ctDNA detects residual disease after neoadjuvant chemoradiotherapy and guides adjuvant therapy in esophageal squamous cell carcinoma.

The diagnostic accuracy of circulating tumor DNA (ctDNA) for detecting molecular residual disease (MRD) after multimodal treatment remains unclear. In a prospective cohort of 132 patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemoradiotherapy (nCRT) followed by clinical response evaluation and surgery, tumor-informed personalized-panel and fixed-panel ctDNA assays are applied to serial blood samples. Personalized ctDNA assay demonstrates a superior baseline detection rate (99.

Pharmacokinetic study of isavuconazonium in human plasma measured by HPLC-MS/MS and its use in healthy Chinese subjects.

Aims: To establish a rapid, sensitive HPLC-MS/MS method for quantifying isavuconazonium in human plasma and characterize its pharmacokinetics in healthy Chinese subjects under fasting and postprandial conditions.

Materials & Methods: Plasma samples were processed via acetonitrile protein precipitation. Separation was performed on an LC-20ADXR Plus C18 column with gradient elution (0.

The impact of conjugation strategies and linker density on the performance of the Spermine-AcDex nanoparticle-splenocyte conjugate.

A common approach in living medicine engineering is modifying cell surfaces with nanomedicines to form nanoparticle-cell conjugates. Despite various available strategies, limited research has examined how conjugation strategies affect the efficiency and stability of the delivery systems. Herein, we prepared polymeric nanoparticles (NPs) with protein payloads and modified them with different linkers.

miR-17-5p Inhibits BNIP3-Mediated Mitochondrial Autophagy to Attenuate Pathological Cardiac Fibrosis.

Background: Cardiac fibrosis plays a critical role in the progression of chronic cardiovascular conditions, with mitochondrial dysfunction acting as a central mechanism underlying pathological myocardial fibrosis. Increasing research shows that microRNAs may modulate the fibrotic process by regulating mitochondrial function via various pathways.

Aims: To examine the involvement of miR-17-5p in modulating mitochondrial autophagy and alleviating pathological cardiac fibrosis.

HSP70-Mediated Autophagy-Apoptosis-Inflammation Network and Neuroprotection Induced by Heat Acclimatization.

Global warming has intensified the health risks associated with heat stress, such as heatstroke and dehydration, underscoring the importance of understanding heat acclimatization (HA). HA involves physiological, psychological, and structural adaptations to prolonged high temperatures, improving heat tolerance and reducing heat-related harm. A key player in this process is HSP70, a conserved protein essential for maintaining cellular balance, regulating cell death, and controlling waste removal.

Validation of a reverse phase high-performance liquid chromatography method for the detection of major components and related substances in nicardipine hydrochloride injection.

A simple, feasible, isocratic elution and stable reversed-phase high performance liquid chromatography was established and verified. Chromatographic conditions were XY-C18, 4.6x150mm, 5μm column; column temperature 50C.

Risk of Osteoarthritis and Arthroplasty Between Baclofen and Tizanidine: A Target Trial Emulation Study.

Background: Preclinical studies have shown that baclofen may reduce the risk of osteoarthritis through its anti-inflammatory effect.

Objective: We aimed to clarify this association by comparing the risks of osteoarthritis and joint replacement surgery in patients receiving baclofen and tizanidine.

Methods: This retrospective cohort study was conducted on the global TriNetX platform (October 31, 2024).

Correction: Su et al. The Relationship between Sarcopenia and Injury Events: A Systematic Review and Meta-Analysis of 98,754 Older Adults. 2022, , 6474.

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Measurement of Maize Leaf Phenotypic Parameters Based on 3D Point Cloud.

Plant height (PH), leaf width (LW), and leaf angle (LA) are critical phenotypic parameters in maize that reliably indicate plant growth status, lodging resistance, and yield potential. While various lidar-based methods have been developed for acquiring these parameters, existing approaches face limitations, including low automation, prolonged measurement duration, and weak environmental interference resistance. This study proposes a novel estimation method for maize PH, LW, and LA based on point cloud projection.

