the significance and effectiveness of single-channel, dual-medium spinal endoscopy- utilizing both water and air media-in the treatment of lumbar spinal stenosis through a posterior side approach with bilateral decompression.

Methods: A total of 168 patients with lumbar spinal stenosis underwent posterior side decompression using single- channel, dual-medium spinal endoscopy. The VAS 、 ODIand JOA scores, as well as postoperative complications-such as cerebrospinal fluid leakage, infection, recurrence, and nerve root injury-were assessed preoperatively, and at 1 day, 1 week, 1 month, and 6 months postoperatively.

Edge/Corner-Sharing 2D Perovskite Functional Layer for Efficient and Stable Inverted Perovskite Solar Cells.

Tuning the surface structure of perovskite films based on two-dimensional (2D) perovskites with narrow octahedral interlayer spacing is essential yet challenging to mitigate quantum and dielectric confinement, achieve interfacial energy-level matching, and promote efficient carrier transport kinetics in inverted perovskite solar cells (PSCs). Innovatively, an n-type 2D perovskite functional layer featuring a distinctive edge/corner-sharing (E/C-sharing) [PbI] octahedral framework is constructed on a 3D film surface by utilizing N-methylethylenediamine cations (MEDA) to regulate the connection modes of [PbI] octahedral units. Specifically, the 2D-MEDAPbI with the E/C-sharing octahedra yields the narrowest interlayer spacing recorded to date (8.

Changes in the Quality of Maxim Fruits from Different Ecotypes During the Growth Process.

The goal of this study was to build an understanding of the quality of fruit Maxim from different ecotypes and to identify the best cultivars, with a view to providing a reference and theoretical basis for the selection and cultivation of . In this study, we systematically evaluated the fruit quality characteristics of five seed sources, namely SH, SG1, GG, HX, and SG2, at four developmental stages, M1-M4, through a principal component analysis, a correlation analysis, and a significance test. Comparisons between the ecotype yielded that GG was significantly better than the other ecotype in oil content (28.

Relationship between surface deformation displacement and energy evolution of red sandstone under uniaxial compression.

The bedding structure, variations in cementation state, and pore network characteristics of red sandstone contribute to significant non-uniform deformation, critically influencing engineering stability. Existing research on external energy input to red sandstone primarily focuses on the relationship between overall rock deformation, axial deformation, and energy evolution, while studies exploring the correlation between red sandstone surface deformation caused by loads change and energy remain limited. To address these gaps, this study employs a 3D visualization test system to collect surface displacement data of red sandstone standard samples synchronously using multiple cameras, combined with micron-scale digital image correlation technology and energy analysis.