Dynamic progression of Wernicke encephalopathy in a gastric cancer patient: Multimodal MRI insights with arterial spin labeling perfusion imaging.

Rationale: Wernicke encephalopathy (WE), a neurological emergency caused by thiamin deficiency, is traditionally diagnosed based on the triad of ophthalmoplegia, ataxia, and confusion. However, this classic presentation occurs in fewer than 10% of cases, complicating early recognition. Untreated cases risk irreversible brain damage or progression to Korsakoff syndrome.

The early changes in behavior and the myelinated fibers of the white matter in the Tg2576 transgenic mouse model of Alzheimer's disease.

Recently, increasing evidences have indicated that abnormal behavior and white matter changes had appeared before senile plaques were formed in Alzheimer's disease (AD). However, the exact nature of these changes in behavior and white matter structure in early AD are unclear. This study used the Morris water maze, an ELISA assay, a transmission electron microscopic technique and new stereological methods to investigate the behavior, Aβ protein expression and white matter structure of Tg2576 transgenic mice at four ages.