[Expression of Concern] miR‑30a inhibits glioma progression and stem cell‑like properties by repression of Wnt5a.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the control GADPH western blots shown in Fig. 5D were strikingly simillar to three lanes in the GAPDH panel shown in Fig. 4D, even though the experimental conditions reported in these figure parts were different, suggesting that one of these figures may have been assembled incorrectly.

Burden and risk factors of stroke worldwide and in China: An analysis from the Global Burden of Disease Study 2021.

Background: Stroke is the leading cause of death and long-term disability worldwide, including China. This study aimed to provide timely updates on stroke burden and stroke-related risk factors to help improve population-based prevention and control strategies.

Methods: Based on the Global Burden of Disease study 2021, incidence rate, prevalence rate, mortality rate, and disability-adjusted life-year (DALY) rate were used to estimate stroke burden trend from 1990 to 2021.

Larval antibiotic exposure causes persistent impacts on honeybees across life stages via metabolic succession.

Gut microbiomes are profoundly important to host health. In apiculture, antibiotics frequently used to exclude bacterial pathogens can be detrimental to the honeybee gut microbiota and host fitness, generally from larvae to adults. However, the mechanisms underlying these persistent effects remain largely unknown.

Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Promising Biomarker for Poststroke Depression After Acute Ischemic Stroke.

Background: Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) was reported to induce inflammatory responses, enhance microglial survival, and contribute to the development of neurodegenerative disorders. We aimed to prospectively investigate the association between plasma sTREM2 levels and poststroke depression (PSD).

Methods: We measured plasma sTREM2 levels in 590 patients with ischemic stroke from 7 participating hospitals of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke) trial.

Breakthrough Recognition in Robotic-Assisted UBE Surgery Based on Force Sensing and VAE-MLP.

Background: Robotic-assisted unilateral biportal endoscopic surgery (UBE) is a more accurate and safer technique than traditional open surgical operations. The penetration recognition of ultrasonic drilling remains one of the challenging techniques of robotic-assisted UBE surgery.

Methods: We propose a force and VAE-MLP-based method for real-time penetration recognition.

[Application of limb shortening/re-lengthening technique and tissue regeneration technique in limb salvage for complex lower limb fractures combined with soft tissue defects].

Objective: To explore the effectiveness of limb shortening/re-lengthening technique combined with tissue regeneration technique in limb salvage for patients with complex lower limb fractures and soft tissue defects.

Methods: Between January 2021 and December 2024, 12 patients with complex lower limb fractures and soft tissue defects caused by trauma were admitted. There were 10 males and 2 females; the age ranged from 18 to 46 years, with an average of 36 years.

Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery.

Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and cellular composition. Exosomes secreted by bone marrow mesenchymal stem cells (BMSCs) are emerging as a promising strategy to promote bone regeneration due to exosomal bioactive cargos. Furthermore, N6-Methyladenosine (m6A) methylation affects osteoblastic differentiation and bone remodeling.

Visible-Light-Mediated Cascade Arylcarboxylation/Cyclization of -Aryl/Benzoyl Acrylamide with CO.

A visible-light-mediated radical cascade arylcarboxylation/cyclization of -alkyl--methacryloylbenzamides and -alkyl--arylmethacrylamides with carbon dioxide (CO) was established. The reactions employed economical CO as the carboxyl source, cesium carbonate as the base, triphenylsilane as the additive, and -Ir(ppy) as the photocatalyst. Novel 1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-4-ylacetic acid derivatives and oxindole-3-acetic acid derivatives were obtained in moderate to good yields.

Multi-Omics Analyses Reveal Metabolic Regulatory Networks in Salinity and Drought Adaptation of Basil QF, a Chinese Cultivar.

The Ocimum genus, valued for its culinary, medicinal, and aromatic uses, is often cultivated in regions affected by drought and salinity. This study investigates the adaptive responses of QingFeng (QF), a newly identified basil cultivar locally known as vegetable "jingjie" in China, to high salinity and drought stress. DNA barcoding, mucilaginous seed analysis, flow cytometry, and karyotyping confirmed QF's identity, revealing a chromosome number of 2n = 76 and a 1C genome size of 2962 ± 36 Mb.

High Plasma Sarcosine Levels Are Associated with Decreased Risks of Adverse Outcomes After Ischemic Stroke: A Multicenter Prospective Study.

Sarcosine has been reported to improve ischemic tolerance in animal models of brain ischemia, but population-based evidence from patients with ischemic stroke is lacking. We conducted a multicenter prospective study to investigate the associations between plasma sarcosine levels and adverse outcomes among patients with ischemic stroke. We measured plasma sarcosine levels among 3473 patients with ischemic stroke from 26 hospitals across China.