Survivors of Non-Hodgkin's Lymphoma: A Comparative Study on Patients With Vincristine-Induced Neuropathy and Their Quality of Life.

Background: Vincristine-induced peripheral neuropathy (VIPN), a common side effect of chemotherapy in survivors of non-Hodgkin's lymphoma (NHL), experience symptoms that may significantly impact quality of life (QoL). The age-related effects on NHL survivors with/without VIPN remain unclear.

Purpose: This study was designed to determine the variation in and severity of symptom manifestations in patients in two age groups as well as the effect of age on functional status and QoL.

Dynapenic Abdominal Obesity and Adverse Health Effects in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis.

Background/objectives: Dynapenic abdominal obesity is characterized by reduced muscle strength and abdominal fat accumulation and is associated with adverse health outcomes in older adults. Evidence from multiple studies conducted in different countries regarding these outcomes is inconsistent. This systematic review and meta-analysis evaluated the association between dynapenic abdominal obesity and adverse health outcomes-specifically falls, disability, and mortality-among middle-aged and older adults.

Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis.

Background: Pulmonary fibrosis (PF) is an age-related interstitial lung disease, which lacks effective drug treatment at present. Quercetin has been shown to have favorable anti-inflammatory and anti-fibrotic properties, and preliminary evidence suggests its potential efficacy and tolerability in PF patients. However, a comprehensive systematic review and evaluation of the protective effects and potential mechanisms of quercetin in PF models remains to be completed.

Instruction-Guided Scene Text Recognition.

Multi-modal models have shown appealing performance in visual recognition tasks, as free-form text-guided training evokes the ability to understand fine-grained visual content. However, current models cannot be trivially applied to scene text recognition (STR) due to the compositional difference between natural and text images. We propose a novel instruction-guided scene text recognition (IGTR) paradigm that formulates STR as an instruction learning problem and understands text images by predicting character attributes, e.

Bortezomib, thalidomide, and dexamethasone versus bortezomib, lenalidomide, and dexamethasone in transplant-eligible newly diagnosed multiple myeloma: a systemic review and meta-analysis.

Background: The current study aimed to compare treatment responses, the incidence of the need for auto-HSCT, and the occurrence of specific adverse events (AEs) between VTD and velcade, VRD induction regimens in patients with transplant-eligible newly diagnosed multiple myeloma (NDMM).

Methods: This systematic review and meta-analysis included 15 studies: six evaluating the VTD regimen and nine evaluating the VRD one. The primary endpoints were response rates after induction therapy and the incidence of a need for autologous hematopoietic stem cell transplantion (auto-HSCT) between the groups.

Accompanying Bi Clusters as Charge Mediators Effectively Enhance Synergetic Redox of BiSnO/ZnInS S-Scheme Heterostructure Composites.

Achieving synergistic oxidation and reduction represents a significant challenge in the field of photocatalysis. In this study, the hydrothermal/in situ construction of Bi atom clusters within BiSnO/ZnInS (BSO/ZIS) heterostructures is reported. These clusters exhibit self-accelerating charge-transfer mechanisms facilitated by internal electric fields and bonding bridges, resulting in highly efficient light absorption and charge-transfer capabilities.

PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. It is characterized by inflammation and fibrosis in the lung parenchyma and interstitium. Given its poor prognosis and limited treatment options, understanding the underlying molecular mechanisms is crucial.

Noncryopexy versus cryopexy treatment during scleral buckling: a systematic review and meta-analysis.

Objectives: To evaluate the differences in surgical outcomes between scleral buckling (SB) with noncryopexy and cryopexy methods.

Methods: We systematically searched the Embase, Medline, Cochrane Library, and Scopus databases for randomized controlled trials (RCTs) published from their inception until January 1, 2024. A random-effects model was applied, and outcomes are presented as risk ratios (RRs) or standardized mean differences with 95% confidence intervals (CIs).

Acetamiprid Exposure Disrupts Gut Microbiota in Adult and Larval Worker Honeybees ( L.).

Acetamiprid is a third-generation neonicotinoid insecticide that is now widely employed for the protection of crops grown in outdoor environments. This is because it is considerably less toxic to pollinating insects than other neonicotinoids. Previous studies have shown that acetamiprid has direct physiological effects on adult and larval bees.

