[Analysis of risk factors for ventilator-associated pneumonia and its prognosis in patients with severe craniocerebral injury].

Objective: To analyze the risk factors for ventilator-associated pneumonia (VAP) and its prognosis in patients with severe craniocerebral injury.

Methods: A prospective observational study was conducted. Patients with severe craniocerebral injury admitted to the Second Affiliated Hospital of Xingtai Medical College from January 2020 to December 2022 were enrolled as the study subjects.

Validation of a reverse phase high-performance liquid chromatography method for the detection of major components and related substances in nicardipine hydrochloride injection.

A simple, feasible, isocratic elution and stable reversed-phase high performance liquid chromatography was established and verified. Chromatographic conditions were XY-C18, 4.6x150mm, 5μm column; column temperature 50C.

Extract Inactivates Isolated from Powdered Infant Formula.

This study aimed to investigate the antibacterial activity and mechanism of extract (PSE) against () isolated from powdered infant formula (PIF). The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and growth curves were measured to evaluate the antibacterial effects. The antibacterial mechanism was elucidated by revealing the changes in cell membrane potential, intracellular reactive oxygen species (ROS) level, cell membrane permeability, protein and nucleic acid leakage, and cell morphology of .

Depositional model of the fan delta of thick glutenite: Example from the Linhe Depression, Hetao Basin, China.

The thick glutenite formed in the Linhe Depression of the Hetao Basin during the Early Cretaceous offers notable exploration potential. However, the sediment comprises a rapidly stacked succession of glutenite featuring poor sortability, with the individual sedimentary layers reaching up to 120 m in thickness. However, the limited core variations coupled with the "dentate box" shape of the well logging curves pose challenges in identifying the sedimentary microfacies of the study area, thereby hindering its exploration and development.

The Emergence of Coxsackievirus A16 Subgenotype B1c: A Key Driver of the Hand, Foot, and Mouth Disease Epidemic in Guangdong, China.

Background: In 2024, mainland China witnessed a significant upsurge in Hand, Foot, and Mouth Disease (HFMD) cases. Coxsackievirus A16 (CVA16) is one of the primary causative agents of HFMD. Long-term monitoring of theCVA16 infection rate and genotype changes is crucial for the prevention and control of HFMD.

Three-Dimensional-Printed Osteochondral Scaffold with Biomimetic Surface Curvature for Osteochondral Regeneration.

Objectives: Treatment of osteochondral defects is hindered by several challenges, including the failure of traditional scaffolds with a predefined cylindrical or cuboid shape to comprehensively match the natural osteochondral tissue. Herein, we employed reverse modeling and three-dimensional (3D) printing technologies to prepare subchondral bone and cartilage.

Methods: The osteochondral scaffold was prepared by bonding the subchondral bone and cartilage layers, and the curvature distribution and biomechanical behavior were compared with those of the native tissue.

Auriculasin induces mitochondrial oxidative stress and drives ferroptosis by inhibiting PI3K/Akt pathway in non-small cell lung cancer.

Non-small cell lung cancer (NSCLC) accounts for the majority of cases of lung cancer with poor outcomes. Auriculasin is a prenylated isoflavone abundant in the root of F. philippinensis with multiple pharmacological effects, including anticancer role.

Construction of a predictive model of 2-3 cm ground-glass nodules developing into invasive lung adenocarcinoma using high-resolution CT.

Background: The purpose of this study was to analyze the imaging risk factors for the development of 2-3 cm ground-glass nodules (GGN) for invasive lung adenocarcinoma and to establish a nomogram prediction model to provide a reference for the pathological prediction of 2-3 cm GGN and the selection of surgical procedures.

Methods: We reviewed the demographic, imaging, and pathological information of 596 adult patients who underwent 2-3 cm GGN resection, between 2018 and 2022, in the Department of Thoracic Surgery, Second Affiliated Hospital of the Air Force Medical University. Based on single factor analysis, the regression method was used to analyze multiple factors, and a nomogram prediction model for 2-3 cm GGN was established.

[Ecological characteristics and seasonal changes of macrozoobenthos in the waters of Miaodao Archipelago, China].

To understand the macrozoobenthic community composition and spatial-temporal distribution characteristics of macrobenthos in the waters of Miaodao Archipelago, Yantai, Shandong and its response to habitat changes, we conducted surveys of macrobenthos and environmental elements in the waters of Miaodao Islands in May (spring), August (summer), and October (autumn) in 2022. Results showed that a total of 127 macrozoobenthic species were recorded, with Mollusca and Annelida (Polychaeta) as the dominant taxa, consisting of 47 and 45 species, respectively. The key dominant species included , , , and () .

Pulmonary Tuberculosis Notification Rate Within Shenzhen, China, 2010-2019: Spatial-Temporal Analysis.