Clinical Features and Therapeutic Evaluation of Central Nervous System Involvement in Pediatric Anaplastic Large Cell Lymphoma.

Background: This study analyzed the clinical features of central nervous system involvement (CNS3) in pediatric anaplastic large cell lymphoma (ALCL) and evaluated the CNCL-ALCL-2017 treatment protocol efficacy.

Methods: The clinical data of 215 pediatric ALCL patients aged ≤18 years, including 16 with CNS3, treated following the CNCL-ALCL-2017 protocol, were enrolled. Independent risk factors of CNS3 were determined using multi-factor logistic regression analysis, and survival curves were constructed.

Clinical characteristics and treatment evaluation of diffuse large B-cell lymphoma in Chinese children and adolescents: a multicenter clinical study of China-Net childhood lymphoma group B-NHL-2017.

Background: China-Net Childhood Lymphoma (CNCL) group B-NHL-2017 study is a prospective multi-center study in China, with the purpose of standardizing the diagnosis and treatment of childhood lymphoma, and improving the prognosis.

Methods: From May 2017 to June 2023, 20 centers participated in the diffuse large B-cell lymphoma (DLBCL) study. The clinical data were analyzed to summarize the clinical characteristics, treatment response and outcome.

Efficacy and safety of transcatheter arterial embolization combined with ablation and regorafenib for unresectable hepatocellular carcinoma patients failing first-line treatment: a real-world study.

Background: Most patients with hepatocellular carcinoma (HCC) have progressed to the intermediate or advanced stage when diagnosed and are ineligible for curative therapies. The currently available therapeutic options, including ablation, radioembolization, transarterial chemoembolization (TACE), and systemic treatment with tyrosine kinase inhibitors (TKIs), provide limited survival benefits. Studies have suggested that the combination treatment may provide better therapeutic outcomes as compared to individual treatments.

Construction of synthetic constitutive promoters and evaluation of their expression strengths in Sf9, HEK293T, and BmN cells.

ObjectivesConstitutive promoters have been widely studied and utilized in silkworm resistance breeding and expression of beneficial proteins, but there is limited research comparing the activities of different promoters across various source cell.MethodsThis study screened three promoters, namely, the gene promoter (p) of nuclear polyhedrosis virus (BmNPV), the cytoplasmic actin 3 promoter (p) and the cytoplasmic actin 4 promoter (p). Enhancer fragments hr3 and hr5 were combined with the three promoters to driving the expression of luciferase () and vacuolar-type ATPase c ().

The avoidance response in plant root to the environmental pollutant triclosan.

Triclosan (TCS), an antimicrobial agent commonly found in personal care products and disinfectants, has raised concerns due to its potential risks for human health and environment. In this study, we observed and investigated an avoidance response in Arabidopsis roots, which exhibited directional growth away from TCS-containing medium. Genetic screening of the mutants impaired in salt stress, abscisic acid (ABA), cytokinin, and auxin signaling pathways revealed that polar auxin transport is essential for mediating this TCS-induced root response.

Ultralarge-Scale Synthesis of Uniformly Dispersive Ultrafine Copper Nanoparticles/Copper(II)-Benzene-1,3,5-tricarboxylate for Selective C2-Acylation of Indole with α-Oxocarboxylic Acids.

Copper nanoparticles (CuNPs) are widely used in nanotechnology due to their cost-effectiveness and unique catalytic properties, yet their large-scale synthesis with high activity, stability, and practicality remains challenging. We present an efficient top-down strategy for ultralarge-scale synthesis of uniformly dispersed ultrafine copper nanoparticles/copper(II)-benzene-1,3,5-tricarboxylate (CuNPs/Cu-BTC or CuNPs/HKUST-1, HKUST = Hong Kong University of Science and Technology) using inexpensive copper powder under ambient conditions. Comprehensive characterization (X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetry analysis (TGA), inductively coupled plasma-mass spectrometry (ICP-MS), and Brunauer-Emmett-Teller (BET) analysis) confirmed the successful synthesis of the catalyst featuring 9 nm CuNPs (18% Cu content) uniformly anchored to the metal-organic frameworks (MOFs).

Diagnosis and treatment of hemothorax following local ablation in patients with primary liver cancer.

Objective: To investigate the diagnosis and treatment methods for hemothorax resulting from local ablation in patients with primary liver cancer.

Methods: A retrospective analysis was conducted on the clinical data of patients who underwent hemothorax after local ablation for liver cancer at the Center for Hepatology and Oncology Interventional Therapy, Beijing You’an Hospital, from January 2022 to December 2023. The study focused on the diagnosis and treatment of postoperative hemothorax, evaluating the effectiveness and safety of these methods.