Postoperative Pain in Vitreoretinal Surgery With Combined Regional-General Anesthesia Versus General Anesthesia: A Systematic Review and Meta-Analysis.

Purpose: To investigate postoperative pain variations in vitreoretinal surgeries conducted with combined regional-general anesthesia or general anesthesia.

Design: Systematic review and meta-analysis.

Methods: A systematic search of the PubMed, Embase, and Cochrane Library databases was conducted to identify relevant randomized controlled trials published before December 26, 2023.

Te modulated heterogeneous remodeling of S atoms in ultrathin ZnInS nanosheets containing S vacancies synergistically enhances CO photoreduction.

Reconfiguration of in situ heterojunction composites without interfacial resistance by substitution of homologous anions for the formation of gradient work function differences inducing the formation of built-in electric field is an effective strategy to enhance the charge separation efficiency. Herein, Te/ZnInS-V (Te/ZIS-V) in situ heterojunction was synthesized by substitution of Te ions for S in ultrathin ZIS containing S vacancies, which can significantly promote photogenerated charge separation, surface electron enrichment, and CO adsorption/activation. The presence of S vacancies and adjacent Te/S double anions, the double active sites constructed by defect engineering promote the desorption of *CO molecules while inhibiting the protonation toward *CHO, which was more favorable for selective CO photoreduction to CO.

Flumethrin exposure perturbs gut microbiota structure and intestinal metabolism in honeybees (Apis mellifera).

Flumethrin mitigates Varroa's harm to honeybee colonies; however, its residues in colonies threaten the fitness of honeybee hosts and gut microbiota. Our previous research has shown that flumethrin induces significant physiological effects on honeybee larvae; but the effects of flumethrin on the gut microbiota and metabolism of adult honeybees are still unknown. In this study, 1-day-old honeybees were exposed to 0, 0.

Cataract Surgery and Incidence of Retinal Vascular Occlusion: Population-Based Cohort Study Using a Target Trial Emulation Framework.

Background: Previous studies suggested an association between cataract surgery and retinal vascular occlusion. However, the association may be attributable to detection bias because postoperative monitoring may be more frequent for those who receive cataract surgery than for those who do not.

Design: Population-based cohort study using target trial emulation framework.

The effects of cold water immersion and partial body cryotherapy on subsequent exercise performance and thermoregulatory responses in hot conditions.

This study investigated the effects of cold water immersion (CWI) and partial body cryotherapy (PBC) applied within a 15-min post-exercise recovery period on thermoregulatory responses, subjective perceptions, and exercise performance under hot conditions (39 °C). Twelve male soccer players participated in team-sports-specific assessments, including Agility T-test (T-test), 20-m sprint test (20M-ST), and Yo-Yo Intermittent Endurance Test Level 1 (YY-T), during two exercise bouts (1 bout and 2 bout) with a 15-min post-exercise recovery period. Within the recovery period, a 3-min of PBC at -110 °C or CWI at 15 °C or a seated rest (CON) was performed.

Risk of age-related macular degeneration in men receiving 5α-reductase inhibitors: a population-based cohort study.

Background: Recent studies suggest that 5α-reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) result in abnormal retinal anatomical alteration.

Objective: To compare age-related macular degeneration (AMD) incidence in BPH patients receiving 5ARIs or tamsulosin.

Design: Retrospective, population-based cohort study using new-user and active-comparator design.

Occurrence and recovery of vocal cord paralysis after minimally invasive McKeown esophagectomy, risk factors, and clinical outcome.

Background: This study aimed to observe the occurrence of recurrent laryngeal nerve injury after McKeown esophagectomy for esophageal squamous cell carcinoma, as well as its recovery and influencing factors within 7 months after surgery.

Methods: From July 2020 to July 2021, among all patients who underwent minimally invasive McKeown esophagectomy, 90 patients who developed vocal cord paralysis after surgery were included in the study. These patients underwent endoscopic vocal cord function assessment every 1 to 2 months and continued until 7 months postoperatively.