Background: Pulmonary tuberculosis (PTB) is a chronic communicable disease of major public health and social concern. Although spatial-temporal analysis has been widely used to describe distribution characteristics and transmission patterns, few studies have revealed the changes in the small-scale clustering of PTB at the street level.

Objective: The aim of this study was to analyze the temporal and spatial distribution characteristics and clusters of PTB at the street level in the Shenzhen municipality of China to provide a reference for PTB prevention and control.

Characterizing Infections in Two Epidemic Waves of SARS-CoV-2 Omicron Variants: A Cohort Study in Guangzhou, China.

Background: After the adjustment of COVID-19 epidemic policy, mainland China experienced two consecutive waves of Omicron variants within a seven-month period. In Guangzhou city, as one of the most populous regions, the viral infection characteristics, molecular epidemiology, and the dynamic of population immunity are still elusive.

Methods: We launched a prospective cohort study in the Guangdong Provincial CDC from December 2022 to July 2023.

Understanding risky driving behaviors among young novice drivers in Nigeria: A latent class analysis coupled with association rule mining approach.

Traffic crashes are significant public health concern in Nigeria, particularly among young drivers. The study aims to explore the underlying pattern of risky driving behaviors and the associations with demographic factors among young drivers in Nigeria. A combined approach of Latent Class Analysis (LCA) and Association Rule Mining is applied to the dataset comprising responses from 684 young drivers who complete the "Behavior of Young Novice Drivers Scale" (BYND) questionnaires.

Exploring Effects and Mechanism of Ingredients of Herba Epimedii on Osteogenesis and Osteoclastogenesis .

Background: Herba Epimedii, a commonly used traditional herb, has been proven effective in ameliorating osteoporosis. However, the active ingredients and potential mechanism need further exploration.

Objective: To screen active ingredients of Herba Epimedii with the effect of ameliorating osteoporosis and to explore their potential mechanisms.

Effect of open versus video-assisted thoracoscopy on perioperative outcomes and survival for cases of thymic carcinomas and thymic neuroendocrine tumors.

Background: The oncology-related indices between open and video-assisted thoracoscopic surgery (VATS) procedures for thymic carcinomas (TCs) and thymic neuroendocrine tumors (TNETs) remain unclear.

Methods: Propensity score matching (PSM) and multivariate Cox proportional risk models were used to evaluate the perioperative outcomes and survival rates of patients undergoing open and VATS for TCs and TNETs at the Second Affiliated Hospital of Air Force Military Medical University Hospital, between 2009 and 2018.

Results: Of the total 126 cases of TCs and TNETs, VATS treatment was used in 39 (30.

Addressing endogeneity between hazardous actions and motorcyclist injury severity by integrating generalized propensity score approach and instrumental variable model.

Motorcyclist hazardous actions (e.g., particularly speed too fast or failing to stop in assured clear distance (ACD)) are commonly identified as risk factors that significantly impact the motorcyclist injury severity.

Inhibitory effects of simeprevir on and itsbiofilm in vitro.

Objectives: () is a Gram-positive opportunistic pathogen that often causes hospital infections. With the abuse of antibiotics, the resistance of gradually increases, and drug repurposing has become a research hotspot in the treating of refractory drug-resistant bacterial infections. This study aims to study the antimicrobial and antibiofilm effects of simeprevir, an antiviral hepatitis drug, on in vitro.

Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019-2021.

Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied.

NCOA2-induced secretion of leptin leads to fetal growth restriction via the NF-κB signaling pathway.

Background: Fetal growth restriction (FGR) is one of the most common fetal complications during pregnancy in the obstetrics department, with poor therapeutic efficacy. The local inflammatory response of the placenta has gradually become known as the main mechanism for the occurrence and development of FGR. The aim of this study was to improve the knowledge of placental inflammatory response mechanisms in regulating gene expression.

Analysis of anti-M antibody status and blood transfusion strategy in Hunan, China.

Background: By analyzing the detection rate of anti-M antibody in patients with the MNS blood group system in the Hunan area, we aimed to explore its clinical significance and blood transfusion strategy.

Methods: We retrospectively analyzed the clinical data of patients who had been confirmed to contain anti-M antibodies through serological methods such as the saline tube method and cassette anti-human globulin method.

Results: Irregular antibody screening tests had been applied to 94,452 patients, from which 652 results were positive.

Corrigendum: Exploration of shared gene signature with development of pre-eclampsia and cervical cancer.

[This corrects the article DOI: 10.3389/fgene.2022.

Oncogenic Role of HMGB1 as An Alarming in Robust Prediction of Immunotherapy Response in Colorectal Cancer.

Objective: To assess the correlation between HMGB1 expression and the patient prognosis in a multicancer context.

Methods: The potential oncogenic role of HMGB1 was explored in forty tumors through the TCGA, GEO, and Oncomine datasets. We analyzed the clinical prognostic value and antitumor immunotherapy of HMGB1 in a multicancer context using GEO (GSE111636).