LGFUNet: A Water Extraction Network in SAR Images Based on Multiscale Local Features with Global Information.

To address existing issues in water extraction from SAR images based on deep learning, such as confusion between mountain shadows and water bodies and difficulty in extracting complex boundary details for continuous water bodies, the LGFUNet model is proposed. The LGFUNet model consists of three parts: the encoder-decoder, the DECASPP module, and the LGFF module. In the encoder-decoder, the Swin-Transformer module is used instead of convolution kernels for feature extraction, enhancing the learning of global information and improving the model's ability to capture the spatial features of continuous water bodies.

Sleep, carotid intima-media thickness, and arterial stiffness: results from a large longitudinal cohort study.

Background: To evaluate the associations of sleep health with carotid intima-media thickness (CIMT) and arterial stiffness.

Methods: A total of 41 465 UK Biobank participants were included. Sleep traits were assessed at baseline via self-reported questionnaires, and a composite sleep score was constructed based on six factors: sleep duration, snoring, insomnia, chronotype, daytime napping, and daytime sleepiness, with higher scores indicating poorer sleep health.

Electrochemical Synthesis of β-Keto Phosphorodithioates via Difunctionalization of Alkenes under Metal-Free Conditions.

An efficient and green one-pot four-component strategy for the synthesis of β-keto phosphorodithioates via difunctionalization of alkenes using air as the oxygen source and cheap phosphorus pentasulfide (PS) as the sulfur and phosphorus source has been successfully reported at room temperature. This method features simple operation, mild conditions, step economy, wide range of substrates, and the avoidance of moisture-sensitive reagents/pre-functionalized substrates. These advantages of this electrochemical protocol are consistent with the concept of green synthetic chemistry, providing a straightforward and efficient pathway to synthesize β-keto phosphorodithioate derivatives.

Remnant cholesterol and post-stroke cognitive function: A multicenter prospective study.

Objective: To explore the association between baseline remnant cholesterol (RC) levels and post-stroke cognitive impairment (PSCI) at three months following the event.

Methods: The data utilized in this research originated from a pre-arranged subsidiary investigation of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). RC levels were determined using the formula: RC (mmol/L) = total cholesterol (TC) - low-density lipoprotein cholesterol (LDL-C) - high-density lipoprotein cholesterol (HDL-C), and cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at three months post-stroke.

Increased plasma thrombospondin-1 is associated with poor prognosis in ischemic stroke patients.

Background And Aims: Thrombospondin-1 (THBS1) plays an important role in the modulation of coagulation, inflammatory response, vascular structure, and blood-brain barrier function, but its impact on clinical outcomes after ischemic stroke remains uncertain. We aimed to examine the relationship between plasma THBS1 levels and ischemic stroke prognosis in a multicenter observational study.

Methods And Results: Plasma THBS1 levels at baseline were measured in 3511 ischemic stroke patients enrolled between August 2009 and May 2013 in 26 hospitals across China.

Visible Light-Induced Radical-Cascade Difluoroalkylation/Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Difluoroalkylated Dihydropyrazoles and Tetrahydropyridazines.

Visible light-induced radical 5/6- difluoroalkylation/cyclization of -allyl and homoallyl aldehyde hydrazones with various fluoroalkyl bromides has been achieved. The reaction was carried out with alkyl difluoroacetates and difluoroacetamide as difluoroalkylation reagents and Eosin Y as an organic photocatalyst. Various difluoroalkylated dihydropyrazoles and tetrahydropyridazines were obtained under metal-free and mild conditions.

Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank.

Background: Several small-sample studies have suggested that biological processes of ageing are implicated with dementia and cognitive function. We aimed to prospectively investigate the associations of biological age with incident dementia, cognitive functions and brain structure based on the UK Biobank.

Methods: A total of 287 846 participants without dementia at baseline (followed until November 2022) were analysed.

Meta-analysis of bone-filling mesh container versus percutaneous kyphoplasty for osteoporotic vertebral compression fractures.

Objective: To evaluate the pros and cons of percutaneous kyphoplasty (PKP) and bone-filling mesh containers (BFC) by means of a meta-analysis in the treatment of osteoporotic vertebral compression fractures (OVCFs).

Materials And Methods: A comprehensive search of Cochrane Library, PubMed, Embase, CNKI, Wanfang Database, and Chinese biomedical literature database was conducted to identify eligible clinical control studies comparing BFC versus PKP for OVCFs published until December 2022. Meta-analysis was performed utilizing Revman 5.